Future Exploration Research Articles

Blood pressure management after endovascular thrombectomy: Insights of recent randomized controlled trials.

The ideal blood pressure (BP) target in patients who undergo endovascular thrombectomy (EVT) with successful reperfusion is uncertain. Observational studies show that elevated BP during this period is associated with a higher risk of intracranial hemorrhage (ICH) and worse clinical outcomes. Several randomized controlled trials (RCTs) have explored whether intensive BP lowering improves clinical outcomes in these patients. This review aims to summarize the recent RCTs that compare intensive and conventional BP management strategies following EVT and discuss the innovative directions to improve. The recently published RCTs failed to demonstrate the benefit of intensive BP control on the functional outcome and decreasing the risk of ICH. The complex mechanism in cerebral blood flow regulation and the inappropriate BP range chosen in RCTs may be the reasons behind the inconsistent results between observational studies and RCTs. Individualized BP management, reducing BP variability, and multi-stage BP management should be paid more attention in future exploration. Intensive BP target did not improve clinical outcomes after successful EVT as compared with a conventional BP target. Further research is required to identify the optimal BP management strategy after reperfusion.

Sedimentary build-ups of pre-salt isolated carbonate platforms and formation of deep-water giant oil fields in Santos Basin, Brazil

In response to the problems of unclear distribution of deep-water pre-salt carbonate reservoirs and formation conditions of large oil fields in the Santos passive continental margin basin, based on comprehensive utilization of geological, seismic, and core data, and reconstruction of Early Cretaceous prototype basin and lithofacies paleogeography, it is proposed for the first time that the construction of pre-salt carbonate build-ups was controlled by two types of isolated platforms: inter-depression fault-uplift and intra-depression fault-high. The inter-depression fault-uplift isolated platforms are distributed on the present-day pre-salt uplifted zones between depressions, and are built on half- and fault-horst blocks that were inherited and developed in the early intra-continental and inter-continental rift stages. The late intra-continental rift coquinas of the ITP Formation and the early inter-continental rift microbial limestones of the BVE Formation are continuously constructed; intra-depression fault-high isolated platforms are distributed in the current pre-salt depression zones, built on the uplifted zones formed by volcanic rock build-ups in the early prototype stage of intra-continental rifts, and only the BVE microbial limestones are developed. Both types of limestones formed into mound-shoal bodies, that have the characteristics of large reservoir thickness and good physical properties. Based on the dissection of large pre-salt oil fields discovered in the Santos Basin, it has been found that both types of platforms could form large-scale combined structural-stratigraphic traps, surrounded by high-quality lacustrine and lagoon source rocks at the periphery, and efficiently sealed by thick high-quality evaporite rocks above, forming the optimal combination of source, reservoir and cap in the form of “lower generation, middle storage, and upper cap”, with a high degree of oil and gas enrichment. It has been found that the large oil fields are all bottom water massive oil fields with a unified pressure system, and they are all filled to the spill-point. The future exploration is recommended to focus on the inter-depression fault-uplift isolated platforms in the western uplift zone and the southern section of eastern uplift zones, as well as intra-depression fault-high isolated platforms in the central depression zone. The result not only provides an important basis for the advanced selection of potential play fairways, bidding of new blocks, and deployment of awarded exploration blocks in the Santos Basin, but also provides a reference for the global selection of deep-water exploration blocks in passive continental margin basins.

Flux Density Stability and Temporal Changes in the Spectra of Millisecond Pulsars Using the GMRT

This paper presents an investigation of the spectral properties of 10 millisecond pulsars (MSPs) discovered by the uGMRT, observed from 2017 to 2023 using band 3 (300–500 MHz) and 4 (550–750 MHz) of the uGMRT. For these MSPs, we have reported a range of spectral indices from ∼0 to −4.8, while averaging the full observing band and all the observing epochs. For every MSP, we calculated the mean flux density across 7–8 subbands, each with approximately 25 MHz bandwidth spanning band 3 and band 4. We computed their modulation indices as well as average and maximum-to-median flux density within each subband. Using the temporal variations of the flux density we calculated the refractive scintillation timescales and estimated a structure function with a time lag for eight MSPs in the sample. We note a significant temporal evolution of the in-band spectra, classified into three categories based on the nature of the best-fit power-law spectra, having single positive spectral indices, multiple broken power laws, and single negative spectral indices. Additionally, indications of a low-frequency turnover and temporal variations of the turnover frequency (to the extent that turnover was observed for some of the epochs while not seen for the rest) were noted for all the MSPs. To the best of our knowledge, this is the first systematic investigation probing temporal changes in MSP spectra as well as in the turnover frequency. Future exploration with dense monitoring combined with the modeling of spectra can provide vital insight into the intrinsic emission properties of MSPs and interstellar medium properties.

