Fresh Approach Research Articles

Harnessing blue light for cost-effective and eco-friendly antimicrobial solutions in poultry farming

Blue light in the visible spectrum naturally fights bacteria and effectively deactivates various Gram-positive and Gram-negative bacteria and fungi using photodynamic processes. It works against drug-resistant strains within these species and is gentler on mammalian cells than ultraviolet rays or chemicals. This study evaluated blue light as an affordable way to sanitize surfaces in poultry settings, such as eggs and litter. The study used an light-emitting diode array to remove harmful Esche¬richia coli and Staphylococcus aureus from these items and observed how blue light affected their survival rates. Blue light (455 nm) at 30 mW/cm2 for one hour decreased the survival of S. aureus and E. coli on solid agar plates to 29.88% and 21.04%, respectively, compared to non-irradiated cultures. Similarly, on untreated surfaces (such as plastic used for feeding and drinking), the survival rates dropped to 25.8% and 15.6%, respectively. The survival percentages on treated eggs were 50% (S. aureus) and 48.2% (E. coli) and 59% (S. aureus) and 36.46% (E. coli) on treated litter. Hence, blue light technology offers a promising alternative to traditional antimicrobial methods by leveraging specific wavelengths to target microbial cells. This approach can significantly reduce the microbial load in poultry environments, enhancing food safety and animal health. This paper reports the first use of blue light as an antibacterial within poultry research in Iraq, offering a fresh approach to disinfection in this field.

Constructing New International Relations Between China and Its Neighbors: A Constructivist Analysis of the Impact of the Belt and Road

The Silk Road Economic Belt and the 21st-Century Maritime Silk Road spearheaded by General Secretary Xi Jinping offers a practical framework for fostering a fresh approach to international relations between China and its neighboring countries. This study thoroughly examines how the Belt and Road Initiative contributes to shaping a new form of international relations between China and its neighboring regions from a constructivist viewpoint. This is achieved through qualitative research, literature analysis, and inductive methodologies. Under the constructivist perspective, The Belt and Road Initiative has transformed the dynamic between China and its neighboring nations on various levels. When looking at it from a horizontal perspective, the focus is on highlighting the unique aspects and qualities of international interactions, such as "common development", "mutual respect", and "harmonious coexistence".Looking at things from an aerial viewpoint, the Belt and Road Initiative delves into a fresh approach to China's relationships with its neighboring countries across three levels: national, subnational, and regional. China prioritizes establishing innovative international relations with neighboring countries through the Belt and Road initiative to stabilize domestic growth and navigate foreign relations amidst the changing development scenario. Faced with intricate regional dynamics stemming from recent historical shifts, China must steadfastly advance the "Belt and Road" project to cultivate a conducive neighboring atmosphere, fostering the development of a shared human destiny.

Inconvenient academic workers? Collective (Re)humanisation through the dialogue of a Freirean Reading Circle

ABSTRACT We argue that academia's performative obsession is inherently dehumanising. We seek to rehumanise academia by sharing a method for collective research and writing. Through a fresh approach to Freirean Reading Circles (FRCs), we offer a series of images and conversations from our circle meetings to demonstrate aspects of humanity often erased in traditional academic writing. Although FRCs can be adapted to different cultural artefacts, our choice of the Japanese novel Convenience Store Woman is purposeful. We explore the novel's theme of what it means to be both human and worker, and challenge the patriarchal bias of ‘great’ literature. Grounded in Paulo Freire's ideas, we demonstrate how academia's dehumanising tendencies can be challenged from within. To humanise our writing, we celebrate the joy and messiness of collective processes, foregrounding the human selves often hidden in sanitised academic writing. We invite you, as readers, to resist dehumanisation by extending our emancipatory project.

Predicting Regression of Barrett's Esophagus-Can All the King's Men Put It Together Again?

