Full Procedure Research Articles

Oncologic Safety in Autologous Fat Grafting Reconstruction after Breast Conservation Treatment: A Systematic Review and Meta-analysis

PURPOSE: Autologous fat grafting (AFG) reconstruction is a widely used method to correct defects after breast conservation treatment (BCT) that has gained popularity within the last decade. Even though it results in aesthetically pleasing outcomes with minimally invasive surgery, the oncological outcomes of the procedure are still being researched. The purpose of this systematic review is to analyze the literature to compare BCT and AFG versus BCT only with cancer recurrence and procedure complications. METHODS: The systematic review was conducted using the PubMed Database with articles from 1970 to 2021. The main search terms used were ‘mammaplasty’, ‘breast conservation’, ‘breast cancer’, ‘fat grafting’, and ‘neoplasm recurrence.’ The inclusion criteria were fat grafting only, partial breast reconstruction, and cancer recurrence. The exclusion criteria were all full breast reconstruction procedures. The statistical analysis was done using patients who received AFG versus no AFG in the BCT population in order to compare complications, cancer recurrence, and metastasis. RESULTS: The PubMed search strategy yielded a total of 146 articles. After applying inclusion and exclusion criteria, a total of 15 articles were used for analysis, with a total of 900 BCT only patients and 1063 BCT AFG patients. Based on the pooled meta-analysis, in the BCT only patients, 4.8% had cancer recurrence and 4.8% had metastasis, and for the BCT and AFG patients, 3% had cancer recurrence and 6.9% had metastasis. The average length of follow up time for BCT only is 58.73 months and for BCT and AFG is 55.24 months. Patients with BCT only versus BCT and AFG showed no statistically significant difference in total cancer recurrence (P=0.99), local cancer recurrence (P=0.84), and metastasis (P=0.36). The fat necrosis and oil cyst rate for BCT only was 21.3 % and for BCT and AFG it was 19.2%. The complication rates for fat necrosis and oil cysts were not statistically different between BCT versus BCT and AFG (P=0.44). CONCLUSION: The results show no significant difference in cancer recurrence or metastasis in the BCT only group versus BCT and AFG, showing that fat grafting is not only an aesthetically pleasing and minimal surgery, but it has safe outcomes with no differences in complications.

Evaluation Of Abutment According to Acp Classification for Patients Undergoing Tooth Supported Full Mouth Rehabilitation - A Study in University Setting

The tooth supported full mouth reconstruction, regards one of the complex procedures for most dentists. It needs efficient diagnosis and elaborate treatment planning to establish optimum esthetics and function. The clinicians should do a proper evaluation of the abutment teeth. The objective of this study was to evaluate the abutments according to ACP classification for patients undergoing tooth supported full mouth rehabilitation.The data was collected from June 2019 to March 2020 at a private dental institution in Chennai and a total of 51 case records of patients requiring full mouth rehabilitation procedure was obtained. Chi-square test was applied to see associations of age, gender and abutment condition and there was statistical significance between age, gender and abutment condition with p value < 0.05 . The results showed that 42% (n=21) of the patients were categorized as ACP Class- I; 34% (n=17) as Class-II; 8% (n=4) as Class-III; and 16% (n=8) as Class IV. The study reported the high occurrence of Class I abutment condition in both male and female population with 38.5% (n=10) and 45.8% (n=11) respectively.The age wise distribution of abutment condition revealed that in group 1, there was equal distribution between Class I, Class II and Class IV with 28.6% (n=2). In group 2, most of the abutments were Class II with 50% (n=3). In group 3 and 4, most of the abutments were Class 1 with 66.7% (n=6) and 50% (n=6) respectively and Class II was common in group 5. In this study, it can be concluded most of the abutments were ideal or minimally compromised followed by moderately compromised abutments in all age groups and both the gender. Full mouth rehabilitation procedures were carried out more in females than in male population.

H-Wing Neoumbilicoplasty: A New Technique for Advanced Abdominoplasty and Umbilical Zones by Gender.

