An experiment was conducted on the topic “Effect of NPK on Growth, Yield and Quality of Chilli’’ during winter season 2021-22 at the Research Field of Department of Horticulture, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj. The observations were recorded on the parameters i.e. Growth, Yield, Germination Percentage, Quality. Which included the Plant Height, Number of Branches, Flowering, Plant Spread, Germination Percentage, TSS, Fruit Color, Fruit Length, Fruit Diameter, Yield/plant, Yield/hectare, Fruit Weight. In order to achieve maximum production without lowering the quality of the chilli, A study was conducted at the Department of Horticulture, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj. Eight treatments were used in the experiment, which was set up in a randomized block design and triple duplicated. Results demonstrates that the treatment (T3) i.e. 140:90:80 NPK combination gives superior Plant height (80.83cm), A greater number of branches (9.66), maximum number of fruits per plant (47.33), Fruit length (10.66 cm), Fruit girth (4 cm), Yield (23.95 t/ha), Gross profit (479,000.00 Rs/ha), Net profit (361,554.00 Rs/ha), B:C ratio (4.07). The level of NPK enhanced the yield, improve the input-use efficiency by the crop and can certainly lower down the expenditure on costly fertilizers to the farmers.