Frequent Route Research Articles

EVALUATING PEDESTRIAN CROSSING ATTRIBUTES AT INTERSECTIONS IN KABUL CITY, AFGHANISTAN: A COMPUTER VISION APPROACH

This study aims to evaluate pedestrian crossing attributes in heterogeneous traffic environments using computer vision. For this purpose, YoloV8 models were optimised to detect pedestrian crossing attributes. Moreover, an OpenCV-based Python programme was developed to track pedestrian trajectories manually. For accuracy, the inverse perspective mapping method is applied to obtain a bird's eye view. Finally, a heatmap of pedestrian trajectories was provided to visualise the pedestrian crossing attributes. The results show that more than three-quarters of pedestrians are engaging in noncompliance crossing behaviours at major intersections in Kabul City, Afghanistan. In addition, pedestrians tend to walk longer, more frequent routes at corners and outside of crosswalks. Furthermore, statistical analysis reveals that pedestrian crossing speed decreased by 5.8% when disobeying crossing rules, indicating the significant effect of pedestrian attributes on crossing speed. In conclusion, this study contributes to a better understanding of pedestrian behaviour in heterogeneous traffic environments using computer vision. The results would provide insightful information to traffic engineers and planners for traffic management.

The search for still unknown pathomechanisms of allergy

In recent decades, atopic diseases, such as atopic dermatitis (AD), allergic asthma (AA), allergic rhinitis (AR), and food allergy (FA) have been estimated rapidly increasing in prevalence. These diseases are characterized by the presence of specific immunoglobulin E (sIgE) and often relate to each other and develop in sequence (the so-called “atopic march”). AD may be the first early manifestation in infants followed by FA often within the first year of life. Moreover, AD is a risk factor for developing sensitization to airborne allergens later in life that can cause clinical manifestations of AA and AR. According to the dual-allergen exposure hypothesis, allergic sensitization to food allergens is promoted through cutaneous exposure, rather than the oral route. Moreover, there is evidence that exposure to food allergens, in particular peanuts, in the airway would also lead to food sensitization. The most frequent route of sensitization for inhalant allergens is still debated. Of note, a recent case report supports the development of sensitization to cat dander through a cat bite. Our review aims to provide an overview of current knowledge and unmet needs in the pathophysiology of respiratory and FAs.

QoS-based energy-efficient hybrid routing protocols in RSU assisted VANET using clustering mechanism

ABSTRACT Vehicular ad hoc networks (VANET) communication framework are employed to improve communication between vehicles on the highway and urban roads. Evaluating the best routing path by satisfying the QoS (Quality of Service) plays a substantial role in networking. Researchers for maximising the routing efficiency have employed numerous methods. But these criteria cannot be attained effectively due to certain limitations, including frequent route failure, high overhead, increased packet loss rate, less throughput and packet delivery rate. Hence, this work presents an effective strategy to offer better communication services with less energy consumption and high flexibility using QoS-based energy efficient routing framework with clustering (QoS_EErcF) network model. Initially, different clusters are formed by considering the constraints like node direction, link reliability, speed and distance. The cluster heads (CH) are chosen from the clusters with the dissemination of gateway nodes and cluster members using an Amended rapid cosine similarity-founded clustering mechanism (Arc_SimC). The best routing strategy for transmitting the data from source to destination is performed by using Integrated Pelican with grasshopper optimisation algorithm (IPel_Ghop). Constraints such as bandwidth, node distance, energy, packet loss rate, network traffic and end-to-end delay are considered to find the optimal path. The results are simulated using MATLAB, whereas the energy efficiency of a proposed model is obtained to be 98.37%, and the packet delivery ratio is attained as 99.60%.