Experimental study on comprehensive detection technology of shallow gas in deep soft soil layer

This study focuses on the underground shallow gas detection project in the Lingkun Island area of the northern entrance tunnel of the Wenzhou City Light Rail S2 line. Based on geological exploration data of shallow gas, we chose the technique of controlled-release gas with static pressure as the experimental foundation, integrating various technologies such as multi-functional in-situ probing, electrical methods, and seismic waves, comprehensively researching shallow gas detection technology in the Lingkun Island area. We conducted field probing experiments to accurately obtain the physical and mechanical properties of gas-rich soil layers and further studied the possibility of determining gas-rich locations. By applying parallel electrical methods, we can accurately identify and distinguish areas of anomalous resistivity in shallow geological structures. Based on abnormal changes in acoustic impedance in strata, we used seismic wave methods, including seismic CT and seismic wave scattering technology, to accurately reveal the presence and depth of shallow gas, providing reliable basis for accurate determination of shallow gas. Finally, we summarized a comprehensive plan for underground shallow gas detection technology, covering on-site data collection, data processing, and image interpretation of results, which will provide valuable references for future shallow gas exploration in relevant areas.

Hydrocarbon accumulation and orderly distribution of whole petroleum system in marine carbonate rocks of Sichuan Basin, SW China

Based on the situation and progress of marine oil/gas exploration in the Sichuan Basin, SW China, the whole petroleum system is divided for marine carbonate rocks of the basin according to the combinations of hydrocarbon accumulation elements, especially the source rock. The hydrocarbon accumulation characteristics of each whole petroleum system are analyzed, the patterns of integrated conventional and unconventional hydrocarbon accumulation are summarized, and the favorable exploration targets are proposed. Under the control of multiple extensional-convergent tectonic cycles, the marine carbonate rocks of the Sichuan Basin contain three sets of regional source rocks and three sets of regional cap rocks, and can be divided into the Cambrian, Silurian and Permian whole petroleum systems. These whole petroleum systems present mainly independent hydrocarbon accumulation, containing natural gas of affinity individually. Locally, large fault zones run through multiple whole petroleum systems, forming a fault-controlled complex whole petroleum system. The hydrocarbon accumulation sequence of continental shelf facies shale gas accumulation, marginal platform facies-controlled gas reservoirs, and intra-platform fault- and facies-controlled gas reservoirs is common in the whole petroleum system, with a stereoscopic accumulation and orderly distribution pattern. High-quality source rock is fundamental to the formation of large gas fields, and natural gas in a whole petroleum system is generally enriched near and within the source rocks. The development and maintenance of large-scale reservoirs are essential for natural gas enrichment, multiple sources, oil and gas transformation, and dynamic adjustment are the characteristics of marine petroleum accumulation, and good preservation conditions are critical to natural gas accumulation. Large-scale marginal-platform reef-bank facies zones, deep shale gas, and large-scale lithological complexes related to source-connected faults are future marine hydrocarbon exploration targets in the Sichuan Basin.

Gate-Based Variational Quantum Algorithm for Truss Structure Size Optimization Problem

Quantum computing has become a pivotal innovation in computational science, offering novel avenues for tackling the increasingly complex and high-dimensional optimization challenges inherent in engineering design. This paradigm shift is particularly pertinent in the domain of structural optimization, where the intricate interplay of design variables and constraints necessitates advanced computational strategies. In this vein, the gate-based variational quantum algorithm utilizes quantum superposition and entanglement to improve search efficiency in large solution spaces. This paper delves into the gate-based variational quantum algorithm for the discrete variable truss structure size optimization problem. By reformulating this optimization challenge into a quadratic, unconstrained binary optimization framework, we bridge the gap between the discrete nature of engineering optimization tasks and the quantum computational paradigm. A detailed algorithm is outlined, encompassing the translation of the truss optimization problem into the quantum problem, the initialization and iterative evolution of a quantum circuit tailored to this problem, and the integration of classical optimization techniques for parameter tuning. The proposed approach demonstrates the feasibility and potential of quantum computing to transform engineering design and optimization, with numerical experiments validating the effectiveness of the method and paving the way for future explorations in quantum-assisted engineering optimizations.

