The significant challenge encountered in utilizing Trombe walls for winter heating is summer overheating, which limits the overall feasibility of the system. In response to this issue, the present study introduces a novel model of a Trombe wall-solar chimney system designed to enhance natural ventilation and address the problem of summer overheating. To assess the performance of the proposed model, a full-scale experimental test rig is constructed in Kirkuk, Iraq. This rig comprises a test room integrated with a Trombe wall-solar chimney system. Additionally, a numerical simulation based on the CFD approach along with a computer code is developed to investigate the behavior of the system. System analysis is conducted for the period August 14th–15th. The parameters studied include chimney height (ranging from 0.0m to 2.0m in 0.5m increments), chimney width (0.2m, 0.3m, 0.4m, and 0.5m), room inlet vent height (ranging from 0.2m to 0.4m with 0.05m increments), and chimney inlet vent height (ranging from 0.2m to 0.4m with 0.05m increments). The results highlight the crucial role of the massive storage wall in sustaining nighttime ventilation in the absence of solar energy by utilizing stored heat to warm the air and maintain the ventilation process. The study establishes that chimney height and width significantly influence airflow rate, while other factors have marginal effects. An empirical equation is formulated to predict the 24-h averaged air changes per hour (ACH), which is a critical measure of system performance in ventilation. This equation is developed using artificial neural network (ANN) techniques. Finally, the findings indicate that the suggested model effectively reduces summertime overheating while generating a satisfactory ventilation rate. This enhances the overall versatility and year-round usability of Trombe wall systems, making them more adaptive and efficient in regions with diverse climatic conditions.