[Translated article] Longitudinal Study of Different Progression Patterns in High-Risk Cutaneous Squamous Cell Carcinoma

Background and objectiveCutaneous squamous cell carcinoma (cSCC) is the second leading cause of skin cancer mortality in Europe. Few studies have analyzed the different pathways of this tumor progression in its natural history. The main objective of this study was to analyze the different metastatic and progression pathways and their temporal occurrence in the evolution of cSCC. Material and methodWe conducted a multicenter, retrospective, and observational study of consecutive high-risk sSCCs included in the SQUAMATA project. ResultsA total of 222 out of the 1346 patients included relapsed. The most frequent route of progression was the lymphatic one (62.6%). A total of 20.2% of the cases with lymphatic progression developed distant metastases. Only 1 case (3.1%) of distant metastasis followed local recurrence without previous lymphatic metastasis. The median time to disease-related mortality was longer in patients who developed systemic metastases than in those who died of locoregional progression. ConclusionsThe mortality of patients with cSCC is mostly due to the regional progression of their lymphatic metastases. The appearance of distant metastases is practically always (96.9%) associated with previous lymphatic metastatic progression. Therefore, in the future, new studies will be needed to assess the regional management of cSCC in both surgical and adjuvant therapies.

If You Cut It Will They Ride? Longitudinal Examination of the Elasticity of Public Transport Ridership in the Post-Pandemic Era

In the past two years, public transport ridership has declined because of COVID-19 pandemic health measures and new working from home policies. This decline in ridership has caused major financial stress on public transport agencies around the world. Several agencies have responded to this financial stress by reducing services. The extent to which these service cuts will affect transit ridership is unknown because of the changing operational environment in the post-pandemic world. Our study uses a longitudinal panel data from Montréal, Quebec, Canada, to explore the relationship between route-level ridership and operational factors over time. We find that public transport ridership demand at the route level is highly elastic when compared to trip frequency and has become more elastic after the COVID-19 pandemic. Our findings imply that agencies cutting service in the post-pandemic era run a much more significant risk of creating a “doom spiral,” where service reductions spur greater declines in ridership, forcing further reductions. Demand was found to be most elastic on more frequent routes, so agencies should prioritize maintaining services on their core routes in the post-pandemic era. This study can be of use to public transit planners and policymakers considering making service changes to attract more riders or trying to respond to post-COVID-19 financial stress.

Identifying nutrition risk in emergency patients: What is the most appropriate screening tool?

The emergency department (ED) is the most frequent access route to the hospital. Nutrition risk (NR) screening allows the early identification of patients at risk of malnutrition. This study aimed to evaluate the feasibility and predictive validity of five different tools in EDs: Nutritional Risk Screening 2002 (NRS-2002), Nutritional Risk Emergency 2017 (NRE-2017), Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT), Malnutrition Universal Screening (MUST), and Malnutrition Screening Tool (MST). Patients with scores ≥3 according to the NRS-2002, ≥1.5 according to the NRE-2017, and ≥2 according to the MUST, RFH-NPT, or MST were classified with NR. Prolonged length of stay (LOS) and 1-year mortality were evaluated. 431 patients were evaluated (57.31 ± 15.6 years of age; 54.4% women) in a public hospital in southern Brazil. The prevalence of NR was: 35% according to the NRS-2002, 43% according to the MST, 45% according to the NRE-2017 and MUST, and 49% according to the RFH-NPT. Patients with NR, had a greater risk of prolonged LOS (P < 0.001). The presence of NR was associated with an increased risk of 1-year mortality according to the NRS-2002 (hazard ratio [HR]: 4.04; 95% CI, 2.513-6.503), MST (HR: 2.60; 95% CI, 1.701-3.996), NRE-2017 (HR: 4.82; 95% CI, 2.753-8.443), MUST (HR: 4.00; 95% CI, 2.385-6.710), and RFH-NPT (HR: 5.43; 95% CI, 2.984-9.907). NRE-2017 does not require objective data and presented predictive validity for all outcomes assessed, regardless of the severity of the disease, and thus appears to be the most appropriate tool for carrying out NR screening in the ED.

Prospects for Controlling Hepatitis B Globally.

