Funded Research Projects Research Articles

Advancing a managed care pharmacy research agenda: Generating real-world evidence to support US Food and Drug Administration Accelerated Approvals and improving benefit design to address health inequities.

To advance their research agenda, the Academy of Managed Care Pharmacy (AMCP) and the AMCP Foundation (AMCPF) invited a sample of AMCP membership to participate in focus groups and tasked them with developing tangible research aims for each of the top 2 previously identified AMCP/AMCPF research priorities: generating real-world evidence (RWE) to support US Food and Drug Administration (FDA) Accelerated Approvals and improving benefit design to address health inequities. The resulting research aims, which were further refined per feedback from additional stakeholders, will serve to guide requests for proposals for funding of specific research projects to address these top managed care priorities. Research aims identified by focus group participants related to generating RWE for FDA Accelerated Approvals include (1) creating a data survey tool for managed care to make RWE more readily available, (2) linking surrogate endpoints to meaningful clinical outcomes for drug development, and (3) improving patient outcomes by determining the optimal sequence of clinical pathways. Research aims identified by focus group participants related to improving benefit design to address health inequities include (1) identifying how the ability to navigate managed care benefit designs may impact inequities, (2) understanding the connection between health inequities and medication adherence, and (3) evaluating the impact of social determinants of health on medication affordability. DISCLOSURES: These proceedings were supported by Bridget Flavin, PharmD, Founder, Connected Content, Ltd. Connected Content, Ltd. received payment from AMCP for the preparation of this manuscript. Flavin is also an adjunct associate professor at the University of Florida College of Pharmacy. Diana Brixner received AMCP Foundation support of sabbatical to conduct this work, support of a medical writer to assist in putting the manuscript together, consulting fees from Millcreek Outcomes Group, Elevar, Sage, Haymarket, and AMCP funding of one trip to Alexandria, VA. This research and the development of this manuscript were funded by AMCP and the AMCP Foundation.

Importance of scientific research for Achieving Sustainable Development Goals during Covid19 Pandemic: Northern Technical University - A Case Study

Scientific progress in any country is measured by the importance that is given to scientific research. Recently, the interest in scientific research has increased by the local and international universities in various fields of sciences, given its importance in achieving sustainable development goals, where several countries and universities have initiated to increase scientific research funds. Moreover, the reputation of scientific research in the universities strongly depends on the quality and quantity of papers that are published in the international journals. Thus, the main goal of this study is to investigate and identify the reality of the scientific research situation at Northern Technical University during Covid19 Pandemic (i.e., from 2020 till now). This study is based on the descriptive approach and method of analysis for the published papers that related to the sustainable development topics, which is adopted by UI GreenMetric ranking. The data of the published papers have been collected from the Google Scholar website using the same methodology that was approved in the UI GreenMetric ranking. Those publications have been classified based on the keywords, university researchers and the affiliation of the university’s colleges and institutes. The present data has been compared with data of previous years. Keyword: UI Green metric, sustainability, renewable energy, environment

РАВНИЩЕ НА ЕЗИКОВАТА КУЛТУРА НА СТУДЕНТИТЕ ПЕДАГОЗИ

The problems related with the level of the language culture of the regular and part time students in pedagogy degree course of the Faculty of Education of Sofia university ‘’St. Kliment Ohridski’’ as potential future primary teachers are discussed in the article. The analysis is based on test study data from a research made in February–May 2022 in the context of the optional discipline Contemporary Bulgarian Language. The test items cover basic language concepts and grammar categories, as well as spelling peculiarities in order the level of the knowledge of contemporary Bulgarian language and the constructs from the different language branches – phonetics, morphology, syntax, lexicology, stylistics – to be revealed. The test study results are interpretedon the basis of comparative analysis. The conclusions and generalizations from the analysis determine the proposed recommendations for the further improvement of the students’ language preparation. The main focus is on the importance of the language preparation and culture of the students in pedagogy as potential primary teachers. The study has been carried out as a part of a project supported by The Scientific Research Fund of Sofia University „St. Kliment Ohridski“ for 2022 under the scientific guidance of Prof. Dr. Habil. Nelly Ivanova.

