Future Assessment Research Articles

Enhancing Sustainability through Ecosystem Services Evaluation: A Case Study of the Mulberry-Dyke and Fish-Pond System in Digang Village

The Mulberry-Dyke and Fish-Pond System, as a paradigm of traditional Chinese agricultural recycling models, represents a distinct ecosystem. This study focuses on the Mulberry-Dyke and Fish-Pond System in Digang Village, Huzhou, as a typical case. The village serves as a core conservation base for the Huzhou Mulberry-Dyke and Fish-Pond System, hosting the Huzhou Agricultural Science and Technology Development Center’s Academician and Expert Workstation and the world’s only Mulberry-Dyke and Fish-Pond System Visitor Center. These facilities provide strategic guidance for the conservation, development, planning, and inheritance of the Huzhou Mulberry-Dyke and Fish-Pond System. Considering the unique environment and limitations in data acquisition, this study employed the Analytic Hierarchy Process (AHP) and Fuzzy Comprehensive Evaluation (FCE) to develop an ecosystem service assessment framework encompassing eight aspects and 29 factors assessing the provisioning, regulating, and cultural services of the Mulberry-Dyke and Fish-Pond System. The results indicate that the ecosystem services of the Digang Village Mulberry-Dyke and Fish-Pond System perform at a high level, with cultural services playing a significant role in the overall ecosystem services. The regulating services are relatively weak, highlighting deficiencies in mulberry land management, while the capacity of provisioning services is strong. These findings are crucial for understanding the value of ecosystem services in Digang Village’s Mulberry-Dyke and Fish-Pond System, identifying management shortcomings, and providing direction for future assessments and management. This study also offers a practical and effective assessment method for ecosystem service evaluation at smaller scales, where the targeted approach and the presence of significant ambiguity and uncertainty in data are prominent.

Food web structure of fish communities of Doce River, 5years after the Fundão dam failure.

The rupture of the Fundão dam is considered the largest mining failure in history, which had a particularly detrimental impact on fish populations, as the mud from the ore tailings significantly altered the water quality and habitat of Doce River basin. This study aimed to assess the trophic structure of fish communities in areas impacted and not impacted by the dam rupture in the Doce River basin. To evaluate the food web structure, community-wide trophic niche, and trophic positions of fish, stable isotopes of carbon (δ13C) and nitrogen (δ15N) were utilized across ten sites (seven impacted and three control). In general, fish appeared to assimilate resources such as invertebrates, algae, and periphyton, although the importance of each resource varied among sites. The site closest to the dam rupture exhibited a more simplified trophic structure compared to the control sites and those nearer the river mouth. In this site, most fish species occupied a similar trophic position. Trophic niches also exhibited the greatest dissimilarity between the site closest to the dam failure and those farther away from it, with an expansion of trophic niche breadth observed with an increase in the distance from the dam rupture. Our study provided valuable insights into the trophic structure of fish communities within the Doce River basin, shedding light on the trophic ecology of the 59 fish species investigated. We also emphasize the importance of our study for future assessments of ore tailings dam failure disasters and evaluating the effectiveness of mitigation measures for Doce River basin recovery.

Diagnosis-Specific Thresholds of the Minimal Clinically Important Difference and Patient Acceptable Symptom State for KOOS After Total Knee Arthroplasty.

