Full-text Publications Research Articles

An Analysis Regarding the Ultimate Outcome of Abstracts Presented at the European Paediatric Surgeons' Association Congress.

The objective of this study is to analyze the conversion rate of abstracts presented at the European Paediatric Surgeons' Association (EUPSA) congress into full-text publications and to conduct a thorough analysis of the attributes and quality of the papers published. Abstract books including the years 2017 to 2022 were reviewed. Searches on PubMed and Google Scholar, utilizing keywords from the titles and the author names, were conducted to trace subsequent full-text publications. A categorical analysis detected variations and trends, with a significance threshold of p < 0.05. Quantitative data were presented as means ± standard deviations, whereas categorical data were represented as counts (n) and percentages (%). A total of 2,139 abstracts were presented at the EUPSA annual meetings during five consecutive congresses. The average number of presented abstracts was 427.6 ± 20.4 per year from across 63 different countries. European countries contributed the majority (71%). The presentations included both oral (n = 817, 38.2%) and poster presentations (n = 1,322, 61.8%). They predominantly focused on clinical topics (90.6%). Single-center retrospective studies were the most common study design (43.7%). Out of all abstracts presented, 1,033 (48.3%) were published within an average time interval of 1.39 ± 1.19 years after presentation. Most journals had an impact factor (IF) between 1 and 5 (74.5%). There was no significant year-to-year variation in publication rates (p = 1). Basic science studies were published in journals with significantly higher IF compared with clinical studies (p < 0.001). The publication rate of abstracts presented at the EUPSA annual congress stands at 48.3%, aligning with the rates observed in other similar studies. This suggests that abstracts submitted to the EUPSA congresses were evaluated and scored rigorously, adhering to international selection criteria. Furthermore, the majority of these abstracts were published in journals with moderate to high IFs, providing quantitative evidence of the scientific quality of research within the field of pediatric surgery.

The impact of distance learning on the health in schoolchildren (literature review)

Distance learning (Dl) is widespread in educational institutions. The COVID-19 epidemic has led to the transfer of only Dl to students in most countries of the world. However, the use of Dl is associated with a number of health risk factors. The purpose of the review is to study the impact of Dl on the health in schoolchildren. A literature search was conducted using PubMed and eLIBRARY.RU search engines. The initial search allowed identifying 21,745 reports, after an independent assessment by two experts, there are still 36 full-text publications containing original data on the impact on the health of schoolchildren. The analysis of the topics of publications allowed establishing all publications to be devoted to the study of the impact of Dl on the health of students during the COVID-19 epidemic, which does not allow differentiating the impact of Dl on health from the influence of self-isolation and fear of covid disease. Most studies do not compare the detected changes in health status during traditional training. The main complaints of students during Dl were complaints of painful sensations in the eyes, decreased vision, headache, back and neck pain, sleep disorders, largely associated with hygienically irrational learning conditions. The revealed changes in mental status (anxiety, depressive manifestations) are largely determined not by the presence of Dl, but by the influence of self-isolation and fear of covid disease. The transition to Dl also led to an increase in body weight in a number of students, a decrease in physical fitness. More pronounced changes in the state of health were noted in schoolchildren of junior classes. Conclusion. The identified adverse changes in the state of health in students can be minimized by the use of Dl in combination with traditional learning and compliance with hygienic requirements for its management.

Harnessing full-text publications for deep insights into C. elegans and Drosophila biomaps