Calculation and experimental determination of equilibrium composition of liquors in certain instances of the Na2O – К2O – Al2O3 – H2O System

Presently, one can definitely state a rising interest to potassium-bearing aluminium ores, which is due to a gradual depletion of conventional raw materials and the fact that the ores that are mined today are leaner and have a more complex composition. At the same time, soda-potassium products, potassium fertilizers, aluminium hydroxide, alumina and alumina materials are in high demand and sell at high prices. Today, the focus is on new deposits of urtite rock and nepheline ores, as well as those of ultrapotassium rischorrite and synnyrite rock. That’s why it is very important to have a basic understanding of the nature and properties of the technically important system Na2O – К2O – Al2O3 – H2O, which defines the performance of the key processes involved, as well as the output and quality of the final product. In this regard, studying phase equilibria in the above system, the information about which is lacking or inconsistent, can be pointed out as one of the current research priorities. Two methods were tested aimed at reducing the time necessary to reach equilibrium in the Na2O – K2O – Al2O3 – H2O system. One involves hydrolytic decomposition of aluminate liquors with aluminium hydroxide used as seed; the other involves a mathematical description of the curves characterizing the kinetics of gibbsite solubility in alkaline liquors with a given mole fraction of K2O. Similar laboratory equipment and materials were used in the experimental study regardless of the way equilibrium was reached and identified. Through experiments, it was established that the process of approaching equilibrium in predominantly potassium aluminate liquors has complex kinetics and mechanics impeding rapid identification of equilibrium composition of liquors. With regard to the technique that involves gibbsite dissolution in weak sodium-potassium liquors, the authors demonstrate how asymptotic approximation functions can be effectively used to determine maximum solubility of aluminium oxide. The results of experiments aimed at defining the equilibrium compositions of liquors at 60 oC in certain instances of the Na2O – К2O – Al2O3 – H2O system have a good and satisfactory correlation with the modelling data based on the additivity principle, which suggests that the modelling technique can effectively be applied to other temperatures and instances of the 4-component system in view. This research was funded by the Russian Science Foundation under the Agreement No. 18-19-00577-П dated April 28, 2021 on granting funds for basic scientific research and exploratory research.

Analysis and Construction of Software Engineering OBE Talent Training System Structure Based on Big Data

Software engineering is one of the most active fields of entrepreneurship and innovation in the world, and it is also the core field of the information technology industry. Software talents as the foundation and support are an important weight to determine the future direction of my country’s software engineering. How to make colleges and universities cultivate compound software talents with innovative ability and engineering ability and how to guide students to closely combine innovative thinking with social practice are a major challenge faced by the current software process education in colleges and universities in my country. At present, the overall quality of software engineers is poor, which cannot meet the needs of enterprises and training objectives. This paper puts forward the application of the OBE (outcome-based education) model in the training of software talents, which can effectively solve the current problems of talent quality and social demand. The analysis shows that there is a high correlation between collaborative education and satisfaction, and the collaborative education model can effectively improve satisfaction. The investment of scientific research funds can effectively improve the overall quality of scientific research team members. The OBE talent training mode can effectively improve the overall test effect, whether in the experimental set or the test set, the test result of the OBE talent training structure is still the highest, the accuracy rate can reach 94.23%, the recall rate can reach 94.51%, and the F1 value can reach 95.13%. It is fully explained that the identification accuracy is the highest when the OBE talent-training structure is adopted.

Development of China's health care system in the time of COVID‐19: Challenges, opportunities, and call for actions

Development of China's health care system in the time of COVID‐19: Challenges, opportunities, and call for actions

Scientific collaboration, research funding, and novelty in scientific knowledge.

