Battery Of Function Tests Research Articles

Comparison of effects of amitriptyline and venlafaxine on cognitive and psychomotor functions in healthy volunteers: A randomized parallel group study

Background: Antidepressant drugs cause various degree of psychomotor and cognitive function impairment. Aim and Objective: The objective of the study was to compare effects of amitriptyline and venlafaxine on cognitive and psychomotor functions in healthy volunteer. Materials and Methods: A prospective double-blind parallel group study involving 28 participants was carried in the clinical pharmacology laboratory. Participants were divided in two groups of 14 each and given single oral doses of amitriptyline 100 mg and venlafaxine 75 mg. Participants undergone battery of cognitive-psychomotor function tests at baseline and 2, 6-, and 24-h post-drug administration and analyzed. Results: Mean age of the participants was 21.93 ± 0.47 years with no significant difference at baseline for psychomotor functions (P > 0.05). Both amitriptyline and venlafaxine affect psychomotor and cognitive function significantly (P < 0.05). On comparing the effects of two drugs on psychomotor functions, at 2 h only statistically significant difference found in memory test score (7.50 ± 1.51 with amitriptyline vs. 9.14 ± 1.10 with venlafaxine, P = 0.003). At 6 h, only statistically significant difference found in six letter cancellation test (SLCT) net score (116.21 ± 36.25 with amitriptyline vs. 145.43 ± 28.12 with venlafaxine, P = 0.025). Memory score improves at 2 h with venlafaxine as compared to amitriptyline while SLCT improves at 6 h with venlafaxine. Twenty-two participants (12 from Group A vs. 10 from Group B, P < 0.05) developed adverse drug event. Sedation and dry mouth were common among amitriptyline group while nausea, vomiting, and muscular pain were common among venlafaxine group. Conclusions: Both amitriptyline and venlafaxine affect psychomotor functions but deterioration is more in amitriptyline group. Venlafaxine can be better therapeutic option with less deteriorating effect on psychomotor functions and less adverse drug reactions.

Effect of meditation on autonomic function in healthy individuals: A longitudinal study.

Context:Meditation is very useful to relieve stress via hypothalamo-pituitory axis. Meditation is considered to be useful to relieve stress and cardio-respiratory health.Aims:To compare the effect of meditation on autonomic function including heart rate variability (HRV) over a period of 3 months of meditation.Settings and Design:Longitudinal study conducted at Physiology Department, AIIMS Bhopal.Methods and Materials:Thirty healthy volunteers doing meditation were evaluated for autonomic function using autonomic function test battery (Ewing's battery) and HRV using Power lab (Ad instrument) and digital electrocardiograph (MARKS).Statistical Analysis Used:Statistical analysis was done using statistical software. Wilcoxon signed rank test was used.Results:Significant change was seen in Valsalva ratio and lying to standing 30:15 ratio. There was no significant change in other parameters studied with 3 months of meditation.Conclusions:Three months of meditation does not have any significant effect on major parameters of autonomic functions.

The evaluation of QTc prolongation and QT dispersion in type 2 diabetes mellitus as an indicator of cardiac autonomic neuropathy

Background: Diabetes mellitus refers to group of metabolic disorders characterized by hyperglycemia due to an absolute or relative deficit in insulin production or action. Diabetes mellitus produces pathological changes in most organs of the body including heart, blood vessels, kidneys, nerves and eyes. Cardiovascular autonomic neuropathy (CAN) is a severely debilitating yet underdiagnosed complication of diabetes. Diabetes-associated cardiovascular autonomic neuropathy damages autonomic nerve fibers that innervate the heart and blood vessels causing abnormalities in heart rate and vascular dynamics.Methods: Total 80 cases of diabetes mellitus were selected. Cardiac autonomic neuropathy in them was diagnosed by a series of tests recommended by Ewing et al, which include - Valsalva ratio, Deep Breath Test, Heart rate response to standing, Postural Hypotension, SHGT Increase in diastolic BP on sustained hand grip. They were divided into 2 groups A and B depending on presence or absence of cardiac autonomic neuropathy. ECG was done to calculate QTc and QTd.Results: In group A mean QTc was 0.344 sec and in group B in patients with mild CAN mean QTc was 0.432, moderate CAN mean QTc was 0.444, and in patients of severe CAN mean QTc was 0.481. p value was 0.001 that it is highly significant. Means more was degree of CAN more was prolongation of QT and similarly more the degree of CAN more was QTd.Conclusions: Diagnosis of cardiac autonomic neuropathy by battery of cardiac autonomic function tests is a comlex procedure. The prolongation of QTc interval and more specifically QTd interval on ECG is a marker in diagnosis of cardiac autonomic neuropathy which can be easily evaluated.