Multiple umbilicoplasty techniques have been described, even more after the advent of full tummy tuck procedures and the neoumbilicoplasty (X-shaped incision) described by the authors in a previous report. The authors decided to upgrade the technique (H-wing incision) because the former procedure is associated with relatively common complications. The authors report a case series of an upgraded technique for neoumbilicoplasty (H-wing technique), comparing its outcomes with their previous standard procedure (X-shaped incision). The authors reviewed their records for neoumbilicoplasties performed between January of 2014 and December of 2019. The authors divided the procedures according to the surgical technique and performed a detailed analysis regarding timing, complications, uses, and quality standards according to patients' opinion through a nonstandardized survey. A total of 407 procedures were distributed between two techniques: X-shaped incision, 179 procedures; and H-wing technique, 228 procedures. The former was performed from January of 2014 to October of 2016 and the latter from September of 2016 to December of 2019. High satisfaction indexes were found for both procedures; however, fewer complications were seen in the H-wing group. The X-shaped incision is thought to generate a greater force of tension over the flaps compared to that from the H-wing technique, which consequently increased the risk of flap necrosis and flattening. The H-wing technique for neoumbilicoplasty decreases the risk of postoperative complications such as dehiscence, skin necrosis, and navel flattening, and maintains high aesthetic standards and satisfaction indexes among patients. The technique can be used after either lipoabdominoplasty or secondary procedures.

Structural Potting of Large Aeronautic Honeycomb Panels: End-Effector Design and Test for Automated Manufacturing.

Structural potting is used to prepare honeycomb panels to fix metallic elements, typical in aircraft doors. In this paper, a full procedure for structural potting using robotic arms is presented for the first time. Automating this procedure requires the integration of, first, machining operations to remove the skin layers and prepare the potting points and, then, resin injection into the honeycomb cells. The paper describes the design, prototyping, and testing of specific end-effectors. Different end-effectors were explored to ensure efficient injection. The results obtained with the prototypes show that the potting quality is adequate to accomplish the required process checks for industrial manufacturing. The injection process time can be reduced by a factor greater than 3.5, together with the extra assets associated with the automation of complex tasks. Therefore, structural potting automation is demonstrated to be feasible with the end-effectors proposed for milling and injection, which are ready for use with conventional robotic arms in manufacturing lines.

Nuclear liquid-gas phase transition within a Brueckner-Hartree-Fock approach* *Sponsored by the National Natural Science Foundation of China (11975077, 11475045), "PHAROS", COST Action CA16214 and the agreement ASI-INAF n.2017-14-H.O

The critical parameters of the liquid-gas phase transition of symmetric nuclear matter are computed using the Brueckner-Hartree-Fock method at finite temperature by employing different realistic nucleon-nucleon potentials. Temperature effects on single-particle potentials, defect functions, and three-body forces are discussed in detail. Results obtained from the full procedure and frozen-correlations approximation are compared. We find critical temperatures of approximately 14 to 19 MeV and critical densities in the range of to , depending on the interactions employed.

Semantics and canonicalisation of SPARQL 1.1

We define a procedure for canonicalising SPARQL 1.1 queries. Specifically, given two input queries that return the same solutions modulo variable names over any RDF graph (which we call congruent queries), the canonicalisation procedure aims to rewrite both input queries to a syntactically canonical query that likewise returns the same results modulo variable renaming. The use-cases for such canonicalisation include caching, optimisation, redundancy elimination, question answering, and more besides. To begin, we formally define the semantics of the SPARQL 1.1 language, including features often overlooked in the literature. We then propose a canonicalisation procedure based on mapping a SPARQL query to an RDF graph, applying algebraic rewritings, removing redundancy, and then using canonical labelling techniques to produce a canonical form. Unfortunately a full canonicalisation procedure for SPARQL 1.1 queries would be undecidable. We rather propose a procedure that we prove to be sound and complete for a decidable fragment of monotone queries under both set and bag semantics, and that is sound but incomplete in the case of the full SPARQL 1.1 query language. Although the worst case of the procedure is super-exponential, our experiments show that it is efficient for real-world queries, and that such difficult cases are rare.

Hierarchical optimal designs and modeling for engineering: A case‐study in the rail sector

AbstractComplex engineering and technological processes typically generate data with a non‐trivial hierarchical structure. To this end, in this article we propose a full procedure for optimizing such processes through optimal experimental designs and modeling. In order to study a hierarchical structure, several types of experimental factors may arise, making the building of the experimental design challenging. Starting from the analysis of a preliminary dataset and a pilot design including nested, branching, and shared experimental factors, as well as a new type of experimental factor called composite‐form‐factor, we build a hierarchical D‐optimal experimental design using genetic algorithms. We apply our proposal to a real case‐study in the rail sector aimed at optimizing the payload distribution of freight trains. In this case‐study we also achieve the best train configuration by minimizing the in‐train forces. The results are very satisfactory and confirm that our full procedure represents a valid method to be successfully applied for solving similar technological problems.