In the rapidly expanding domain of scientific research, tracking and synthesizing information from the rapidly increasing volume of publications pose significant challenges. To address this, we introduce a novel high-throughput pipeline that employs ChatGPT to systematically extract and analyze connectivity information from the full-texts and abstracts of 24,237 and 150,538 research publications concerning Caenorhabditis elegans and Drosophila melanogaster, respectively. This approach has effectively identified 200,219 and 1,194,587 interactions within the C. elegans and Drosophila biomaps, respectively. Utilizing Cytoscape Web, we have developed a searchable online biomaps that link relevant keywords to their corresponding PubMed IDs, thus providing seamless access to an extensive knowledge network encompassing C. elegans and Drosophila. Our work highlights the transformative potential of integrating artificial intelligence with bioinformatics to deepen our understanding of complex biological systems. By revealing the intricate web of relationships among key entities in C. elegans and Drosophila, we offer invaluable insights that promise to propel advancements in genetics, developmental biology, neuroscience, longevity, and beyond. We also provide details and discuss significant nodes within both biomaps, including the insulin/IGF-1 signaling (IIS) and the notch pathways. Our innovative methodology sets a robust foundation for future research aimed at unravelling complex biological networks across diverse organisms. The two databases are available at worm.bio-map.com and drosophila.bio-map.com.

Pharmacovigilance study of tyrosine kinase inhibitors: Analysis of adverse reactions

The aim of the study is to analyze reports of adverse drug reactions published in the scientific literature occurring during and after the use of kinase inhibitors for the treatment of rheumatologic diseases to determine their type, frequency, and severity. The search was conducted in the MEDLINE and PubMed databases from January 2005 to May 2022. We found a total of 291 publications, from which we selected suitable ones for data extraction. We conducted descriptive and variation analyses as the main statistical analyses. We determined mean values, standard deviation, minimum, maximum, and 95% confidence intervals. The PICOS tool was used to evaluate the results. The analyzed population includes patients with rheumatologic and oncologic diseases. There is a significant interest in the drug safety of kinase inhibitors, as they represent a rapidly evolving and reliable pharmacological class. Clarifying the safety profile of their representatives remains important. In-depth review of full-text publications shows that the high frequency of reported serious ADRs is rather due to increased interest in reporting and publishing these cases than to their high frequency of occurrence.

Clinically Applied Biomechanics of Mesh-reinforced Ventral Hernia Repair: A Practical Review.

Ventral hernia repair is inherently prone to recurrence. This article is a practical review that summarizes the literature on the biomechanics of ventral hernia repairs to provide clinically applicable, evidence-based recommendations to reduce hernia recurrence. A practical review of all relevant literature in PubMed concerning the mechanics of ventral hernia repairs and the forces involved was conducted in August 2023. Of the 598 full-text publications retrieved, 29 satisfied inclusion criteria. Among these, 5 articles included enough numeric data for a quantitative analysis of the ultimate tensile strength of the layers of the abdominal wall. The utilization of mesh in ventral hernia repairs is recommended to strengthen weakened abdominal wall tissue. It is essential to primarily close the anterior sheath with a robust mesh-tissue overlap to promote "load-sharing" between the mesh and the abdominal wall. This approach reduces mesh deformity and stress on fixation points, leading to lower hernia recurrence rates. Minimizing mesh fixation (when placed in the retromuscular plane) can reduce postoperative pain and hospital stay without significantly affecting hernia recurrence. Orienting mesh according to abdominal anisotropy is crucial for reducing mesh stiffness, improving healing, and preventing recurrence. Future studies with advanced computer modeling will continue to provide further insights into mesh biomechanics and abdominal wall healing.

Electronic Health Interventions and Cervical Cancer Screening: Systematic Review and Meta-Analysis.

