Event Abstract Back to Event The sensitivity to different types of milk in patients with Ulcerative colitis Irina Besu1*, Aleksandra Konic-Ristic2, Njegica Jojic3, Dragan Popovic4 and Zorica Juranic1 1 Institute of Oncology and Radiology of Serbia, Experimental Oncology, Serbia 2 Institute for Medical Research, Department of Nutrition and Metabolism, Serbia 3 KBC Zvezdara, Department of Gastroenterology and Hepatology, Serbia 4 Clinical Center of Serbia, Institute of Gastroenterology and Hepatology, Serbia Objective: Ulcerative colitis (UC) is a form of inflammatory bowel disease, which is treated as an autoimmune disease. The aim of this study was to determine the prevalence of the increased levels of serum antibodies to different types of milk: fresh cow’s milk (FCM), fresh goat’s milk (FGM), boiled cow’s milk (BCM) and boiled goat’s milk (BGM) in patients with UC. Methods: Seventeen patients with UC (15 with proven increased, mainly IgG and IgE immunity to cow’s milk proteins (CMP) and 2 without it) were included in this research. Levels of serum IgA, IgG and IgE antibodies to FCM, FGM, BCM and BGM were determined by ELISA test. The statistical analysis of data was performed by Wilcoxon rank sum test. Results: The levels of serum anti-FCM IgA, IgG and IgE antibodies were significantly higher than levels of serum anti-BCM (p=0.0313; p=0.0256; p=0.0029) respectively. Statistical analysis of IgG and IgE immunoreactivity to BGM and BCM showed that the levels of anti-BCM IgG and IgE antibodies were significantly higher in comparison to levels of anti-BGM IgG and IgE antibodies (p=0.0066; p=0.0005). The level of serum anti-FCM IgG antibody was significantly higher than level of serum anti-FGM (p=0.0125). The level of IgE immunity to FGM is significantly higher than level of IgE immunity to BGM (p=0.0231). Conclusion: These results indicate that patients with UC with increased immunity to CMP, could consider the use of BGM as the alternative protein source. Keywords: Immunoreactivity, Milk, antibody, IgA, IgG, IgE Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune-mediated disease pathogenesis Citation: Besu I, Konic-Ristic A, Jojic N, Popovic D and Juranic Z (2013). The sensitivity to different types of milk in patients with Ulcerative colitis. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00805 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Irina Besu, Institute of Oncology and Radiology of Serbia, Experimental Oncology, Belgrade, Serbia, irina.besu@ncrc.ac.rs Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Irina Besu Aleksandra Konic-Ristic Njegica Jojic Dragan Popovic Zorica Juranic Google Irina Besu Aleksandra Konic-Ristic Njegica Jojic Dragan Popovic Zorica Juranic Google Scholar Irina Besu Aleksandra Konic-Ristic Njegica Jojic Dragan Popovic Zorica Juranic PubMed Irina Besu Aleksandra Konic-Ristic Njegica Jojic Dragan Popovic Zorica Juranic Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.