This study provides a comprehensive comparison of well-to-wheel (WTW) energy demand, WTW GHG emissions, and costs for conventional ICE and alternative passenger car powertrains, including full electric, hybrid, and fuel cell powertrains. Vehicle production, operation, maintenance, and disposal are considered, along with a range of hydrogen production processes, electricity mixes, ICE fuels, and battery types. Results are determined based on a reference vehicle, powertrain efficiencies, life cycle inventory data, and cost estimations. Powertrain performance is measured against a gasoline ICE vehicle. Energy carrier and battery production are found to be the largest contributors to WTW energy demand, GHG emissions, and costs; however, electric powertrain performance is highly sensitive to battery specific energy. ICE and full hybrid vehicles using alternative fuels to gasoline, and fuel cell vehicles using natural gas hydrogen production pathways, are the only powertrains which demonstrate reductions in all three evaluation categories simultaneously (i.e., WTW energy demand, emissions, and costs). Overall, however, WTW emission reductions depend more on the energy carrier production pathway than on the powertrain; hence, alternative energy carriers to gasoline for an ICE-based fleet (including hybrids) should be emphasized from a policy perspective in the short-term. This will ease the transition towards a low-emission fleet in Switzerland.