Cervical cancer is a significant cause of mortality in women. Although screening has reduced cervical cancer mortality, screening rates remain suboptimal. Electronic health interventions emerge as promising strategies to effectively tackle this issue. This systematic review and meta-analysis aimed to determine the effectiveness of electronic health interventions in cervical cancer screening. On December 29, 2023, we performed an extensive search for randomized controlled trials evaluating electronic health interventions to promote cervical cancer screening in adults. The search covered multiple databases, including MEDLINE, the Cochrane Central Registry of Controlled Trials, Embase, PsycINFO, PubMed, Scopus, Web of Science, and the Cumulative Index to Nursing and Allied Health Literature. These studies examined the effectiveness of electronic health interventions on cervical cancer screening. Studies published between 2013 and 2022 were included. Two independent reviewers evaluated the titles, abstracts, and full-text publications, also assessing the risk of bias using the Cochrane Risk of Bias 2 tool. Subgroup analysis was conducted based on subjects, intervention type, and economic level. The Mantel-Haenszel method was used within a random-effects model to pool the relative risk of participation in cervical cancer screening. A screening of 713 records identified 14 articles (15 studies) with 23,102 participants, which were included in the final analysis. The intervention strategies used in these studies included short messaging services (4/14), multimode interventions (4/14), phone calls (2/14), web videos (3/14), and internet-based booking (1/14). The results indicated that electronic health interventions were more effective than control interventions for improving cervical cancer screening rates (relative risk [RR] 1.464, 95% CI 1.285-1.667; P<.001; I2=84%), cervical cancer screening (intention-to-treat) (RR 1.382, 95% CI 1.214-1.574; P<.001; I2=82%), and cervical cancer screening (per-protocol; RR 1.565, 95% CI 1.381-1.772; P<.001; I2=74%). Subgroup analysis revealed that phone calls (RR 1.82, 95% CI 1.40-2.38), multimode (RR 1.62, 95% CI 1.26-2.08), SMS (RR 1.41, 95% CI 1.14-1.73), and video- and internet-based booking (RR 1.25, 95% CI 1.03-1.51) interventions were superior to usual care. In addition, electronic health interventions did not show a statistically significant improvement in cervical cancer screening rates among women with HPV (RR 1.17, 95% CI 0.95-1.45). Electronic health interventions had a greater impact on improving cervical cancer screening rates among women in low- and middle-income areas (RR 1.51, 95% CI 1.27-1.79). There were no indications of small study effects or publication bias. Electronic health interventions are recommended in cervical cancer screening programs due to their potential to increase participation rates. However, significant heterogeneity remained in this meta-analysis. Researchers should conduct large-scale studies focusing on the cost-effectiveness of these interventions. CRD42024502884; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=502884.

WHICH IS MORE EFFECTIVE IN REDUCING BLOOD PRESSURE IN HYPERTENSION PATIENTS: A LOW SALT DIET OR THE DIETARY APPROACHES TO STOP HYPERTENSION (DASH)?

Background: Hypertension is a disease that requires early attention. One effort to prevent increased blood pressure in hypertension sufferers is to implement a diet that has been consulted with nutrition experts. Objectives: The aim of preparing this literature review is to compare the effectiveness of implementing a low-salt diet and dietary approaches to stop hypertension from the results of previous research. Design: The design used in preparing this article is a systematic review. Data Sources: This systematic review used 5 search databases to collect articles, including SCOPUS, Pubmed, Google Scholar, DOAJ, and ScienceDirect with the search year range 2019-2024. Review Methods: The researchers used the JBI Critical Appraisal guidelines to determine articles suitable for this systematic review. Then, the selected articles were reviewed comprehensively using a narrative approach. Results: Search results obtained 10,685 publications. Researchers filtered by eliminating duplicate publications, reviewing articles, and focusing on the Issue of Interest in Table 1 totaling 9,578 publications. Researchers re-screened the title (n = 598), abstract (n = 387), and full text (n = 113) of each publication that did not meet the inclusion criteria in Table 1. The researchers found 9 full-text publications that met the requirements for use in this systematic review. However, researchers only used 7 publications because 2 publications were considered to have a risk of bias. Conclusion: Based on the results of a systematic review that has been carried out, it was found that implementing the DASH diet will be more effective than implementing a low-salt diet.

