Advanced and free learning environment coupled with the creative learning activities is assumed to be a motivational variable. In the present study, we applied an innovative learning strategy involving students in order to achieve positive impact on their attitude towards science, desire to learn science and future career choices. The study experiment was focused on enhancing the research skills of the students; apply knowledge for solving real world problems, positively changing the students’ attitude towards science, raising students’ self-efficacy and enhance positivism toward science related subjects. This research assumes that if the attitude and perception of post-secondary students is changed and made positive about science, then they might choose to study related science subjects for example, mathematics, engineering and science at university level studies. Therefore, it will also impact students’ career choices after university studies and they might enter scientific careers. Our study focused on evaluating various changes in the attitude, desire and self-efficacy of participating students when traditional instruction is replaced through the innovative learning environment. A total of 120 students participated in our experiment where researchers assisted students to experience hands on different research activities. Pre and posttest were used to evaluate the change in students’ attitude and desire towards science, knowledge and self-efficacy. The study results have shown that significant changes in the performance of students’ for-example, student noticed positive attitude towards their own research abilities, desire to learn science, self-efficacy, learning and career choices. However, results did not show any differences based on gender as such.