Infection with the hepatitis B virus (HBV) is highly prevalent globally. Over 250 million people suffer from chronic hepatitis B, and more than 800,000 patients die each year due to hepatitis B complications, including liver cancer. Although protective HBV vaccines are recommended for all newborns, global coverage is suboptimal. In adults, sexual transmission is by far the most frequent route of contagion. The WHO estimates that 1.5 million new HBV infections occur annually. Oral nucleos(t)ide analogues entecavir and tenofovir are the most frequent antivirals prescribed as HBV therapy. Almost all patients adherent to the medication achieve undetectable plasma viremia beyond 6 months of monotherapy. However, less than 5% achieve anti-HBs seroconversion, and viral rebound occurs following drug discontinuation. Therefore, nucleos(t)ide analogues need to be lifelong. New long-acting formulations of tenofovir and entecavir are being developed that will maximize treatment benefit and overcome adherence barriers. Furthermore, new antiviral agents are in development, including entry inhibitors, capside assembly modulators, and RNA interference molecules. The use of combination therapy pursues a functional HBV cure, meaning it is negative for both circulating HBV-DNA and HBsAg. Even when this goal is achieved, the cccDNA reservoir within infected hepatocytes remains a signal of past infection, and HBV can reactivate under immune suppression. Therefore, new gene therapies, including gene editing, are eagerly being pursued to silence or definitively disrupt HBV genomes within infected hepatocytes and, in this way, ultimately cure hepatitis B. At this time, three actions can be taken to push HBV eradication globally: (1) expand universal newborn HBV vaccination; (2) perform once-in-life testing of all adults to identify susceptible HBV persons that could be vaccinated (or re-vaccinated) and unveil asymptomatic carriers that could benefit from treatment; and (3) provide earlier antiviral therapy to chronic HBV carriers, as being aviremic reduces the risk of both clinical progression and transmission.

Estudio longitudinal de los diferentes patrones de progresión en el carcinoma cutáneo de células escamosas de alto riesgo

Background and objectiveCutaneous squamous cell carcinoma (cSCC) is the second leading cause of skin cancer mortality in Europe. Few studies have analyzed the different pathways of this tumor progression in its natural history. The main objective of this study was to analyze the different metastatic and progression pathways and their temporal occurrence in the evolution of cSCC. Material and methodWe conducted a multicenter, retrospective, and observational study of consecutive high-risk sSCCs included in the SQUAMATA project. ResultsA total of 222 out of the 1346 patients included relapsed. The most frequent route of progression was the lymphatic one (62.6%). A total of 20.2% of the cases with lymphatic progression developed distant metastases. Only 1 case (3.1%) of distant metastasis followed local recurrence without previous lymphatic metastasis. The median time to disease-related mortality was longer in patients who developed systemic metastases than in those who died of locoregional progression. ConclusionsThe mortality of patients with cSCC is mostly due to the regional progression of their lymphatic metastases. The appearance of distant metastases is practically always (96.9%) associated with previous lymphatic metastatic progression. Therefore, in the future, new studies will be needed to assess the regional management of cSCC in both surgical and adjuvant therapies.

Centralized multicasting AODV routing protocol optimized for intermittent cognitive radio ad hoc networks

The advancement of wireless technology is affected by Spectrum scarcity and the overcrowding of free spectrum. Cognitive Radio Ad Hoc Networks (CRAHNs) have emerged as a possible solution to both the scarcity and overcrowding challenges of the spectrum. The CRAHNs ensure that the Secondary Users (SUs) do co-exist with Primary Users (PUs) in a non-interfering manner. The SUs access the licensed spectrum opportunistically when they are idle. CRAHNs have many use cases which include intermittent networks here referred to as intermittent CRAHNs (ICRAHNs). For example, the Military (MCRAHNs). MCRAHN is complex and characterized by a dynamic topology which is subject to frequent partitioning and route breakages due to attacks and destruction in combat. This study optimizes the routing protocols for intermittent networks such as the MCRAHNs. ICRAHN routing is a challenge due to the network’s intermittent attribute, which is subject to destruction in the case of MCRAHN which is characterized by frequent link breakages. To better understand the routing in this network scenario, this paper presents two analytic models for the AODV and MAODV protocols based on queuing theory. The analytic models simulate unicast and multicast AODV in terms of factors such as queuing delay, throughput, and network scalability. Numerical analysis shows that MAODV outperforms AODV. Furthermore, the suggested routing protocols' performance was tested using network simulations utilizing the following metrics: throughput, Routing Path delay, Node Relay delay, and Spectrum Mobility delay. The simulation findings suggest that the MAODV protocol outperforms the AODV protocol.