The primary pre-neoplastic lesion of the lower esophagus in the vicinity of the gastroesophageal junction (GEJ) is any Barrett's esophageal lesions (BE), and esophageal neoplasia has increased in the US population with predispositions (Caucasian males, truncal obesity, age, and GERD). The responses to BE are endoscopic and screening cytologic programs with endoscopic ablation of various forms. The former have not been proven to be cost-effective and there are mixed results for eradication. A fresh approach is sorely needed. We prospectively followed 2229 mostly male veterans at high risk for colorectal cancer in a 27-year longitudinal long-term study, collecting data on colorectal neoplasia development and other preneoplastic lesions, including BE and spontaneous regression (SR). Another cross-sectional BE study at a similar time period investigated antigenic changes at the GEJ in both BE glandular and squamous mucosa immunohistochemistry and the role of inflammation. Ten of the prospective cohort (21.7%) experienced SR out of a total of forty-six BE patients. Significant differences between SR and stable BE were younger age (p < 0.007); lower platelet levels (p < 0.02); rectal p87 elevation in SR (p < 0.049); a reduced innate immune system (InImS) FEREFF ratio (ferritin: p87 colonic washings) (p < 0.04). Ancillary testing showed a broad range of neoplasia biomarkers. InImS markers may be susceptible to intervention using commonplace and safe medical interventions and encourage SR.

Summary of Varieties and Diversities of Nanomaterials Used in Food Safety and Quality

In all fields of life sciences, the trends toward sustainability, enhanced product safety, and high standards of quality are significant. The food industry uses intelligent packaging to meet these needs. These systems can continuously monitor a product's quality status and notify the customer of any changes. Conventional methods can only satisfy the needs of regular laboratory food analysis. Thus, in the cases of major food safety concerns, quick, economical, and time-saving analysis techniques, including portable, on-site, and home testing kits, are desperately needed. Nonetheless, there is a chance that nanoparticles could be harmful to people's health. Nanotechnology, for instance, can be applied to food processing to improve food's overall quality, including taste, flavor, and bioavailability. It can also help products last longer on the shelf. Moreover, nanotechnology is often applied to food packaging to deliver innovative packaging and serve as an antimicrobial agent. It can offer fresh approaches to thwart fraud and serve as a valuable weapon in our toolbox to prevent bioterrorism. As a result, it is advised to set up a sufficient regulatory framework to control any dangers related to applications of nanotechnology. This review addresses the classification and safety issues involved in the application of nanotechnology in food safety and packaging.

Fecal microbiota transplantation as a new way for OVA-induced atopic dermatitis of juvenile mice

Children all over the world suffer from atopic dermatitis (AD), a prevalent condition that impairs their health. Corticosteroids, which have long-term negative effects, are frequently used to treat AD. There has been a growing body of research on the gut microbiota’s function in AD. Nevertheless, the function and underlying mechanisms of fecal microbiota transplantation (FMT) in AD children remain to be established. Therefore, in order to assess the preventive effects of FMT treatment on AD and investigate the mechanisms, we constructed an ovalbumin (OVA)-induced juvenile mouse AD model in this investigation. This study explored the role and mechanism of FMT treatment in AD through 16S RNA sequencing, pathological histological staining, molecular biology, and Flow cytometry. Results demonstrated that the FMT treatment improved the gut microbiota’s diversity and composition, bringing it back to a level similar to that of a close donor. Following FMT treatment, OVA-specific antibodies were inhibited, immunoglobulin (Ig) E production was decreased, the quantity of mast cells and eosinophils was decreased, and specific inflammatory markers in the skin and serum were decreased. Further mechanistic studies revealed that FMT treatment induced CD103+ DCs and programmed cell death ligand 1 (PD-L1)/programmed cell death 1 (PD-1) expression in skin-draining lymph nodes and promoted Treg production to induce immune tolerance and suppress skin inflammation. Meanwhile, changes in the gut microbiota were substantially correlated with Th2 cytokines, OVA-specific antibodies, and PD-L1/PD-1. In conclusion, FMT regulates the Th1/Th2 immunological balance and the gut microbiota. It may also inhibit AD-induced allergy responses through the PD-L1/PD-1 pathway, and providing a unique idea and possibly a fresh approach to the treatment of AD.