Disruptive advancements in science and technology often rely on new ideas and findings, which in turn brings us to focus on the value of novelty in scholarly activities. Using Web of Science publication data from European regions for the period between 2008 and 2017, this study examines, first, the impact of scientific collaboration on novelty of research. Here, five levels of collaboration are considered for each article–country, three levels of regions, and institutions, and novelty is measured with keywords information. Second, we investigate both the effect and moderating effect of research funding on novelty. Our findings show that there is a negative and significant relationship between scientific collaboration and novelty. Furthermore, funded papers show lower novelty than the unfunded, but funding does have a significant moderating effect on the relationship between collaboration and novelty. This study contributes by linking diverse levels of collaboration and funding sources to article’s novelty and thus extending the scope of bibliometric research of publications.

Problems and Countermeasures in the Management of Scientific Research Project Funds in Colleges and Universities

In recent years, my country has vigorously promoted the "delegation, regulation and service" of scientific and technological project management, and various government departments have successively formulated a number of preferential policies for deepening the reform of the scientific research project funding management system, striving to use policy and mechanism innovation to promote the innovation of scientific and technological talents. However, at present, there are still a series of problems in China's higher education, such as the lack of the right to use scientific research personnel funds, the imperfect performance evaluation and accountability system. This paper analyzes and discusses the management of higher education scientific research plan funds based on the problem, provides suggestions for reform measures of higher education scientific research program funds management, and provides reference for higher education research management staff.

INFLUENCE OF URBAN LAND EXPROPRIATION ON CRIME RATE BASED ON AFFECTIVE DISORDER AND ANXIETY FACTORS

INFLUENCE OF URBAN LAND EXPROPRIATION ON CRIME RATE BASED ON AFFECTIVE DISORDER AND ANXIETY FACTORS

STUDY ON THE IMPACT OF JOB SECURITY ON JOB PERFORMANCE AND ANXIETY SENSITIVITY OF GRASS-ROOTS EMPLOYEES IN HIGH STAR HOTELS