Performance differences between aphasia and healthy aging on an executive function test battery

Purpose: Executive function (EF) deficits commonly co-occur with other linguistic and non-linguistic deficits in aphasia. The questions about whether, and to what extent, people with aphasia (PWA) present deficits on different executive functions (EFs) is relatively understudied.Method: In this study, four EFs, set-switching, updating, inhibition, and dual task processing were evaluated in aphasia and healthy groups. Three groups of participants: 30 healthy young, 30 healthy old, and 10 PWA were assessed on four tasks, Colour Trails Test (CTT 1 and 2), Conners’ Continuous Performance Test II (CPT II), n-back (1- and 2-back), and divided attention task that tapped into different EFs. In order to examine performance differences on the EF tasks between the participant groups, repeated measures and multivariate analysis of variances with follow-up pairwise comparisons were computed. Pearson product-moment correlations were conducted to evaluate the strength and direction of the association between aphasia severity (on Western Aphasia Battery-Revised) and executive functioning.Result: PWA demonstrated significantly diminished performance on all EF tasks in comparison to healthy groups and differences were distinct on the higher-level complexity tasks such as the 2-back and CTT 2. The healthy older group demonstrated elevated response times on the CTT, CPT II, and divided attention tasks, and decreased sensitivity scores on the CPT II and n-back in comparison to the younger group. Also, aphasia severity correlated with reduced performance on selective EF measures.Conclusion: This study emphasises the importance of investigating EF deficits in PWA and its potential relationship to language behaviour. Understanding EF is critical for comprehension of linguistic and non-linguistic deficits and in planning treatment for PWA.

Brain-Derived Microparticles (BDMPs) Contribute to Neuroinflammation and Lactadherin Reduces BDMP Induced Neuroinflammation and Improves Outcome After Stroke.

Microparticles (MPs, ~size between 0.1 and 1 mm) are lipid encased containers derived from intact cells which contain antigen from the parent cells. MPs are involved in intercellular communication and regulate inflammation. Stroke increases secretion of brain derived MP (BDMP) which activate macrophages/microglia and induce neuroinflammation. Lactadherin (Milk fat globule–EGF factor-8) binds to anionic phospholipids and extracellular matrices, promotes apoptotic cell clearance and limits pathogenic antigen cross presentation. In this study, we investigate whether BDMP affects stroke-induced neuroinflammation and whether Lactadherin treatment reduces stroke initiated BDMP-induced neuroinflammation, thereby improving functional outcome after stroke. Middle aged (8–9 months old) male C57BL/6J mice were subjected to distal middle cerebral artery occlusion (dMCAo) stroke, and BDMPs were extracted from ischemic brain 24 h after dMCAo by ultracentrifugation. Adult male C57BL/6J mice were subjected to dMCAo and treated via tail vein injection at 3 h after stroke with: (A) +PBS (n = 5/group); (B) +BDMPs (1.5 × 108, n = 6/group); (C) +Lactadherin (400 μg/kg, n = 5/group); (D) +BDMP+Lactadherin (n = 6/group). A battery of neurological function tests were performed and mice sacrificed for immunostaining at 14 days after stroke. Blood plasma was used for Western blot assay. Our data indicate: (1) treatment of Stroke with BDMP significantly increases lesion volume, neurological deficits, blood brain barrier (BBB) leakage, microglial activation, inflammatory cell infiltration (CD45, microglia/macrophages, and neutrophils) into brain, inflammatory factor (TNFα, IL6, and IL1β) expression in brain, increases axon/white matter (WM) damage identified by decreased axon and myelin density, and increases inflammatory factor expression in the plasma when compared to PBS treated stroke mice; (2) when compared to PBS and BDMP treated stroke mice, Lactadherin and BDMP+Lactadherin treatment significantly improves neurological outcome, and decreases lesion volume, BBB leakage, axon/WM injury, inflammatory cell infiltration and inflammatory factor expression in the ischemic brain, respectively. Lactadherin treatment significantly increases anti-inflammatory factor (IL10) expression in ischemic brain and decreases IL1β expression in plasma compared to PBS and BDMP treated stroke mice, respectively. BDMP increases neuroinflammation and aggravates ischemic brain damage after stroke. Thus, Lactadherin exerts anti-inflammatory effects and improves the clearance of MPs to reduce stroke and BDMP induced neurological deficits.