Digital health and some thematic shifts in bioethics in academic publications after the pandemic

Abstract Background Digital health (DH) presents vast opportunities, but also dynamic shift in viewpoints, which is reflected in academic works. Since DH concerns patient data, a major issue is complying with the bioethical principles, and ensuring patients’ privacy and security. The aim of this research is to explore avenues, in which ethics and privacy are reflected in DH, especially in terms of research, legislation, artificial intelligence (AI) and blockchain applications in medicine and public health. Methods Literature search for full text publications in PubMed, Scopus and ScienceDirect focused on ethics and privacy in DH in the period 2019-2023 found 325 articles in English authored by academicians. Six thematic categories were identified: ethics (fundamental principles; ethics in using novel DH tools); privacy (in use of apps/wearables; as a challenge/barrier to DH interventions/technologies); ethics/privacy in: DH research (data gathering, use, sharing); policy and legislation (for DH applications); AI and blockchains (in medicine and public health). Results Articles were from 32 countries: USA-24.3%; UK-13.5%; Germany-7.7%; Canada-7.4%; Australia-6.7%; Netherlands, Italy, Switzerland-4.7% each; China, India-3.0% each and 20.3% from 22 other countries; 86.5% in medical/DH journals. Only 10.2% were published in 2019; 17.8% - 2020; 19.4% - 2021; 27.1% - 2022 and 25.5% - 2023. Privacy was discussed in 26.5%; ethics-23.7%; research-19.4%; AI-15.1%; policy and legislation-9.5% and blockchains-5.5% of the articles. The publication activity of all six categories increased after the unfold of the pandemic in 2020. In 2023 publications for ethics (13%), privacy (5.8%) and research (6.3%) decreased; for legislation (12.9%), AI (14.3%) and blockchains in healthcare (16.8%) increased. Conclusions The pandemic and its aftermath present a change in academic interest. Traditional ethical fundaments in DH slightly lose position in favor of top notch technologies and apt legislation. Key messages • The pandemic and modern technologies enforced new digital health applications. Further research will reveal the needs of AI and blockchain applications respecting privacy and the ethical principles. • Besides existing legislation and regulations, in order to catch up with the dynamic developments in DH, the legal base needs to become more flexible. Technologies change, privacy importance does not.

How far do oral lectures at European Orthodontic Society congresses reach? A comparison of abstract publication rates, article citations, and social media mentions.

This study investigated the scientific impact of oral abstracts presented in five consecutive European Orthodontic Society (EOS) congresses in terms of full-text publication rates as well as citations and social media metrics (altmetrics) of the resulting articles. PubMed (http://www.ncbi.nlm.nih.gov/pubmed) and Google Scholar (http://scholar.google.nl/) were screened to identify published articles originally presented as lectures at EOS 2015-2019. EOS date, abstract title, subject, number of authors, authors' names, first author's country of origin, and type of affiliation were extracted from congress abstract books. Altmetric Attention Scores (AASs), number of X (formerly Twitter) posts, Mendeley reads, and citations of the articles were retrieved from Altmetric Explorer and Web of Science (WoS) databases, respectively. Abstract details, full publication rates and Altmetric mentions and WoS citations of the related articles were analysed using univariable and multivariable logistic regression. In total, 51.79 to 73.91% of the lectures presented at EOS 2015-2019 were converted into peer-reviewed articles. There was a median interval of 10.95 months (interquartile range 20.5 months) between conference and publication dates. EOS congress year (overall Wald test P-value = .04) and number of authors (overall Wald test P-value < .01) were significant predictors for full-text publication of oral lectures. There was no significant effect of EOS presentation on AASs, citations, X posts, and Mendeley readers (P > .05). Journal impact factors and quartile rankings were not considered to determine the impact of the journals that published articles originally presented as EOS oral abstracts. Overall, 61.30% of EOS 2015-2019 lectures were published as full-length articles. Multi-authored abstracts presented higher odds of publication, whereas oral abstracts presented at EOS 2015 and 2018 had the lowest probabilities to reach full publication. EOS abstract-based articles were assigned similar numbers of citations and AASs to articles not presented at EOS congresses.

