Kim et al. (Proc. Jangjeon Math. Soc. 21(4):589–598, 2018) have studied the central Fubini polynomials associated with central factorial numbers of the second kind. Motivated by their work, we introduce degenerate version of the central Fubini polynomials. We show that these polynomials can be represented by the fermionic p-adic integral on mathbb{Z}_{p}. From the fermionic p-adic integral equations, we derive some new properties related to degenerate central factorial numbers of the second kind and degenerate Euler numbers of the second kind.