Opportunities and Challenges in the Development of Antibody-Drug Conjugate for Triple-Negative Breast Cancer: The Diverse Choices and Changing Needs.

Triple-negative breast cancer (TNBC) is a highly heterogeneous breast cancer subtype, which is also characterized by the aggressive phenotype, high recurrence rate, and poor prognosis. Antibody-drug conjugate (ADC) is a monoclonal antibody with a cytotoxic payload connected by a linker. ADC is gaining more and more attention as a targeted anti-cancer agent. Clinical studies of emerging ADC drugs such as sacituzumab govitecan and trastuzumab deruxtecan in patients with metastatic breast cancer (including TNBC) are progressing rapidly. In view of its excellent clinical efficacy and good tolerability, Sacituzumab govitecan gained accelerated approval by the FDA for the treatment of advanced metastatic TNBC in 2020. This review discusses the treatment status and challenges in TNBC, with an emphasis on the current status of ADC development and clinical trials in TNBC and metastatic breast cancer. We also summarize the clinical experience and future exploration directions of ADC development for TNBC patients.

Three‐Dimensional Electrostatic Hybrid Particle‐In‐Cell Simulations of the Plasma Mini‐Wake Near a Lunar Polar Crater

AbstractLunar polar region has become the focus of future explorations due to the possible ice reservoir in the permanently shadowed craters. However, the space environment near the polar crater is quite complicated, and a plasma mini‐wake can be caused by the topographic obstruction. So far, three‐dimensional (3D) numerical simulations of the mini‐wake around a crater far larger than the Debye length are still limited. Here we present a 3D electrostatic hybrid particle‐in‐cell model to study the plasma mini‐wake of a polar crater on scale of about 1 km. It is found that the mini‐wake can begin upstream from the crater with a cone angle of about 8.8°. There is a plasma void with extra electrons near the leeward crater wall, where the electric potential can be as low as −60 V. A part of solar wind ions can be diverted into the crater, and the ratio of the diverted flux is about 4% on the crater bottom and about 18% on the windward crater wall, which provide an important source for the surface sputtering. Further studies show that the mini‐wake can change with the solar wind parameters and the crater shapes. Our results are helpful to assess the space environment and the water loss rate of a polar crater, and have general implications in studying the plasma mini‐wake caused by a crater on the other airless bodies.

Research of the impact of uniaxial tension on the thermoelectric properties of NbCoX (X=Ge, Sn, Pb) compounds

Half-Heusler materials have been confirmed as excellent thermoelectric materials. To simulate the stress conditions in engineering applications, we adopt uniaxial tensile strain to assess the impact of lattice changes on NbCoX (X=Ge, Sn, Pb) compound's thermoelectric performance. The research reveals that when NbCoX compounds are stretched by 1.5 %, the material almost does not decrease the power factor but significantly reduces thermal conductivity, thereby enhancing the ZT value. At a carrier concentration of 1E22 cm−3 and a temperature of 873 K, the predicted ZT values for p-type NbCoSn compound reach 0.359 and 0.354 after stretching by 1.5 % in the x-y and z directions, respectively. Compared to the previous original values, this improvement is approximately 1.5 times, highlighting the significant role of tensile strain in enhancing thermoelectric performance. This may be attributed to changes in compound lattice symmetry induced by strain, leading to increased defects and interfaces, which complicate phonon transport paths, resulting in a decrease in the average phonon mean free path and consequently lowering thermal conductivity. Additionally, with the increase in atomic number of Ge, Sn, and Pb, their thermoelectric figure of merit also increases continuously, with ZT values remaining higher under stretching than compression. Such research provides a new avenue for designing and optimizing high-performance thermoelectric materials and offers insights into strain engineering for future exploration of thermoelectric materials.

