Research Funding Research Articles

Challenges to ethical public engagement in research funding: a perspective from practice

European research funding organizations (RFOs) are increasingly experimenting with public engagement in their funding activities. This case study draws attention to the challenges they face in preparing, implementing, and evaluating ethical public engagement in the context of setting funding priorities, formulating calls for proposals, and evaluating project proposals. We discuss challenges related to seven themes: (1) recruiting participants; (2) commitments and expectations; (3) meaningful dialogue and equal engagement; (4) accommodating vulnerability; (5) funding call formulations; (6) lack of expertise in engagement ethics; and (7) uncertainty, resource constraints, and external factors. To address these challenges, we propose the following seven interventions: (1) developing comprehensive recruitment strategies with experienced recruiters and community organizations; (2) establishing clear communication of roles, expectations, and outcomes through codes of conduct; (3) training mediators to address power imbalances; (4) designing flexible engagement methods and providing tailored support; (5) implementing collaborative feedback loops for inclusive funding call formulation; (6) enhancing ethical standards through internal expertise and external advisory inputs; and (7) developing adaptive strategies for flexible and ethical public engagement. These recommendations emphasize the need for context-adaptive insights to support funding organizations to implement ethical public engagement activities, even when faced with organizational constraints and a lack of ethical expertise.

Biomedical researchers' perspectives on the reproducibility of research.

We conducted an international cross-sectional survey of biomedical researchers' perspectives on the reproducibility of research. This study builds on a widely cited 2016 survey on reproducibility and provides a biomedical-specific and contemporary perspective on reproducibility. To sample the community, we randomly selected 400 journals indexed in MEDLINE, from which we extracted the author names and emails from all articles published between October 1, 2020 and October 1, 2021. We invited participants to complete an anonymous online survey which collected basic demographic information, perceptions about a reproducibility crisis, perceived causes of irreproducibility of research results, experience conducting reproducibility studies, and knowledge of funding and training for research on reproducibility. A total of 1,924 participants accessed our survey, of which 1,630 provided useable responses (response rate 7% of 23,234). Key findings include that 72% of participants agreed there was a reproducibility crisis in biomedicine, with 27% of participants indicating the crisis was "significant." The leading perceived cause of irreproducibility was a "pressure to publish" with 62% of participants indicating it "always" or "very often" contributes. About half of the participants (54%) had run a replication of their own previously published study while slightly more (57%) had run a replication of another researcher's study. Just 16% of participants indicated their institution had established procedures to enhance the reproducibility of biomedical research and 67% felt their institution valued new research over replication studies. Participants also reported few opportunities to obtain funding to attempt to reproduce a study and 83% perceived it would be harder to do so than to get funding to do a novel study. Our results may be used to guide training and interventions to improve research reproducibility and to monitor rates of reproducibility over time. The findings are also relevant to policy makers and academic leadership looking to create incentives and research cultures that support reproducibility and value research quality.

Dynamic Contract Design in the Presence of Double Moral Hazard

We consider a stylized incentive management problem over an infinite time horizon, where the principal hires an agent to provide services to customers. Customers request service in one of two ways: either via an online or a traditional offline channel. The principal does not observe the offline customers’ arrivals, nor does she observe whether the agent exerts (costly) effort that can increase the arrival rate of customers. This creates an opportunity for the agent (i) to divert cash (that is, to under-report the number of offline customers and pocket respective revenues) and also (ii) to shirk (that is, not to exert effort), thus leading to a novel and thus far unexplored double moral hazard problem. To address this problem, we formulate a constrained, continuous-time, stochastic optimal control problem and derive an optimal contract with a simple intuitive structure that includes a payment scheme and a potential termination time of the agent. We enrich the model to allow the principal to either (i) dynamically adjust the prices for the services in both channels or (ii) monitor the agent. Both tools help the principal to alleviate the double moral hazard problem. We derive respective optimal strategies for using those tools that guarantee the highest profits. We show that the worse the agent’s past performance is, the lower the prices should be set and the more the principal should monitor the agent. This paper was accepted by Ilia Tsetlin, behavioral economics and decision analysis. Funding: The work of F. Tian is financially supported by the Hong Kong RGC Funding [RGC General Research Fund 2023/24 17502023], HKU Seed Fund for Basic Research for New Staff (2022), and the HKU Business School Shenzhen Research Institute [SZRI2023-BRF-04]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01169 .