Features of refeeding syndrome in pediatric intensive care unit patients (literature review)

Introduction. Restoration of nutrition in patients with nutritional deficiency hospitalized in intensive care units is a complex process due to the high risk of the development of refeeding syndrome. Refeeding syndrome is insufficiently studied in children not only with regard to pathogenesis and intensive care, but also with regard to its influence on the further development of the child.Materials and methods. A non-systematic review of literature sources was performed. Domestic publications were searched in the database on the eLibrary website, foreign publications were searched in PubMed, Google Scholar, Cophrane Library, Cyberleninka, ResearchGate databases in the period 2017–2024. 73 full-text publications describing risk factors, peculiarities of mechanisms of refeeding syndrome development in children, clinical picture and methods of intensive therapy were analyzed.Results. The review analyzed and systematized the stratified risk factors, peculiarities of pathogenesis and clinical picture of refeeding syndrome in children depending on developing metabolic disorders. The connection of refeeding syndrome on the progression of nutritional deficiency is shown. The main methods of intensive therapy, including nutritional support for patients with high-risk and developed refeeding syndrome are determined.Conclusion. Currently, there is no unambiguous definition and diagnostic criteria for refeeding syndrome in children. Timely intensive therapy in cases of refeeding syndrome development allows to correct nutritional deficiency, to increase the survival rate of patients, can influence further growth and development of the child.

Hormonal status in women with respiratory viral infections during critical periods

Pregnancy and menopause are critical periods in a woman’s life. Due to physiological changes in the neuroendocrine system regulation, susceptibility to respiratory viral infections increases in these periods, while affecting all organs and systems of the human body. The aim of this review was to analyze the literature data on the effect of acute respiratory viral infections on neuroendocrine regulation in women during pregnancy and menopause. We reviewed full-text publications in the public domain from the PubMed, eLibrary.ru, and Google Scholar databases with a coverage period of more than twenty years (2000–2023). Disruptions of the progesterone and estrogen production during infection with the influenza A (H1N1) and influenza B viruses have been shown in experimental studies. Hormonal status changes in pregnant women are detected during infection with the influenza A virus (H3N2) and depend on antiviral antibody titers and the presence of fetoplacental insufficiency. Pregnant women with COVID-19 may experience changes in the brain structure activities, as indicated by a high frequency of those in olfactory sensitivity and psychoemotional disorders. During menopause, infection with the SARS-CoV-2 virus leads to changes in the production of thyroxine, prolactin, estradiol, testosterone, cortisol, 17-hydroxyprogesterone, and dehydroepiandrosterone sulfate.

Cultural adaptations of the WHO iSupport for dementia: A scoping review.

The World Health Organisation (WHO) has developed iSupport for Dementia, a self-paced online training programme for caregivers of people with dementia which is adaptable to different cultural contexts. This scoping review aims to understand the iSupport adaptation process in different countries and provide recommendations for future adaptations. A systematic search was done in electronic databases such as Pubmed, MEDLINE, APA PsycINFO, and EMBASE to obtain relevant publications up to 18 February 2024. Only full-text publications describing iSupport cultural adaptation process were included. The publications obtained were reviewed using the Cultural Adaptation Process framework. Thirteen publications from ten studies were eligible for inclusion. Based on the Cultural Adaptation Process framework, the steps undertaken in the studies were grouped into: (i) setting the stage, (ii) initial adaptation, and (iii) adaptation iterations. The three significant players in this process are the intervention developer (researchers), the cultural adaptation specialist (researchers, caregivers, and dementia care professionals), and the target community (caregivers). In the publications reviewed, cultural adaptation was mostly undertaken using a co-design process between researchers, caregivers, and dementia care professionals deciding on necessary modifications. iSupport for Dementia is a versatile programme to support caregivers and is readily available for adaptation to different cultural settings. It is essential to engage caregivers early in co-designing its cultural adaptations to ensure their needs can be met by this online tool.

Management of dermatosis papulosa nigra: a systematic review.