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes

Reactive changes of glial cells during neuroinflammation impact brain disorders and disease progression. Elucidating the mechanisms that control reactive gliosis may help us to understand brain pathophysiology and improve outcomes. Here, we report that adult ablation of autism spectrum disorder (ASD)-associated CHD8 in astrocytes attenuates reactive gliosis via remodeling chromatin accessibility, changing gene expression. Conditional Chd8 deletion in astrocytes, but not microglia, suppresses reactive gliosis by impeding astrocyte proliferation and morphological elaboration. Astrocyte Chd8 ablation alleviates lipopolysaccharide-induced neuroinflammation and septic-associated hypothermia in mice. Astrocytic CHD8 plays an important role in neuroinflammation by altering the chromatin landscape, regulating metabolic and lipid-associated pathways, and astrocyte-microglia crosstalk. Moreover, we show that reactive gliosis can be directly mitigated invivo using an adeno-associated virus (AAV)-mediated Chd8 gene editing strategy. These findings uncover a role of ASD-associated CHD8 in the adult brain, which may warrant future exploration of targeting chromatin remodelers in reactive gliosis and neuroinflammation in injury and neurological diseases.

Safeguarding Earth's biodiversity by creating a lunar biorepository.

Earth's biodiversity is increasingly threatened and at risk. We propose a passive lunar biorepository for long-term storage of prioritized taxa of live cryopreserved samples to safeguard Earth's biodiversity and to support future space exploration and planet terraforming. Our initial focus will be on cryopreserving animal skin samples with fibroblast cells. An exemplar system has been developed using cryopreserved fish fins from the Starry Goby, Asterropteryx semipunctata. Samples will be expanded into fibroblast cells, recryopreserved, and then tested in an Earth-based laboratory for robust packaging and sensitivity to radiation. Two key factors for this biorepository are the needs to reduce damage from radiation and to maintain the samples near -196° Celsius. Certain lunar sites near the poles may meet these criteria. If possible, further testing would occur on the International Space Station prior to storage on the Moon. To secure a positive shared future, this is an open call to participate in this decades-long program.

Incidence and influencing factors of kinesiophobia in patients with chronic heart failure: a scoping review.

Kinesiophobia denotes an excessive and irrational apprehension towards physical activity or exercise among patients, stemming from a perception of susceptibility to painful injury or re-injury. Cardiac rehabilitation stands pivotal in the secondary prevention spectrum for individuals with cardiovascular ailments, with exercise constituting a cornerstone of this regimen. However, the emergence of kinesiophobia poses a formidable challenge, diminishing patient adherence to cardiac rehabilitation protocols, particularly among those grappling with chronic heart failure. To bolster exercise-based rehabilitation initiatives in this cohort, a thorough comprehension of the multifaceted factors precipitating kinesiophobia is imperative. This review endeavors to delineate prevailing evidence and prevalence concerning kinesiophobia triggers in chronic heart failure patients, while pinpointing research lacunae for future exploration. Employing a scoping review methodology, our investigation culled data from diverse scholarly databases, including Embase, PubMed, Scopus, CINAHL, Web of Science, Medline, Sinomed, CNKI, Wangfan, and VIP. After thorough evaluation, 9 studies that met the inclusion criteria were ultimately incorporated. Our findings underscore a notable prevalence of kinesiophobia in chronic heart failure patients, predominantly influenced by socio-demographic factors, psychological and cognitive factors, disease and treatment factors, as well as lifestyle and behavior. Armed with these insights, future interventions can be tailored to mitigate kinesiophobia levels, fostering enhanced engagement in exercise-centric cardiac rehabilitation endeavors among patients grappling with chronic heart failure.

MDia2 is an important mediator of MRTF-A-dependent regulation of breast cancer cell migration.

Actin cytoskeletal dysregulation gives rise to metastatic dissemination of cancer cells. This study mechanistically investigates the impact of specific functional disruption of MRTF (a transcriptional co-factor of SRF) on breast cancer cell migration.This study establishes a novel mechanism linking mDia2 to MRTF-dependent regulation of cell migration and provides clinical evidence for the association between MRTF activity and increased malignancy in human breast cancer.Findings from these studies justify future exploration of specific small molecule inhibitor of the MRTF-SRF transcriptional complex as a potential therapeutic agent in breast cancer.