EXAMINING SEX DIFFERENCES WITHIN THE RELATIONSHIP BETWEEN PHYSICAL ACTIVITY AND EXECUTIVE FUNCTION IN OLDER ADULTS

Research has demonstrated sex-associated differences in physical activity and its benefits on cognition in older adults. The present study explored differential associations between moderate-to-vigorous physical activity (MVPA) and executive function, which is known to decline with aging. N = 53 older adults without cognitive impairment (M = 73.19 years, SD = 6.53) wore accelerometers (Actigraph GT3X+) during 7 consecutive days. Activity intensity was categorized as light, moderate, or vigorous based on Freedson Adult Vector Magnitude cutpoints. Participants completed a battery of executive function tests: Digit Symbol Substitution Test, Verbal Fluency, Trail Making Test, and Stroop Color-Word Test. A cognitive composite score was created using confirmatory factor analysis. Women had a higher mean MVPA (4.57%) than men (2.64%, t (19.04) = -2.49, p = .022). However, executive function performance did not differ by sex (t (26.20) = 1.67, p =.107). The interaction between sex and time in MVPA did not predict performance on executive function, adjusting for age and education. Older age was the only significant predictor of poorer executive function (β = -0.038, p = .003). The current sample had limited engagement in MVPA (range 0.18-10.87%). These findings suggest that the amount of engagement in MVPA in a free-living environment may not be sufficient to demonstrate sex-associated differences in executive function performance. Future studies should explore executive function performance with other intensity levels and examine other areas of cognition.

Acoustic slow wave sleep enhancement via a novel, automated device improves executive function in middle-aged men.

As slow-wave activity (SWA) is critical for cognition, SWA-enhancing technologies provide an exciting opportunity to improve cognitive function. We focus on improving cognitive function beyond sleep-dependent memory consolidation, using an automated device, and in middle-aged adults, who have depleted SWA yet a critical need for maximal cognitive capacity in work environments. Twenty-four healthy adult males aged 35-48 years participated in a randomized, double-blind, cross-over study. Participants wore an automated acoustic stimulation device that monitored real-time sleep EEG. Following an adaptation night, participants were exposed to either acoustic tones delivered on the up phase of the slow-wave (STIM) or inaudible "tones" during equivalent periods of stimulation (SHAM). An executive function test battery was administered after the experimental night. STIM resulted in an increase in delta (0.5-4 Hz) activity across the full-night spectra, with enhancement being maximal at 1 Hz. SWA was higher for STIM relative to SHAM. Although no group differences were observed in any cognitive outcomes, due to large individual differences in SWA enhancement, higher SWA responders showed significantly improved verbal fluency and working memory compared with nonresponders. Significant positive associations were found between SWA enhancement and improvement in these executive function outcomes. Our study suggests that (1) an automated acoustic device enhances SWA; (2) SWA enhancement improves executive function; (3) SWA enhancement in middle-aged men may be an important therapeutic target for enhancing cognitive function; and (4) there is a need to examine interindividual responses to acoustic stimulation and its effect on subsequent cognitive function. This study has been registered with the Australian New Zealand Clinical Trials Registry. "The efficacy of acoustic tones in slow-wave sleep enhancement and cognitive function in healthy adult males". https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=371548&isReview=true. ACTRN12617000399392.

Age- and Gender-Related Changes in Physical Function in Community-Dwelling Brazilian Adults Aged 50 to 102 Years.

