Full Rate Research Articles

Pressure effects on both fluorescent emission and charge transport properties of organic semiconductors: a computational study.

External pressure can regulate the photophysical property and charge transport performance of organic semiconductors, however, the underlying mechanism at the microscopic level is still elusive. Using thermal vibrational correlation function coupled quantum mechanics/molecular mechanics and full quantum charge transfer rate theory, we systematically explore the influence of pressure on fluorescence emission and charge transport behaviours of representative cyclooctatetrathiophene (COTh). It is found that, upon pressurization, the intramolecular configurations of COTh became more twisted, leading to the blue-shifted emission. The fluorescence quantum efficiency (FQE) of COTh crystals decreases monotonically in a wide pressure range of 0-4.38 GPa, because the increase of intermolecular electronic energy transfer rate constant (keet) is larger than the decrease of internal conversion rate constant (kic), and the variation of keet is dominant. The decrease in kic is attributed to the decreasing reorganization energy, reflecting the suppression of the low-frequency flipping vibrations of four thiophene rings and the high-frequency stretching vibrations of central cyclooctatetraene, while the keet increase is due to the simultaneous increase in exciton coupling and spectra overlap. Moreover, we predicted that the hole mobility of COTh increases monotonically by nearly an order of magnitude from 0.39 to 3.00 cm2 V-1 s-1 upon compression, because of the increase in transfer integral and the decrease of charged reorganization energy. Furthermore, its hole mobility exhibits obvious anisotropy. Our work systematically builds the external pressure, molecular packing, luminescence and transport properties relationships of organic semiconductors and provides theoretical guidance for the rational design of pressure responsive organic semiconductors with excellent photoelectric performance.

Research on Data Mining of Network Security Hazards Based on Machine Learning Algorithms

Abstract With the development and progress of science and technology, an excellent algorithm for data mining of network security hazards is sought, which can effectively discover potential dangers in the network. Based on the XGBoost machine learning algorithm, the differential evolution (DE) algorithm is used to train the XGBoost algorithm, and then an optimized DE-XGBoost algorithm is proposed. The construction of an optimal mining and evaluation model is based on this. The DE-XGBoost algorithm’s performance is assessed against cybersecurity hazards using nominal-type posture indicators when data mining cybersecurity hazards. The experimental results show that the DE-XGboost algorithm has the lowest execution time and memory usage during mining, 5min and 82MB respectively, when the number of records in the dataset is 3,500. The DE-XGboost algorithm averages a digging full rate of 92.3%, which is the highest in terms of digging full rate. The posture evaluation experiment uses the DE-XGboost model to predict the posture value that matches the real value with the maximum number of sample points, which is 10 samples. The DE-XGboost algorithm is the perfect choice for cybersecurity data mining due to its optimal performance and best mining effect.

Salvage treatments for barnyardgrass (Echinochloa crus-galli) control in rice following simulated failed herbicide application

Abstract Florpyrauxifen-benzyl was commercialized in 2018 to target barnyardgrass and aquatic or broadleaf weeds. Field studies were conducted from 2019 to 2021 in Stoneville, MS, to evaluate barnyardgrass control following a simulated failure of florpyrauxifen-benzyl or other common postemergence rice herbicides. In the first field study, florpyrauxifen-benzyl was applied at 0 and 15 g ai ha–1 to rice at the two- to three-leaf stage to simulate a failed application targeting barnyardgrass. Sequential herbicide treatments included no herbicide and full rates of imazethapyr, quinclorac, bispyribac-Na, and cyhalofop applied 7 or 14 d after florpyrauxifen-benzyl treatment. The second field study was designed to evaluate barnyardgrass control with florpyrauxifen-benzyl following simulated failure of postemergence rice herbicides. Initial herbicide treatments included no herbicide and half rates of imazethapyr, quinclorac, bispyribac-Na, and propanil. Sequential applications at 7 or 14 d after the initial herbicide treatments included florpyrauxifen-benzyl at 0 and 30 g ai ha–1. Results from the first study indicated barnyardgrass control 21 d after final treatment (DAFT) was greater with sequential treatments at 7 compared with 14 d after initial treatment (DA-I) with no initial application of florpyrauxifen-benzyl. Therefore, delaying sequential treatments until 14 d after initial florpyrauxifen-benzyl at 15 g ha–1 allowed barnyardgrass to become too large to control with other rice herbicides. Rough rice yield was reduced in plots where quinclorac application was delayed from 7 to 14 DA-I with no initial application of florpyrauxifen-benzyl. The second study suggested that florpyrauxifen-benzyl application should be delayed 14 d after a herbicide failure. Although no differences in barnyardgrass control 21 DAFT were detected whether florpyrauxifen-benzyl was applied 7 or 14 DA-I of any herbicide utilized, >85% control was only achieved when florpyrauxifen-benzyl application was delayed 14 DA-I. These results demonstrate barnyardgrass control options following simulated failed applications of common rice herbicides.