Tracing the influence of caffeine on the pharmacokinetic parameters of three headache relieving pharmaceuticals applying synchronous fluorescence spectroscopy

A simple, sensitive, and selective first derivative synchronous fluorimetric method was developed and optimized to track the influence of caffeine content in beverages on the pharmacokinetic parameters of three pharmaceuticals used in relieving headache namely, aspirin (ASP), ibuprofen (IBU), and ergotamine tartrate (ERG). A full validation procedure was carried out to impart validity to the proposed method to apply it to biological fluids. The unique dissolving power of micellar solutions was utilized to avoid multiple extraction steps for both the in vitro and in vivo experiments, aiming to obtain acceptable recoveries and to accomplish sustainability, where 0.1 M sodium dodecyl sulphate (SDS) was used for this purpose. Moreover, the developed bioanalytical method was subjected to full validation to avoid interferences emerging from biological matrices. The greenness of the proposed method was assessed according to the Analytical Eco-Scale and proved to be excellent green carrying a score of 98%.

Towards field implementation of photoluminescence in the built environment for passive cooling and lighting energy efficiency

Photoluminescent materials are widely considered crucial elements in sustainable lighting, and they are also gaining credit in passive cooling applications in buildings. In this study, we investigate different photoluminescent pigments, connecting their emission behavior to the specific afterglow color and evaluating their potential use as passive cooling and lighting energy-saving solutions. In particular, we analyze the spectral behavior of the selected pigments to obtain for the first time corrected luminescence spectral responses. The same materials are then characterized through photometric methods, considering realistic environmental boundary conditions to better evaluate their potential as light sources in a real urban environment. Results demonstrate the influence of spectral properties and irradiation power on the registered radiance of the pigments. Furthermore, the presence of simultaneously excited multiple emitters produces non-negligible differences between the emission spectra from the monochromatic and the full range excitation procedure. At the same time, an almost perfect agreement can be found in the case of single emitters. Finally, the data are discussed to present the complementarity between passive cooling andlighting actions.

Testing the applicability of standardised growth curves (SGCs) for OSL signals of quartz grains from the Yangtze Delta, China

The standardised growth curve (SGC) technique has the potential to save instrument time for equivalent dose (D e ) determination when applying single-aliquot regenerative-dose (SAR) protocol during optically stimulated luminescence (OSL) measurements. In this study, we test the applicability of two commonly used SGC procedures for OSL signals of quartz grains from aqueous deposits of the Yangtze Delta in China, which have been reported for weak luminescence signals and suffering from partial bleaching. Multiple silt-sized and sand-sized fractions of quartz samples from eight cores are used to construct SGCs by test dose standardisation (TD-SGC) and least-squares normalisation (LS-SGC), respectively. Three strategies, i.e. region-specific (SGC R ), region with core-specific (SGC R + C ) and core-specific (SGC C ), are adopted to categorise these normalised data into different SGC datasets. The large variability of dose response signals is substantially reduced by the SGC procedures for most of these datasets. Hence, common SGCs for a variety of samples from the Yangtze Delta can be established, irrespective of their distinctive particle sizes and luminescence characteristics. The D e values are then estimated using both TD-SGC and LS-SGC procedures for samples from a specific core. Comparing to the full SAR protocol, the TD-SGC procedure roughly gives reproducible D e estimates lower than ∼100 Gy while the LS-SGC procedure derives generally consistent D e estimates of up to ∼230 Gy. Although LS-SGC C and LS-SGC R + C procedures replicate the most consistent D e values, the LS-SGC R procedure performs better in efficiency with a slightly less accuracy. In addition to careful comparison of LS-SGC and full SAR procedures, we suggest that a synchronous ratio derived by the chosen regenerative dose and its response signal for re-normalisation can be used to predict the LS-SGC D e reliability on samples from similar sedimentary environments. • Standardised growth curves (SGCs) are applied to quartz samples from the Yangtze Delta. • SGC procedures are compared using three strategies. • Least-squares (LS) SGC D e values are consistent with those obtained by full SAR. • LS-SGC D e reliability is predicted by the chosen regenerative dose and signal.