Dermatosis papulosa nigra (DPN) is a variant of seborrheic keratosis that typically presents as hyperpigmented pedunculated papules on the face, trunk, and/or back in those with skin of color. Although benign, the lesions can cause significant discomfort and distress. Management options are limited and often unaffordable, as treatment is elective in most cases. This study was undertaken to provide an updated summary of safe and efficacious treatments for DPN. Five databases were searched to identify full-text publications reporting on treatments and outcomes in adults with DPN. Seventeen publications met inclusion criteria and were included: six cohort studies, one randomized controlled trial, five case report studies, one case series, and four pilot studies. Treatment options included simple excision, curettage, electrodesiccation, cryotherapy, topicals, and laser therapies. These modalities varied in their documented outcomes and associated potential adverse effect profiles. Postinflammatory hyperpigmentation is a common adverse effect that often leads to patient dissatisfaction. It can be mitigated with topical treatments aimed at reducing local inflammation. Study limitations included small sample size in individual studies, lack of consistent reporting of Fitzpatrick skin type, and lack of comparison to the standard treatment of electrodesiccation or curettage. Ultimately, treatment should consider the patient's Fitzpatrick type, treatment area, associated costs, and potential adverse effects.

A scoping review of preclinical intensive care unit-acquired weakness models.

Animal models focusing on neuromuscular outcomes are crucial for understanding the mechanisms of intensive care unit-acquired weakness (ICU-AW) and exploring potential innovative prevention and treatment strategies. To analyse and evaluate preclinical ICU-AW models. We manually searched five English and four Chinese databases from 1 January 2002, to 1 February 2024, and reviewed related study references. Full-text publications describing animal models of muscle weakness and atrophy in critical illness were included. Detailed information about model types, animal species, sex, age, induction methods, outcome measures, drawbacks and strengths was extracted from each included study. A total of 3,451 citations were initially retrieved, with 84 studies included in the final analysis. The most frequently studied animal model included rodents (86.9%), 64.3% of which were male animals. ICU-AW animal models were mostly induced by comprehensive intensive care unit (ICU) interventions (38.1%) and sepsis (51.2%). Most studies focused on limb muscles (66.7%), diaphragm muscles (21.4%) or both (9.5%). Reported outcomes primarily included muscular pathological changes (83.3%), electrophysiological examinations of muscles (57.1%) and animal grip strength (16.6%). However, details such as animal age, mortality data, experimental design, randomisation, blinding, sample size and interventions for the experimental group and/or control group were inadequately reported. Many preclinical models are used to study ICU-AW, but the reporting of methodological details is often incomplete. Although current ICU animal models can mimic the characteristics of human ICU-AW, there is no standard model. Future preclinical studies should develop a standard ICU-AW animal model to enhance reproducibility and improve scientific rigor in exploring the mechanisms and potential treatment of ICU-AW.

Clinicopathologic features, demographics, disease burden, and therapeutics in alopecic sarcoidosis: a case series and systematic review.

Alopecic sarcoidosis is an uncommon cutaneous manifestation of sarcoidosis. Scarring and nonscarring alopecic sarcoidosis have been reported; however, information on the epidemiology, systemic disease associations, and treatment efficacy is limited. To address these gaps, we conducted a retrospective chart review and systematic literature review of alopecic sarcoidosis cases. Full-text English publications from PubMed, Scopus, and Google Scholar from inception to August 2023 were analyzed. Treatment evidence quality was assessed using the modified Oxford Centre for Evidence-Based Medicine rating scale. Three patients with biopsy-proven alopecic sarcoidosis were included as a case series, all demonstrating systemic sarcoidosis and 2 requiring multiple therapies. Among 1778 search results, 60 articles representing 77 cases of alopecic and scalp sarcoidosis were included. Patients were categorized into 4 distinct alopecic subgroups. Black patients constituted the majority of all subgroups. Extracutaneous sarcoidosis burden was high across all alopecic subgroups, with ocular disease appearing overrepresented. Topical and oral corticosteroids were the main treatments. Though scarring alopecia patients had poor outcomes despite receiving immunomodulators/cx, limited data suggest potential efficacy of tumor necrosis factor-alpha inhibitors. This study has a small sample size. Our findings underscore the importance of evidence-based strategies for improving alopecic sarcoidosis management. Prompt diagnosis and systemic evaluation, especially for scarring alopecia, are essential for timely intervention to optimize patient outcomes.

