This paper is based on the research and development of the first fully prefabricated subway station in Changchun as the engineering background. Through the first large-scale shaking table test of a fully prefabricated subway station structure in China, the macroscopic phenomena of the model system in an actual earthquake occurrence were qualitatively reproduced. Based on the macroscopic phenomena of video surveillance, the seismic responses of the model structure were graded and evaluated. The analysis showed that under the same earthquake action, the seismic responses of the lower layer of the station were stronger than those of the upper layer, the Beijing wave was the strongest, the Taft wave was the second strongest, and the Mingshan wave was the weakest. The acceleration and lateral displacement of the model foundation and the acceleration, structural strain, joint deformation and soil pressure of the model structure were tested and analysed. The results showed that the closer the main frequency of seismic wave was to the main frequency of the model system, the more intense the seismic response was. With an increase in seismic intensity, obvious phenomena of low-frequency amplification and high-frequency filtering occurred. Shear deformation occurred laterally in the model foundation, and the peak displacement appeared obviously asymmetrical in the process of left and right lateral displacement. The existence of the underground structure obviously changed the propagation law of the seismic wave in the model foundation, and the closer the structure was, the more significant the difference was. The strength of the mortise-groove joint was better than that of the prefabricated component, which showed excellent integrity and mechanical properties. The model station structure had excellent cooperative work and deformation resistance properties. When rare earthquake loading occurs, the vault would gradually degenerate into a three-hinged arch mechanism and maintain a relatively stable state.