Actinomycete inoculant improves the growth and yield of rainfed lowland and upland rice under field conditions

This study aimed to assess the effectiveness of actinomycete inoculant in enhancing the growth and yield of rainfed lowland and upland rice across wet and dry seasons in real field conditions. This field assessment took place at four sites, comprising two rainfed lowland and two rainfed upland ecosystems, over two cropping seasons (dry and wet seasons). The experiments involved testing both soil-based and carbonized rice hull (CRH) inoculants. Actinomycetes were found to be effectively carried by CRH and soil, and evidence from field studies in rainfed lowland and upland conditions showed that the actinomycete inoculant significantly improved rice production even under stressful environmental conditions. Regarding plant height, root depth, and tiller number, the inoculated treatments outperformed both the control and the full fertilization rates. Rice yield significantly increased with the application of actinomycete inoculum in both lowland and upland experiments. Inoculation alone led to substantial improvements, with yield increases of up to 48% in Lowland Site 1, 50% in Lowland Site 2, 78% in Upland Site 1, and 43% in Upland Site 2. Similarly, growth was enhanced by inoculation alone, reaching up to 50% in Lowland Site 1, 75% in Lowland Site 2, 24% in Upland Site 1, and 26% in Upland Site 2. When added to the full rate of fertilization, the inoculant significantly boosted yield by up to 16% in Lowland Site 1, 82% in Upland Site 1, and 40% in Upland Site 2. Additionally, growth substantially improved with inoculation in conjunction with the full rate of fertilization, reaching as much as 50% in lowland site 1, and 24% in upland site 1. Actinomycete inoculant proves to be a valuable alternative and addition to agricultural fertilizer management, as it was found to significantly increase growth and yield even in adverse weather conditions.

Interindividual variability in appetitive sensations and relationships between appetitive sensations and energy intake

BackgroundAppetitive sensations (AS) are signals that guide eating behaviors. Marked short-term inter-individual variability in AS has been reported but the long-term stability of individual ratings and their dietary implications are not well characterized.ObjectivesThis study explored the stability of inter-individual ratings of hunger, fullness and thirst for 17 weeks; determined the relationships between these sensations, eating patterns and energy intake (EI); as well as the associations between ratings and selected individual characteristics (age, gender, BMI).MethodsA 17-week observational study collected hourly appetitive ratings and dietary intake data from 97 (90 completers, 7 partial completers) healthy adults at weeks 1, 9, and 17.ResultsThere were marked and stable inter-individual differences over the 17 weeks for hunger (week 1 vs. week 9, r = 0.72 (p < 0.001); week 1 vs. week 17, r = 0.67 (p < 0.001); week 9 vs. week 17, r = 0.77 (p < 0.001)); fullness (week 1 vs. week 9 r = 0.74 (p < 0.001); week 1 vs. week 17, r = 0.71 (p < 0.001); week 9 vs. week 17, r = 0.81 (p < 0.001)); and thirst (week 1 vs. week 9 r = 0.82 (p < 0.001); week 1 vs. week 17, r = 0.81 (p < 0.001); week 9 vs. week 17, r = 0.88 (p < 0.001)). Cross-correlation functions revealed EI and eating pattern exerted stronger effects on AS than the reverse. However, the absolute effect sizes were small. Path analyses also indicated that there were weak relationships between AS and EI. No robust effects of the studied individual characteristics were observed.ConclusionThis study found that acute and chronic sensations of hunger, fullness and thirst are relatively stable within individuals but vary markedly between individuals. In addition, the present data indicate AS are poorly associated with dietary patterns or with EI under conditions of relatively stable energy balance.