This article was updated on May 1, 2024 because of a previous error, which was discovered after the preliminary version of the article was posted online. The byline that had read "Ahmed K. Emara, MD 1 *, Ignacio Pasqualini, MD 1 *, Alison K. Klika, MS 1 , Melissa N. Orr, BS 1 , Pedro J. Rullán, MD 1 , Nicolas S. Piuzzi, MD 1 , and the Cleveland Clinic Arthroplasty Group†" now reads "Ahmed K. Emara, MD 1 *, Ignacio Pasqualini, MD 1 *, Yuxuan Jin, MS 1 , Alison K. Klika, MS 1 , Melissa N. Orr, BS 1 , Pedro J. Rullán, MD 1 , Nicolas S. Piuzzi, MD 1 , and the Cleveland Clinic Arthroplasty Group†". Literature-reported minimal clinically important difference (MCID) and patient acceptable symptom state (PASS) thresholds for patient-reported outcome measures demonstrate marked variability. The purpose of this study was to determine the minimal detectable change (MDC), MCID, and PASS thresholds for the Knee injury and Osteoarthritis Outcome Score (KOOS) Pain subdomain, Physical Function Short Form (PS), and Joint Replacement (JR) among patients with osteoarthritis (OA) who underwent primary total knee arthroplasty (TKA). A prospective cohort of 6,778 patients who underwent primary TKA was analyzed. Overall, 1-year follow-up was completed by 5,316 patients for the KOOS Pain, 5,018 patients for the KOOS PS, and 4,033 patients for the KOOS JR. A total of 5,186 patients had an OA diagnosis; this group had an average age of 67.0 years and was 59.9% female and 80.4% White. Diagnosis-specific MDCs and MCIDs were estimated with use of a distribution-based approach. PASS values were estimated with use of an anchor-based approach, which corresponded to a response to a satisfaction question at 1 year postoperatively. The MCID thresholds for the OA group were 7.9 for the KOOS Pain, 8.0 for the KOOS PS, and 6.7 for the KOOS JR. A high percentage of patients achieved the MCID threshold for each outcome measure (KOOS Pain, 95%; KOOS PS, 88%; and KOOS JR, 94%). The MDC 80% to 95% confidence intervals ranged from 9.1 to 14.0 for the KOOS Pain, 9.2 to 14.1 for the KOOS PS, and 7.7 to 11.8 for the KOOS JR. The PASS thresholds for the OA group were 77.7 for the KOOS Pain (achieved by 73% of patients), 70.3 for the KOOS PS (achieved by 68% of patients), and 70.7 for the KOOS JR (achieved by 70% of patients). The present study provided useful MCID, MDC, and PASS thresholds for the KOOS Pain, PS, and JR for patients with OA. The diagnosis-specific metrics established herein can serve as benchmarks for clinically meaningful postoperative improvement. Future research and quality assessments should utilize these OA-specific thresholds when evaluating outcomes following TKA. Doing so will enable more accurate determinations of operative success and improvements in patient-centered care. Prognostic Level II . See Instructions for Authors for a complete description of levels of evidence.

Unveiling intricate transformation pathways of emerging contaminants during wastewater treatment processes through simplified network analysis

As the key stage for purifying wastewater, elimination of emerging contaminants (ECs) is found to be fairly low in wastewater treatment plants (WWTPs). However, less knowledge is obtained regarding the transformation pathways between various chemical structures of ECs under different treatment processes. This study unveiled the transformation pathways of ECs with different structures in 15 WWTPs distributed across China by simplified network analysis (SNA) we proposed. After treatment, the molecular weight of the whole component of wastewater decreased and the hydrophilicity increased. There are significant differences in the structure of eliminated, consistent and formed pollutants. Amino acids, peptides, and analogues (AAPAs) were detected most frequently and most removable. Benzenoids were refractory. Triazoles were often produced. The high-frequency reactions in different WWTPs were similar, (de)methylation and dehydration occurred most frequently. Different biological treatment processes performed similarly, while some advanced treatment processes differed, such as a significant increase of -13.976 (2HO reaction) paired mass distances (PMDs) in the chlorine alone process. Further, the common structural transformation was uncovered. 4 anti-hypertensive drugs, including irbesartan, valsartan, olmesartan, and losartan, were identified, along with 22 transformation products (TPs) of them. OH2 and H2O PMDs occurred most frequently and in 80.81 % of the parent-transformation product pairs, the intensity of the product was higher than parent in effluents, whose risk should be considered in future assessment activity. Together our results provide a macrography perspective on the transformation processes of ECs in WWTPs. In the future, selectively adopting wastewater treatment technology according to structures is conductive for eliminating recalcitrant ECs in WWTPs.

