10009 Background: Older adults with cancer facing decisions with competing health outcomes may favor maintaining quality of life (QOL), independence, or cognition over prolonging survival. The goal of this study was to elicit preferences among outcomes from older adults starting CT. Methods: This is a secondary analysis of an ongoing prospective study aimed at identifying and addressing vulnerabilities in older adults (age ≥65) starting CT (NCT02517034). Patients completed 3 tools assessing preferences in health outcomes: 1) Health Outcomes Tool: rates the relative importance of 4 outcomes (survival, function, freedom from pain, and freedom from symptoms) using a visual analog scale (VAS); 2) Now vs. Later Tool: rates the relative importance of QOL at 3 times: today,1 year (y) in the future , and 5y in the future using a VAS; and 3) Attitude Scale: rates subjects’ agreement with statements related to outcomes. We measured the proportion of patients reporting other outcomes being “as important” or “more important” than survival and studied their characteristics. Results: 121 patients (median age 71y, 47% male, 72% Stage IV, 31% gastrointestinal cancer) were included. 52% had poor physical function, 50% needed help with instrumental activities of daily living (e.g. cooking or transportation), and 73% had poor social support. On the Health Outcomes Tool, 44% rated other outcomes as more important than survival. On the Now vs. Later tool, 59% considered current QOL more/as important as QOL at 1y, and 58% considered current QOL more/as important as QOL at 5y. On the Attitude Scale, 58% agreed/strongly agreed with: “I would rather live a shorter life than lose my ability to take care of myself”; and 81% agreed/strongly agreed with: “It is more important to me to maintain my thinking ability than to live as long as possible”. Patients with good physical function and/or good social support were more likely to consider survival as the most important outcome, regardless of stage. Conclusions: Half of older patients rated other outcomes (particularly cognitive ability) as being more important than survival. Eliciting which outcomes are the most important for older patients can help define treatment goals and improve shared decision-making.
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