Principal causes of acute poisoning in an emergency service: experience between 2014 and 2021 at a University Hospital in Southwestern Colombia

Acute poisonings are a global public health problem, which implies costs and disease burden for society. In Colombia, there is a significant underreporting of data on acute poisoning and data gaps on the toxicological profile of the population. This study aims to identify the epidemiology of acute poisoning in a high-complexity hospital in southwestern Colombia. A descriptive study with retrospective data collection was performed. The variables were expressed through the measure of central tendency and dispersion. Categorical variables were described in proportions. A total of 406 patients were included. The median age was 31 years (IQR 23–48), 56.2% were male, and only 19.2% had a history of mental illness. Suicidal intent represented 58.8% of the cases, and the most frequent route of exposure was the oral route (81.6%). The most prevalent groups of substances were pesticides (34.2%) and medicines (32%). The most common etiological agent was organophosphates (16.5%). Cholinergic toxidrome was the most common. The average stay in the ICU was 4.5 days (± 4.8), and the mortality was 4.2%. The principal causes of acute poisoning were drugs and pesticides, with a predominant etiology of organophosphates and depressants of the central nervous system. There was a significant predominance of young male patients with suicidal intent, low mental disorders, elevated unemployment rate, and similar mortality reported in other studies. This study improves the knowledge about acute poisoning in southwestern Colombian to carry out multicenter analytic studies.

Risk factors associated to adverse drug events in hospitalized patients

To determine prevalence, causes and risk factors of ADE in hospitalized patients. Analytical, observational, case-control study of patients with ADE. For statistical analysis, the following were calculated: percentages, frequencies, averages; odds ratio, χ2 test and multiple binary logistic regression. Data analysis was carried out with the Statistical Package, for the Social Sciences 23 program. A 132 patients were registered: 66 cases (26 EM and 40 RAM) and 66 controls; with average age of 35 years (SD 17.41). The prevalence of adverse drug events was 3.6%. The most frequently reported medications: antibiotics and anti-inflammatories. The frequency of adverse events by gender was: 39.3% men and 60.7% women. The services with the greatest patient care: emergencies, surgery; the most frequent route of administration: intravenous (32.3%). The main symptoms: skin. (32.3%) frequent symptoms: cutaneous. Associated symptoms RAM: type A pruritus (OR: 8.5; p = 0.001; IC95%: 0.035-0.393), type B pruritus (OR: 11; p = 0.001; CI95%: 0.021-0.368) urticaria (OR: 19; p = 0.005; IC95%: 0.007-0.412). Risk factors Associated EAM: female (OR: 2.6; p = 0.05; CI95%: 1.33-5.43), history of allergy (OR: 3.4; p = 0.033; CI95%: 1.04-8.40), prolonged hospital stays (OR: 5.4; p = 0.023; IC95%: 3.82-6.74). Patient safety is a priority when prescribing any drug, which represents a key point in prevention.

Efficacy of short-course treatment for prevention of congenital transmission of Chagas disease: A retrospective cohort study.

In regions with controlled vector transmission of T. cruzi, congenital transmission is the most frequent route of infection. Treatment with benznidazole (BZ) or nifurtimox (NF) for 60 days in girls and women of childbearing age showed to be effective in preventing mother to child transmission of this disease. Reports on short-course treatment (≤30 days) are scarce. Retrospective cohort study. Offspring of women with Chagas disease who received short-course treatment (≤30 days) with BZ or NF, attended between 2003 and 2022, were evaluated. Parasitemia (microhaematocrit and/or PCR) was performed at <8 months of age, and serology (ELISA and IHA) at ≥8 months to rule out congenital infection. A total of 27 women receiving ≤30 days of treatment and their children were included in this study. NF was prescribed in 17/27 (63%) women, and BZ in 10/27 (37%). The mean duration of treatment was 29.2 days. None of the women experienced serious adverse events during treatment, and no laboratory abnormalities were observed. Forty infants born to these 27 treated women were included. All newborns were full term, with appropriate weight for their gestational age. No perinatal infectious diseases or complications were observed. Several studies have shown that treatment of infected girls and women of childbearing age for 60 days is an effective practice to prevent transplacental transmission of T. cruzi. Our study demonstrated that short-duration treatment (≤30 days) is effective and beneficial in preventing transplacental transmission of Chagas disease.