Validation of Pedsql™ Duchenne Muscular Dystrophy Module (Acute Version 3.0), in Young Children (Age 5-7)

Objective: The goal of this project was to accurately translate the “PedsQLTM 3.0 DMD” Module into Urdu and to assess its validity in health-related quality of life in the Duchenne muscular dystrophy (DMD)” children age 5 to 7 years reported by their parents. Method: The study was conducted with the parents/caregivers of DMD children in Rising Sun Institute, PSRD, Hope,Gosha e Shifa, Special gems, Ghazali Foundation Rawalpindi and DHQ hospital Jhang. Study was cross cultural validation including 56 primary care givers. First of all questionnaire of primary care giver was translated in Urdu by using forward translation, the second step was reconciliation of items; in this the best Urdu translation was selected. Backward translation was completed in the third phase, and a review was conducted to evaluate the full forward-backward procedure in order to produce a final forward translation. Validity & Reliabity were measured. To determine in the internal consistency Cronbach’s Alpha was used Test-Retest reliability was checked. Content Validity Index and Content Validity Ratio were measured through 5 experts. To analyze the collected data SPSS 26 was used. Results: The results showed that in both genders from age 5 to 7 years DMD affects the quality of life of child as reported by parents. The value of Cronbach's alpha was 0.913.After factor analysis KMO was 0.793 and because the p value was less than 0.05, the test was significant. Conclusion: Urdu version of “PedsQLTM Duchenne Muscular Dystrophy Acute Version 3.0(age 5-7) Parent report for young children” is a stable and consistent instrument for assessing quality of life measures of the DMD children and can be applied in Urdu speaking population throughout the world. Keywords: Duchenne Muscular Dystrophy, “PedsQL™ 3.0 DMD Module”, Urdu translation, validity, quality of life.

Experimental Investigation of Oxide Leaching Methods for Li Isotopes.

To examine the applicability of different leaching methods used to extract secondary oxides from silicate solids for lithium isotope (δ7Li) measurement, this study has conducted leaching experiments on five different types of silicate solids, including a fresh basalt, two weathered basalts, a Yellow River sediment (loess‐dominated) and a shale. Four factors were assessed in the experiments: the concentration of the leaching reagent hydroxylamine hydrochloride (HH), the leaching temperature (20 °C vs 95 °C), the leaching time and the reagent/solid ratio. Based on elemental concentrations and Li isotopes, 0.04 mol l−1 hydroxylamine hydrochloride (HH) in 25% v/v acetic acid at room temperature for 1 h with 40 ml g−1 reagent/solid ratio is recommended. At high temperatures, low δ7Li and high magnesium/iron ratios indicate that minerals other than secondary oxides are dissolved. With increased leaching time, there is no evidence for Li isotopic fractionation at room temperature. However, longer leaching time or increased reagent/solid ratios may increase the risk of leaching from non‐oxide phases. Meanwhile, results suggest that low concentrations of HH are not sufficient to target the secondary oxides evenly, while high concentrations of HH can leach out more non‐oxides. We also examined the optimal oxide leaching method within a full sequential leaching procedure (i.e., exchangeable, carbonate, oxide, clay and residual phases). Elemental concentrations show that no elements exist exclusively in oxides, so it is essential to analyse multi‐elemental concentrations to verify that the leaching has accessed this phase in a given sample. Comparing secondary oxides with their corresponding solutions, we estimate the isotopic fractionation (Δ7Lioxide‐solution) is −16.8‰ to −27.7‰.

The Formation of Criminal and Police Proceedings in the Russian Law of the XVIII - Early XIX Century

The author researches the formation of the sectorial differentiation of legal norms regulating the investigation and analysis of criminal acts of different gravity in the Russian law of late XVIII - first half of XIX centuries. It is shown that Russian legislation of XIX century used two methods of formulating procedural norms that regulated the investigation, analysis, prevention and suppression of offences. It is suggested that the first method should be called a centralized one, as the norms of procedural character are contained in one part of the Law Code of the Russian Empire. An example of this is the systematization of the criminal procedure norms in Book II «On Criminal Court Proceedings», Vol. XV of this Code. Thus, the question of the existence of the criminal process as a sector of Russian law can be answered positively. The second method, which the author calls decentralized, means that procedural prescriptions are aligned with material norms and scattered throughout different parts of the Law Code of the Russian Empire. An example of this are the norms constituting a part of the police law - the police process. The legislation of the early XIX century categorized offences as either crimes or offences of little significance. Offences of little significance did not lead to criminal punishments, and their investigation did not require a full criminal procedure. Procedural actions in cases of little significance, as well as the activities of the police to prevent and suppress criminal actions, were regulated by a large number of legal prescriptions in the Russian law, which could be put together under a common name «the police process». In order to denote the degree of separateness of these norms in the Russian legislation, the author introduces the concept «the direction of legal regulation». It means a stable aggregate of accumulated and somewhat separate measures united by a common subject and key methods of influencing the society. The direction of legal regulation is the predecessor of the sector of law. The conducted research allowed the author to establish that by the XIX century the Russian legislator systematized the procedural norms on the investigation and analysis of crimes and offences of little importance as an independent branch - the criminal process, and the direction of legal regulation - the police process.