The So-Called Ansbert, his ‘Historia de expeditione’ and Related Sources as a Research Problem *

Abstract The article dealing with the so-called Ansbert, his ‘Historia de expeditione Friderici imperatoris’ and related sources offers a research overview and analysis of the topic as it has evolved over the past 200 years and presents a new and more productive way to approach the narrative – the most important source documenting Frederick Barbarossa’s crusade ( 1188–1190 ). Firstly, the circumstances of the source’s reappearance in 1826 are explained, showing the troubled fate of the Strahov manuscript, where the narrative is extant in its fullest form. Secondly, the course of the academic discussion is traced, the main protagonist being Anton Chroust, the author of an edition used to this day. The main characteristics of the source are explained and the historiographical debate on the ‘Tageno-Ansbert-Frage’ is analysed, demonstrating that in almost desperate attempts to solve the question of authorship, the interconnectedness of sources and the exact manner of composition, research has gone up a blind alley, hindering more result-yielding questions from even being asked, which has not been remedied even by crusading studies that have bloomed in the past 100 years. Finally, a fresh approach to the topic is introduced: the narrative may be researched more viably through the lens of the functions and aims the source may have followed and the role the crusading idea may have played in it. Rediscovery of the ‘Historia’, p. 362. – The ‘Tageno-Ansbert-Frage’, p. 363. – Anton Chroust Enters the Scene, p. 365. – Karl Zimmert Disagrees, p. 367. – Towards the Modern Edition, p. 368. – The Edition, p. 371. – Reactions and Aftermath, p. 375. – The So-Called Ansbert in Crusading Studies and Barbarossa’s Biographies?, p. 377. – ‘Historia de Expeditione’ and its Modern Translations, p. 380. – New Horizons?, p. 385.

The Emergence of Acceptance and Commitment Sandtray Therapy: A Novel Framework

This paper introduces Acceptance and Commitment Sandtray Therapy (ACST) as a new branch of sand therapy theory. As a novel framework, it offers a fresh approach to conducting sandtray therapy and provides additional avenues for pursuing research. The creation and articulation of ACST is an evolution of my unique experience as an enthusiastic and dedicated student of both Acceptance and Commitment Therapy (ACT) and Sandtray Therapy (STT). Part of this article’s purpose is to introduce ACT’s foundational philosophy and theory. I achieve this by briefly describing radical behaviorism, functional contextualism, and relational frame theory. However, the primary focus of this paper is to highlight the six core psychological processes used in ACST and provide an example using a fictitious client’s tray with those processes in mind. Suggested protocols for implementing this framework, along with therapeutic interventional prompts appropriate for its application, are also offered. This work is significant in that it bridges two worlds: the contextual behavioral science realm of ACT and the interpersonal neurobiology domain of STT. With the emergence of this new model, new possibilities are on the horizon for both professional communities.

BCED-Net: Breast Cancer Ensemble Diagnosis Network using transfer learning and the XGBoost classifier with mammography images.

Breast cancer poses a significant global health challenge, characterized by complex origins and the potential for life-threatening metastasis. The critical need for early and accurate detection is underscored by the 685,000 lives claimed by the disease worldwide in 2020. Deep learning has made strides in advancing the prompt diagnosis of breast cancer. However, obstacles persist, such as dealing with high-dimensional data and the risk of overfitting, necessitating fresh approaches to improve accuracy and real-world applicability. In response to these challenges, we propose BCED-Net, which stands for Breast Cancer Ensemble Diagnosis Network. This innovative framework leverages transfer learning and the extreme gradient boosting (XGBoost) classifier on the Breast Cancer RSNA dataset. Our methodology involved feature extraction using pre-trained models-namely, Resnet50, EfficientnetB3, VGG19, Densenet121, and ConvNeXtTiny-followed by the concatenation of the extracted features. Our most promising configuration combined features extracted from deep convolutional neural networks-namely Resnet50, EfficientnetB3, and ConvNeXtTiny-that were classified using the XGBoost classifier. The ensemble approach demonstrated strong overall performance with an accuracy of 0.89. The precision, recall, and F1-score values, which were all at 0.86, highlight a balanced trade-off between correctly identified positive instances and the ability to capture all actual positive samples. BCED-Net represents a significant leap forward in addressing persistent issues such as the high dimensionality of features and the risk of overfitting.