Cutoff points for physical function tests are commonly used in clinical practice for the evaluation, monitoring, and treatment of older adults. Previous studies have shown that, while age-related patterns of muscle strength change are similar between ethnic groups, strength values differ significantly independent of age. Whether the same applies to other physical function tests is presently unclear. This study investigated age- and gender-related changes of performance on a battery of physical function tests in Brazilian community dwellers. The study followed a cross-sectional design. Participants were community-dwelling adults. Candidates were considered eligible if they were 18 years or older, lived independently, and possessed sufficient physical and cognitive abilities to perform all of the measurements required by the protocol. Physical function tests included isometric handgrip (IHG), 5 times sit-to-stand (5×STS) test, Timed Up and Go, 1-leg stance, and walking speed (WS) at usual and fast pace. Two-thousand eight-hundred and four people were enrolled. Mean age was 68.0 (7.0) years (range 50-102 years), and 2262 (80.7%) were women. Men displayed better IHG and balance, while women showed higher performance on the 5×STS and WS tests. A gender-specific pattern of decline in physical performance was observed. Specifically, women showed a linear age-dependent decline in all tests. In men, only in the IHG, 1-leg stance, and WS test at a fast pace was there a linear decline with age. In both genders, the lowest mean values of physical function tests were higher than the proposed cutoffs for sarcopenia. Our findings indicate that the performance on different physical function tests decreases with advancing age in Brazilian adults, following a gender-specific pattern. In none of the tests did the lowest mean values reach the cutoffs for sarcopenia. This suggests that region-specific cutoffs might be necessary to identify older people at risk of adverse events.

EXAMINING OF THE CORRELATION BETWEEN THE FUNCTIONAL MOVEMENT SCREEN AND THE CARDIO FITNESS TEST IN STUDENTS STUDYING IN THE FACULTY OF SPORTS SCIENCES

This study was conducted to examine the correlation between the scores of the Functional Movement Screen (FMS) and the scores of the Cardio Fitness Test (CFT) in students studying in the Faculty of Sports Sciences. The sample group was composed of totally 25 students, including 14 males and 11 females aged between 22-24 years. The Functional Movement Screen (FMS) test battery including seven stations as deep squat, hurdle step, in-line lunge, shoulder mobility, active straight-leg raise, trunk stability, and rotary trunk and the Cardio Fitness Test (CFT) battery including six stations as resting heart rate, heart rate recovery, body flexibility, upper body strength, core strength, and lower body strength were applied to the sample group in different days. It was found that there was a statistically significant positive correlation between the total scores of the Functional Movement Screen (FMS) and the total scores of the Cardio Fitness Test (CFT) (r =0.60, p<0.001). While no statistically significant correlation was found between the lower body total scores of the relevant test batteries, there was a statistically significant positive correlation between the upper extremity total scores (r=0.48, p<0.05). Consequently; the significant correlation found between the Functional Movement Screen test battery, used in posture analysis and posture rehabilitation, and the Cardio Fitness Test formed the opinion that these two tests can be used in the field in combination. It may be recommended to apply this correlation in larger groups and assess the gender and age differences. Article visualizations:

Anterior cruciate ligament reconstructed females who pass or fail a functional test battery do not exhibit differences in knee joint landing biomechanics asymmetry before and after exercise.

A functional test battery (FTB) has been proposed to evaluate the readiness of return to activity after ACLR. However, there is limited evidence documenting the usefulness of an FTB. Therefore, the purpose of the current investigation was to compare knee joint landing biomechanics asymmetry during double-leg jump landing (DLJL) and single-leg jump cutting (SLJC) between healthy females and ACLR females who pass (ACLR-pass) or fail (ACLR-fail) an FTB before and after the completion of a sustained exercise protocol. Eighteen ACLR females (ten ACLR-pass and eight ACLR-fail) and twelve healthy females performed an FTB including The 2000 International Knee Documentation Committee Subjective Knee Evaluation Form, the Knee Outcome Survey Activities of Daily Living Scale, quadriceps strength, and single-leg hop tests. DLJL and SLJC knee joint biomechanics asymmetry were measured before and after exercise. During DLJL, there were significant main effects of group on peak anterior tibial shear force (ATSF) asymmetry [F(2,27) = 3.86, p < 0.05, [Formula: see text] = 0.214] and peak vertical ground reaction force (vGRF) asymmetry [F(2,27) = 3.34, p = 0.05, [Formula: see text] = 0.198]. During SLJC, there was a significant group main effect for peak ATSF asymmetry [F(2,27) = 3.494, p = 0.04, [Formula: see text] = 0.206]. ACLR-fail exhibited greater asymmetry in peak ATSF during DLJL and SLJC compared to healthy females. In addition, ACLR-pass exhibited greater asymmetry in peak ATSF and peak vGRF during DLJL and SLJC, respectively, compared to healthy females. However, ACLR-fail did not exhibit any significant differences in landing biomechanics asymmetry during either task compared with ACLR-pass. Furthermore, the completion of a sustained exercise protocol did not affect knee joint landing biomechanics asymmetry across groups. II.