Cerebral Abscess In A Child With Unknown Origin Of Infection

Introduction: The incidence of brain abscesses is higher in developing countries. The classic triad of fever, headache, and focal neurological signs was seen in 9–28% of the pediatric cases. Brain abscesses occur infrequently with potentially life-threatening conditions. Case Report: The patient was a child 1 year 8 months old with a main complaint of weakness in the left arm and leg progressively for one month. She had a local seizure on her left arm and leg one month before admission with a duration of 30 minutes. She was irritable for the last two weeks. The strength of the upper and lower extremities was 3 respectively. The physiology reflex was hyper-reflex on the upper and lower extremities. A Head non-contrast CT scan showed a hypodense lesion on the right parietal with a perifocal edema lesion. A head contrast CT scan showed a hypodense lesion on the right parietal with ring enhancement measuring approximately 6,2 cm x 4,5 cm. Craniotomy evacuation abscess with near total capsulectomy was done on initial and capsule resection was done. Discussion: Brain abscess is a focal pyogenic infection of the brain parenchyma, and the frontotemporal lobe is the most common site of brain abscess, followed by frontal-parietal, parietal, occipital lobes, and cerebellar. The most common risk factors that predispose a child to the formation of a brain abscess include congenital heart disease, sinus and otogenic infections, and poor dental hygiene. The triad of brain abscess, including headache, fever, and neurological symptoms is only present in (15%) of the cases reported. Medical treatment is recommended in patients without increased intracranial pressure, with symptoms of less than 1 week long and abscess of less than 2 cm seen in tomography. The suggested time of treatment is between 6 and 8 weeks with intravenously administered antibiotics. A full recovery rate from the infection of about 60–70% is reported in the case of early diagnosis and proper therapy Conclusion: Cerebral abscess in pediatrics with unknown origin of infection may happen in 12%. Early diagnosis and treatment of pediatric cerebral abscesses can reduce morbidity and mortality rates. A broadspectrum antibiotic is an optimal treatment in the postoperative evacuation of cerebral abscess cases with unknown origin infection.

Trajectory planning at a signalized road section in a mixed traffic environment considering lane-changing of CAVs and stochasticity of HDVs

Connected and automated vehicles (CAVs) are projected to bring significant benefits to traffic efficiency and driving comfort. However, the realization of full CAV penetration rate will take a long time. In this paper, a framework is proposed for planning the trajectories of vehicles at a signalized road section in a mixed traffic environment consisting of CAVs, human-driven vehicles (HDVs) and connected and automated buses (CABs). In the proposed trajectory planning framework (TPF), both the lane-changing (LC) behavior of CAVs and the stochasticity of HDVs are considered. The whole TPF is composed of a planning module, a running module, and a switching module. In the planning module, the mixed integer programming (MIP) models for trajectory planning with/without LCs are formulated to optimize the trajectories of CAVs/CABs. A parsimonious algorithm is designed to determine a suitable planning time horizon for the MIP models. The running module and the switching module are designed to ensure the driving safety of vehicles. To consider the stochasticity of HDVs, the concept of α-trajectory is employed in simulations to produce predicted trajectories of HDVs, while the actual trajectories of HDVs are generated by a stochastic car-following model. Here, α is a parameter between 0 and 1 related to one randomly changing parameter of HDVs, and α-trajectory is a series of predicted trajectories generated for HDVs based on the value of α. A rolling time horizon scheme is applied for TPF to account for the time-varying traffic situations. Numerical experiments under different traffic states and market penetration rates (MPRs) of CAVs/CABs are conducted to validate the performance of the proposed TPF. The average improvement in travel time and fuel consumption can reach up to 28.9 %, 17.8 % and 52.2 %, 35.3 % under medium and heavy traffic, respectively, and the average improvement in driving comfort is over 20 % in most traffic scenarios. The comparison experiment without fixed rolling time window (FTW) shows the advantage of setting FTW in adapting to the time-varying traffic situations, especially under heavy traffic. The sensitivity analysis shows that the values of α1 and α2 associated with α-trajectory can affect the performance of the proposed TPF in varying degrees. Finally, the length of the control zone is suggested to be set to 300–500 m.