Multi-method analysis revealed the mechanism of substrate selectivity in NHase: A gatekeeper residue at the activity center

Recognizing the critical need to elucidate the molecular determinants of this selectivity offers a pathway to engineer enzymes with broader and more versatile catalytic capabilities. Through integrated methods including phylogenetic analysis, molecular docking, and structural analysis, we identified a pivotal amino acid residue, αTrp116, linking the substrate binding pocket and the active site of a NHase from Pseudonocardia thermophila JCM 3095 (PtNHase). This residue acts as a crucial determinant of substrate specificity within the NHase enzyme. The mutant αW116R modified the substrate specificity of PtNHase, significantly enhancing its catalytic efficiency towards aromatic substrates. The catalytic activity for aromatic compounds such as 3-Cyanopyridine was 14-fold that of the wild-type, whereas its activity for aliphatic substrates diminished to one-sixth. MD simulations revealed that replacing αTrp116 with Arg allowed aromatic nitrile substrates to achieve more favorable conformations within the active site. Based on the mutant αW116R, we further constructed a combinatorial variant Pt-4, tailored for aromatic substrates, which exhibited an enzyme activity 50 times that of the wild-type. These results highlight the critical influence of amino acid residues in the enzyme's active site on substrate specificity and offer fresh perspectives and approaches for the evolution of enzymes.

Poetry unveiled: Multimodality and aesthetic responses as a fresh approach to teaching and reading verse

AbstractIn secondary English classrooms, poetry is often a text that is least liked because it is viewed as being “inaccessible,” reserved for the elite, and/or too abstract. Part of the reason for this also lies in the traditional, colonial structures of introducing poetry such as relying on canonical texts and close reading analysis. Yet, outside of the classroom poetry is used in more accessible and engaging manners. With the advancements of technology, there also includes multimodal ways in which to read and write poetry that could be much more interesting for both educators and youth. This paper opens a discussion to consider multimodal and aesthetic responses to including poetry such as using digital apps like PhoneMe, a free accessible platform that allows users to post their written poems, record themselves reciting poems, and pin their poems directly on to an interactive digital map. The uniqueness of PhoneMe—a layered multimodal approach—can provide a more engaging way to teach and learn poetry.

Detectable Adhesives: Nondestructive Detection of Adhesion

AbstractMetal‐to‐metal adhesives are vital across diverse sectors including automotive, aerospace, and industrial assembly. However, traditional adhesion detection methods are mainly based on the fracture mechanism, posing challenges for nondestructive detection. Here, a nondestructive method that leverages electrical signals to monitor the adhesion state of metal interfaces in real‐time is presented. The approach utilizes detectable adhesives (DA) synthesized from poly(ionic liquid) (PIL), which not only exhibit robust adhesion properties (4.9 MPa) but also function as ionic conductors. By correlating changes in capacitance and resistance with the adhesive state, the method allows for in situ monitoring of the curing process, prediction of adhesion strength, and early detection of potential failures. This dual‐sensing capability, combining electrical and mechanical aspects, enhances understanding of adhesive behavior in diverse conditions, presenting a fresh approach for digitally transforming adhesive technologies.

More than one way to peel an orange : A fresh approach to building an effective lease administration function

This paper explores the evolving landscape of lease administration, prompted by shifts in labour markets, growing complexities of financial reporting for lease agreements and the emergence of robust lease management technology. Lease administration emerges as a critical business function, with a focus on managing lease data, ensuring accurate rent payments and navigating compliance and landlord relationships, while providing realtime reporting capability for business stakeholders. In addition, lease administrators transition from labour-intensive manual processes to a more analytical and technical approach. Given the altered environment in lease management requirements, tools and skill sets, now is an ideal juncture for companies to assess their current lease administration operating model, and the paper introduces a perfect assessment tool. The Lease Administration Framework, a proactive lease administration management system, highlights strategies and decisions for managing a company’s real estate portfolio while considering the use of in-house teams and outsourced service providers. The paper advocates for a tailored approach to be aligned with organisational needs, while emphasising the importance of evaluating talent, technology and risk tolerance in the decision-making process. By following the framework, corporate real estate (CRE) leaders can ensure financial prudence, gain the agility to allocate resources strategically, invest in growth initiatives and weather economic uncertainties.