Director Liability Protection and the Quality of Independent Directors

We study whether legal liability protection helps companies to recruit and retain high-quality independent directors. We conduct difference-in-differences analyses exploiting the 1999 Ninth Circuit Court of Appeals Ruling on the Silicon Graphics case, which substantially raised the bar for filing securities class action (SCA) lawsuits as a shock. We document supporting evidence for the talent attraction hypothesis by showing improvements in newly recruited independent director quality following the ruling, but only for candidates who are previously not exposed to SCA litigation risk. The effects are stronger for firms facing greater litigation risk ex ante or smaller local supplies of director candidates. Results are more evident for experience-based quality dimensions. We also analyze a sample of voluntary independent director departures and find little support for the talent retention hypothesis, suggesting that more complex factors enter into a director’s continuation decision once a director is already exposed to SCA litigation risk. A policy implication is that liability protection can be useful in attracting more unexposed high-quality candidates to the pool of public boards but does little to attract high-quality candidates who are already in the pool of public firms. This paper was accepted by Gustavo Manso, finance. Funding: H. Zou acknowledges the financial support from a competitive General Research Fund (GRF) grant from the Research Grants Council of the Hong Kong Special Administrative Region, China [Project No. HKU 17513816]. S. Shen acknowledges the financial support from the National Natural Science Foundation of China [Grants 72202164 and 72332003]. The work was partially carried out while R. W. Masulis visited the University of Hong Kong as an FBE visiting researcher, and he thanks the Faculty of Business and Economics of the University of Hong Kong for its sponsorship. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2020.03743 .

Petroleum Engineering Research Shifts Focus From Oil and Gas to New Horizons

Undergraduate education in petroleum engineering (PE) has survived the latest downturn in the industry, and enrollment has started to show an uptick in numbers. However, a different trend is evident in graduate training and academic research: the number of researchers being trained in oil and gas topics is drastically dropping. The story can be summarized in Fig. 1. Funding trends in PE departments have been shifting away from oil and gas research. These shifts require large investments in skill-building, expertise, and laboratory infrastructure, which makes it much harder to reverse the trend. Consequently, the shift may permanently alter the identity of PE departments, something that will not impact only graduate education but could alter the overall identity of these departments and the workforce they train. The data shared in Fig. 1c shows that more than 50% of the 2023 research awards, which will fund graduate students earning degrees between 2025 and 2026, are going to be invested in geothermal, carbon management, hydrogen, emissions, and other topics that do not support improving oil and gas resource extraction. While 73% of the 2023 MSc and PhD graduates still studied oil and gas topics around reservoir, production, fracturing, and drilling, as shown in Fig. 1a, this number is expected to drop to under 50% for 2026 graduates. Fig. 1b reveals the accelerated trend of this transition, where only 65% of the publications generated from these departments in 2023 covered oil and gas topics. Under 60% of the 2024 and 2025 graduates who published in 2023 are building expertise in oil and gas research and development. The team collected data to study the trends over the past 10 years. It included over $137 million in external research funding and over 1,900 thesis/dissertations, in addition to over 1,100 publications in 2023. More details about these numbers can be found in SPE 220735. The trends in graduate training and research funding over the past 10 years are shown in Fig. 2, where the axis for graduate training is shifted by 3 years to account for the lag between the date funding was received and the graduation date for the students it supported. When looking at numbers rather than percentages (Fig. 3), oil and gas research funding to four of the major PE departments in the US dropped from $30 million in 2014 to under $10 million in 2023 as shown in Fig. 3a. Funding in these departments now hovers at around $20 million, where the gap was filled by transitioning to the study of sustainable geoenergy topics relating to carbon and hydrogen storage and the extraction of geothermal energy, as shown in Fig. 3b.

The Prospects of Phytomedicines and Nanomedicines to Treat Leishmaniasis: A Comprehensive Review.