Метод прискореної кількісної оцінки компонентів реконфігуровних сигнатурних систем кіберзахисту

Recently, various approaches have been successfully used in information security tools to detect harmful activity, including artificial intelligence technologies. But only the signature approach can completely eliminate recognition errors. That is especially important for critical infrastructure objects. One of the main disadvantages of signature tools is the high computational complexity. Therefore, the developers of such systems turn to hardware implementation, primarily on a reconfigurable platform, that is, using FPGAs. The ability to quickly reprogram FPGAs gives reconfigurable security systems unprecedented flexibility and adaptive possibilities. There are many different approaches to the construction of hardware pattern matching circuits (that are parts of signatures). Choosing the optimal technical solution for recognizing a specific set of patterns is a non-trivial task. For a more efficient distribution of patterns between components, it is necessary to solve an optimization task, the objective function of which includes the quantitative technical characteristics of hardware recognition schemes. Finding these values at each step of the algorithm by performing the full digital circuit synthesis procedure by the CAD is an unacceptably slow approach. The method proposed in this study for the accelerated quantitative evaluation of components of reconfigurable signature-based security systems, based on the use of the so-called evaluation functions, allows solving the problem.

The advice less taken: The consequences of receiving unexpected advice

AbstractAlthough new information technologies and social networks make a wide variety of opinions and advice easily accessible, one can never be sure to get support on a focal judgment task. Nevertheless, participants in traditional advice taking studies are by default informed in advance about the opportunity to revise their judgment in the light of advice. The expectation of advice, however, may affect the weight assigned to it. The present research therefore investigates whether the advice taking process depends on the expectation of advice in the judge-advisor system (JAS). Five preregistered experiments (totalN= 2019) compared low and high levels of advice expectation. While there was no evidence for expectation effects in three experiments with block-wise structure, we obtained support for a positive influence of advice expectation on advice weighting in two experiments implementing sequential advice taking. The paradigmatic disclosure of the full procedure to participants thus constitutes an important boundary condition for the ecological study of advice taking behavior. The results suggest that the conventional JAS procedure fails to capture a class of judgment processes where advice is unexpected and therefore weighted less.

Construction quality evaluation of asphalt pavement based on BIM and GIS

Construction quality evaluation is critical to guarantee the long-term performance of asphalt pavement. Exiting evaluation approaches lag and limit the efficiency of quality control. To solve this problem, this study proposed a new construction quality evaluation framework, which was a combination of the building information model (BIM) and geographic information system (GIS). The framework performed the real-time and full-process quality evaluation on asphalt pavement construction. The framework was applied in the Phnom Penh-west Halluk highway construction project, in which the GIS early located and warned the sections with poor construction quality and the BIM models acquired the comprehensive information on the road sections. The framework made it possible to understand the construction quality in real time and full procedure. The results demonstrated that the framework provided a good information environment for construction quality evaluation. The future study will focus on construction quality control using the quality evaluation results

Osteosarcoma diagnosed in a dog using a formalin-fixed fine-needle aspirate biopsy.