Urban resilience assessment from the perspective of cross-media carbon metabolism

With the accelerating pace of globalization, uncertainty and unknown risks within open and complex urban systems increase with the occurrence of problems such as the conflict between humans and natural land use, water scarcity, and the continuing loss of biodiversity. Thus, the improvement of urban resilience has emerged as an important issue in the context of global urbanization. However, a knowledge gap remains in its evaluation from the perspective of systematic resource/element metabolic processes. To understand the urban resilience response mechanism better and depict metabolic processes systematically, an urban resilience assessment framework of “robustness-adaptability-restorability-coordination” based on the cross-media carbon metabolism network model was established. Principles of material flow analysis and ecological network analysis were applied to examine the urban resilience of Guangzhou, China, from 2010 to 2020. Results showed the urban resilience level decreased from a carbon metabolism perspective during the study period. This was reflected in an overall decline in system robustness and restorability, relatively unchanged adaptability, and a non-beneficial coordination relationship. Recommendations such as regulating key sectors (e.g., agriculture and construction) were proposed to improve urban resilience. This research will bring a new insight into future urban resilience assessment and contribute the urban sustainable development.

Using iterative 2δ‐technique and 4δ‐outlier test for evaluating the geochemical background concentrations of trace elements in topsoil at Cao Bang province, Vietnam

AbstractThis study investigated the geochemical background values for seven trace elements in topsoil samples collected from highland areas within Cao Bang province, Vietnam. Total concentrations of these elements were determined, revealing the following order of mean concentration: Zn > Cr > Pb > Cu > As > Ni > Co. The background values were calculated using two different methods including iterative 2δ‐technique and 4δ‐outlier test. The 4δ‐outlier test yielded the following background concentrations (dry weight) for the seven elements: As (24.41 ± 12.42 mg kg−1), Co (15.64 ± 10.57 mg kg−1), Cr (49.31 ± 33.41 mg kg−1), Cu (29.77 ± 27.14 mg kg−1), Ni (22.52 ± 13.33 mg kg−1), Pb (38.06 ± 31.48 mg kg−1), Zn (71.79 61.09 mg kg−1). The 2δ‐technique, on the other hand, resulted in the following background concentrations (dry weight) for the same elements: As (8.41 ± 8.57 mg kg−1), Co (5.06 ± 4.31 mg kg−1), Cr (26.72 ± 26.20 mg kg−1), Cu (25.31 ± 24.81 mg kg−1), Ni (8.02 ± 7.83 mg kg−1), Pb (28.12 ± 27.58 mg kg−1), Zn (51.91 ± 49.44 mg kg−1). These results provide valuable baseline data for future environmental assessments and monitoring programs in the region. They also highlight the potential impact of human activities, such as mining, on the geochemical landscape of highland areas.

Assessment on Strength and Stiffness Properties of Aged Structural Timber

Despite the growing popularity of wood and wood-based products in the construction industry, there has been insufficient focus on assessing the condition, preservation, and potential reuse of existing timber. While numerous standards evaluate the quality of freshly sawn timber, there is currently no standardized system for assessing the strength properties of aged and reused timber. The lack of these guidelines is also one of the reasons the results obtained in numerous research are often fluctuating, and we cannot draw clear conclusions. The matter is further complicated by the lack of data on old in-situ wood and its exploitation, which would help to evaluate its condition. Consequently, there is a real practical need to assess the condition of old timber to avoid unnecessary demolition and the loss of valuable and structurally sound building material. What sets this study apart from others is that, in addition to destructive testing, the 4-point non-destructive (ND) bending tests were conducted on all four faces of test specimens. This provided an opportunity to assess the wood visually and then find connections to associate external characteristics with real properties. This methodology aimed to determine whether it is feasible to visually assess the most practical way to use wooden elements in construction. If this question arises, which face of the beam would be better suited for the tension side and which for the compression side? The old timber used in testing originated from an old library building located on Vaksali Street, Tartu, Estonia and is estimated to be about 120 years old. This paper investigates and compares the collected data with a Nordic standard for grading fresh-sawn timber and two established Italian standards for visually assessing aged timber. This comparison contributes to developing a standardized framework for future visual assessments. ND and destructive four-point bending tests were performed to validate and find appropriate visual characteristics to determine the strength and stiffness of the timber elements. The primary goals of this study were first to compare the results obtained from existing ND methods with actual results and secondly to provide guidelines for better visual grading of wood in the future, based on Nordic Standard INSTA 142 (2010) and Italian standards UNI 11119 (2004) and UNI 11035 (2010) Contrary to previous research conclusions, the visual assessment results yielded unexpected outcomes. The results show that the grading standards significantly underestimated the real strength of the wood, and even more, none of the visual assessments overestimated the real strength of the specimens. Therefore, based on prior research and the findings derived from this study, there is evident a substantial potential for extensive development and optimization within this field.