Analysis of adult vaccination in Shandong Province from 2018 to 2022

Objective: To analyze the utilization of adult vaccination among people aged 18 and above in Shandong Province from 2018 to 2022. Methods: Data on vaccination units in 2022 and individual cases of vaccination information for people aged 18 and above were extracted from the Shandong Immunization Information System. A descriptive analysis was conducted on the distribution of adult vaccination units and adult vaccination varieties. The total vaccination amount and vaccination rate were calculated. Results: By the end of 2022, there were 3 948 vaccination units providing adult vaccination in Shandong Province, with 0.36 adult vaccination clinics per 10 000 people. Adult vaccination including RabV(rabies vaccine for human use), InfV(influenza vaccine), HPV(human papillomavirus), HepB(hepatitis B vaccine), PPV23(23-valent pneumococcal polysaccharide vaccine), MenACYW135(meningococcal polysaccharide vaccine group ACYW135), MMR(measles, mumps and rubella combined attenuated live vaccine), HEV(hepatitise E vaccine), RZV(recombinant zoster vaccine), TV(tetanus vaccine) and HF(haemorrhagic fever with renal syndrome vaccine) vaccines were administered, with a cumulative dose of 40.056 9 million and an average of 0.1 doses per person per year from 2018 to 2022. The top three vaccines were RabV, InfV and HPV, accounting for 31.48%, 22.57%, and 15.93% of the total vaccination amount, respectively. The annual vaccination dose for adults increased from 3.477 3 million in 2018 to 13.308 6 million in 2022, with an average annual growth rate of 56.55%. The cumulative 5-year doses of RabV and TV were 15.90 doses per 100 people and 0.21 doses per 100 people. The average annual vaccination rate of InfV was 2.28%. The cumulative full vaccination rates of HPV, HepB, PPV23 and RZV were 12.44%, 1.61%, 0.52% and 0.17%, respectively. The cumulative 5-year doses of RabV and TV were 29.19 doses per 100 people and 0.43 doses per 100 people in the age group of 20 to<30 years old. The vaccination rates of InfV and PPV23 were 9.08% and 1.27% in the age group of 70 to<80 years old. The vaccination rate of RZV was 0.11% in the age group of 50 to<60 years old. The HPV vaccination rate was 18.09% in the age group of 20 to<30 years old, and the HepB, MenACYW135, MMR and HEV vaccination rates were 6.21%, 9.55%, 2.65%, and 2.83% in the 18-19 age group, respectively. Conclusion: There are relatively few types of adult vaccination in Shandong Province, with narrow coverage and low vaccination rates.

CONTROL OF THE OF MAIN PESTS OF WINTER OILSEED RAPE IN THE CONDITIONS OF VINNYTSIA REGION

This article highlights the issue of improved and substantiated elements of the winter oilseed rape protection system against main pests in the Vinnitsa region, which is based on clarification of the species composition of phytophagy in winter oilseed rape, their harmfulness and limiting their numbers when applying seed treatment with insecticides and poisoners. spraying crops with drugs during the growing season of the crop. The species composition of the harmful entomofauna of winter oilseed rape was clarified and 22 species of insects belonging to 6 orders and 16 families were identified. The largest species diversity is characterized by the number of Coleoptera, the share of species of which was 60,2% of the total. The effectiveness of modern insecticides of poisoners against pests of winter oilseed rape and optimized methods of their application were evaluated. It has been established that the highest technical efficiency of insecticide poisoners is noted in versions with poisoners with mixtures of Force 200 SC + Cruiser 350 FS, consumption rate of 1,0+2,0 l/t. and Cruiser 350 FS, w.s.c. at the full consumption rate of 4,0 l/t is a highly effective method of controlling the number of cruciferous fleas. Initial efficiency during the first three days after emergence was 92,0% and 90,5%. During the growing season of winter rape during the testing of insecticides, the highest technical efficiency – 93,3% for spraying rape seedlings against cruciferous fleas was shown by Confidor 20%, w.s.c. Confidor, 20% of the national capital, it provided technical efficiency at the level of 95,3%. This ensured a yield of 3.46 t/ha, and the yield increase was conventionally 0,53 t/ha of the crop.

COVID-19 vaccination implementation in 52 African countries: trajectory and implications for future pandemic preparedness

IntroductionTo end the COVID-19 pandemic, the WHO set a goal in 2021 to fully vaccinate 70% of the global population by mid-2022. We projected the COVID-19 vaccination trajectory in 52...

Adherence Behaviors and Related Factors Among Elderly Hypertensive Patients in China: Evidence from the China Health and Retirement Longitudinal Study.

