In this paper we start the study of Schur analysis for Cauchy–Fueter regular quaternionic-valued functions, i.e. null solutions of the Cauchy–Fueter operator in R4\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\\mathbb {R}}^4$$\\end{document}. The novelty of the approach developed in this paper is that we consider axially regular functions, i.e. functions spanned by the so-called Clifford-Appell polynomials. This type of functions arises naturally from two well-known extension results in hypercomplex analysis: the Fueter mapping theorem and the generalized Cauchy–Kovalevskaya (GCK) extension. These results allow one to obtain axially regular functions starting from analytic functions of one real or complex variable. Precisely, in the Fueter theorem two operators play a role. The first one is the so-called slice operator, which extends holomorphic functions of one complex variable to slice hyperholomorphic functions of a quaternionic variable. The second operator is the Laplace operator in four real variables, that maps slice hyperholomorphic functions to axially regular functions. On the other hand, the generalized CK-extension gives a characterization of axially regular functions in terms of their restriction to the real line. In this paper we use these two extensions to define two notions of rational function in the regular setting. For our purposes, the notion coming from the generalized CK-extension is the most suitable. Our results allow to consider the Hardy space, Schur multipliers and their relation with realizations in the framework of Clifford-Appell polynomials. We also introduce two notions of regular Blaschke factors, through the Fueter theorem and the generalized CK-extension.