Modern problems of railway transport in Russia, such as the general technical condition of transportation assets, and relevant issues of their safe operation, substitution of imported equipment and its components, implementation of the programs of technological development give rise to the need to create new equipment and technologies, constructing schemes for long-term development of transport based on new safety requirements and strategic planning. Current level of developments does not allow to completely eliminate damage, failures and accidents regarding railway transportation assets manufactured in accordance with the current regulatory framework. Solving these problems is possible by identifying the actual state of an object regarding cyclic, corrosion, wear and other damage accumulated during operation, which determines the onset of limit states of the basic elements of an asset, taking into account resource recovery technologies at various stages of the life cycle, both in standard (design) operating conditions and beyond them.The article refers to the problems associated with ensuring safe operation of railway transport, with the aim of substantiating based on existing regulatory and technical documents of new approaches to the analysis of damageability, vulnerability of objects and assessment of the risks of accidents and disasters. The development of interaction through a system of new problem statements and regulatory and technical documents, as well as more active involvement in the use and development of the fundamental laws of physics, chemistry, and mechanics of real-life processes in the environment, make it possible to implement new concepts, strategies, and developments of advanced research for technical objects with the use of digital and intelligent technologies.