The real-time monitoring of solid particles in pipelines has been widely used in industry, especially during sand production in the petroleum industry. The monitoring result is determined by the vibration force response characteristics of sand-wall collision. In this paper, the process of the sand-wall collision was analyzed by Hertz contact theory, and the main vibration frequency from the sand-wall collision was calculated. The corresponding sand-wall impacting experiment was also investigated. Based on the theoretical and experimental research, the results showed that the main frequency of the sand vibration signal is inversely proportional to the diameter of the sand, and the initial velocity of the sand impact wall has little effect on the main frequency of the vibration signal. Besides, the sand-liquid film-wall experiment and simulation results showed that fluid viscosity little affect the stress transmission under low viscosity (less than 40 mPa·s), and the viscosity has the greatest effect on stress transfer under the high viscosity of 90 mPa·s. The above research lays the foundation for the detection ability of solid particles in pipe flow.