Fine-needle aspirate (FNA) biopsy is considered a quick technique to access and identify the cell types present in a pathologic lesion or make a diagnosis. Often, clinicians want to know if they are dealing with an inflammatory lesion with or without infectious agents or a neoplastic lesion. At times, neoplastic lesions may be confounded by the presence of inflammatory cells. We aimed to evaluate the application of a formalin-fixed FNA, designated the cytologic/histopathologic (CytoHisto) technique, to determine the diagnostic quality and ability to arrive at a definitive diagnosis without the use of concentrated cell block or invasive full tissue biopsy procedures during sample collection. A 10-cc syringe with a 22-gauge 1-inch needle attached was used to obtain a sizable FNA biopsy sample from a thigh mass in a dog. The needle was removed from the syringe, and the material was expulsed from the syringe directly into 10% buffered formalin. After 24-48-h fixation, a strainer was used to facilitate placement of the fixed granular material into a micromesh biopsy processing/embedding cassette, and the sample was processed as a routine histopathology sample. A microtome was used to make thin sections stained with H&E initially. Then, subsequent sections were stained with immunohistochemical (IHC) stains vimentin, MUM1, and CD18. Alkaline phosphatase staining was performed on a previously Wright's-stained cytology following IHC results. All sections were coverslipped and viewed under a light microscope. When unable to perform incisional or excisional biopsies, this CytoHisto, FNA in formalin technique was useful for collection and subsequent processing as a histopathology sample, with sectioning and then staining with H&E and IHC stains. Neoplastic cells were strongly immunoreactive for vimentin but negative for MUM1 and CD18. Scattered leukocytes within the background stained positively with CD18. The CytoHisto technique is minimally invasive and allows for sectioning similar to a full-thickness excisional or incisional biopsy with subsequent H&E and IHC staining, and special stains allow for a definitive diagnosis of osteosarcoma. The CytoHisto technique is a practical diagnostic technique to pursue in clinical practice that minimizes patient invasiveness and maximizes sample collection time, similar to the routine FNA technique.

A novel and efficient impedance matching technique based on fragment discrete structure and genetic algorithm

This paper proposes a novel and efficient design technique to achieve multi-frequency impedance matching. The matching network is mainly constructed based on fragment discrete structure, which consists of regularly distributed metallic microstrip stubs, where some of them are connected whereas others are not. Different designs are generated by determining the interconnections between each two stubs. To facilitate the design procedure, a theory based on port impedance substitution is rigorously developed to calculate the resulted performance (reflection coefficient) of each design. Finally, the optimal design is obtained by using the derived formulas and genetic algorithm. The full optimization procedure is totally free of electromagnetic (EM) simulation and is quite timesaving. Three different examples of mismatched frequency-varying complex load are adopted to illustrate the steps and functionality of the proposed method. The accuracy of the proposed fast-calculation method is also verified by EM simulation and experimental results.

Effective analysis of chronic kidney disease prediction using HRNN algorithm

Chronic Kidney Disease is a catch-all phrase for a variety of kidney illnesses. Chronic Renal Disease is another name for it. The illness affects 5 to 10% of the world's population. Chronic Kidney Disease is a worldwide health issue. Often these instances of Chronic Kidney Disease get it underdiagnosed or are eventually diagnosed in developing and underdeveloped countries; it is one of the main reasons why a greater percentage of these kinds of cases come from underdeveloped and developing countries as opposed to developed countries where most people have regular check-ups and diagnosis. Machine-learning systems could be used to identify Chronic Kidney Disease in what seems like a quick and accurate manner, allowing doctors to verify their test results in a relatively short period of time, going to allow a doctor to respond and recognise more sick people in less time than if he or She must go through the full diagnosis procedure by hand. Machine learning algorithms can be used for prediction, and exactness is determined by comparing various algorithms including such as Hybrid-Recurrent Neural Networks (HRNN). This method is used to forecast a dataset derived from a patient's medical history.

An automated approach to the alignment of compound refractive lenses.

Compound refractive lenses (CRLs) are established X-ray focusing optics, and are used to focus the beam or image the sample in many beamlines at X-ray facilities. While CRLs are quite established, the stack of single lens elements affords a very small numerical aperture because of the thick lens profile, making them far more difficult to align than classical optical lenses that obey the thin-lens approximation. This means that the alignment must be very precise and is highly sensitive to changes to the incident beam, often requiring regular readjustments. Some groups circumvent the full realignment procedure by using engineering controls (e.g. mounting optics) that sacrifice some of the beam's focusing precision, i.e. spot size, or resolution. While these choices minimize setup time, there are clear disadvantages. This work presents a new automated approach to align CRLs using a simple alignment apparatus that is easy to adapt and install at different types of X-ray experiments or facilities. This approach builds on recent CRL modeling efforts, using an approach based on the Stochastic Nelder-Mead (SNM) simplex method. This method is outlined and its efficacy is demonstrated with numerical simulation that is tested in real experiments conducted at the Advanced Photon Source to confirm its performance with a synchrotron beam. This work provides an opportunity to automate key instrumentation at X-ray facilities.