Multi-Hop and Mesh for LoRa Networks: Recent Advancements, Issues, and Recommended Applications

A comprehensive review is presented on the latest approaches to solutions focusing on multi-hop and mesh LoRa networks through the evaluation of simulations and real-world experiments, based on papers published between 2015 and 2023. The approaches are systematically classified into four (4) aspects: energy awareness, concurrent access and duty cycle regulations, routing protocols, and security. The first aspect encompasses parameter selection, distance, and clustering. The second aspect focuses on network segregation and time synchronisation. The third aspect covers proactive, reactive, and hybrid routing protocols. The aspect of security includes privacy and Denial-of-Service (DoS). Findings show a consensus that multi-hop networks and adherence to radio duty cycle are able to lower average power consumption. Concurrent access method can improve network performance, but more research is needed due to different conclusions. Reactive protocols have a slight advantage over proactive protocols in terms of node deployment scalability and lower power consumption due to less frequent routing table updates. Hybrid protocols are only beneficial in specific topology deployments. Security is still a major concern for LoRa networks, particularly on attacks such as Man-In-The-Middle (MITM), spoofing, wormholes, flooding, packet replay, and information disclosure. The upcoming trend of implementing machine learning algorithms to multi-hop and mesh LoRa networks opens up a wide range of possibilities, ranging from airspace efficiency, efficient route selection, and improving data throughput. A detailed discussion of the aspects’ issues and recommended industry applications that will benefit from multi-hop and mesh LoRa networks are also provided.

Charging infrastructure for electric vehicles in New Zealand

The uptake of electric vehicles (EV) is closely interlinked with the availability of charging infrastructure. Fast charging stations (FCS) can facilitate the uptake of EV, but their installation requires significant investments affecting their profitability. An optimal determination of charging locations and capacities based on associated costs can help to provide infrastructure efficiently. As initial FCS affect installations and costs in later years, a strategic infrastructure development plan over multiple years is required to expand the infrastructure to satisfy the charging demand of a growing EV fleet, while pursuing the goal of minimal costs. Based on former work, a model for the investment-optimal allocation and sizing of FCS over multiple years (including costs for grid connection) is developed. For the first time, a multi-periodic capacitated Arc-Cover Path-Cover formulation with an investment-optimal objective is proposed and applied to New Zealand. The results are analysed with respect to the locations and sizes of FCS, the impact on the coverage of traffic flows, and the related trends over time. They indicate that FCS are to be located along highly trafficked corridors in densely populated regions for being applied profitably. The chosen station locations have below-average installation costs and are capable of covering high shares of EV traffic on inter-regional and highly frequented routes.

An Emergency Message Routing Protocol for Improved Congestion Management in Hybrid RF/VLC VANETs

Unexpected traffic incidents cause safety concerns and intense traffic congestion on crowded urban road networks. Vehicular ad-hoc network (VANET)-aided Intelligent Transport Systems (ITS) aim to mitigate these risks through timely dissemination of alert messages. However, conventional Radio frequency (RF) mobile ad-hoc routing protocols are ill-suited for dynamic VANET environments due to high mutual interference, packet collisions, high end-to-end delay from frequent route discoveries, and periodic beaconing requirements. Fortunately, the quickly emerging Visible Light Communications (VLC) provide complementary short-range connectivity with high bandwidth and low interference. This paper proposes an efficient adaptive routing protocol for emergency messages in dense VANET scenarios leveraging a hybrid RF/VLC system. When an incident or congestion happens, the source vehicle disseminates the information to the incoming vehicles as quickly as possible using a combination of VLC and RF communication networks. Multi-hop relays extend the connectivity if the direct links are blocked. The coverage area is partitioned into zones based on road segments, intersections, and traffic flows. The Road Side Units (RSU)s are intelligently assigned to zones and they analyze the historical traffic data to characterize each zone and decide a response strategy. We also propose a congestion detection scheme that utilizes traffic simulations to forecast the clearance times under different response strategies. The highest-scoring strategy is selected based on the predicted impacts on travel time, emissions, and driver stress levels. The proposed algorithm adaptively uses the selected strategy to proactively alleviate the predicted congestion through optimized routing and control. Overall, the protocol maximizes safety and efficiency during emergencies by leveraging the hybrid RF/VLC, incorporating real-time congestion forecasting and dynamic rerouting into the response strategies.

