In 2012, total GHG emissions in transport sector reached 88 Million ton CO2eq. The emissions generated in the road accounted for 94% of the transport sector. Currently, there are many efforts to operate an education and campaign for eco-driving. However study for eco-friendly vehicle control considering road alignment is limited. Therefore, the purpose of this study is to address fuel-efficient driving strategy in horizontal curve section. To fulfill the goal, designed ideal freeway horizontal curve road follows regulations about road structure. And safety speed is calculated for considering vehicle`s safety on horizontal curve road. Authors composed the acceleration and deceleration scenario for each horizontal curve section and generated the speed profiles that are limited by the safety speed. Speed profiles are converted into force that horizontal curve affect to fuel consumption. Then, we calculated fuel consumption using Comprehensive Modal Emission Model. Then, we developed eco-driving strategy by selecting most fuel-efficient scenario. To validate this strategy, we selected study site and compared fuel consumption for eco and manual driving. As the result, fuel consumption when driver used eco-driving was lessened by 20.73% than that of manual driving.