Physical Activity to Reduce Pain Scale in Diabetic Neuropathy Patients: A Scoping Review.

This study aims to identify physical activity that can reduce pain scales in diabetic neuropathy patients. The scoping review method was used in this research using three databases and one search engine, namely PubMed, CINAHL, Sage Journal, and Google Scholar. Inclusion criteria include full-text articles and publications in English and Indonesian between 2012-2022 with a minimal quasi-experimental design. Critical Appraisal was used to assess the article's bias. Research found 12 articles discussing the effectiveness of activity training in reducing the pain scale in diabetic neuropathy patients from the results of a scoping review of 12 studies, articles were found that used pain scales such as the Visual Analog Scale (VAS), Numeric Rating Scale (NRS), Foot Health Status Questionnaire Pain Score (FHSQ), and Leeds Assessment of Neuropathic symptoms and signs Scale for pain assessment, in measuring pain intensity. Some variations of physical activity include aerobic exercise, resistance exercise, vibration, and a combination of aerobic and resistance training. 30minutes each session for 8weeks with a frequency of 6 days/week. These studies used various designs, namely RCT, Experiment, and Quasi-experimental Pre test-post test with control group design Physical activity improves blood circulation and minimizes peripheral nerve damage so that pain intensity can decrease. Conclusion: Physical activity intervention is effective in reducing pain scales in diabetic neuropathy patients and can be a supportive therapy for diabetic neuropathy patients who experience pain.

Thermochromic Polymers in Food Packaging: A Comprehensive Systematic Review and Patent Landscape Analysis

This study addresses the gap in research on the application of thermochromic polymers (TPs) in food packaging and their potential for real-time temperature monitoring, aiding in the assessment of food quality and shelf-life. TPs exhibit a visible color change in response to temperature variations. A comprehensive systematic review (SR) across multiple engineering peer-review databases using predefined terms was conducted. Additionally, international patent databases were investigated using the same predefined terms. Independent experts reviewed the methodology to identify and address potential biases. A total of 288 eligible articles and 922 patents were identified. After a duplicate selection and extraction process according to the inclusion criteria, four related full-text publications were selected from the initial 288 articles, and five relevant patents were selected from the 922 patents. The qualitative review suggests that TPs hold significant promise as food packaging materials due to their unique physical properties. The study concludes that TPs offer valuable properties for the food packaging industry, meriting further investigation to exploit their benefits fully.

Mechanisms of the reprotoxic effect of lead: A literature review

Introduction: The demographic situation in the Russian Federation over the past decades is noted for a low birth rate. According to the State Report by the Federal Service for Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor), in 2023, 75.4 million Russian people experienced combined exposure to multiple chemicals. Chemical exposure, particularly that to lead as an occupational and environmental risk factor, has a significant impact on the human reproductive system, starting from childhood. Objective: To search, summarize, and systematize published data on adverse effects of lead on the reproductive system as a basis for further development of therapeutic and preventive measures. Materials and methods: The sources for the bibliography search were the PubMed search engine, the Scopus abstract and citation database of peer-reviewed scientific literature, the eLibrary and CyberLeninka Russian electronic scientific libraries. The search was conducted among Russian and English-language publications issued in 2004–2024. Of over 500 articles screened, 36 full-text publications describing the results of epidemiological studies of lead exposure and its adverse effects on the reproductive system of laboratory animals and/or humans were selected for this review, of which 23 articles were published within the past 5 years. Results: The most frequent effects observed in a large number of studies assessing reproductive toxicity of lead include a change in the weight of the reproductive organs, disruption of their histological structure, cytotoxic effects on spermatozoa, their motility, viability, and integrity, the presence of abnormalities, as well as changes in the level of hormones in tissues and blood serum, activity and amount of enzymes associated with the reproductive system. The effect of lead on the reproductive system is inevitably accompanied by a change in the expression of genes responsible for regulation of inflammatory processes, activation or inhibition of apoptosis, antioxidant protection, regulation of the function of enzyme systems and hormonal changes. Conclusion: Further study of lead effects on the reproductive system will help reveal mechanisms of toxicity, which can subsequently be considered “critical points” for preventive health and therapeutic measures to be focused on.