BackgroundAs a typical service industry, the service attitude and service level of grass-roots employees directly affect the quality of hotel products. According to the field survey, the psychological safety of employees will affect their work attitude and efficiency, thus affecting the brand and efficiency of the hotel. In particular, it is very important to study the relationship and influencing factors between job performance and anxiety sensitivity.Subjects and MethodsFrom the perspective of job security, this study collected 1243 effective questionnaires from the grass-roots employees of high-star hotels in China's first tier cities, and discussed the impact of job security on the job performance of grass-roots employees of high-star hotels through reliability and validity analysis, correlation analysis, regression analysis and other research methods. The self-awareness scale compiled by fenigstein, Scheier and Buss (1975) includes three dimensions: internal self-awareness, public self-awareness and social anxiety. In this study, the social anxiety dimension was selected, including 6 items, and scored with 5 points (0 = very inconsistent with me, 4 = very consistent with me). Single factor verification is conducted for this dimension, and the fitting indicators are as follows: χ 2/df = 1.64, NNFI = 0.98, CFI = 0.99, GFI = 0.99, RMSEA = 0.037. The Cronbach coefficient of social anxiety subscale α Is 0.72.ResultsJob prospect security, promotion security, job stability security and job execution security had significant positive effects on job performance, while interpersonal security had no effect on job performance. In addition, the study also found that there was a negative correlation between prospect security and promotion performance. Similarly, there is a significant negative correlation between job stability and self-efficacy. There was a very significant positive correlation among state anxiety, trait anxiety and anxiety. The “anxiety” component of personality characteristics plays a great role in the generation of sense of security. The correlation coefficient between LCAS and trait anxiety was 0.408, while the correlation coefficient between LCAS and state anxiety was 0.395. Both reached a significant level (P < 0.01). Self efficacy was positively correlated with job stability. Research shows that foreign language anxiety, gender and self-efficacy can be measured as comprehensive variables.ConclusionEnsuring employees' work safety is helpful to improve employees' actual work efficiency. The grass-roots staff of high star hotels will carry out team building driven by material interests. The grass-roots employees of high star hotels will make efficient work dedication on the basis of ensuring career development, welfare benefits and clarifying the scope and links of work. This study puts forward three management enlightenment: improve the development system of grass-roots employees in high star hotels and improve their job security; Optimize the construction of working team in high star hotels to ensure the psychological safety of grass-roots employees; Improve the incentive mechanism of high star hotels and improve the work performance of grass-roots employees. Finally, strengthen positive cognitive education, carry out targeted education for relevant personnel, correctly guide positive emotions, turn some blind and optimistic impulsive emotions into rational motives, and guide them to carry out relevant activities according to their own advantages and characteristics. Clarify the goal of motivation by example, and regularly hold activities such as successful model sharing, experience introduction and project display, so as to set a successful example for positive emotions, clarify the specific objectives of the activities, form strong psychological motivation, stimulate internal potential and help the realization of positive behavior. Strengthening professional guidance is to make the motivation of winning the bid behavioral.AcknowledgementsThe Project to Improve the Basic Research Ability of Young and Middle-aged Teachers in Guangxi Colleges and Universities “Research on the Path to Improve the efficiency of High-quality Development of Rural Tourism in Guangxi Ethnic Villages” (Project Number: 2022KY0773). Supported by The Project to Improve the Basic Research Ability of Young and Middle-aged Teachers in Guangxi Colleges and Universities “Research on Tourism Development of the Xiangjiang Campaign Long March Site under the Vision of Targeted Poverty Alleviation” (Grant No.2020KY21001); Supported by The school-level scientific research fund of Guilin University Of Aerospace Technology supported the “Study on Spatial Differentiation and Influencing Factors of Tourism Efficiency of the Red Tourism Circle in Northern Guangxi” (Grant No. XJ20KT31); Supported by Guilin Institute of Aerospace Industry College Student Innovation and Entrepreneurship Training Program “Research on Customized Tourism Consumption Behavior-Taking Research Tourism as an Example”(Grant No.: 202011825058). Supported by Guilin Institute of Aerospace Industry College Student Innovation and Entrepreneurship Training Program “An Exploration of the Integration Model of Party History Learning and Education and Red Tourism for College Students in Ethnic Areas Based on Cultural Confidence”(Grant No.202111825057).

STUDY ON THE RELATIONSHIP BETWEEN CROWDSOURCING TASK DESCRIPTION AND WINNING THE BID

STUDY ON THE RELATIONSHIP BETWEEN CROWDSOURCING TASK DESCRIPTION AND WINNING THE BID

Mobile Arts for Peace (MAP): creating art-based communication structures between young people and policy-makers from local to national levels

ABSTRACT This article will provide an overview of how the Arts and Humanities Research Council (AHRC) Global Challenges Research Fund (GCRF) project Mobile Arts for Peace (MAP) has attempted to explore the use of interdisciplinary art-based practices for peacebuilding in Rwanda. In particular, we will detail how performance has been used to create a two-way system of communication between young people and policy-makers based on the issues that young people face towards developing an approach to teaching and learning informed by and with young people.

Which educational follow-up method do atrial fibrillation patients prefer: in-person, online or app-based education?