Unlocking multi-photon excited luminescence in pyrazolate trinuclear gold clusters for dynamic cell imaging

The family of coinage-metal-based cyclic trinuclear complexes exhibits abundant photophysical properties, promising for diverse applications. However, their utility in biochemistry is often hindered by large particle size and strong hydrophobicity. Meanwhile, the investigation into multi-photon excited luminescence within this family remained undocumented, limiting their potential in bio-imaging. Herein, we unveil the multi-photon excited luminescent properties of pyrazolate-based trinuclear gold(I) clusters, facilitated by excimeric gold(I)···gold(I) interactions, revealing a nonlinear optical phenomenon within this family. Furthermore, to address issues of poor biocompatibility, we employ electrospinning coupled with hydroxypropyl-beta-cyclodextrin as the matrix to fabricate a flexible, durable, transparent, and red emissive film with a photoluminescence quantum yield as high as 88.3%. This strategy not only produces the film with sufficient hydrophilicity and stability, but also achieves the downsizing of trinuclear gold(I) clusters from microscale to nanoscale. Following the instantaneous dissolution of the film in the media, the released trinuclear gold(I) nanoparticles have illuminated cells and bacteria through a real-time, non-toxic, multi-photon bio-imaging approach. This achievement offers a fresh approach for utilizing coinage-metal-based cyclic trinuclear complexes in biochemical fields.

Hotstar: Revolutionizing the Indian entertainment market with digital technologies

The present case study investigates into how Hotstar, a well-known online entertainment platform, has altered and changed the Indian entertainment industry. The case study explores the history of Hotstar, from its founding to its expansion into international markets, highlighting the technological innovations and calculated moves that have propelled the company’s success. This Case Study looks at how Hotstar collects content, enhances user experience, and makes money. It also highlights how Hotstar is changing sports broadcasting and taking on traditional broadcasters. Hotstar is well-positioned for future expansion because to its commitment to innovation and customer-centricity, even in the face of financial, regulatory, and competitive challenges. By examining Hotstar’s past and assessing the key factors that contributed to its success, this essay provides insights into the digital entertainment market and illuminates likely future developments in the space. The study also investigates Hotstar’s current financial and competitive challenges, highlighting the need for fresh approaches.

Enhanced photocatalytic degradation of organic pollutants via black phosphorus-mediated electron transfer in g-C3N4/BiOI: Degradation mechanisms and biotoxicity assessment

Photocatalysis is a promising strategy for organic pollutant removal, yet developing a capable photocatalyst remains challenging. Using black phosphorus (BP) as an electron buffer material, the ternary composite photocatalysts of xBP/g-C3N4/BiOI were prepared through a straightforward hydrothermal method. Tetracycline (TC) and Rhodamine B (RhB) removals were 100 % (120 min) and 99 % (90 min) by photocatalytic process on 2.5 %BP/g-C3N4/BiOI under xenon lamp irradiation. Photoluminescence and electrochemical measurements confirmed BP's role in reducing charge transfer barriers between g-C3N4 and BiOI, achieving effective separation of photogenerated electrons. The degradation mechanisms of TC and RhB on 2.5 %BP/g-C3N4/BiOI were revealed by the quenching experiments, electron paramagnetic resonance spectroscopy tests, three-dimensional excitation-emission matrix fluorescence spectrum, and liquid chromatography-mass spectrometry analyses. Plant toxicity assessment experiments confirmed the non-toxic nature of the TC and RhB degradation solutions. Plants grown in the treated solutions exhibited declining trends in both Malondialdehyde and Peroxidase indices compared to untreated solutions. This study offers a fresh approach to advanced photocatalyst design using charge transfer buffer materials.

Thermophilic bacterial agent inoculation enhances biodrying of kitchen waste: Insights into process properties, organic degradation, bacterial communities and metabolic pathways

The high moisture content of kitchen waste (KW) restricts the future treatment and resource utilization. Biodrying is an effective approach to remove the water of KW. However, conventional biodrying only uses the heat generated by the indigenous microorganisms to remove water, which has long treatment cycle and low moisture removal rate. Microbial bioaugmentation is an emerging approach to improve the biodrying efficiency of KW. In this study, a thermophilic bacterial agent (TBA) composed of Bacillus, Geobacillus and Acinetobacter was used to promote water evaporation during the biodrying process. Based on the results, the moisture removal rate of experimental group inoculated with TBA was 82.20 %, which was notably higher than CK group without inoculation. Moreover, TBA significantly increased the amount of organic matter degradation. Microbial community analysis revealed that TBA could promote the proliferation of thermophilic bacteria and make bacterial community more tolerant to high temperature environment. Further analysis of metabolic pathways showed that quorum sensing and glyoxylate and dicarboxylate metabolism were enhanced by TBA inoculation, which can help microorganisms to better adapt to high temperature environment and release more energy to facilitate the water evaporation. This study offers a fresh approach to improve the water removal efficiency in biodrying process.