Timing for Safe Return to Sport after Medial Patellofemoral Ligament Reconstruction: The Role of a Functional Test Battery.

The purpose of this article was to analyze clinical and functional results after medial patellofemoral ligament (MPFL) reconstruction and to establish if a computer-assisted physical test battery could determine a "safe timing" to return to sport. We hypothesized that "time-based" criteria to declare safe return to sport could not be reliable to predict functional recover. Fifty-eight young athletic patients were selected after isolated reconstruction of MPFL. The minimum follow-up was 8 months. All the patients were evaluated subjectively with Kujala and Short Form 36 (SF-36) scores and objectively through a standardized computer-assisted physical battery of seven tests (Back in Action, Corehab). No patient was lost at the end point of follow-up and no recurrence of patellar dislocation was reported. At 8 months, 31 patients (53.4%) returned to sport at preoperative levels, and 23 (39.6%) participated in sports at lower levels. The subjective evaluation reported an increase of Kujala (60-92.7) and SF-36 score (28.6/25.4-52.2/53.6). At computer-assisted objective assessment, only 23 patients (39.6%) fulfilled the criteria for safe return to sport, while 31 (53.4%) got an insufficient outcome and 4 (6.9%) failed to complete the test. From our data, clinical scores after MPFL reconstruction provide only little insight into return to sport. The introduction of a computer-assisted objective analysis in the decision-making process for proper return to sport is necessary to evaluate functional recovery and dynamic knee stability.

Propionate relieves pentylenetetrazol-induced seizures, consequent mitochondrial disruption, neuron necrosis and neurological deficits in mice

The present research was designed to evaluate the protective effects and underlying mechanisms of propionate, a bioactive food additive, on mitochondrial disruption, neuron necrosis and neurological deficits after epilepsy seizures. Epilepsy seizures was induced by repetitive injections of pentylenetetrazol at a dose of 37 mg per kg. Propionate (37.5, 50 and 75 mg/kg) as well as sodium valproate (300 mg/kg) were administrated intragastrically (i.g.) 1 h before each PTZ injection and continued for 40 days. The influence of propionate was assessed by many biochemical assays and neurobehavioral experiments. The results of gas chromatography (GC) analysis indicated that increased concentration of propionate can be explored in hippocampus area of propionate + PTZ treated animals. Propionate decreased epilepsy seizure intensity, increased latency of seizures. Meanwhile, propionate treatment reversed the structure disruption of the mitochondria, improved ATP level and lessened 8-OHdG level in the brains of animals with seizures. In addition, we find propionate pretreated can increase activities of the antioxidant enzymes (CAT, SOD, as well as GSH-Px) in mitochondria. Additionally, propionate reduced neuronal loss in hippocampus and our results suggest that HIF-1α/ERK pathway and neuron necrosis exists potential linkage during epileptogenesis. Moreover, as a result, propionate administration can significantly improve the neurological function estimated by a battery of functional tests. In conclusion, treatment with propionate attenuates mitochondrial disruption, hippocampal apoptosis and neurological deficits in a mouse model of epilepsy seizures. Therefore, propionate, currently used as a food preservative, has a potential additional advantage of ameliorating epilepsy seizures.

Patients with schizophrenia have impaired muscle force-generating capacity and functional performance.