Abstract Funding Acknowledgements Type of funding sources: Other. Main funding source(s): The AF-EduCare study is a project supported by the Fund for Scientific Research, Flanders (T002917N). The AF-EduApp study is supported by an BMS/Pfizer European Thrombosis Investigator Initiated Research Program (ERISTA) grant. Background Atrial fibrillation (AF) is a common cardiac arrhythmia with a complex treatment strategy based on three pillars: anticoagulation, rate and rhythm control, and risk factor management. Compliance with these pillars leads to improved outcomes. Patient education and involvement are fundamental to optimize AF patients’ care. There is a need for new strategies to involve patients in their care and raise their awareness of their condition. Purpose We are studying three personalized follow-up methods for AF management and wanted to evaluate patients’ preference. Methods An open, prospective, randomized trial is currently performed at three Belgian hospitals. A total of 1.232 AF patients hospitalized or coming for an out-patient visit were included and randomized to a control group or three education groups: in-person, online or app-based education. The educational intervention focuses on four elements: Improving patients’ knowledge about AF, highlighting the importance of OAC adherence using electronic tools, improving self-care capabilities based on their AF risk factors, and reachability of an AF specialized team. Patients in the in-person group were followed personally at the hospital, while the patients in the online and app group received education via an online platform or mobile application, respectively. Patients were followed up for at least 12 months, at which they received a questionnaire to assess their satisfaction about the educational intervention. Results On-treatment analyses were performed for 643 patients (292 in-person, 233 online, 118 app-based). When asked for a general score (on ten) to describe their appreciation of the educational intervention, in-person education scored significantly higher (in-person: 8.75±1.25; online: 8.30±1.55; app: 8.10±1.69; p&amp;lt;0.001). Evaluating which follow-up method(s) they would prefer for the future, in-person scored highest (Fig 1), still there was a clear appreciation for the approach they had received in the year before: online scored higher in the online group than in the other groups (in-person: 12.8%; online: 19.9%; app: 10.5%; p=0.023) and app-based higher in the app-group than in the other groups (in-person: 11.5%; online: 13.3%; app: 32.6%; p&amp;lt;0.001). Moreover, most patients in all groups were satisfied with the answers given to their questions (in-person: 91.6%; online: 89.1%; app: 96.6%; p=0.059) and acknowledged that they had learned more about AF due to the extra education (in-person: 84.2%; online: 85.8%; app: 89.7%; p=0.345). The educational effort improved their motivation to be aware of, and be involved in their health, most significantly in the app group (in-person: 75.4%; online: 77.0%, app: 87.2%; p=0.021). Conclusion AF patients are satisfied about additional educational follow-up in general. Despite new electronic tools and the need to come to the hospital, in-person education is subjectively still the preferred modality.

FOR THE 105th ANNIVERSARY OF THE SOUTH USSURIYSK BRANCH OF THE RUSSIAN GEOGRAPHICAL SOCIETY

In 1916, the South Ussuriysk branch of the Amur Department of the Imperial Russian Geographical Society was created in the city of Nikolsk-Ussuriysk. It was a public organization whose main task was to study the natural resources of the south of the Far East (Ussuriysk Territory). The branch became the first scientific organization in Primorye which carried out scientific research work and published its results («Izvestia», «Notes», scientific articles and monographs). South Ussuriysk branch specialized in studying the flora of the Far Eastern region. The need to find funds for scientific research led to the creation of economic and commercial structures – Factory of educational materials, an agricultural farm, a silk station, etc. The branch became one of the organizers of the First Congress on the study of the Ussuri region in natural history (1922). In 1929, due to duplication in research, the department was reorganized – scientific departments moved to the Far Eastern Regional Research Institute as a branch, economic departments – to various state structures. The branch had been the part of the institute until the beginning of 1932, later the Gornotezhnaya station was created on the basis of its scientific subdivisions, which in the same year became part of the Far Eastern branch of the USSR Academy of Sciences.

