When the Fluid Mosaic Model (FMM) of biological membrane structure was introduced 42 years ago, it was visualized as a basic model for cell membranes that could explain existing data on membrane proteins and lipid structures and their dynamics. According to the (FMM), a membrane was described as a biological fluid of proteins and lipids oriented in two dimensions. The basic structure of all cell and organelle membranes is the lipid bilayer. Protein molecules are distributed in different regions of the bilayer and perform diverse functions. Cell membranes are active, fluid structures, and most of their molecules are able to travel in the plane of the membrane (Singer and Nicolson, 1972). The viscosity of a lipid membrane largely depends on whether the acyl chains attached to glycerophospholipids are grouped into a rigid state or exist in a relatively disordered, fluid state. Long chain saturated fatty acids maximize Van der Waals forces, and increase the viscosity of the membrane (Chapman and Benga, 1984). Fluidity is defined as the ease of movement and represents the reciprocal of the viscosity of the membrane (Lee, 1991). The fluid properties of biological membranes are critical for various cell functions. Still slight changes in membrane fluidity may cause unusual function and pathological processes (Garcia et al., 2005). After more than 40 years, the (FMM), described by Singer and Nicolson is still relevant to recognize the structure, function, and dynamics of biological membranes (Nicolson, 2014). However, several biological processes cannot be explained on the basis of this typical phospholipid orientation and utilize other phospholipid conformations (Catala, 2012) that are described in this article.