Non-adherence or partial adherence is the main reason for poor therapeutic effect of hypertension. This paper aims to assess adherence behaviors and related factors among elderly hypertensive patients in China. Participants aged ≥60 years, with hypertension, and with complete data in 2018 interviews of the China Health and Retirement Longitudinal Study (CHARLS) were included. The adherence behaviors included medication, blood pressure monitoring and the combined adherence behaviors. Referring to the social-ecological theory, correlates of adherence behaviors were divided into three layers, namely demographic characteristics, health behaviors, living environment and retirement. Univariate and multivariable logistic regression models were performed to identify factors of adherence behaviors. The prevalence of medication adherence (76.58%) was higher than that of blood pressure monitoring adherence (20.08%), and the full adherence rate was 18.53%. Self-rated health status, smoking status, living area, and health education status were detected to be associated with medication adherence and blood pressure monitoring adherence (all p < 0.05). Gender, sleep duration, health examination, and physical exercise were also detected to be associated with blood pressure monitoring adherence (all p < 0.05). Self-rated health status and health education status were detected to be associated with partially and fully adherence, while age, living area, and life satisfaction were detected to be associated with partially adherence, smoking status, sleep duration, health examination, and pension reliance were detected to be associated with fully adherence (all p < 0.05). Our study reveals the poor adherence behaviors of elderly hypertensive patients in China. This is most evident among those who were male, 60-69 years old, living in rural areas, self-reported being healthier, those without health examination and health education. Targeting these vulnerable populations, we suggest to strengthen health education, increase the publicity of basic public health services and enhance the self-management ability of hypertensive patients.

An Empirical Research on the Impact of Gasoline Taxes on Consumer-Level Retail Prices

This paper uses provincial-level gasoline retail price data in Canada to study the effect of tax reform on gasoline retail prices. It uses a dynamic difference-in-difference strategy to estimate the dynamic treatment effect of tax reform to see the dynamic changes of treatment effect in post-reform periods. We find that on average, the tax cut tends to be close to or around the full passthrough rate to the gasoline retail price. The treatment effect does not diminish over time and it is immediate after the tax reform. This means that the gasoline tax cut goes directly to consumers, it will work as a great macroeconomic tool in fighting the current inflation. The implications of effective gasoline taxation policy allow governments to adjust the gasoline taxation when needed to fight off inflation knowing that almost full taxation changes would pass down to the retail level. We conducted an additional robustness check to the robustness of our results.

Ketogenic Dietary Effects on Sleep, Cognition and Behavior in MCI: Baseline Sleep Results

AbstractBackgroundSleep disturbances in dementia occur often, are reported as neuropsychiatric symptoms, and are associated with higher caregiver burden and institutionalization. In mild cognitive impairment (MCI), sleep changes co‐occur with increasing neuropsychiatric symptoms and cognitive decline. Diet quality, like sleep, is a modifiable risk factor for Alzheimer’s disease. It is unknown how dietary interventions may impact sleep quality. This controlled clinical trial investigates for the first time a modified Mediterranean ketogenic diet (MMKD) compared to a low‐fat American Heart Association diet (AHAD) over 4 months on multiple sleep indices in adults with amnestic MCI. Here we report our baseline sleep findings.MethodThe WatchPAT Central Plus, an FDA approved home sleep test, was used to assess sleep quality. The WatchPAT quantifies numerous measures including total sleep time, pulse and sleep efficiency. Sleep‐disordered breathing is measured via the apnea‐hypopnea index (AHI) and oxygen‐desaturation index (ODI). Time spent in sleep stages is also quantified along with full night oxygen saturation and pulse rate. Independent samples t‐tests compared baseline sleep differences among male and female MCI participants.ResultA total of 64 MCI participants completed the baseline sleep assessments (mean age 70.2±7.0, BMI 27.0±4.3; 64.1% women). Mean sleep duration was 6 hrs46 min and 83.9% sleep efficiency. Mean AHI was 17.3±12.2 and mean ODI was 8.2±7.5 measured as &gt;3% 02 desaturations, indicating on average moderate severity sleep apnea (AHI&gt;15). Overnight sleep percentage by sleep stage (estimated from heart rate and accelerometer) averaged 15.4% in deep sleep and 22.3% in REM sleep. Mean REM latency was 105 minutes. Oxygen saturation averaged 94% and pulse, 61 bpm. Women had higher resting pulse (64.3bpm, p&lt;.001). Sleep measures did not significantly differ by sex.ConclusionThe MCI sample, on average, had moderate severity sleep apnea at baseline, with sleep duration and efficiency slightly below standard recommendations of 7‐8 hours and efficiency &gt; 85%, respectively. Future work will compare longitudinal changes in sleep quality across diet intervention groups. Understanding potential therapeutic effects of the MMKD on sleep quality and cognitive change will be vital in adding to the portfolio of targeted non‐pharmacological interventions for Alzheimer’s disease prevention.

