Background: Liver cancer presents a significant global health challenge, particularly in Asia, due to high incidence rates and the difficulty of early detection. Despite advances in medical imaging, the accurate segmentation and prediction of liver tumors remain critical for effective treatment planning. Deep-learning is a revolutionary tool in medical imaging, offering promising solutions for automated analysis of liver cancer using CT images. Methods: This study develops a framework based on deep-learning- for the segmentation, and prediction cancer of the liver from Computed Tomography images. The framework leverages advanced convolutional neural network (CNN) architectures, including U-Net and its variants, optimized with class balancing methods. The model is trained and authenticated using a high-quality annotated images, dataset of liver CT images. Key techniques such as transfer learning, data augmentation, and hyper parameter tuning are employed to enhance model performance. Evaluation metrics include accuracy, sensitivity, specificity, Dice-coefficient, and (IoU).Intersection over Union Results: The design of proposed program achieved significant improvements in segmentation, accuracy, with an average Dice, Similarity-Coefficient (DSC) of 0.96 for liver segmentation and 0.84 for the tumor segmentation. The results demonstrate the superior performance of the model's compared to the other traditional methods and other existing deep learning models. Cascaded fully convolutional networks (FCNs) combined with 3D Conditional Random Fields (CRFs) showed robust performance, achieving true value accuracy rates of approximately 99.55% for liver segmentation. Conclusion: This study presents a novel and effective deep learning framework for liver cancer segmentation and prediction, highlighting the clinical applicability and relevance of the developed models in real-world medical settings. The findings highlight the potential in deep-learning for enhancing liver cancer diagnosis, facilitating early detection, timely interventions, and improved patient outcomes. This research contributes in increasing the body of knowledge in medical image analysis, enlighten the way for future advancements in the field. Keywords: Computed Tomography, Deep Learning, Machine Learning, U-Net, 3D, Segmentation, Fully Convolutional Networks, Conditional Random Fields, Dice Similarity Coefficient, Intersection over Union, Conventional Neural Network
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