The global shift in lifestyle has prompted health agencies to redirect their focus from poverty-related diseases to the emergence of lifestyle diseases prevalent in privileged regions. As a result, these diseases have been labeled as "neglected diseases," receiving limited research attention, funding, and resources. Neglected Tropical Diseases (NTDs) encompass a diverse group of vector-borne protozoal diseases that are prevalent in tropical areas worldwide. Among these NTDs is leishmaniasis, a disease that affects populations globally and manifests as skin abnormalities, internal organ involvement, and mucous-related abnormalities. Due to the lack of effective and safe medicines and vaccines, it is crucial to explore alternative resources. Phytomedicine, which comprises therapeutic herbal constituents with anti-leishmanial properties, holds promise but is limited by its poor physicochemical properties. The emerging field of nanomedicine has shown remarkable potential in revitalizing the anti-leishmanial efficacy of these phytoconstituents. In this investigation, we aim to highlight and discuss key plant constituents in combination with nanotechnology that have been explored in the fight against leishmaniasis.

The Ones and Zeros of Carbon Capture

Leading services companies and specialty software firms alike have launched various tools and digital suites to assist carbon capture and storage (CCS) project operators with everything from ideal siting of facilities and pipelines to the efficient operations and around-the-clock monitoring of those facilities. CCS holds the promise of big business if industry can efficiently and economically operate at scale the slate of planned facilities. Oil and gas companies have been making investments in the space with aims to become leaders in a segment—ironic since the petroleum business is also one of the emitters of CO2 into the atmosphere. Last month, supermajor ExxonMobil executed the largest offshore CO2 storage lease in the US with the Texas General Land Office. The 271,000-plus-acre site complements the onshore CO2 storage portfolio ExxonMobil is developing and further solidifies the US Gulf Coast as a CCS leader, according to the operator. In an October 2024 report, the US Department of Energy (DOE) issued a draft strategy for carbon management technologies through 2030, stating that carbon capture and direct air capture are “essential” to achieving net-zero greenhouse gas emissions by 2050. The report says CCS projects will grow dramatically over the next decade and beyond, adding that 18 CCS facilities are operating now in the US. DOE’s near-term CCS strategy through 2030 incorporates focusing research, development, demonstration, and deployment funding on priority use cases; building out CO2 transportation and storage infrastructure where it likely will be needed most in the future; supporting the implementation of effective and evidence-driven policies and regulations related to carbon management at other federal agencies; engaging communities and workers to ensure projects deliver benefits and mitigate potential risks to public health and the environment; and supporting climate diplomacy efforts to accelerate the adoption of carbon management at scale globally in a way that aligns with the Paris Agreement. “DOE is funding a variety of technologies to assist in decarbonization in the industrial and power sectors,” the report explained. “These approaches include carbon management as well as electrification, fuel switching, materials substitution, efficiency, and other emissions-reductions measures. In parallel, DOE is working to envision and develop transformative emissions reductions approaches that will create new options in the long term.” The US government has been an active participant in making funding available for the advancement of CCS technologies. In 2024 alone, almost $3.5 billion was made available between two separate programs—CCS large-scale pilot projects ($937 million) and CCS demonstration projects ($2.5 billion)—as part of the Bipartisan Infrastructure Law. In June 2023, ceremonial shovels were plunged into the dirt in Ector County, Texas, to mark the start of construction for the largest direct air capture facility in the world, designed to capture 500,000 metric tons of CO2 from the atmosphere every year. Occidental subsidiary OnePointFive’s $1-billion Stratos project is located on a 65-acre site made up of a network of air contactors, pellet reactors, a centrifuge, and a calciner—all known components that operate in other industries.

