To assess the effects of high-quality comprehensive nursing in combination with Longxue Tongluo capsules on the rescue effect and nerve function of acute stroke patients, 120 patients admitted to the emergency department of our hospital from January 2020 to December 2021 were separated into a control group and a study group at random. The control group received conventional treatment and routine emergency care. Based on the control group, the study group was given Longxue Tongluo capsules and high-quality comprehensive nursing. The receive-diagnosis time and diagnosing-treatment time of the study group were shorter relative to the control group, and the rescue success rate and total effective rate were higher. The National Institutes of Health Stroke Scale score in the study group presented lower when compared to the control group, and the activity of daily living score in the study group presented higher when compared to the control group. Relative to the control group, the nursing satisfaction of patients in the study group was better. In conclusion, high-quality comprehensive care combined with Longxue Tongluo capsules can promote the rescue effect, improve nerve function, and promote the ability of daily living activities of acute stroke patients.