Patients with schizophrenia have impaired physical health. However, evidence of how skeletal muscle force-generating capacity (FGC), a key component of functional performance, may contribute to the impairment is scarce. Thus, the aim of this study was to investigate the patient groups' skeletal muscle FGC and its association with functional performance. Leg-press FGC was assessed along with a battery of functional performance tests in 48 outpatients (28 men, 34±10years; 20 women, 36±12years) with schizophrenia spectrum disorder (ICD-10, F20-29), and compared with 48 healthy age- and gender-matched references. Results revealed reduced one-repetition maximum (1RM) in men (-19%, P<.01) and a trend toward reduction in women (-13%, P=.067). The ability to develop force rapidly was also impaired (men: -30%; women: -25%, both P<.01). Patients scored worse than healthy references on all physical performance tests (stair climbing: -63%; 30-second sit-to-stand (30sSTS): -48%; six-minute walk test (6MWT): -22%; walking efficiency: -14%; and unipedal stance eyes open: -20% and closed: -73%, all P<.01). 1RM correlated with 6MWT (r=.45), stair climbing (r=-.44), 30sSTS (r=.43), walking efficiency (r=.26), and stance eyes open (r=.33) and closed (r=.45), all P<.01. Rapid force development correlated with 6MWT (r=.54), stair climbing (r=-.49), 30sSTS (r=.45), walking efficiency (r=.26), and stance eyes open (r=.44) and closed (r=.51), all P<.01. In conclusion, skeletal muscle FGC and functional performance are reduced in patients with schizophrenia and should be recognized as important aspects of the patient groups' impaired health. Resistance training aiming to improve these components should be considered an important part of clinical treatment.

Methodological Considerations for a Vascular Function Test Battery

There is a dearth of information regarding the reliability of non-invasive measures of vascular function taken in a single testing session. This study aimed to determine the test-retest reliability of a test battery of vascular function measures: automated blood pressure (BP), laser Doppler imaging with iontophoresis (LDI), digital volume pulse (DVP), pulse wave velocity (PWV), augmentation index (AIx) measured by pulse wave analysis (PWA) and flow-mediated dilation (FMD) taken within and between sessions. Measures were taken in 21 non-smoking males intra-session and again inter-session (one week apart) to determine repeatability and reproducibility, respectively. There was moderate to excellent repeatability (ICC: 0.53-0.93; CV=2.2-18.1%) and reproducibility (ICC: 0.71-0.96; CV 1.9-14.2%) for BP, DVP stiffness index, PWV, AIx, AIx normalised to heart rate (75 bpm), absolute and percentage FMD. Repeatability of the DVP reflection index was moderate (ICC: 0.64; CV=9.5%) but there was poor reproducibility (ICC: 0.17; CV=15.1%). Moreover, the repeatability and reproducibility of the LDI measures ranged from poor to good (ICC: 0.31-0.84; CV=28.4-36.7%). These data indicated that there was considerable variability in the repeatability and reproducibility of measurements of endothelial function and arterial stiffness taken in a battery of measurements, which needs careful consideration in future research designs.

Preseason Functional Performance Test Measures Are Associated With Injury in Female College Volleyball Players.

Preseason functional performance test measures have been associated with noncontact time-loss injury in some athletic populations. However, findings have been equivocal with many studies consisting of heterogeneous populations. To determine if preseason standing long jump and/or single-leg hop test scores are associated with a noncontact time-loss injury to the lower quadrant (LQ = low back or lower-extremities) in female Division III college volleyball (VB) players. Prospective cohort study. National Collegiate Athletic Association Division III female VB teams. A total of 82 female college VB players (age = 18.9 [1.0]y). Standing long jump and single-leg hop test measures were collected at the start of the official preseason. Athletic trainers tracked all time-loss injuries and their mechanisms. Athletes were categorized as at risk if their preseason standing long jump <80% height, bilateral single-leg hop <70% height, and had a SLH side-to-side asymmetry >10%. The noncontact time-loss overall injury rate for the LQ region in at-risk athletes was 13.5 (95% confidence interval [CI], 4.3-31.5) per 1000 athletic exposures. At-risk athletes were significantly more likely to experience a noncontact time-loss injury than VB players in the referent group (rate ratio = 6.2; 95% CI, 1.9-17.2; P = .008). The relative risk of sustaining a noncontact time-loss injury to the LQ was 4 times greater in the at-risk group (relative risk = 4.6; 95% CI, 2.1-10.1; P = .01). At-risk athletes were 6 times more likely to experience a foot or ankle injury (relative risk = 6.3; 95% CI, 2.1-19.2; P = .008). Suboptimal performance on a battery of functional performance tests is associated with a significantly greater risk of noncontact time-loss injury to the LQ in female Division III college VB players.