Integrating project-based infrastructures with long-term greenhouse gas observations in Africa

There is a lack of long-term greenhouse gas (GHG) measurement infrastructures in Africa. This limits our understanding of the temporal dynamics of the biosphere-atmosphere exchange of carbon in response to climate change. Where relevant infrastructures have been established in externally funded research projects, they have often not been successfully transferred to local institutions at project termination, nor maintained in the long term. This leads to loss of capacity and continuity in primary data. We describe a collaborative approach where eddy-covariance (EC) towers for continuous long-term observation of carbon dioxide and energy fluxes were constructed under two consecutive German-funded research projects and designed to complement existing South African infrastructures. They will be transferred to partner institutions at project termination, supported by deliberate capacity building actions for long term sustainability. Joint activities were implemented to i) strengthen technical expertise for infrastructure maintenance, ii) introduce new generation of academic scientists to the topic, iii) co-develop a training concept to enhance local capacity to continue teaching the topic, iv) improve the uptake and use of data by the research community, v) improve data use and access by stakeholders, and vi) facilitate knowledge exchange between institutions. Co-designed activities included training, apprenticeships and knowledge exchange, student exchange, co-supervision, and public outreach. Following a similar model in international research projects could significantly benefit 1) national capacity for emission inventories, 2) development of long-term GHG observation networks, and 3) the global scientific community via improved availability of data. While we specifically focus on a network of GHG observations, the principles are applicable for the infrastructure to observe other surface/atmosphere exchange processes or other long term observational infrastructure.

FINANCIAL PROVISION OF SCIENTIFIC ACTIVITIES IN THE CONTEXT OF THE STRATEGIC DEVELOPMENT OF THE NATIONAL ECONOMY

Topicality. The modern system of financing research studies in Ukraine is designed to provide an effective and comprehensive solution to such urgent tasks as creating the necessary institutional prerequisites for the timely innovations introduction in all areas of the national economic complex of the country, ensuring technological restructuring; creating the necessary conditions for the development of scientific and educational potential, preventing the departure of the country's scientific personnel abroad and creating conditions for the return of those who were forced to leave the country as a result of Russian aggression in Ukraine. Today, at all levels of government, the matter of the effective use of funds allocated in Ukraine for scientific and innovative activities is increasingly emerging. Therefore, the formation of an effective system for financing scientific activities, the result of which is the creation of an innovative product, is an important and urgent task.Aim and tasks. The purpose of the article is to identify current problems of financing research and development in Ukraine and justify ways to solve them.Research results. The article uses methods of statistical analysis of data on the state of development of scientific activity as elements of a systematic analysis of the implementation of scientific research and development by sources of funding in Ukraine. The results of the analysis show that the total amount of research and development funding for the period 2018-2020 increased in Ukraine by only 2%, and the distribution of funding in the National Academy of Sciences of Ukraine is based on the number of scientific workers in a scientific institution, , in connection with which, to a certain extent, it is also associated the insufficient efficiency of the financial resources use by individual scientific institutions. At the same time, funding from the state budget increased by 22% and funding from the funds of business sector organizations decreased by 36%. In the last three years in Ukraine, the largest amount of funding was provided to scientific and technical (experimental) developments, but their share in 2020 decreased compared to 2018 to 51.7%.Conclusion. The development of science in Ukraine is impossible without sufficient and timely funding and changes in the principles and taking into account which it is necessary to build a system for financing scientific research and technical developments, which will include: the creation of a Foresight Research Center under the National Academy of Sciences of Ukraine with appropriate tasks and expert functions; fast and efficient implementation of research results; economic feasibility and security of methods and mechanisms for attracting investments; multiple sources of funding; comprehensiveness and flexibility, which implies the ability to simultaneously finance planned technical and technological innovations, effectively redistributing cash flows. The management system of the National Academy of Sciences of Ukraine should contribute to the effective management of budgetary funds, and changes in the organization of research can significantly increase funding for priority areas of research. Financing of scientific research should become one of the priority directions for the strategic development of Ukraine along with the need to strengthen the defense capability.