Family issues and custodial mothers' quest for justice: Evidence from Colombia.

Access to justice is limited for many worldwide. Although prior research generally recognizes the legal needs and barriers faced by women, less is known about mothers. This study examined the legal needs of mothers in different family configurations and the actions they took in response to these needs through the lens of help-seeking theories. We used unique data from the 2016 Colombian Quality of Life Survey (QLS) to produce descriptive statistics on the legal needs of mothers in two-parent families and custodial mothers. We then conducted multivariate analyses to examine the factors associated with having a family issue and seeking institutional help. Custodial mothers were more likely than mothers in two-parent families to have reported any legal need, and to report a family legal issue. The most frequent legal issues related to the family were issues with child support, custody, and/or visitation. The most frequent action taken to resolve issues was through an institutional actor. Among custodial mothers, single, younger mothers and mothers with more children were more likely to experience family legal issues, but they were not the ones seeking institutional help-those mothers were often more socioeconomically advantaged. That more socioeconomically disadvantaged mothers are more likely to experience a family legal issue but less likely to seek institutional help, the most frequent route to action, calls for research that examines the barriers faced by these mothers and policies to improve their access to justice.

Distributed Detour Routing Scheme for Link Failure with Minimized Overhead in LEO Satellite Networks

The mobility of low Earth orbit (LEO) satellites causes the LEO satellite network to experience topology changes. Topology change includes periodic topology change that occurs naturally and unpredictable topology change that occurs due to instability of the inter-satellite link between satellites. Periodic and unpredictable topology change causes frequent topology change, requiring massive communications throughout the network due to frequent route convergence. LEO satellites have limited onboard power because they operate on batteries. The waste of limited satellite onboard resources shortens the lifespan of the satellite, and achieving stable end-to-end transmission is challenging for the network. In this regard, minimizing communication overhead is a fundamental consideration when designing a routing scheme. In this paper, we propose a distributed detour routing scheme with minimal communication overhead. This routing scheme consists of a rapid detour, selective flooding, and link recovery procedures. When a link failure occurs in the network, a rapid detour can detect link failure using only a precalculated routing table. Subsequently, selective flooding searches for the optimal detour point within the minimum hop region and flood to detour point. After link recovery, a procedure is defined to traverse the pre-detour path and switch it back to the original path. The simulation results show that the proposed routing scheme achieves a reduction of communication overhead by 97.6% compared with the n-hop flooding approach.

People who inject oral morphine favor experimentation with injectable opioid substitution