Association of long-term exposure to ozone with cardiovascular mortality and its metabolic mediators: evidence from a nationwide, population-based, prospective cohort study

Previous studies about chronic effects of ozone (O3) on cardiovascular mortality are scarce and inconclusive. We aimed to investigate the association between cardiovascular mortality and a broad range of long-term O3 exposure levels. This analysis included 3,206,871 participants aged 35-75 years enrolled in the ChinaHEART study. Participants were recruited from the 31 provinces of the Chinese mainland between January 2015 and December 2020. The five-year average O3 concentrations before baseline visits were calculated to represent long-term exposure. Over a median follow-up period of 4.7 (interquartile range: 3.7-6.2) years, 35,553 (1.1%) participants died from cardiovascular diseases (CVD). Following multivariable adjustment, nonlinear relationships were identified between O3 concentrations and CVD and ischemic heart disease (IHD) mortality, with inflection points at 85.44 and 88.15μg/m3, respectively. Above these points, a 10.0μg/m3 increase in the O3 level was associated with a 13.9% (hazard ratio [HR]: 1.139, 95% confidence interval [CI]: 1.096-1.184) and 25.0% (HR: 1.250, 95% CI: 1.151-1.357) greater risk of CVD and IHD mortality, respectively. Conversely, O3 exposure exhibited a linear relationship with ischemic stroke mortality. Moreover, the metabolic factors explained more than half of the association between O3 exposure and CVD mortality. Substantial influences of long-term O3 exposure on CVD mortality were identified, with notable mediation proportions attributed to metabolic factors. These findings could facilitate the air quality standard revisions and risk reduction strategy making in the future. This study was supported by the CAMS Innovation Fund for Medical Science (2021-1-I2M-011), the CAMS Innovation Fund for Medical Science (CIFMS, 2022-I2M-C&T-A-010), the National High Level Hospital Clinical Research Funding (2022-GSP-GG-4), the Ministry of Finance of China and National Health Commission of China, the 111 Project from the Ministry of Education of China (B16005).

Global burden of dementia in younger people: an analysis of data from the 2021 Global Burden of Disease Study

Dementia among younger people is rapidly emerging as a global health concern; however, comprehensive research on its shifting burden trends remains insufficient. Data on the prevalence, incidence, mortality, and disability-adjusted life years (DALYs) associated with dementia occurring in individuals <70 years were extracted from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021. Average annual percentage changes (AAPCs) were calculated to assess trends in age-specific rates (ASRs), including age-specific prevalence rates (ASPRs), age-specific incidence rates (ASIRs), age-specific mortality rates (ASMRs), and age-specific DALY rates (ASDRs) while young-onset dementia (YOD) burden trends were analyzed. The correlation between ASR/AAPC and the sociodemographic index (SDI) was evaluated. In 2021, the global prevalence of dementia in individuals <70 years increased by 122.33%, with a 128% increase in new cases since 1990. Concurrently, deaths and DALYs of individuals <70 years with dementia rose by 119.28% and 119.77%, respectively. The AAPCs of YOD ASRs during 1990-2021 initially increased and then decreased with increasing SDI levels, with the highest AAPCs of ASPR (2.20 [95%CI: 2.08-2.32] per 100,000), ASIR (2.25 [95%CI: 2.06-2.45] per 100,000), ASMR (2.04 [95%CI: 1.93-2.15] per 100,000), and ASDR (2.06 [95%CI: 1.99-2.13] per 100,000) observed in middle-SDI levels. Additionally, females <70 years bore a higher burden of dementia globally, and gender differences are still widening. The growth rate of YOD is accelerating, particularly in the middle to high SDI region with females bearing a disproportionately higher burden of YOD. This work was supported by grants from the National High level Hospital Clinical Research Funding, CAMS Innovation Fund for Medical Sciences, and the National Natural Science Foundation of China.

Association between seizure reduction during ketogenic diet treatment of epilepsy and changes in circulatory metabolites and gut microbiota composition

