In the present study, the added resistance, heave, and pitch of the KRISO Container Ship (KCS) in waves, at both model scale and full scale, are predicted numerically in regular head waves, for four wavelengths and three wave heights. The ISIS-CFD viscous flow solver, implemented in the Fidelity Fine Marine software provided by CADENCE, was employed for the numerical simulations. The spatial discretization was based on the finite volume method using an unstructured grid. The unsteady Reynolds-averaged Navier–Stokes (RANS) equations were solved numerically, with the turbulence modeled by shear stress transport (k-ω) (SST). The free-surface capturing was based on the volume-of-fluid method. The computed solutions were validated through comparisons with towing test data available in the public domain. To predict the uncertainties in the numerical solution, a systematic grid convergence study based on the Richardson extrapolation method was performed for a single wave case on three different grid resolutions. Specific attention was given to the free-surface and wake flow in the propeller plane. The purpose was to compare the numerical results from the model- and full-scale tests to examine the scale’s effect on the ship’s performance in regular head waves. The comparison between the model scale and full scale showed obvious differences, less accentuated for the free-surface topology and clearly observed in terms of boundary layer formation in the propeller’s vicinity.