ELM-based control system applications: A bibliometric analysis and review

This study conducts a bibliometric analysis of the extreme learning machine (ELM) research, with a particular emphasis on ELM-based control systems and applications. The objective of this study is to identify research trends, collaboration opportunities, and challenges in ELM applications. The analysis comprises the identification and retrieval of 3,174 articles from Scopus between 2018 and 2023. VOSviewer 1.6.20 is used for data interpretation, identifying six distinct keyword clusters and revealing both well-established research areas and emerging fields with significant potential for future exploration. Key research trends indicate a shift towards advanced or hybrid approaches, with recent interest in integrating optimization techniques. In the analysis, opportunities for collaboration with leading researchers are also highlighted. The findings emphasize the wide range of applications for ELM in improving the robustness of control systems while also highlighting important issues that need to be addressed. Finally, this study provides valuable insights into the current state and future directions of ELM research, especially ELM-based control systems.

Mechanochemical synthesis of (Mg1−x Fe x )2SiO4 olivine phases relevant to Martian regolith: structural and spectroscopic characterizations

Abstract To fabricate metals from the base materials for future Mars exploration, synthesis of representative olivine phases and their structural and spectroscopic characterizations are of crucial importance. Using mechanochemical technique that mimics the mechanical weathering, a complete solid solution of (Mg1−x Fe x )2SiO4 has been synthesized to investigate the associated crystal chemical properties. X-ray powder diffraction data Rietveld analysis confirms that each polycrystalline sample crystallizes in space group Pbnm. The average crystallite size ranges between 80(1) nm and 223(4) nm. Each lattice parameter increases with increasing Fe-content due to the larger Fe2+ radius than that of Mg2+, following Vegard’s rule. For a given nominal chemical composition, substitution of Mg with Fe at the M1-site (4a: 0,0,0) is preferred to the M2-site (4c: x,y,¼). As a consequence, the average Fe-content lies slightly below the equivalence line for x = 0.2–0.8, indicating that the Fe/Mg ratio in the amorphous scattering content is most likely greater than unity. Characteristic Raman spectral features of the olivines have been explained in terms of the chemical composition (x). Simple regression models are demonstrated based on both X-ray diffraction and Raman spectroscopic data for the calculation of Mg/Fe in olivines. Diffuse reflectance UV/Vis spectra RATD analysis shows each olivine phase possesses direct band-gap between 3.38(3) eV and 4.90(3) eV. This study could keep valuable information to relevant databases for future human missions on Mars, in particular, for precise estimation of the representative olivines from the remote X-ray diffraction and spectroscopic data.

Confined Z-Pinch Magnetic Nozzle : A New Approach to Space Propulsion System that Utilizes Trapped Charged Particles

This paper provides a theoretical overview of a Z-pinch magnetic nozzle plasma propulsion system designed for Low Earth Orbit (LEO). The system utilizes trapped charged particles from the spacecraft's environment and magnetic confinement to generate thrust, reducing the need for onboard propellants. By employing a magnetic mirror configuration, the plasma is confined and accelerated to create propulsion. The proposed propulsion system is tailored to function in the dynamic space radiation environment of LEO, particularly in polar orbits, accounting for variations in solar activity that affect trapped protons and electrons. The mechanism involves converting magnetic plasma energy into directed kinetic energy, facilitating efficient plasma detachment and momentum transfer to the spacecraft. This study examines the feasibility, design overview, and constraints of implementing this propulsion technology. Key challenges include the variability of the space environment, technological complexities, radiation effects, plasma detachment efficiency, energy requirements, and material durability. Overcoming these challenges through innovative engineering and rigorous testing is essential for successful implementation. The Z-pinch magnetic nozzle plasma propulsion system promises to advance space propulsion technology, offering a more efficient and cost-effective method for satellite operations in LEO. With further research and development, it has the potential to support future satellite missions and space exploration initiatives.