The ketogenic diet (KD) is a high fat, sufficient protein, and low carbohydrate dietary therapy for drug-resistant epilepsy. The underlying mechanisms of action of the KD remain unclear. In mice, the microbiota is necessary for the anti-seizure effect and specific microbes influence circulatory levels of metabolites that are linked to seizure reduction. However, it remains unclear which changes are linked to seizure reduction in patients with epilepsy. We analysed the serum metabolome of children with drug-resistant epilepsy (n=14) before and after three months on KD. Metabolomic changes were correlated to the gut microbiome and treatment outcome, i.e., seizure reduction. In this prospective observational study, we uncovered associations between microbial species and serum metabolites that correlated with seizure reduction. Plasmalogens were most strongly linked to seizure reduction and had significant positive correlations with several gut microbes (e.g., Faecalibacterium prausnitzii, Alistipes communis, Alistipes shahii, and Christensenella minuta) while significant negative correlations were found for five strains of Escherichia coli. Infant-type Bifidobacteria correlated negatively with other metabolites associated with seizure reduction. The microbes and metabolites identified here may contribute to the therapeutic effect of the KD in children with drug-resistant epilepsy. Several of these metabolites (e.g., plasmalogens) play important roles in neurobiology and may influence seizures. Based on our findings, anti-seizure therapeutic strategies could be developed involving the targeted manipulation of the gut microbiota and/or its metabolites. This study was supported by the Swedish Brain Foundation, Margarethahemmet Society, Sunnerdahls Handikappfond, Stockholm County Council Research Funds, and Linnea & Josef Carlssons Foundation.

Gut microbiota in women with polycystic ovary syndrome: an individual based analysis of publicly available data

Polycystic ovary syndrome (PCOS) represents a prevalent endocrine disorder affecting numerous females worldwide. Dysbiosis of gut microbiota has been linked to the occurrence of PCOS; however, research into the characteristics of gut microbiota in PCOS patients, especially those from different regions and with different testosterone level, remains limited. Additionally, it is still unclear whether gut microbiota helps to distinguish different PCOS subtypes. We searched four electronic databases (PubMed, Web of Science, Cochrane Library, and ClinicalTrials.gov) from Jan 1, 2010 to May 1, 2024. This combined analysis included studies providing the raw data of gut microbiota in PCOS patients. We reanalyzed the characteristics of gut microbiota in PCOS patients from different regions and with different testosterone level. Fourteen publications satisfying the inclusion criteria were included in the combined analysis. Based on data from 948 individuals, we found alpha-diversity was not significantly different between PCOS and healthy control (HC) groups. However, gut microbiota composition was distinct in PCOS patients compared with healthy individuals. Specifically, Fusobacterium, Ruminococcus_gnavus_group, and Escherichia-Shigella increased, while Dysosmobacter, Schaedlerella, Merdimonas, Clostridiisalibacter, Flintibacter etal. decreased in PCOS women. Regionally, Alistipes was enriched in primarily European patients, while Blautia and Roseburia were more abundant in Chinese patients. Subtype analysis revealed that the gut microbiota of PCOS patients with higher testosterone level (PCOS-HT) differed significantly from those with lower testosterone level (PCOS-LT). Prevotella, Blautia, Dialister, Ruminococcus_torques_group and UCG-002 were enhanced in PCOS-HT patients, while Alistipes, Dysosmobacter, Phocaeicola and Faecalibacterium were diminished. Importantly, a set of eight genera effectively differentiated PCOS-HT patients from PCOS-LT patients with an AUC of 0.95. This systematic anatomization of gut microbiota revealed the microbial characteristics of PCOS patients, particularly those with different testosterone level, thus laying the foundations for further research into pathogenesis of PCOS, and the development of effective diagnostic, treatment, and intervention strategies. This work was supported by the National Natural Science Foundation of China (No. 81973217, 82260304), the Hainan Province Clinical Medical Center (QWYH202175), and the Specific Research Fund of The Innovation Platform for Academicians of Hainan Province (YSPTZX202311).

Impact of CCR5Δ32 on the risk of infection, Staphylococcus aureus carriage, and plasma concentrations of chemokines in Danish blood donors