The Probability of Ship Collision during the Fully Submerged Towing Process of Floating Offshore Wind Turbines

As global warming intensifies, the development of offshore wind farms is swiftly progressing, especially deep-water Floating Offshore Wind Turbines (FOWTs) capable of energy capture in deep-sea regions, which have emerged as a focal point of both academic and industrial interest. Although numerous researchers have conducted comprehensive and multifaceted studies on various components of wind turbines, less attention has been paid to the operational stage responses of FOWTs to wind, waves, and currents and the reliability of their structural components. This study primarily employs a theoretical analysis to establish mathematical models under a series of reasonable assumptions, examining the possibility of collisions between FOWT transport fleets and other vessels in the passage area during the towing process. Using the model, this paper takes the Wanning Floating Offshore Wind Farm (FOWF) project, which is scheduled to be deployed in the South China Sea, as its research object and calculates the probability of collisions between FOWTs and other vessels in three months from the pier near Wanning, Hainan, to a predetermined position 22 km away. The findings of the analysis indicate that the mathematical model developed in this study integrates the quantities and velocities of navigational vessels within the target maritime area as well as the speeds, routes, and schedules of the FOWT transport fleet. By employing statistical techniques and geometric calculations, the model can determine the frequency of collisions between various types of vessels and the FOWT transport fleet during the transportation period. This has substantial relevance for future risk assessments and disaster prevention and mitigation measures in the context of FOWT transportation.

Investigation of sex-based differences in the immunotoxicity of silver nanoparticles

The growing application of silver nanoparticles (AgNPs) in consumer, healthcare, and industrial products has raised concern over potential health implications due to increasing exposure. The evaluation of the immune response to nanomaterials is one of the key criteria to assess their biocompatibility. There are well-recognized sex-based differences in innate and adaptive immune responses. However, there is limited information available using human models. The aim was to investigate the potential sex-based differences in immune functions after exposure to AgNPs using human peripheral blood mononuclear cells (PBMCs) and plasma from healthy donors. These functions include inflammasome activation, cytokine expression, leukocyte proliferation, chemotaxis, plasma coagulation, and complement activation. AgNPs were characterized by dynamic light scattering and transmission electron microscopy. Inflammasome activation by AgNPs was measured after 6- and 24-hours incubations. AgNPs-induced inflammasome activation was significantly higher in the females, especially for the 6-hour exposure. No sex-based differences were observed for Ag ions controls. Younger donors exhibited significantly more inflammasome activation than older donors after 24-hours exposure. IL-10 was significantly suppressed in males and females after exposure. AgNPs suppressed leukocyte proliferation similarly in males and females. No chemoattractant effects, no alterations in plasma coagulation, or activation of the complement were observed after AgNPs exposure. In conclusion, the results highlight that there are distinct sex-based differences in inflammasome activation after exposure to AgNPs in human PBMCs. The results highlight the importance of considering sex-based differences in inflammasome activation induced by exposure to AgNPs in any future biocompatibility assessment for products containing AgNPs.

