The number of working points and response speed are two essential characteristics of proton exchange membrane fuel cell (PEMFC). The improper setting of the number of working points and response speed may reduce the life of PEMFC and increase the hydrogen consumption of the vehicle. This paper explores the impact of the response speed as well as the working points of the PEMFC on the hydrogen consumption in the real-system level. In this paper a dynamic model of the PEMFC system is established and verified by experiments. The model is able to reflect the dynamic response process of PEMFC under a series different number of working points and different response speed. Based on the proposed model, the influence of working points and the response speed of PEMFC on the hydrogen consumption in the vehicle under different driving cycles is analyzed and summarized, for the first time, in the open literature. The results highlight that the hydrogen consumption will decreases in both cases that with the increase of working point number and increase of response speed. However, the reduction range of hydrogen consumption trends to smaller and may reach to an optimal level considering the trade-off between the hydrogen saving and the other costs, for example the control cost. Also, with a more complex driving cycle, the working points and response speed have a greater the impact on the hydrogen consumption in the vehicle applications.