Effect of intra‐nasal insulin therapy on food intake among African American adults: the FIINAAL study

AbstractBackgroundIntranasal insulin is a promising treatment for cognitive decline in Alzheimer’s Disease (AD) and mild cognitive impairment (MCI). However, intranasal insulin has been shown to promote weight loss, leading to concerns about decreased appetite, decreased food intake, and unintentional weight loss as negative side effects among metabolic and ingestive behavior effects of intranasal insulin sprays among AD and MCI patients. But, side effects related to food intake and appetite are not well studied, particularly among African American adults who are under‐represented in AD research.Method39 middle‐aged, cognitively normal, community‐dwelling African American adults (Table 1) were enrolled in the Food Intake and Intranasal Insulin in African American Adults (FIINAAL) study assessing effects of intranasal insulin on acute food intake and appetite ratings. This double‐blind, placebo‐controlled, randomized crossover study compared a single intranasal dose of 10 IUs of Novologã insulin, delivered with the Kurveã device, to an intranasal placebo. Participants ate a eucaloric, macronutrient‐balanced lead‐in diet for three days prior to each dose. The dose was administered in the morning following an overnight fast. An ad libitum test lunch followed the dose and participants rated their appetite immediately before and after each dose, and after the meal. Mixed effects linear model t‐tests were used to compare differences in food intake and appetite ratings between insulin and placebo conditions.ResultThere were no significant differences in test lunch energy (calories) or macronutrient intake between insulin and placebo conditions. However, fullness ratings increased significantly more after receiving a dose of insulin than after a dose of placebo (Figure 1). In addition, desire to consume sweet and fatty foods decreased significantly more after insulin than after placebo (Figure 2).ConclusionIn middle aged African American adults, acute intranasal insulin administration was associated with a reduced desire to eat palatable foods and with increased feelings of fullness, but not with reduced food intake at a test meal. Because reduced appetite appears to be an acute side effect of intranasal insulin administration, future work should study whether chronic intranasal insulin administration results in reduced appetite and, consequently, reduced food intake and body weight over time.

Oral glucose has little or no effect on appetite and satiety sensations despite a significant gastrointestinal response.

The effect of oral glucose-induced release of gastrointestinal hormones on satiety and appetite independently of prevailing plasma glucose excursions is unknown. The objective is to investigate the effect of oral glucose on appetite and satiety sensations as compared to isoglycemic IV glucose infusion (IIGI) in healthy volunteers. A crossover study involving two study days for each participant. Nineteen healthy participants (6 women, mean age 55.1 [SD 14.2] years; mean body mass index 26.7 [SD 2.2] kg/m2). Each participant underwent a 3-h 50-g oral glucose tolerance test (OGTT) and, on a subsequent study day, an IIGI mimicking the glucose excursions from the OGTT. On both study days, appetite and satiety were indicated regularly on visual analog scale (VAS), and blood was drawn regularly for measurement of pancreatic and gut hormones. Difference in appetite and satiety sensations during OGTT and IIGI. Circulating concentrations of glucose-dependent insulinotropic polypeptide (P < .0001), glucagon-like peptide 1 (P < .0001), insulin (P < .0001), C-peptide (P < .0001), and neurotensin (P = .003) increased significantly during the OGTT as compared to the IIGI, whereas glucagon responses were similarly suppressed (P = .991). Visual analog scale-assessed ratings of hunger, satiety, fullness, thirst, well-being, and nausea, respectively, were similar during OGTT and IIGI whether assessed as mean 0-3-h values or area under the curves. For both groups, a similar, slow increase in appetite and decrease in satiation were observed. Area under the curve, for prospective food consumption (P = .049) and overall appetite score (P = .044) were slightly lower during OGTT compared to IIGI, whereas mean 0-3-h values were statistically similar for prospective food consumption (P = .053) and overall appetite score (P = .063). Despite eliciting robust responses of appetite-reducing and/or satiety-promoting gut hormones, we found that oral glucose administration has little or no effect on appetite and satiety as compared to an IIGI, not affecting the release of appetite-modulating hormones. ClinicalTrials.gov: NCT01492283 and NCT06064084.