The CC chemokine receptor 5 (CCR5) is a suggested receptor for Staphylococcus aureus leukotoxin ED. Homozygosity for the Δ32 deletion (CCR5Δ32) protects against human immunodeficiency virus infection and possibly also against leukotoxin ED. We examined the impact of CCR5Δ32 on the susceptibility to S.aureus infection, all-cause infections, and S.aureus nasal carriage, respectively, and on the concentrations of circulating chemokines in blood donors. We included 95,406 participants from the Danish Blood Donor Study (DBDS) genotyped for >650,000 single nucleotide polymorphisms. The CCR5Δ32 (rs333, MAF: 0.12) was imputed from a reference panel and validated. Infectious outcomes were identified by diagnosis codes and redeemed prescription of antibiotics in national health registers. Data on S.aureus nasal carriage and forty-seven inflammatory biomarkers were available for 6721 and 7811 participants, respectively. Cox, logistic, and linear regression models adjusted for relevant confounders were used to explore said associations. During more than 700,000 person-years of observation, we found that CCR5Δ32 was associated with neither an increased risk of redeemed dicloxacillin, hospital-treated S.aureus-associated infection (replicated in 345,996 Icelanders), redeemed antibiotics, all-cause infection, and nor with S.aureus nasal carriage. We discovered an association between CCR5Δ32 and elevated CCL4 concentrations, which were 1.26-fold higher in Δ32-heterozygotes (95%-CI: 1.23-1.30) and 2.64-fold higher in Δ32-homozygotes (95%-CI: 2.41-2.90) compared with wildtype homozygotes. Conversely, concentrations of CCL2, CXCL-10, and CCL11 were slightly lower among Δ32-heterozygotes. Results from this CCR5Δ32 high-prevalent cohort do not support the idea that CCR5Δ32 affects the risk of S.aureus carriage or infection to any relevant degree, in this northern European context. CCL4 was the main chemokine affected by CCR5Δ32 and was observed in higher concentration among Δ32-carriers. This study cannot rule out that S.aureus is a previous driver of CCR5Δ32 selection. The Health Research Fund of Central Denmark Region, Aarhus University, Danish Administrative Regions, Bio- and Genome Bank Denmark, Danish Blood Donor Research Foundation, Aase & Ejnar Danielsens Foundation, Højmosegård Grant, National Institute of Allergy and Infectious Diseases, and A.P. Møller Foundation for the Advancement of Medical Science.

Gut microbiome metabolites, molecular mimicry, and species-level variation drive long-term efficacy and adverse event outcomes in lung cancer survivors

The influence of the gut microbiota on long-term immune checkpoint inhibitor (ICI) efficacy and immune-related adverse events (irAEs) is poorly understood, as are the underlying mechanisms. We performed gut metagenome and metabolome sequencing of gut microbiotas from patients with lung cancer initially treated with anti-PD-1/PD-L1 therapy and explored the underlying mechanisms mediating long-term (median follow-up 1167 days) ICI responses and immune-related adverse events (irAEs). Results were validated in external, publicly-available datasets (Routy, Lee, and McCulloch cohorts). The ICI benefit group was enriched for propionate (P=0.01) and butyrate/isobutyrate (P=0.12) compared with the resistance group, which was validated in the McCulloch cohort (propionate P<0.001, butyrate/isobutyrate P=0.002). The acetyl-CoA pathway (P=0.02) in beneficial species mainly mediated butyrate production. Microbiota sequences from irAE patients aligned with antigenic epitopes found in autoimmune diseases. Microbiotas of responsive patients contained more lung cancer-related antigens (P=0.07), which was validated in the Routy cohort (P=0.02). Escherichia coli and SGB15342 of Faecalibacterium prausnitzii showed strain-level variations corresponding to clinical phenotypes. Metabolome validation reviewed more abundant acetic acid (P=0.03), propionic acid (P=0.09), and butyric acid (P=0.02) in the benefit group than the resistance group, and patients with higher acetic, propionic, and butyric acid levels had a longer progression-free survival and lower risk of tumor progression after adjusting for histopathological subtype and stage (P<0.05). Long-term ICI survivors have coevolved a compact microbial community with high butyrate production, and molecular mimicry of autoimmune and tumor antigens by microbiota contribute to outcomes. These results not only characterize the gut microbiotas of patients who benefit long term from ICIs but pave the way for "smart" fecal microbiota transplantation. Registered in the Chinese Clinical Trial Registry (ChiCTR2000032088). This work was supported by Beijing Natural Science Foundation (7232110), National High Level Hospital Clinical Research Funding (2022-PUMCH-A-072, 2023-PUMCH-C-054), CAMS Innovation Fund for Medical Sciences (CIFMS) (2022-I2M-C&T-B-010).

