Future Development Of Diabetes Research Articles

Studies of prediabetes in the spontaneously diabetic BB rat.

It is now well established that human type I diabetes is a chronic autoimmune process characterized by a rather “silent” prediabetic stage of several months to years in duration. (1) An important issue in diabetes research is the identification during the prediabetic period of subjects I at high risk of developing diabetes. Several immunologic and metabolic parameters have been studied to assess their reliability as predictors of 5 future development of diabetes in high risk individuals. Even if the combination of several of these factors proves to be highly specific in I defining the high risk individuals these studies require a lengthy follow-up period to ascertain their sensitivity and reliability in predicting impending diabetes.KeywordsMajor Histocompatibility ComplexBeta CellIslet AllograftAutoimmune Beta CellPrediabetic StageThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Glucose tolerance and excessively large infants: A twelve year follow-up study

1. Obesity, abnormal glucose curves, and repeated delivery of infants in excess of 4,500 grams are significant with regard to the future development of diabetes. Seventynine per cent of the patients in our study who had this triad are now diabetic.2. Of the 67 patients tested, 24 (36 per cent) are diabetic and 14 (21 per cent) have an abnormal curve in the nonpregnant state.3. Sixty per cent of the women who were delivered of one or more large infants now have a diabetic or prediabetic curve.