The Length-Weight Relationships of Twelve Fish Species from the Heishui River, China

Length-weight relationships are presented for twelve fish species collected at 22 sampling points in the Heishui River, a priority tributary for fish conservation in the mainstream of the Baihetan Reservoir area, China. A combination of gill nets was used for sampling over a period between November 2018 and May 2021. The gill nets consisted of 12 nets per point with dimensions of 20 × 2 m (length and width), mesh size ranging from 20 to 80 mm, and soaking depth ranging from 40 to 160 cm. In addition, fixed gill nets were employed, with 10 nets per point having dimensions of 10 to 30 m in length and 1.5 to 2.5 m in width. The mesh size of these fixed gill nets was 10, 15, or 20 mm. This study presents the length-weight relationships of twelve species for the first time in the Heishui River Basin, including the new maximum body length of Pseudorasbora parva (Temminck and Schlegel, 1846). The slope (b) values for the assessed species ranged from 2.5 to 3.5. All the estimated relationships are highly significant (P<0.05) with a high coefficient of determination R2 ranging from 0.9574 to 0.9997. It is expected that the results obtained from this study will contribute to filling the knowledge gap in this area and also assist fisheries scientists in future assessment studies.

Complex facies architecture of unusual pyroclastic density current deposits at the Rincón de la Vieja Volcano, Costa Rica

Pyroclastic Density Currents (PDCs) constitute a complex, multiphase, and multiscale volcanic process generated in a wide spectrum of eruptive scenarios and being among the most deadly and destructive volcanic hazards. Over the north flank of the Rincón de la Vieja Volcano, Costa Rica, previous works identified PDC deposits related to the plinian Río Blanco eruption, which is the largest Holocene explosive event recorded at this volcano. However, so far, there have been no in-depth studies aimed at understanding the eruptive style, and dynamics of the parental PDCs. This work presents, for the first time, a detailed facies analysis and architecture reconstruction (plus a geochemical characterization and novel C14 age determinations) of these outstanding deposits. The presence of cauliflower bombs, juvenile mega-blocks, scorias, and pumices, coupled with the scarcity of accidental and/or accessory lithics, is interpreted here as evidence of an unusual eruptive style. We propose that the Río Blanco eruption was a single complex eruption consisting of two successive phases, each involving the drainage of distinct magma batches. The PDCs were related to the sudden spill out of a lava-pool (Arenal-type PDC), during the collapse of an ultraproximal pyroclastic cone that was built in an initial plinian phase. The collapse of this ultraproximal cone produced a leading-edge pumice-rich PDC, which increased its mobility through fragmentation-induced fluidization. This leading edge PDC was followed by successive high concentrated, mafic, modified granular flow pulses derived from the lava-pool spill out. These modified granular flows were highly channelized in proximal zones, but when they reached the main break in slope, the basal underflow froze en masse while its upper, more diluted part started to decouple and move in a more unconfined manner. After the decoupling, the material feeding towards the basal zone of the surviving current produced a new underflow by rapid suspension sedimentation (“surge-derived pyroclastic flows”). Finally, our results indicate that the generation of Arenal-type PDCs is an underestimated scenario that should be considered in future short-term hazard and risk assessments at the Rincón de la Vieja Volcano, as well as in many other stratovolcanoes worldwide.

One Score to Rule Them All? Comparing the Predictive and Concurrent Validity of 30 Hearts and Flowers Scoring Approaches.

The Hearts and Flowers (H&F) task is a computerized executive functioning (EF) assessment that has been used to measure EF from early childhood to adulthood. It provides data on accuracy and reaction time (RT) across three different task blocks (hearts, flowers, and mixed). However, there is a lack of consensus in the field on how to score the task that makes it difficult to interpret findings across studies. The current study, which includes a demographically diverse population of kindergarteners from Boston Public Schools (N = 946), compares the predictive and concurrent validity of 30 ways of scoring H&F, each with a different combination of accuracy, RT, and task block(s). Our exploratory results provide evidence supporting the use of a two-vector average score based on Zelazo et al.'s approach of adding accuracy and RT scores together only after individuals pass a certain accuracy threshold. Findings have implications for scoring future tablet-based developmental assessments.

