Objectives: Nuclear transcription factor, Peroxisome Poliferator Activated Receptorγ (PPARγ) has been implicated in blood pressure regulation and vascular signalling that involves G-protein coupled receptors (GPCR). GPCR function depends on relative activation of multiple signalling pathways which is still not clear. Therefore, we have investigate the expression of genes that are related to GPCR signalling in hypertension and modulation by PPARγ. Design & Methods: Male SHRs and WKY controls were treated for 2 months with / with-out GW1929 (30 mg/kg orally), a PPARγ ligand and expression of genes were determined by PCR array. RNAs from aortic homogenates were used in this array analysis that included 84 genes from 16 different pathways involved in GPCR signalling. Results: In SHR, expression of 5 genes were up-regulated (3-5 fold) compared to their WKY controls. Among the up-regulated genes, expression of Cdkn1b and S1pr2 remains unchanged in GW1929 treated SHR. On the contrary expression of Ccl2, Ctgf and Gnas genes were significantly (p<0.05) reduced in GW1929 treated SHR. Similarly, in SHR, expression of 8 genes were significantly reduced (3-12 fold). Among these genes, Agtr1b, Ucp1, IL2, Drd1a were unchanged in GW1929 treated SHR while improving the expression of Bai1, Grm1, Grm5, Oprk1 gene (p<0.05) expression. Conclusion: This data suggests that GPCR signalling genes are involved in the regulation of blood pressure in SHR and PPARγ ligand-mediated blood pressure reduction may involve transcriptional regulation of these genes. We also suggests that cAMP, PKC, PI-3 kinase, Protein tyrosine kinase and Rho kinase pathways are involved in the regulation of blood pressure in SHR