A field experiment was conducted to study the effect of different rates of poultry manure on growth, yield, incidence and severity of fusarium wilt on three varieties of pepper (Capsicum annuum). The research was carried out at the Crop Science and Horticulture research farm of the Faculty of Agriculture, Nnamdi Azikiwe University Awka, Anambra State-06⁰15ˈ2ˈˈN,7⁰6ˈ59ˈˈand 51m above sea level. The experiment lasted from June to August 2019 wet season planting. The pepper varieties used include: California wonder (green), Efia red and Nsukka yellow. The three pepper varieties received 0tons/ha, 8tons/ha and 16tons/ha of poultry manure. It was a 3 x 3 factorial experiment laid out in a Randomized Complete Block Design (RCBD) and replicated thrice. Variety influenced (P<0.05) plant height where the Nsukka yellow pepper gave the tallest plants (46.60cm) while the shortest was the green variety (27.0cm) at 8WAT. Highest number of leaves were obtained in red variety (167.9) which was significantly different (P<0.05) from the other varieties. No significant difference was observed in the leaf area of the three varieties (P>0.05) at the second and fourth WAT though Nsukka yellow had the largest leaf area at 4WAT and, Efia red was largest at 6WAT. Poultry manure application influenced leaf area (P<0.05) at 2nd, 4th and 6WAT. Poultry manure at 16 tons/ha gave the largest leaf area at 2nd, 4th, 6th and 8WAT. There was a significant (P<0.05) varietal effect on incidence and severity of diseases where the green variety had the highest incidence and severity of wilt. Poultry manure also influenced incidence and severity of Fusarium wilt disease where highest incidence and severity was obtained at 0tons/ha. There was a significant interaction (P<0.05) effect of variety and poultry manure rates which was observed on plant height at 2nd,4th ,6th and 8WAT. Yellow x 8tons/ha gave the tallest plants at 8WAT. Effect poultry manure rates on the number of fruits, weight gain, fruit length, fruit diameter, number of locus and fruit girth were not significantly different (P>0.05), though the highest (5.70) number of fruits was obtained at 8ton/ha poultry manure application This was followed by 4.93 at 16ton/ha, while the least number of fruits was produced when 0ton/ha was applied Poultry manure at 8tons/ha also produced the highest pepper fruit weight with a mean value of (5.700g) though not statistically different from the other two varieties. It is therefore that farmers should adopt the application of 8tons/ha poultry manure, as this was most suitable in terms of yield and increase beyond this level may not lead to appreciable marginal increase in yield as observed in this investigation.