Exploring UK sonographers’ views on the use of professional supervision in clinical practice – Stage one findings of a mixed method study

IntroductionProfessional Supervision has been described across multiple professional groups, however to date, minimal research has been conducted exploring the use of professional supervision within the United Kingdom (UK) sonographer workforce. MethodsAn online self-administered survey was conducted to explore UK sonographers views on the use of professional supervision in practice. The survey was open to sonographers, consultant or clinical specialist sonographers, ultrasound managers and professional body officers. Multiple choice questions were utilised to obtain quantitative data on the provision of support mechanisms, with free text questions allowing qualitative data to be elicited further to explore thoughts of participants. ResultsA total of 112 participants completed the survey in full and response rates varied across the subgroups. Varying support mechanisms were in place for sonographers. However only 55.4 % of sonographers felt supported in the clinical workplace. Thematic analysis of qualitative data highlighted that workload pressures, staffing and retention of sonographers, were key concerns that professional supervision could improve. It was highlighted that time to undertake professional supervision could be challenging, however if training for professional supervision was in place then this could provide improved quality of care and staff support. ConclusionParticipants highlighted the challenges faced by UK sonographers and the positive impact that professional supervision could have on retention and staff support. There are limited support mechanisms in place for UK sonographers and this is impacting on how participants felt they were being supported in the workplace. Stage 2 of this research project will explore sonographers’ views in more detail. Implications for practiceThe approach to support mechanisms for sonographers should be considered to support improvement of professional wellbeing and retention of the sonographic workforce.

HPV Vaccine Usage Among the U.S. Military Academy Corps ofCadets (2018-2025).

Human papillomavirus (HPV) is a common sexually transmitted virus that infects over 13 million people every year. Over 80% of sexually active adults will acquire HPV at some point in their lives, which is concerning since certain high-risk strains of HPV can cause six types of cancer. Vaccination against HPV is safe and effective, but despite high vaccine efficacy, vaccination rates are low among both service members and civilians. We conducted a retrospective, cross-sectional study to identify the percentage of United States Military Academy (USMA) Cadets who had received at least one HPV vaccine and those who completed the vaccine series. Deidentified vaccination and demographic data were retrieved from the Defense Health Agency Military Health System Data Repository (MDR) for all Cadets who were enrolled at USMA between January 2018 and May 2022 (graduating classes of 2018-2025). To identify the population of Cadets for our study and confirm presence of "any" vaccine in the MDR, Tdap vaccination information was also retrieved. The study population was defined as any Cadet who was enrolled at USMA between January 2018 and May 2022 (graduating classes of 2018-2025) and had record of an HPV and/or Tdap vaccine in the MDR. We compared demographic information between the identified population and known demographics of the USMA population to confirm that the retrieved data were consistent with population demographics. Descriptive statistics were performed to identify demographic differences based on vaccinated and unvaccinated Cadets and to determine the percentage of Cadets who received at least one HPV vaccine. Vaccine series completion was defined as the receipt of three HPV vaccine doses among those who reported receiving at least one dose of HPV vaccine or two doses if vaccinated before the age 15. A total of 9,567 Cadets were assessed for eligibility with 9,433 having Tdap and/or HPV vaccine on record. Of these Cadets, 5,738/9,433 (60.8%) had received at least one HPV vaccine. Of those starting the series, 4,492 completed the two- or three-dose series for a completion rate of 47.6%. We found HPV vaccine completion rate among female Cadets (55.6%) is higher than that of male Cadets (45.2%). More Cadets from minority groups received one vaccine; however, full completion rates were similar for both the groups (48.1%). In contrast, the percentage of Cadets vaccinated against Tdap was 97.2%. Most of those vaccinated received their first vaccine between the ages of 11 and 15 (53.0%) and their final vaccine after they turned 16 (68.9%). Though the vaccination rate among the Corps of Cadets is comparable to the public, it is still less than the 80.0% goal set by the Healthy People 2030 objective. Based on these results, we recommend that the USMA modify its policy on HPV vaccine administration to encourage more vaccine uptake. We also conclude that further studies on the rationale for avoiding the vaccine are necessary to better inform educational campaigns and mitigate stigma.

The MidPIC study: Midwives’ knowledge, perspectives and learning needs regarding preconception and interconception care