Level evaluation of concrete dam fractures based on game theory combination weighting-normal cloud model

Hazard evaluation of concrete dam fractures is vital for safe operations. The width (S1), length (S2), and depth (S3) of fractures are adopted as the assessment index, and the game theory combination weighting-normal cloud model is introduced. The normal cloud model of certain dam fractures is subsequently established. The weight coefficients of each index are calculated using game theory combination weighting, and the certainty degree of each index is determined using the cloud model. Finally, the hazard levels of the concrete dam fractures are judged. The proposed model solves the fuzziness and randomness of different indexes; the conclusions demonstrate that the model is feasible for the hazard assessment of concrete dam fractures, and its accuracy is very high; therefore, a new approach can be provided for future hazard-level assessments of concrete dam fractures.

Pre-operative immune cell numbers and ratios are associated with peri-operative adverse outcomes in transfused patients

Background and objectivesTransfusion-related immune modulation (TRIM) and associated adverse outcomes during major surgery are increasingly important to patients and health services internationally. A panel of pre-operative blood tests is an essential part of the pre-operative anaesthetic assessment. This panel of blood tests commonly considers numbers of immune cells (i.e., lymphocytes, monocytes, and neutrophils and cell ratios) that may be used as biomarkers to evaluate and potentially predict post-operative adverse outcomes.DesignThis retrospective data collection from eight hospital databases, within the Royal Brisbane and Women's Hospital, considered only patients who received blood transfusion during surgery (2016–2018) (n = 2,121). The association between pre-operative immune cell numbers and ratios and adverse outcomes were assessed. Adverse outcomes were coded using the International Classification of Diseases-10 (ICD-10) coding which specifically considered transfusion-related immune modulation. Results were adjusted for confounding factors.ResultsAfter adjustment, decreased pre-operative lymphocyte numbers and increased neutrophil/lymphocyte ratio (NLR) were associated with increased odds of developing infection; decreased NLR with decreased odds of developing adverse renal outcomes; and decreased lymphocyte numbers with decreased odds of developing adverse cardiovascular outcomes. Monocyte numbers, neutrophil numbers, and the lymphocyte/monocyte ratio (LMR) were not associated with increased adverse outcomes after adjustment.ConclusionPre-operative lymphocyte numbers and NLR are associated with adverse outcomes during peri-operative transfusion. Future assessment of peri-operative immune modulation should include the assessment of immune cell function and numbers.

Effects of Ramadan intermittent fasting on performance, physiological responses, and bioenergetic pathway contributions during repeated sprint exercise.

This investigation aims to elucidate the impact of Ramadan intermittent fasting on performance, physiological responses, and bioenergetic pathway contributions during repeated sprints. Fourteen active male Muslim athletes (age = 22.4 ± 1.8 years, body weight = 69.5 ± 3.8 kg, height = 176 ± 5.1 cm) executed a repeated sprint protocol, consisting of ten 20-meter sprints with 15-s passive recovery intervals, during both fasting and non-fasting conditions. The fasting session was conducted after a 12-14 h fast following Sahur (the pre-dawn meal during Ramadan). In contrast, the non-fasting session occurred before the Ramadan fasting period began, during the same hours of the day, at a time when fasting was not yet required for the athletes. Bioenergetic pathway contributions during repeated sprints were quantified using the PCr-LA-O2 method. The mean sprint time during fasting sessions was 3.4 ± 0.3 s compared to 3.3 ± 0.2 s in non-fasting sessions, indicating a trend approaching the threshold of significance for slower times in the fasted state (p = 0.052, effect size (ES) = 0.34). In terms of bioenergetic contributions, the total metabolic energy expenditure (TEE) was slightly lower during fasting sessions (236.5 ± 22 kJ) compared to non-fasting sessions (245.2 ± 21.7 kJ), but this difference was not statistically significant (p = 0.102, ES = 0.40). Similarly, metabolic energy expenditure per sprint was 23.7 ± 2.2 kJ in fasting conditions compared to 24.5 ± 2.2 kJ in non-fasting conditions (p = 0.106, ES = 0.35). The oxidative energy contribution did not differ significantly between fasting (34.2 ± 4.1 kJ) and non-fasting conditions (34.2 ± 4.1 vs. 35.5 ± 5.2 kJ; p = 0.238, ES = 0.28). Similarly, lactic (60.4 ± 7.6 vs. 59.2 ± 8.3 kJ; p = 0.484, ES = 0.15); and alactic (149.3 ± 19.9 vs. 143 ± 21.5 kJ; p = 0.137, ES = 0.30) energy contributions showed no significant differences between the fasting and non-fasting sessions. The percentage of performance decrement (Pdec) and the percentage contributions of oxidative, lactic, and alactic pathways to the total energy expenditure did not differ significantly between the fasting and non-fasting conditions, indicating a similar bioenergetic profile across both conditions. The present findings indicate no significant differences in performance metrics and metabolic outcomes between fasted and non-fasted states. Future assessments with longer duration and higher intensity protocols may provide further insights.