BackgroundThe French Addictovigilance network has observed the existence of the intravenous use of oral morphine capsules among people suffering from opioid use disorders. According to persons who inject morphine, these capsules are easy to dissolve and then inject, giving them the image of an "injectable" opioid substitution treatment (OST). In France, validated OSTs are only available orally, so dissolving morphine capsules represents the only alternative for patients who are not sufficiently relieved by oral forms.This practice presents risks related to the potential persistence of particles of the oral galenic in the injectable solution, despite its filtration, but also risks—notably of overdose—related to the pharmacological effects of opioids and to variations of the quantities of morphine extracted during the dissolution of the capsules. We conducted an online survey among the people concerned to collect data on their needs and expectations regarding a possible injectable substitution.MethodAn anonymous online survey including all voluntary respondents residing in France and using oral morphine intravenously was conducted in partnership with the Psychoactif harm reduction organization, from 23/03/2020 to 01/04/2021.ResultsThe analysis of the 157 exploitable questionnaires showed that 41% of the respondents obtained their drugs only from illegal markets. The others received, regularly or occasionally, medical prescriptions, reimbursed in 84% of cases. For 78% of the respondents, injection was the most frequent route of morphine administration, with 3.8 ± 2 injections per day. 56% of the respondents were receiving an OST, on prescription (79%), monthly (86%), in addition to morphine.Skenan® capsules were the most frequently used (81%) and 47.2% of the respondents had already experienced injection-related complications. 95% of the respondents were in favor of experimenting with an injectable morphine substitution. Those who never received medical prescriptions were the youngest (< 25 years) respondents, they reported only occasional use of morphine, and always intravenously.ConclusionOral morphine capsules dissolved and injected intravenously are not a safe and sustainable injectable substitution. Respondents wish to be able to benefit from an injectable substitution with a formulation adapted to the intravenous route. The availability of an injectable substitution would facilitate harm reduction and entry into care for the people concerned, particularly the youngest who have never received morphine prescriptions.

Sporotrichosis in Argentina: clinical and epidemiological analysis

Sporotrichosis is an implantation mycosis caused by Sporothrix spp. It is distributed worldwide and can be found in vegetation and soil. The most frequent route of infection is by trauma with elements contaminated with fungal propagules. Since domestic cats are the most affected animals and can transmit this infection to humans, sporotrichosis is considered a zoonosis. Clinical presentations include nodular lymphangitis, fixed cutaneous, pulmonary (rare), and disseminated (exceptional). To analyze the epidemiology of sporotrichosis in Argentina during 2010 and 2022. To describe the clinical presentation, diagnostic methods, and treatment of cases diagnosed during this period. To know the circulating genotypes and to observe possible associations with the geographic location where the infection was acquired. Analytical, retrospective, and observational study. We analyzed the medical records of patients with sporotrichosis from 12 health institutions in Argentina, between 2010 and 2022. We present 54 cases in which the most frequent clinical form was nodular lymphangitis, and the treatment of choice was itraconazole. Conventional diagnosis was made in all cases. Culture of clinical samples was more sensitive than direct examination because it allowed the isolation of Sporothrix spp. in all 54 cases. Molecular identification was performed in 22 cases, with Sporothrix schenkii sensu stricto being the most frequently isolated species. This study allowed to know the epidemiology of this mycosis in Argentina, as well as the availability of diagnostic methods and the treatment of choice.

FlexDATE: Flexible and Disturbance-Aware Traffic Engineering With Reinforcement Learning in Software-Defined Networks

Traffic Engineering (TE) is an important network operation that routes/reroutes flows based on network topology and traffic demands to optimize network performance. Recently, new emerging applications pose challenges to TE with dynamic network conditions, where frequent routing updates are required to maintain good network performance with Software-Defined Networking (SDN). However, flow rerouting operations could lead to considerable Quality of Service (QoS) degradation and service disruption, which is often neglected by existing TE solutions. In this paper, we apply a new QoS metric named network disturbance to measure the negative impact of flow rerouting operations performed by TE. To achieve near-optimal load balancing performance and mitigate network disturbance together in dynamic network scenarios, we propose a flexible and disturbance-aware TE solution called that combines Reinforcement Learning (RL) and Linear Programming (LP). Specifically, leverages RL to intelligently identify flexible numbers of critical flows for each traffic matrix and reroutes these critical flows based on LP optimization to improve network performance with low disturbance. Empowered by a customized actor-critic architecture coupled with Graph Neural Networks (GNNs), can generalize well to unseen traffic scenarios and remain resilient to single link failures. Extensive simulations are conducted on five real-world network topologies to evaluate with real and synthetic traffic traces. The results show that can achieve the performance target (i.e., 90% of optimal performance) in 99% of network scenarios and effectively mitigate the average and maximum network disturbance by up to 9.1% and 38.6%, respectively, compared to state-of-the-art TE solutions.