Functional Dendrimers Research Articles

Synthesis and properties of a new class of polyether dendritic fragments: Useful building blocks for functional dendrimers

Polyether dendritic sectors 1–4 from the first to the fourth generations, respectively, were prepared by a convergent approach from readily available 4-tert-butylphenol, phloroglucinol and 1,3-dibromopropane. Using a three-step iterative synthetic sequence involving mono-O-alkylation of [Gn]-OH with excess 1,3-dibromopropane, bis-O-alkylation of the resulting compound with 5-benzyloxyresorcinol 5 followed by hydrogenolysis with palladium catalyst, [G(n+1)]-OH of the next higher generation could be prepared in good yields. These dendritic sectors have good solubility properties and are inert in both acidic and basic media, and do not show any redox behaviour from −2.0 to +1.9 V. Hence they are useful dendritic building blocks for the preparation of functional dendrimers.

Facile construction of acid-base and redox stable polyether-based dendritic fragments

Polyether based dendritic fragments ot up in the fourth generation can be synthesized in good yields from phloroglucinol and 1,3-dibromopropane These dendritic fragments are stable in acid-base or redox conditions and can be linked to various functional core groups to form functional dendrimers which can he served as models to study the influence ot the dendritic structure on the physical, chemical and electrochemical properties of the interior core.