Research funding disparity in uterine cancer: An analysis of funding and race in relation to the burden of disease

Research funding disparity in uterine cancer: An analysis of funding and race in relation to the burden of disease

Factors and mediators impacting the number of undergraduate research mentees at a research-intensive Hispanic-serving institution.

Engaging in undergraduate research experiences is known to have broad and positive impacts on college students. Despite the benefits, achieving faculty buy-in and support can be challenging even when faculty have strong research funding. In order to understand how to better support undergraduate research programs, we applied quantitative models to explore how the impact of research funding is mediated by faculty beliefs about undergraduate research mentoring in STEM disciplines. The results indicate that faculty characteristics and beliefs about the benefits and barriers of mentoring undergraduate students in research impact the number of students mentored even when accounting for research funding levels of the individual faculty. Practical recommendations are presented based on the models from this research project in order to provide insight into how centers or units on a campus may work with faculty to support and encourage mentoring of undergraduates in research in the biomedical sciences.

Centering equity, diversity, and inclusion in youth digital mental health: findings from a research, policy, and practice knowledge exchange workshop

BackgroundYouth mental health service organizations continue to rapidly broaden their use of virtual care and digital mental health interventions as well as leverage artificial intelligence and other technologies to inform care decisions. However, many of these digital services have failed to alleviate persistent mental health disparities among equity-seeking populations and in some instances have exacerbated them. Transdisciplinary and intersectional knowledge exchange is greatly needed to address structural barriers to digital mental health engagement, develop and evaluate interventions with historically underserved communities, and ultimately promote more accessible, useful, and equitable care.MethodsTo that end, the Digital, Inclusive, Virtual, and Equitable Research Training in Mental Health Platform (DIVERT), the Maritime Strategy for Patient Oriented Research (SPOR) SUPPORT (Support for People and Patient-Oriented Research and Trials) Unit and IWK Mental Health Program invited researchers, policymakers, interprofessional mental health practitioners, trainees, computer scientists, health system administrators, community leaders and youth advocates to participate in a knowledge exchange workshop. The workshop aimed to (a) highlight local research and innovation in youth-focused digital mental health services; (b) learn more about current policy and practice issues in inclusive digital mental health for youth in Canada, (c) participate in generating action recommendations to address challenges to inclusive, diverse and equitable digital mental health services, and (d) to synthesize cross-sector feedback to inform future training curriculum, policy, strategic planning and to stimulate new lines of patient-oriented research.ResultsEleven challenge themes emerged related to white-colonial normativity, lack of cultural humility, inaccessibility and affordability of participating in the digital world, lack of youth and community involvement, risks of too much digital time in youth's lives, and lack of scientific evidence derived from equity-deserving communities. Nine action recommendations focused on diversifying research and development funding, policy and standards, youth and community led promotion, long-term trust-building and collaboration, and needing to callout and advocate against unsafe digital services and processes.ConclusionKey policy, training and practice implications are discussed.

Future Energy Breakthroughs: Implications for the Hydrocarbon Economies of the Arabian Gulf

AbstractCountries in the Arabian Gulf are reliant upon hydrocarbons for revenues, exports, industries and funding services. It is largely assumed that the global energy transition will be gradual, as reflected in planning and strategy documents. However, energy breakthroughs can change the global energy system. This Perspective article seeks to provoke a discussion about potential energy breakthroughs, the plausibility of their rapid expansion at scale, and the implications they may have for the hydrocarbon economies in the Arabian Gulf. Based upon feasibility, scalability, and adoption potential energy breakthroughs are outlined, their probability are assessed, and potential impacts on the hydrocarbon economics of the region are evaluated. The calls to actions are concluded with aim to support the region to be better prepared to track breakthroughs, and be proactively engaged to benefit from them. These include: 1) annual regional research‐policy interface meetings, 2) tailored research and development funding that fosters regional collaboration, 3) investment into breakthrough technologies and energy transition inputs, and 4) seeking synergy in economic diversification regionally to avoid duplication and counterproductive competition.

