Abstract. The Greenland Ice Sheet (GrIS) has been losing mass since the 1990s as a direct consequence of rising temperatures and has been projected to continue to lose mass at an accelerating pace throughout the 21st century, making it one of the largest contributors to future sea-level rise. The latest Coupled Model Intercomparison Project Phase 6 (CMIP6) models produce a greater Arctic amplification signal and therefore also a notably larger mass loss from the GrIS when compared to the older CMIP5 projections, despite similar forcing levels from greenhouse gas emissions. However, it is also argued that the strength of regional factors, such as melt–albedo feedbacks and cloud-related feedbacks, will partly impact future melt and sea-level rise contribution, yet little is known about the role of these regional factors in producing differences in GrIS surface melt projections between CMIP6 and CMIP5. In this study, we use high-resolution (15 km) regional climate model simulations over the GrIS performed using the Modèle Atmosphérique Régional (MAR) to physically downscale six CMIP5 Representative Concentration Pathway (RCP) 8.5 and five CMIP6 Shared Socioeconomic Pathway (SSP) 5-8.5 extreme high-emission-scenario simulations. Here, we show a greater annual mass loss from the GrIS at the end of the 21st century but also for a given temperature increase over the GrIS, when comparing CMIP6 to CMIP5. We find a greater sensitivity of Greenland surface mass loss in CMIP6 centred around summer and autumn, yet the difference in mass loss is the largest during autumn with a reduction of 27.7 ± 9.5 Gt per season for a regional warming of +6.7 ∘C and 24.6 Gt per season more mass loss than in CMIP5 RCP8.5 simulations for the same warming. Assessment of the surface energy budget and cloud-related feedbacks suggests a reduction in high clouds during summer and autumn – despite enhanced cloud optical depth during autumn – to be the main driver of the additional energy reaching the surface, subsequently leading to enhanced surface melt and mass loss in CMIP6 compared to CMIP5. Our analysis highlights that Greenland is losing more mass in CMIP6 due to two factors: (1) a (known) greater sensitivity to greenhouse gas emissions and therefore warmer temperatures and (2) previously unnotified cloud-related surface energy budget changes that enhance the GrIS sensitivity to warming.