Emblica Officinalis Fruit Extract Research Articles

Modulatory role of Emblica officinalis fruit extract against arsenic induced oxidative stress in Swiss albino mice

Arsenic, an important human toxin, is naturally occurring in groundwater and its accumulation in plants and animals have assumed a menacing proportion in a large part of the world, particularly Asia. Epidemiological studies have shown a strong association between chronic arsenic exposure and various adverse health effects, including cardiovascular diseases, neurological defects and cancer of lung, skin, bladder, liver and kidney. The protective role of the fruits of Emblica officinalis (500 mg/kg b.wt.) was studied in adult Swiss albino mice against arsenic induced hepatopathy. Arsenic treated group (NaAsO 2, 4 mg/kg b.wt.) had a significant increase in serum transaminases and lipid peroxidation (LPO) content in liver, whereas significant decrease was recorded in hepatic superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) and serum alkaline phosphatase activity. Combined treatment of Emblica and arsenic (pre and post) declined the serum transaminases and LPO content in liver whereas significant increase was noticed in SOD, CAT, GST and serum alkaline phosphatase activities. Liver histopathology showed that Emblica fruit extract had reduced karyolysis, karyorrhexis, necrosis and cytoplasmic vacuolization induced by NaAsO 2 intoxication. Thus it can be concluded that pre- and post-supplementation of E. officinalis fruit extract significantly reduced arsenic induced oxidative stress in liver.

Fruit Extract of Emblica Officinalis (Amla) Protects Radiation Induced Biochemical Lesions In The Brain of Swiss Albino Mice

Fruit Extract of Emblica Officinalis (Amla) Protects Radiation Induced Biochemical Lesions In The Brain of Swiss Albino Mice

Biosynthesis of Gold and Silver Nanoparticles Using <I>Emblica Officinalis</I> Fruit Extract, Their Phase Transfer and Transmetallation in an Organic Solution

The design, synthesis and characterization of biologically synthesized nanomaterials have become an area of significant interest. In this paper, we report the extracellular synthesis of gold and silver nanoparticles using Emblica Officinalis (amla, Indian Gooseberry) fruit extract as the reducing agent to synthesize Ag and Au nanoparticles, their subsequent phase transfer to an organic solution and the transmetallation reaction of hydrophobized silver nanoparticles with hydrophobized chloroaurate ions. On treating aqueous silver sulfate and chloroauric acid solutions with Emblica Officinalis fruit extract, rapid reduction of the silver and chloroaurate ions is observed leading to the formation of highly stable silver and gold nanoparticles in solution. Transmission Electron Microscopy analysis of the silver and gold nanoparticles indicated that they ranged in size from 10 to 20 nm and 15 to 25 nm respectively. Ag and Au nanoparticles thus synthesized were then phase transferred into an organic solution using a cationic surfactant octadecylamine. Transmetallation reaction between hydrophobized silver nanoparticles and hydrophobized chloroaurate ions in chloroform resulted in the formation of gold nanoparticles.

Protective effect of a 50% hydroalcoholic fruit extract ofEmblica officinalis against anti-tuberculosis drugs induced liver toxicity

The present report showed the hepatoprotective property of a 50% hydroalcoholic extract of the fruits of Emblica officinalis (fruit) (EO-50) against antituberculosis (anti-TB) drugs-induced hepatic injury. The biochemical manifestations of hepatotoxicity induced by rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA), either given alone or in combination were evaluated. In vitro studies were done on suspension cultures of rat hepatocytes while sub-acute studies were carried out in rats. The hepatoprotective activity of EO-50 was found to be due to its membrane stabilizing, antioxidative and CYP 2E1 inhibitory effects.

Protection Against Radiation Induced Chromosome Damage byEmblica OfficinalisFruit Extract

SUMMARYThe protective ability of Emblica officinalis fruit extract (aqueous) in three different concentrations ranging from 1 to 10% has been studied on chromosome aberrations in Allium sativum root tips exposed to 810r X-irradiation. Germinating Allium roots were treated with various concentrations of extract for 12 h before and after irradiation. Protection against radiation induced chromosome bridges and fragments were observed. It was shown that all the concentrations of extract provide protection against radiation induced chromosome damages in both pre and post-irradiation treatments. The radioprotective effects may be attributed to the antioxidation system of ascorbic aci—gallic aci—reducing sugar—tannins as contained by the Emblica fruit.