Less Is More: A Pilot Study Assessing The Benefit Of Exercise Frequency For Older Adults

There are countless benefits of exercising for older adults including a maintenance of bone density, muscle mass, and the preservation of muscular strength and endurance. Although older adults benefit from exercising it may be more convenient, more accessible, and less of a burden to exercise less times per week. PURPOSE: The purpose of this pilot study is to quantify if there are any added benefits to exercising three days a week compared to two days a week. METHODS: Participants included community dwelling adults (N=36, M=74.34±7.91 years) who self-selected exercise frequency by joining a multi-component fitness class offered in their local community. Classes were held either two or three days per week depending on the location. The Functional Fitness Test and Short Physical Performance Battery were conducted two times 6 months apart at all locations. Results were analyzed using repeated measures ANOVA. RESULTS: A significant group-by-time interaction was observed for hand-grip strength, F (1, 18) = 7.92, p = .01, with the two days per week group improving by 13% and the three days per week group decreasing by 1.9%. Interactions were not significant for chair stands test, arm curl test, 8 Foot Up-and-Go, or Gait speed, p> .05. There was a significant time effect for the chair stand test [F (1, 15) = 7.54, p = .01], gait speed [F (1, 19) = 7.91, p = .01], and hand-grip strength [F (1, 18) = 4.61, p = .04] with all tests indicating improvements from the first to second test. Univariate effect sizes indicate a trend toward greater improvements in the 2 d/wk group when compared to the 3 d/wk group with the exception of the arm curl which favors 3 d/wk. CONCLUSION: Although results are preliminary, this study indicates that handgrip strength was enhanced when participants were involved in a multi-component exercise program two days per week (13%). Chair stands test, arm curl test, 8 Foot Up-and-Go, and Gait speed increased regardless of the number of days per week of exercise. Notable limitations to the study are the number of males (N=6) compared to females (N=30) and participant’s self-selection of exercise frequency. Also, we did not track outside influences such as physical activity levels, health status, and history of disease. Future studies should confirm these results using an experimental design in a larger, more diverse sample.

Can a physical activity similar to activities of daily living cause dynamic hyperinflation and change the thoracoabdominal configuration in patients with chronic obstructive pulmonary disease?

Introduction: COPD is characterized by the ventilatory limitation, with reduction of the inspiratory reserve volume and dynamic hyperinflation (DH), which changes the configuration of the thoracic compartment, resulting in a disadvantage in respiratory muscle kinetics, and reduced functional capacity. The optoelectronic plethysmography (OEP) has been used to monitor changes in thoracoabdominal mobility. The Glittre-ADL test is a short battery of functional tests that simulate activities of daily living. In mild and moderate COPD, the effect of Glittre-ADL on thoracoabdominal kinetics and DH is understudied.Objective: The aim of our study was to evaluate the acute effects of the Glittre-ADL test on lung function and thoracoabdominal mobility using OEP in patients with mild and moderate COPD.Materials and methods: Twenty-five male and female patients between 45 and 80 years of age with COPD were submitted to the exercises that simulated Glittre-ADL test. Spirometry and OEP were performed before and after the test.Results: After the Glittre test, increases were found in EV (p=0.005), percentage of contribution of the abdominal compartment (p=0.054) and expiratory reserve volume (ERV) (p=0.006) and reductions were found in the contribution of the upper thoracic compartment (p=0.008) and inspiratory capacity (IC) (p=0.040).Conclusion: The acute effect of ADL was a change in thoracoabdominal kinetics, especially the percentage of contribution of the abdominal compartment, as demonstrated by OEP. These findings, together with the reduction in IC and increase in ERV, after the Glittre-ADL test suggest the occurrence of DH, even in patients with mild to moderate COPD according to the GOLD classification.

Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases.