Statistical downscaling of high-resolution precipitation in India using convolutional long short-term memory networks

Abstract Statistical downscaling of the General Circulation Model (GCM) simulations are widely used for accessing climate changes in the future at different spatiotemporal scales. This study proposes a novel Statistical Downscaling (SD) model established on the Convolutional Long Short-Term Memory (ConvLSTM) Network. The methodology is applied to obtain future projection of rainfall at 0.25° spatial resolution over the Indian sub-continental region. The traditional multisite downscaling models typically perform downscaling on a single homogeneous rainfall zone, predicting rainfall at only one grid point in a single model run. The proposed model captures spatiotemporal dependencies in multisite local rainfall and predicts rainfall for the entire zone in a single model run. The study proposes a Shared ConvLSTM model providing a single end-to-end supervised model for predicting the future precipitation for entire India. The model captures the regional variability in rainfall better than a region-wise trained model. The projected future rainfall for different scenarios of climate change reveals an overall increase in the rainfall mean and spatially non-uniform changes in future rainfall extremes over India. The results highlight the importance of conducting in-depth hydrologic studies for different river basins of the country for future water availability assessment and making water resource policies.

Sliding and Paraesophageal Hiatal Hernias are Distinct Diseases: Surgeons are Responsible for Delineating the Differences

The outcomes for sliding and paraesophageal hiatal hernias (PHH) are jointly reported. By combining outcomes of sliding hernia and PHH repair, surgeons are conflating the outcomes of surgical management for GERD with the outcomes of PHH repair. PHH is a distinct clinical entity from sliding hernia, requiring a more complex operation with higher risk of complications and, ultimately, comparatively diminished outcomes. The practice of combining PHH and sliding hernia surgical data confounds the true outcomes of ARS and contributes to misconceptions that reduce referral rates. Current and future research assessments must be based on accurate discrimination between the 2 anatomic presentations. Surgeons have a responsibility to ensure this distinction is clearly drawn when disseminating their ARS outcomes.

Polygenic Risk Score in Predicting Esophageal, Oropharyngeal, and Hypopharynx Cancer Risk among Taiwanese Population.

Esophageal cancer shares strong associations with oropharyngeal and hypopharyngeal cancers, primarily due to shared risk factors like excessive tobacco and alcohol use. This retrospective study at Taichung Veterans General Hospital involved 54,692 participants, including 385 with squamous cell carcinoma (SCC) of the esophagus, oropharynx, or hypopharynx. Using a polygenic risk score (PRS) derived from 8353 single-nucleotide polymorphisms, researchers aimed to assess its correlation with cancer incidence and prognosis. The study found a 1.83-fold higher risk of esophageal, oropharyngeal, and hypopharyngeal SCCs in participants with a high PRS (Q4) compared to the low-PRS group (Q1). Esophageal cancer risk demonstrated a significant positive association with the PRS, as did hypopharyngeal cancer. Clinical parameters and staging showed limited associations with PRS quartiles, and the PRS did not significantly impact recurrence or mortality rates. The research highlighted that a higher PRS is linked to increased susceptibility to esophageal and hypopharyngeal cancer. Notably, a specific polygenic risk score, PGS001087, exhibited a discernible association with SCC risk, particularly in specific subtypes and advanced disease stages. However, it was not significantly linked to clinical cancer staging, emphasizing the multifactorial nature of cancer development. This hospital study reveals that a higher PRS correlates with increased susceptibility to esophageal and hypopharyngeal cancers. Notably, PGS001087 shows a discernible association with SCC risk in specific subtypes and advanced stages, although not significantly linked to clinical cancer staging. These findings enhance our understanding of genetic factors in upper aerodigestive tract cancers, particularly esophageal SCC, guiding future research and risk assessment strategies.