Preconception and interconception care improves health outcomes of women and communities. Little is known about how prepared and willing Australian midwives are to provide preconception and interconception care. The aim of this study was to explore midwives’ knowledge, perspectives and learning needs, and barriers and enablers to delivering preconception and interconception care. We conducted a cross-sectional exploratory study of midwives working in any Australian maternity setting. An online survey measured midwives’ self-rated knowledge; education needs and preferences; attitudes towards pre and interconception care; and views on barriers, enablers; and, future service and workforce planning. Quantitative data were analysed descriptively and demographic characteristics (e.g., years of experience, model of care) associated with knowledge and attitudes regarding pre- and interconception care were examined using univariate logistic regression analysis. Qualitative data were captured through open-ended questions and analysed using inductive content analysis. We collected responses from (n = 338) midwives working across all models of care (full survey completion rate 96%). Most participants (n = 290; 85%) rated their overall knowledge about pre and interconception health as excellent, above average or average. Participants with over 11 years of experience were more likely to report above average to excellent knowledge (OR 3.11; 95% CI 1.09, 8.85). Online e-learning was the most preferred format for education on this topic (n = 244; 72%). Most (n = 257; 76%) reported interest in providing pre and interconception care more regularly and that this is within the midwifery scope of practice (n = 292; 87%). Low prioritisation in service planning was the most frequently selected barrier to providing preconception and interconception care, whereas continuity models and hybrid child health settings were reported as enablers of pre and interconception care provision. Findings revealed that midwives are prepared and willing to provide preconception and interconception care. Pre and post registration professional development; service and funding reform; and policy development are critical to enable Australian midwives’ provision of pre and interconception care.

Safety and Efficacy of Venetoclax Salvage Therapy in Relapsed/Refractory Multiple Myeloma with and without t(11;14)

Background: The BCL2 inhibitor Venetoclax (Ven) is an effective treatment option in multiple myeloma (MM). However, despite the recent inclusion in European MM treatment guidelines, no approval has yet been granted for the treatment of MM and the optimal dosage, combination partners and timing of treatment remain under investigation. Methods: We conducted an analysis of 40 MM patients treated with Ven at our institution from November 2017 until June 2022. 64% of them had a t(11;14), all were heavily pretreated with a median of 7 lines of prior lines of therapy, and 75% were penta-refractory. High-risk features were enriched in the cohort (47% for all 38 with FISH available via IMWG criteria). Risk was evenly distributed between patients with and without t(11;14). Patients received either Ven alone or in combination with other MM drugs over a median of 5 cycles. Results: The full cohort overall response rate reached 53%, ten patients (25%) achieved partial remission (PR), seven patients (17.5%) went into VGPR and four patients (10%) had a complete remission (CR). Moreover, stable disease (SD) for three months or longer was achieved in seven patients (18%). The median progression-free survival was 5.1 months and the duration of response reached 9.6 months. Subgroup analysis revealed that patients harboring t(11;14) had significantly increased PFS and OS: Median PFS reached 11.2 vs. 4.4 months and median OS was not reached vs. 12.8 months, respectively. Overall, hematological AEs grade 3 or higher were documented in 65% of patients and three high-grade infectious complications (7.5%) occurred. Two of these patients died from sepsis, another recovered from pneumonia with severe sequelae. Interestingly, in contradiction to the BELLINI experience, all high-grade infectious complications occurred in the t(11;14) positive cohort. Conclusion: In our real-world analysis, Ven demonstrated to be an effective MM treatment option for t(11;14) positive relapsed/refractory MM. However, the significant infectious complications suggest antibiotic prophylaxis and careful monitoring of patients undergoing Ven treatment.

Agricultural biomass feedstock for biofuels production in Ukraine

Ukraine has a large potential of biomass available for the production of solid, gaseous and liquid biofuels. According to 2021 data, the bioenergy potential is about 25 Mtoe, of which 49% is agricultural residues and 30% is energy crops (in case of growing on 2 mln ha). Of the agriresidues, only sunflower husk is now widely used for energy, while the potential of straw, corn stalks and sunflower stalks is practically untapped for this purpose. For Ukraine, one of the promising directions is priority use of corn stalks for the production of energy and solid biofuels such as briquettes and pellets. Another prospective area is growing energy crops. Ukraine has 3-4 mln ha of unused (marginal) agricultural land, which can be engaged for growing energy crops such as willow, poplar, miscanthus (for solid biofuels) and corn silage for biogas. Growing energy crops as biomass feedstock and its further use for the production of heat and power becomes competitive in light of growing prices of natural gas and issues with providing security of its supply. An important but less-developed sector of Ukraine’s bioenergy is motor biofuels. Having such a big potential of agribiomass, the country could produce bioethanol and biodiesel including the advanced biofuels from lignocellulosic feedstock. It is necessary to create favourable conditions for the development of domestic production of motor biofuels. This may include a reduction in the excise tax, the abolition of compulsory tax bill for the full rate of excise duty when transporting bioethanol, the introduction of an export duty on rapeseed, and some other measures.