BackgroundRetinal optical coherence tomography findings in Lewy body diseases and their implications for visual outcomes remain controversial. We investigated whether region‐specific thickness analysis of retinal layers could improve the detection of macular atrophy and unravel its association with visual disability in Parkinson's disease.MethodsPatients with idiopathic Parkinson's disease (n = 63), dementia with Lewy bodies (n = 8), and E46K mutation carriers in the α‐synuclein gene (E46K‐SNCA) (n = 4) and 34 controls underwent Spectralis optical coherence tomography macular scans and a comprehensive battery of visual function and cognition tests. We computed mean retinal layer thicknesses of both eyes within 1‐, 2‐, 3‐, and 6‐mm diameter macular discs and in concentric parafoveal (1‐ to 2‐mm, 2‐ to 3‐mm, 1‐ to 3‐mm) and perifoveal (3‐ to 6‐mm) rings. Group differences in imaging parameters and their relationship with visual outcomes were analyzed. A multivariate logistic model was developed to predict visual impairment from optical coherence tomography measurements in Parkinson's disease, and cutoff values were determined with receiver operating characteristic analysis.ResultsWhen compared with controls, patients with dementia with Lewy bodies had significant thinning of the ganglion cell–inner plexiform layer complex within the central 3‐mm disc mainly because of differences in 1‐ to 3‐mm parafoveal thickness. This parameter was strongly correlated in patients, but not in controls, with low contrast visual acuity and visual cognition outcomes (P < .05, False Discovery Rate), achieving 88% of accuracy in predicting visual impairment in Parkinson's disease.ConclusionOur findings support that parafoveal thinning of ganglion cell–inner plexiform complex is a sensitive and clinically relevant imaging biomarker for Lewy body diseases, specifically for Parkinson's disease. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

An Exploratory Factor Analysis of Sensor-Based Physical Capability Assessment.

Physical capability (PC) is conventionally evaluated through performance-based clinical assessments. We aimed to transform a battery of sensor-based functional tests into a clinically applicable assessment tool. We used Exploratory Factor Analysis (EFA) to uncover the underlying latent structure within sensor-based measures obtained in a population-based study. Three hundred four community-dwelling older adults (163 females, 80.9 ± 6.4 years), underwent three functional tests (Quiet Stand, QS, 7-meter Walk, 7MW and Chair Stand, CST) wearing a smartphone at the lower back. Instrumented tests provided 73 sensor-based measures, out of which EFA identified a fifteen-factor model. A priori knowledge and the associations with health-related measures supported the functional interpretation and construct validity analysis of the factors, and provided the basis for developing a conceptual model of PC. For example, the “Walking Impairment” domain obtained from the 7MW test was significantly associated with measures of leg muscle power, gait speed, and overall lower extremity function. To the best of our knowledge, this is the first time that a battery of functional tests, instrumented through a smartphone, is used for outlining a sensor-based conceptual model, which could be suitable for assessing PC in older adults and tracking its changes over time.

Cognitive function and oral health among ageing adults.

There is inconclusive evidence that cognitive function is associated with oral health in older adults. This study investigated the association between cognitive function and oral health among older adults in England. This longitudinal cohort study included 4416 dentate participants aged 50years or older in the English Longitudinal Study of Ageing during 2002-2014. Cognitive function was assessed at baseline in 2002/2003 using a battery of cognitive function tests. The self-reported number of teeth remaining and self-rated general oral health status was reported in 2014/2015. Ordinal logistic regression was applied to model the association between cognitive function at baseline and tooth loss or self-rated oral health. Cognitive function at baseline was negatively associated with the risk of tooth loss (per each 1 standard deviation lower in cognitive function score, OR: 1.13, 95% CI: 1.05-1.21). When cognitive function score was categorized into quintiles, there was a clear gradient association between cognitive function and tooth loss (P-trend=0.003); people in the lowest quintile of cognitive function had higher risk of tooth loss than those in the highest quintile (OR: 1.39, 95% CI: 1.12-1.74). A similar magnitude and direction of association were evident between cognitive function and self-rated oral health. This longitudinal study in an English ageing population has demonstrated that poor cognitive function at early stage was associated with poorer oral health and higher risk of tooth loss in later life. The gradient relationship suggests that an improvement in cognitive function could potentially improve oral health and reduce the risk of tooth loss in the ageing population.