You have accessJournal of UrologyProstate Cancer: Detection & Screening IV1 Apr 2014MP67-14 PREDICTIVE VALUE OF NEGATIVE 3T MULTIPARAMETRIC PROSTATE MRI ON 12 CORE BIOPSY RESULTS James Wysock, Andrew Rosenkrantz, Xiaosong Meng, Marc Bjurlin, Fabio Zattoni, William Huang, Michael Stifelman, Herbert Lepor, and Samir Taneja James WysockJames Wysock More articles by this author , Andrew RosenkrantzAndrew Rosenkrantz More articles by this author , Xiaosong MengXiaosong Meng More articles by this author , Marc BjurlinMarc Bjurlin More articles by this author , Fabio ZattoniFabio Zattoni More articles by this author , William HuangWilliam Huang More articles by this author , Michael StifelmanMichael Stifelman More articles by this author , Herbert LeporHerbert Lepor More articles by this author , and Samir TanejaSamir Taneja More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2081AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES While substantial evidence correlates suspicion for focal lesions on multiparametric prostate MRI (mpMRI) with likelihood of prostate cancer (PC), the predictive value (NPV) of a negative mpMRI remains variable across studies. This study reports cancer detection rates (CDR) in men undergoing 12-core systematic prostate biopsy (PB) following a negative prebiopsy mpMRI (NegMRI). METHODS Biopsy results in consecutive men undergoing trans-rectal ultrasound-guided systematic 12-core PB following a pre-biopsy 3T NegMRI between December 2011 and August 2013 were reviewed. A single radiologist reviewed all cases. Clinical characteristics, CDR, and NPV rates were summarized. A multivariate analysis was performed to identify factors predictive of cancer detection. RESULTS Of 333 men undergoing PB with prebiopsy mpMRI available during the study period, 67 (20.1%) had NegMRI. Tables 1 and 2 display results. For the entire cohort, biopsy naïve, men with prior negative biopsy and men enrolled in active surveillance, overall CDR was 17.9%, 8.3%, 8.3% and 42.1%, respectively, and detection of Gleason sum ≥ 7 (GS≥7) was 1.5%, 0%, 4.2% and 0%, respectively. The NPV for all cancers was 82.1%, 91.7%, 91.7%, and 57.9%, and for GS≥7 cancer was 98.5%, 100%, 95.8% and 100%, respectively. At multivariate analysis, being either biopsy-naïve or having a prior negative biopsy were significant predictors of a benign PB. CONCLUSIONS Negative prebiopsy mpMRI confers an overall NPV of 82% on 12-core biopsy for all cancer and of 98% for GS≥7. Based upon biopsy indication, these findings assist in risk stratification for detection of high risk disease and may provide guidance in the decision to pursue biopsy. © 2014FiguresReferencesRelatedDetailsCited byMendhiratta N, Rosenkrantz A, Meng X, Wysock J, Fenstermaker M, Huang R, Deng F, Melamed J, Zhou M, Huang W, Lepor H and Taneja S (2015) Magnetic Resonance Imaging-Ultrasound Fusion Targeted Prostate Biopsy in a Consecutive Cohort of Men with No Previous Biopsy: Reduction of Over Detection through Improved Risk StratificationJournal of Urology, VOL. 194, NO. 6, (1601-1606), Online publication date: 1-Dec-2015. Volume 191Issue 4SApril 2014Page: e754 Peer Review Report Advertisement Copyright & Permissions© 2014MetricsAuthor Information James Wysock More articles by this author Andrew Rosenkrantz More articles by this author Xiaosong Meng More articles by this author Marc Bjurlin More articles by this author Fabio Zattoni More articles by this author William Huang More articles by this author Michael Stifelman More articles by this author Herbert Lepor More articles by this author Samir Taneja More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...