Whole-body positron emission tomography (PET) with F-fluorodeoxyglucose (FDG) has proven to be a very effective staging imaging modality in manymalignant tumours, particularly in lung cancer, malignant melanoma, lymphoma, colorectal cancer and head and neck tumours [1–7]. Since PET images have a fairly high resolution (,6 mm), even small lesions with an increased FDG uptake can be detected. This represents a critical advantage of PET over the conventional cross-sectional imaging modalities CT and MRI. PET can be used to identify tumour tissue on the basis of FDG uptake, rather than on the basis of morphological appearance or size, and thus also in lesions with a size less than 1 cm. Unfortunately, FDG–PET provides little anatomical information, and therefore it is sometimes difficult to determine where the lesions detected are located and what they represent. It is important for the surgeon to know precisely where lesions are located, especially for small tumours. Currently, comparison and juxtaposition of PET images and CT images serves to define the localization of the lesions. Owing to the different image slice thickness, the different positioning of the patient during the two examinations and the different states of nutrition, i.e. fasting for 4 h prior to FDG–PET, it is often very difficult and time consuming to match the images for exact anatomical localization. Image co-registration has been used to overcome these problems [8]. It has been recognized that proper image co-registration is rather difficult for whole-body examinations with separate scanners. For identical patient positioning during PET and CT scanning, special ‘‘cast forming’’ vacuum mattresses or other immobilization methods should be used. However, patients frequently find these methods of immobilization uncomfortable. Logistic problems also limit the use of image co-registration of PET and CT with separate scanners. Scheduling problems arise when performing the two examinations one after the other. These limitations restrict image co-registration with separate scanners to individual cases. In our experience, the exact localization of lesions is often not possible when juxtaposing PET and CT images. Examinations had to be repeated for exact image co-registration. As a result, image co-registration with separate scanners has never become routine in our practice. To overcome the problems related to software fusion, various prototype systems combining molecular and morphologic imaging have been developed. Hasegawa and colleagues proposed an integrated SPECT/CT scanner [9], and in 1999 Townsend and his colleagues at the University of Pittsburgh presented a prototype integrated PET/CT scanner by combining a CT scanner and a partial ring, rotating PET scanner in a single gantry [10, 11]. Such systems are attractive not only because of the ‘‘hardware’’ image coregistration capabilities but also because the CT data can be used to correct PET scans for patient self-absorption of the PET emission rays. This decreases the acquisition time for the correcting attenuation scans by an order of magnitude compared with the conventional techniques used in PET for this purpose, and decreases the overall imaging time by up to 30% depending on the CT system used. In March 2001, the first clinical integrated PET/ CT device (Discovery LS, GE Medical Systems, Milwaukee, USA) was installed at the University Hospital of Zurich in Switzerland. This novel inline system consists of a dedicated high resolution/ high sensitivity full-ring PET scanner (Advance Nxi) and a very fast high-end multi-detector spiral CT scanner (Light Speed Plus). The axes of both systems are mechanically aligned so that simple translation of the patient table by 60 cm moves the patient from the CT into the PET gantry. The resulting PET and CT images are ‘‘hardware’’ coregistered to an accuracy in the range of 1 mm. Data acquisition in the combined system is as follows. At 45–55 min post-injection of FDG and after bladder emptying a multidetector computed tomography scan is performed from the pelvic floor to the head (scan length, 86.7 cm) and normal end-expiration. Immediately after CT scanning, a PET emission scan is obtained covering the identical axial field of view using six PET fields of view. The acquisition time is 4 min at each table position. With this protocol it is The British Journal of Radiology, 75 (2002), S36–S38 E 2002 The British Institute of Radiology
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