Research on the Clustering of Emotional Elements in Art and Design Based on Visual Language Communication

Since many different emotional expressions can be found in artistic and design compositions, it can be challenging to effectively extract and analyze emotional information from such a wide range of artworks. This study uses deep learning approaches to extract and cluster emotional aspects from art and design works to address this problem. The suggested method uses DBSCAN (Density-Based Spatial Clustering of Applications with Noise) for clustering and combines the VGG-16 and Bi-LSTM models for feature extraction from images. The suggested approach works better than existing models in extracting emotional information pieces, according to experimental results. With a Macro-F1 assessment score of 0.9241, the suggested technique can efficiently examine emotional inclinations in artistic and design works in practical applications. In conclusion, this study discusses the potential applications of the suggested emotion element extraction and clustering method in the field of emotional analysis in art and design, offering fresh approaches to issues in this area.

The Significance of Food Fortification for Prevention of Major Health Challenges due to Micronutrient Deficiencies (MND) for Under 5 Years Children in Bangladesh

Vitamins and minerals, known as micronutrients, are needed in trace levels for healthy growth and development as well as heightened immunity against illness. They need to come from outside sources because the body isn&amp;apos;t able to produce them. Inadequate and inappropriate physical and intellectual development results from malnutrition in vulnerable people, including early childhood, expectant and nursing mothers, and the aged people. Meals fortification is a safe and practical way to boost consumption of macronutrients by providing essential nutrients in meals. Long-term developmental goals are impacted by vitamin deficiencies. In order to raise public awareness of the advantages of food fortification, an educational program is required. An extensive summary of Bangladesh&amp;apos;s current women&amp;apos;s and children&amp;apos;s micronutrient deficient status is provided in this article. This study also covers the effectiveness of current intervention programs as well as their current issues. Almost half of all expectant and nursing mothers suffer from anemia. High levels of deficiencies are associated with several critical factors, including sickness, malabsorption, infestation, inadequate nutrition, and poor cleanliness. There have been several attempts at interventions, and some success has been achieved. Issues with coverage, quality, and compliance still exist. Even though severe deficiencies have been somewhat addressed by current intervention initiatives, micronutrient deficiencies in Bangladesh continue to be a major concern. A more comprehensive strategy is required to enhance the current intervention initiatives. Additionally, fresh approaches of intervention are proposed in order to prevent and treat specific micronutrient deficiencies.

Control interfacial charge transfer behavior by creating surface defects on structure unit of heterojunction to drive carrier separation for enhancing photocatalytic CO2 reduction

Controlling interfacial charge transfer behavior of heterojunction is an arduous issue to efficiently drive separation of photogenerated carriers for improving the photocatalytic activity. Herein, the interface charge transfer behavior is effectively controlled by fabricating an unparalleled VO-NiWO4/PCN heterojunction that is prepared by encapsulating NiWO4 nanoparticles rich in surface oxygen vacancies (VO-NiWO4) in the mesoporous polymeric carbon nitride (PCN) nanosheets. Experimental and theoretical investigations show that, differing with the traditional p-n junction, the direction of built-in electric field between p-type NiWO4 and n-type PCN is reversed interestingly. The strongly codirectional built-in electric field is also produced between the surface defect region and inside of VO-NiWO4 besides in the space charge region, the dual drive effect of which forcefully propels interface charge transfer through triggering Z-Scheme mechanism, thus significantly improving the separation efficiency of photogenerated carriers. Moreover, the unique mesoporous encapsulation structure of VO-NiWO4/PCN heterostructure can not only afford the confinement effect to improve the reaction kinetics and specificity in the CO2 reduction to CO, but also significantly reduce mass transfer resistance of molecular diffusion towards the reaction sites. Therefore, the VO-NiWO4/PCN heterostructure demonstrates the preeminent activity, stability and reusability for photocatalytic CO2 reduction to CO reaction. The average evolution rate of CO over the optimal 10 %-VO-NiWO4/PCN composite reaches around 2.5 and 1.8 times higher than that of individual PCN and VO-NiWO4, respectively. This work contributes a fresh design approach of interface structure in the heterojunction to control charge transfer behaviors and thus improve the photocatalytic performance.