Introduction. Penile cancer (PC) is one of the rare tumors, accounting for 1-2% of all neoplasms of the genitourinary system. The clinical course of the cancer process raises many questions among both urologistsoncologists in hospitals and outpatient doctors. A retrospective analysis of articles indicates that this process has not been sufficiently studied and requires more clinical observations to determine the diagnosis and correct treatment tactics for such patients.Materials and methods. Clinical observations of the development of human cancer in patients are presented. An analysis of original articles was also carried out in the following databases: Pubmed, Scopus, Scopus, Web of Science from 2007 to 2022, dedicated to this disease.Results. When a tumor of the penis was detected, one patient underwent surgical intervention to the extent of amputation of the glans penis. In the second patient, total damage to the penis was revealed, which required more radical surgical treatment including: Emasculation with urethroplasty. The third patient underwent radiation therapy and subsequently circumcision of the foreskin. The postoperative period in patients was without complications. No relapse was observed.Conclusion.Penile cancer, despite its rarity, is a pressing problem in modern oncology. Even with proper examination and treatment, it is difficult to predict the further development of the disease. These clinical cases force specialists to examine patients more carefully so as not to miss pathology that can cripple the patient and change his future lifestyle, and also shows different options for treatment outcomes for penile cancer.