Aseptic failure of total hip arthroplasty as an early complication requiring revision surgery: a comprehensive literature review

Background: The undertaking of hip joint endoprosthesis surgery carries the inherent risk of complications. During the perioperative and early postoperative phases, septic complications take precedence, notably those associated with infection. Conversely, aseptic complications encompass issues unrelated to infection. Accurate risk stratification for complications following hip prosthesis implantation should be grounded in research adhering to the principles of Evidence-Based Medicine.Aim of the study: This paper aimed to present a critical literature review Material and methods: The literature review was conducted using international medical databases such as PubMed, Scopus, and PEDro. The review was based on criteria that included clinical studies and full-text publications published in English. The search period covered the last decade, spanning from 2014 to 2024.Results: The review highlights aseptic loosening and dislocation as the predominant causes of early THA failures. Addressing these complications requires a multifaceted approach, including patient education, meticulous surgical techniques, and robust postoperative rehabilitation programs. Future research should focus on improving implant materials and techniques to further reduce the incidence of aseptic failures. Dislocation and loosening of the hip joint prosthesis are direct reasons for qualifying the patient for revision surgery and reconstruction of the damaged prosthesis components. Individual biomechanical characteristics of the patient, genetic predispositions, obesity, or improper positioning of the prosthesis in relation to the limb axis are also potential risk factors for dislocation.Conclusions: Aseptic complications remain a significant challenge in THA. By understanding the causes and implementing effective preventative strategies, the incidence of early failures can be reduced, improving patient outcomes and prosthesis longevity. The gradual introduction of a well-planned and individualized rehabilitation program, along with the patient's adherence to treatment recommendations, is crucial for minimizing the risk of mechanical damage.

Current principles of hybrid imaging of breast cancer: a review of the literature

Background. Breast cancer is a major global public health problem and is the most common malignancy affecting women. Bone metastases are a common complication of advanced breast cancer, with nearly 65% of patients developing bone metastases. The presence of bone metastases can cause severe morbidity and mortality, as well as impair quality of life and increase the risk of skeletal damage. Accuratedetection and reliable assessment of therapeutic responses to bone metastases are imperative to inform treatment decisions, preserve quality of life, and ultimately improve overall survival. Thus, early identification of bone metastases is essential for effective treatment strategies and improved patient outcomes. Purpose – describe the modern principles and capabilities of hybrid imaging used for diagnosis, staging and follow-up of breast tumors. Illustrations are provided to better summarize and demonstrate the main concepts. Materials and methods. The analysis of full-text publications, which were selected through a literature search in foreign databases (PubMed, Scopus, ScienceDirectElsevier) for the period 2019–2023, was carried out. Results and discussion. During the analytical review of the literature, the experience of using modern methods of diagnosing breast tumors in Ukraine and abroad was analyzed. The selection of radiopharmaceutical drugs and tracers is considered. It has been established that the use of hybrid PET/CT and PET/MRI is the most promising imaging modality for the evaluation of breast cancer, providing a fully integrated morphological and functional imaging assessment. Conclusions. Hybrid imaging plays a key role in the diagnosis, staging, treatment selection, and follow-up of breast tumors. Awareness of this disease can reduce delay in diagnosis and facilitate interdisciplinary expert care.