Research on the Efficiency of Science and Technology Finance and Influencing Factors in the Yangtze River Economic Belt

Science and Technology(S&amp;T) finance is the catalyst of economic growth and financial innovation. Based on the input-output panel data of S&amp;T finance in the Yangtze River economic belt from 2015 to 2019, this paper uses the Three-stage DEA model to measure the efficiency of S&amp;T finance in provinces and cities in the Yangtze River economic belt，and Tobit regression model is used to explore the factors affecting the efficiency of S&amp;T finance.The results show that: first, the efficiency level of S&amp;T finance in the Yangtze River economic belt is not high as a whole, and is significantly affected by environmental variables. Second, the main reason for the low efficiency of S&amp;T finance in the Yangtze River economic belt is the low scale efficiency. Third, the efficiency of S&amp;T finance in the Yangtze River economic belt is affected by many factors.Therefore, it is suggested that the government should optimize the investment mode of scientific research funds, promote the scale efficiency of small and medium-sized S&amp;T enterprises, create a good market environment and improve the ability of S&amp;T innovation.

TEAD4 regulates trophectoderm differentiation upstream of CDX2 in a GATA3-independent manner in the human preimplantation embryo.

TEAD4 regulates trophectoderm differentiation upstream of CDX2 in a GATA3-independent manner in the human preimplantation embryo.

Is Collaborative Open Science Possible With Speech Data in Psychiatric Disorders?

Provision of mental health care is almost entirely built on a singular medium—naturally occurring spoken language conversations. However, datasets of spoken language from patients experiencing mental health issues are surprisingly difficult to obtain. In this commentary, we discuss some of the reasons behind this, and highlight successful approaches adopted in other areas of clinical linguistics and pose some ways forward, especially for the study of psychosis. Across disciplines, researchers are rapidly adopting Open Science principles for data sharing. This movement encourages researchers, clinicians, and institutions to provide fully open access to research data, programs, and publications. For example, the National Institutes of Health’s Strategic Plan for Data Science requires that newly funded research projects share data in accord with the FAIR principles1 for open access and that they include in their budget requests for the resources necessary to complete open access. Although many disciplines, funding agencies, researchers, journals, libraries, and institutions have adopted this new model, the movement has also encountered significant resistance, particularly for open sharing of spoken language data, including spoken language data from clinical populations (SLDCP). We can identify at least 6 barriers to open sharing of SLDCP.2 Some of these barriers come from the interpretation of regulations by various institutions, while others pertain to the prevailing public perception regarding SLDCP. Here we consider each of these barriers and the ways in which systems, such as TalkBank3 or Databrary4 manage to overcome them. With emerging collaborative efforts to study language in psychosis (eg, https://discourseinpsychosis.org/), we anticipate the commentary here to eventually inform “speech bank” infrastructures for psychiatric disorders.

Biobanking of human pluripotent stem cells in China.

In recent years, significant progress has been made internationally in the development of human pluripotent stem cell (hPSC)‐derived products for serious and widespread disorders. Biobanking of the cellular starting materials is a crucial component in the delivery of safe and regulatory compliant cell therapies. In China, key players in these developments have been the recently launched National Stem Cell Resource Center (NSCRC) and its partner organizations in Guangzhou and Shanghai who together, have more than 600 hPSC lines formally recorded in the Chinese Ministry of Science and Technology's stem cell registry. In addition, 47 of these hPSCs have also been registered with the hPSCreg project which means they are independently certified for use in European Commission funded research projects. The NSCRC are currently using their own cell lines to manufacture eight different cell types qualified for clinical use, that are being used in nine clinical studies for different indications. The Institute of Zoology at the Chinese Academy of Sciences (IOZ‐CAS) has worked with NSCRC to establish Chinese and international standards in stem cell research. IOZ‐CAS was also a founding partner in the International Stem Cell Banking Initiative which brings together key stem cell banks to agree minimum standards for the provision of pluripotent stem cells for research and clinical use. Here, we describe recent developments in China in the establishment of hPSCs for use in the manufacture of cell therapies and the significant national and international coordination which has now been established to promote the translation of Chinese hPSC‐based products into clinical use according to national and international standards.