Research hotspots and trends of mesenchymal stem cell-derived extracellular vesicles for drug delivery: a bibliometric and visualization analysis from 2013 to 2023

IntroductionOur study aims to provide a comprehensive overview of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in drug delivery research, focusing on the period between 2013 and 2023. Given the increasing global interest in this field, we utilized bibliometric tools to explore publication trends, key contributors, and thematic research clusters.MethodsData was collected from the Web of Science (WoS) database, and an in-depth bibliometric analysis was conducted using VOSviewer. The analysis encompassed bibliographic coupling, co-citation, co-authorship, and co-occurrence trends, offering a structured insight into global research activity. We also employed Citespace to further analyze thematic clusters in this domain.ResultsOur analysis revealed a total of 1,045 publications related to MSC-EVs in drug delivery over the past decade, showing a steady increase in research output. China led in publication count, H-index, prolific authors, and research funding, while the United States ranked highest in total citations, average citation counts, and H-index performance. Pharmaceutics emerged as the leading journal by publication volume, with the Journal of Controlled Release having the strongest total link strength. Top institutions driving research included Shanghai Jiao Tong University, Zhejiang University, and Harvard University. VOSviewer analysis identified four major research clusters: tissue engineering, cancer, neurological diseases, and targeted delivery. Citespace analysis refined this further into ten thematic areas, including differentiation, tissue regeneration, and drug resistance.DiscussionThis bibliometric assessment provides a holistic visualization of the research landscape for MSC-EVs in drug delivery, underlining the significant contributions of China and the United States. Our findings underscore the increasing global importance of MSC-EV research and highlight emerging themes that will likely guide future research directions. The insights from this study offer a foundational framework for identifying nascent frontiers in MSC-EV-based drug delivery.

An analysis of the effects of sharing research data, code, and preprints on citations.

Calls to make scientific research more open have gained traction with a range of societal stakeholders. Open Science practices include but are not limited to the early sharing of results via preprints and openly sharing outputs such as data and code to make research more reproducible and extensible. Existing evidence shows that adopting Open Science practices has effects in several domains. In this study, we investigate whether adopting one or more Open Science practices leads to significantly higher citations for an associated publication, which is one form of academic impact. We use a novel dataset known as Open Science Indicators, produced by PLOS and DataSeer, which includes all PLOS publications from 2018 to 2023 as well as a comparison group sampled from the PMC Open Access Subset. In total, we analyze circa 122'000 publications. We calculate publication and author-level citation indicators and use a broad set of control variables to isolate the effect of Open Science Indicators on received citations. We show that Open Science practices are adopted to different degrees across scientific disciplines. We find that the early release of a publication as a preprint correlates with a significant positive citation advantage of about 20.2% (±.7) on average. We also find that sharing data in an online repository correlates with a smaller yet still positive citation advantage of 4.3% (±.8) on average. However, we do not find a significant citation advantage for sharing code. Further research is needed on additional or alternative measures of impact beyond citations. Our results are likely to be of interest to researchers, as well as publishers, research funders, and policymakers.

The suitability of skilled talent training in higher vocational colleges based on AI and 5G network connection in the context of educational transformation and upgrading

The development of artificial intelligence (AI) and 5G network technology has changed the production and lifestyle of people. AI also has promoted the transformation of talent training mode under the integration of college industry and education. In the context of the current transformation of education, AI and 5G networks are increasingly used in the education industry. This paper optimizes and upgrades the training mode of skilled talents in higher vocational colleges by using its advanced methods and technologies of information display. This means is helpful to analyze and solve a series of objective problems such as the single training form of the current talent training mode. This paper utilizes the principles and laws of industry university research (IUR) collaboration for reference to construct and optimize the talent training mode based on the analysis of the requirements of talent training and the role of each subject in talent training. Then, the ecological talent training environment can be realized. In the analysis of talent training mode under the cooperation of production and education, the correlation coefficients of network construction, environment construction, scientific research funds, scientific research level, and policy support were 0.618, 0.576, 0.493, 0.785, and 0.451, respectively. This showed that the scientific research level had the greatest impact on talent training in the talent training mode of IUR collaboration, while policy support had less impact on talent training compared with other factors. The combination of AI and 5G network technology with the talent training mode of IUR cooperation can effectively analyze the influencing factors and problems of the talent training mode. The hybrid method is of great significance to the talent training strategy and fitting degree.