Isolation and biochemical screening of Phosphate Solubilizing Bacteria from Kans grass rhizosphere of Fly Ash Dump Sites near NTPC, Angul

Soil bacteria, capable of converting insoluble phosphorus into soluble, plant-accessible forms, collectively known as phosphate-solubilizing bacteria (PSB), have emerged as an eco-friendly and cost-effective solution for supplying phosphorus to plants. This study presents preliminary insights into the rhizospheric bacterial population associated with the vigorously growing kans grass (Saccharum spontaneum L.) at different fly ash disposal sites of NTPC, Kaniha in Angul district, Odisha. In the quest for efficient plant growth promoting rhizobacteria (PGPR) strains with diverse beneficial activities, a total of sixteen bacterial isolates were collected from the rhizosphere of chosen plant species and identified, with only ten isolates underwent biochemical characterization. Among these, four isolates exhibiting a higher phosphate-solubilizing index were further characterized, serving as a foundation for future exploration of the bio-prospective potential of rhizosphere bacteria in this unique ecological niche. Further assessment of these isolates, showcasing several plant growth-promoting (PGP) traits, is essential to determine their efficacy as potent PGPR agents.

A Bibliometric Analysis of the Implementation of Diversity, Equity, and Inclusion (DEI) in the Technology Industry

This study presents a comprehensive bibliometric analysis of research on Diversity, Equity, and Inclusion (DEI) in the technology industry, focusing on thematic clusters, research trends, potential research topics, and author collaborations. The analysis reveals that diversity and inclusion are central themes, with significant attention also given to gender diversity, equality, and innovation. Recent research trends highlight emerging areas such as accessibility, disability, and artificial intelligence. Potential research topics identified include accessibility and inclusive design, intersectionality, and the role of leadership in promoting DEI. The author collaboration network shows strong intra-group collaborations but limited inter-group interactions, suggesting opportunities for broader interdisciplinary research. This analysis provides valuable insights into the current state of DEI research in the tech industry and identifies key areas for future exploration to foster more inclusive and equitable environments.

Biometric based payment system

The increasing need for secure and convenient payment methods has fueled the exploration of biometric authentication systems. This paper presents a Biometric Based Payment System designed to streamline transactions while prioritizing security. The system employs a fingerprint sensor (R307) to ensure robust user identification, complemented by a 4x4 keypad for versatile input and an I2C OLED display for clear feedback. At its core, the system leverages an ESP32 microcontroller and robust SHA-256 encryption to protect sensitive information during storage and transmission. Transaction data resides in a centralized MySQL database on an Apache server, and users manage payment history through a web interface. The system emphasizes security and ease of use, with the potential for future exploration of multi-factor authentication, offline capabilities, and blockchain integration to further enhance its robustness

Neuromodulatory Compensation of Cortical Neural Activity on Electrodeposited Pt/Ir Modified Microelectrode Arrays for Temperature Transients.

Temperature has a profound influence on various neuromodulation processes and has emerged as a focal point. However, the effects of acute environmental temperature fluctuations on cultured cortical networks have been inadequately elucidated. To bridge this gap, we have developed a brain-on-a-chip platform integrating cortical networks and electrodeposited Pt/Ir modified microelectrode arrays (MEAs) with 3D-printed bear-shaped triple chambers, facilitating control of temperature transients. This innovative system administers thermal stimuli while concurrently monitoring neuronal activity, including spikes and local field potentials, from 60 microelectrodes (diameter: 30 μm; impedance: 9.34 ± 1.37 kΩ; and phase delay: -45.26 ± 2.85°). Temperature transitions of approximately ±10 °C/s were applied to cortical networks on MEAs via in situ perfusion within the triple chambers. Subsequently, we examined the spatiotemporal dynamics of the brain-on-a-chip under temperature regulation at both the group level (neuronal population) and their interactions (network dynamics) and the individual level (cellular activity). Specifically, we found that after the temperature reduction neurons enhanced the overall information transmission efficiency of the network through synchronous firing to compensate for the decreased efficiency of single-cell level information transmission, in contrast to temperature elevation. By leveraging the integration of high-performance MEAs with perfusion chambers, this investigation provides a comprehensive understanding of the impact of temperature on the spatiotemporal dynamics of neural networks, thereby facilitating future exploration of the intricate interplay between temperature and brain function.