Evaluation of Immunodiagnostic Performances of Neospora caninum Peroxiredoxin 2 (NcPrx2), Microneme 4 (NcMIC4), and Surface Antigen 1 (NcSAG1) Recombinant Proteins for Bovine Neosporosis.

Bovine neosporosis is among the main causes of abortion in cattle worldwide, causing serious economic losses in the beef and dairy industries. A highly sensitive and specific diagnostic method for the assessment of the epidemiology of the disease, as well as it surveillance and management, is imperative, due to the absence of an effective treatment or vaccine against neosporosis. In the present study, the immunodiagnostic performance of Neospora caninum peroxiredoxin 2 (NcPrx2), microneme 4 (NcMIC4), and surface antigen 1 (NcSAG1) to detect IgG antibodies against N. caninum in cattle were evaluated and compared with that of the indirect fluorescent antibody test (IFAT). The results revealed that NcSAG1 had the highest sensitivity and specificity, with values of 88.4% and 80.7%, respectively, followed by NcPrx2, with a high sensitivity of 87.0% but a low specificity of 67.0%, whereas NcMIC4 showed sensitivity and specificity of 84.1% and 78.9%, respectively, when compared with IFAT. A high degree of agreement was observed for NcSAG1 (k = 0.713) recombinant protein, showing the highest diagnostic capability, followed by NcMIC4 (k = 0.64) and NcPrx2 (k = 0.558). The present study demonstrates that NcSAG1 is helpful as an antigen marker and also demonstrates the potential immunodiagnostic capabilities of NcPrx2 and NcMIC4, which could serve as alternative diagnostic markers for detecting N. caninum infection in cattle. These markers may find utility in future treatment management, surveillance, and risk assessment of neosporosis in livestock or other animal host species. Further research should be directed toward understanding the in vivo immune response differences resulting from immunization with both recombinant proteins.

Efficiency of Different Techniques in Collecting Insects in Environments Exposed to Palm Oil and Spent Engine Oil Effluents in Abakiliki, Ebonyi State

This study investigates the ecological consequences of palm oil and spent engine oil effluents on insect populations, employing a comparative analysis of two widely used collection techniques: pitfall traps and sweep netting. The aim was to assess the effectiveness of these methods in capturing and quantifying insect diversity and abundance in polluted environments. The research was conducted in selected sites exposed to palm oil and spent engine oil effluents, with corresponding control sites for comparison. Pitfall traps and sweep netting were deployed simultaneously to collect insects across various habitats impacted by the aforementioned effluents. The collected specimens were then identified to the lowest taxonomic level possible, and population data were analyzed to evaluate the relative impact of each effluent type on insect communities. Furthermore, statistical analyses were employed to compare the efficiency of pitfall traps and sweep netting in detecting changes in insect populations. The study revealed that pitfall traps recorded significantly higher number of insects (72.93%) than sweep nets (27.07%) in sites exposed to palm oil effluent (P<0.05). The result obtained in the site exposed to spent engine oil effluent showed that pitfall traps recorded significantly higher number of insects (80.61%) than sweep nets (19.39%) (P<0.05). This study contributes to the ecological repercussions of industrial effluents on insect populations, offering a methodological comparison that can enhance the precision of future insect-related environmental assessments.