Frequency Of Papillary Carcinoma Research Articles

Incidental Thyroid Carcinoma Diagnosed after Total Thyroidectomy for Benign Thyroid Diseases: A Prospective Observational Study

Background: The term “incidental” denotes malignant tumors of the thyroid gland detected postoperative in surgical specimens resected for benign disease. As cancer, thyroid is the commonest endocrine malignancy and their incidence increases over the past 15-20 years. In Egypt, it represents 2.2% of total cancers. It constitutes 30% of endocrine malignancies and 12-49% of head and neck tumors. Objective: The aim of this study was to determine the incidence and histological features of incidental cancers in patients who had total thyroidectomy for benign thyroid diseases. Patients and Methods: This Study is a prospective, empirical study carried out at Al-Zahraa University Hospital during the period from April, 2016 to April, 2018. The study included 100 cases had total thyroidectomy of previously diagnosed benign thyroid diseases and fulfilled the inclusion criteria. Results: In this study, 100 patients underwent total thyroidectomy. The female (n=86) to male (n=14) ratio was 6.14: 1 and the age ranged from 19 to 69 years. The incidental carcinoma in this study found in 12 (12%) patients. The frequency of papillary carcinoma was 9 % of all thyroid diseases and 75% of the incidental thyroid cancer (ITC) (9/12). Also, frequency of follicular carcinoma was 1.4% of all thyroid diseases (three cases) and 16.66% of the ITC. Conclusion: The non-irrelevant incidence of ITC, the eventuality of multifocal and bilaterality and the possible occurrence of relapse support that total thyroidectomy without residuum is a valuable option for treating benign thyroid conditions.

Incidental Thyroid Carcinoma Diagnosed after Total Thyroidectomy for Benign Thyroid Diseases: A Prospective Observational Study

Background: The term “incidental” denotes malignant tumors of the thyroid gland detected postoperative in surgical specimens resected for benign disease. As cancer, thyroid is the commonest endocrine malignancy and their incidence increases over the past 15-20 years. In Egypt, it represents 2.2% of total cancers. It constitutes 30% of endocrine malignancies and 12-49% of head and neck tumors. Objective: The aim of this study was to determine the incidence and histological features of incidental cancers in patients who had total thyroidectomy for benign thyroid diseases. Patients and Methods: This Study is a prospective, empirical study carried out at Al-Zahraa University Hospital during the period from April, 2016 to April, 2018. The study included 100 cases had total thyroidectomy of previously diagnosed benign thyroid diseases and fulfilled the inclusion criteria. Results: In this study, 100 patients underwent total thyroidectomy. The female (n=86) to male (n=14) ratio was 6.14: 1 and the age ranged from 19 to 69 years. The incidental carcinoma in this study found in 12 (12%) patients. The frequency of papillary carcinoma was 9 % of all thyroid diseases and 75% of the incidental thyroid cancer (ITC) (9/12). Also, frequency of follicular carcinoma was 1.4% of all thyroid diseases (three cases) and 16.66% of the ITC. Conclusion: The non-irrelevant incidence of ITC, the eventuality of multifocal and bilaterality and the possible occurrence of relapse support that total thyroidectomy without residuum is a valuable option for treating benign thyroid conditions.

The Prevalence of Thyroid Cancer in Patients with Multinodular Goiter

Background: Thyroid cancer is the most common endocrine carcinoma, as it accounts for almost 90% of all endocrine malignancies. The incidence of thyroid carcinoma is about 1-3 cases in every 100,000 population. During the last 30 years, the rate of thyroid cancer incidence has increased worldwide. Objective: The aim of this work was to determine the frequency of thyroid carcinoma in multinodular goiter in patients undergoing thyroidectomy to make a strategy to perform total thyroidectomy (TT) as a rule of treatment. Patients and methods: This retrospective study included the medical charts and surgical data of a total of 50 patients who underwent surgery for goiter at General Surgery Department, Aswan University Hospital between 2015 and 2018. Results: The present study showed that the frequency of papillary carcinoma was 6% of all thyroid diseases (from 50 patients), 60% of incidental thyroid carcinoma as the frequency was high in the 4th decade of life. The present study showed that the frequency of follicular carcinoma was 2% of all thyroid diseases (one case), 20% of ITC. Patient was in the 4th decade. The present study showed that the frequency of undifferentiated thyroid cancer was 2% of all thyroid diseases. Conclusion: It could be concluded that, according to the finding of this study, total thyroidectomy is the preferred method in benign thyroid disease for which surgery is indicated. The advantages of TT include reduction of recurrence rate, achieves a permanent cure of thyroid disorders.

Incidental thyroid carcinoma after thyroidectomy for benign thyroid disease in Suez Canal region

Background The term ‘incidental’ thyroid cancer is a term applied to a very small, unsuspected cancer identified incidentally on pathologic examination of thyroid tissue removed for benign disease. Aim The aim was to evaluate the prevalence of incidental thyroid carcinoma (ITC) after thyroidectomy for benign thyroid lesions with its different pathological types. Patients and methods The study population was selected by comprehensive sampling. All the patients attended the General Surgery Department in the Suez Canal University hospital for thyroidectomy of previously diagnosed benign thyroid diseases within the period between 1 July 2009 and 31 December 2014 and fulfilled the inclusion criteria. Results In this study, 211 patients underwent thyroidectomy. The female (n=179) to male (n=32) ratio was 5.6 : 1, and the age ranges from 18 to 75 years. The highest age incidence was found to be in the fifth decade of life (60 patients). In this study, the incidental carcinoma was found in 22 (10.4%) patients. The frequency of papillary carcinoma was 8.5% of all thyroid diseases and 81.8% of ITC (18/22). Moreover, the frequency of follicular carcinoma was 1.4% of all thyroid diseases (three cases) and 13.6% of ITC. Conclusions A correct preoperative assessment, with a careful selection of nodules for fine-needle aspiration cytology on the basis of ultrasound pattern, could better address the choice of surgical procedure.

Broad fibrovascular cores may not be an exclusively benign feature in papillary lesions of the breast: a cautionary note

AimsA prominent fibrovascular stromal core is one of the widely accepted histological features of breast papillomas, but some papillary carcinomas also show such broad fibrovascular cores, leading to confusion in...

Carcinoma thyroid in multi and uninodular goiter.

To determine the frequency and profile of carcinoma in multi-nodular goiter and solitary thyroid nodule. Case series. Surgical Unit-I, Ward-3 of Jinnah Postgraduate Medical Centre, Karachi, from January 1999 to January 2009. Cases with solitary thyroid nodules and multi-nodular goiter were included. Patients under 12 years of age, cystic benign lesion in solitary thyroid nodules or those multi-nodular goiters which were not causing pressure symptoms, cosmetic problems or sign of malignancy were excluded. In solitary thyroid nodule, hemithyroidectomy was done and if histopathology examination revealed carcinoma thyroid then completion thyroidectomy was done. In multi-nodular goiter sub-total thyroidectomy done. Results were described as frequency percentages and mean. Out of 397 patients of multi-nodular goiter only one patient was found to be papillary carcinoma (0.25%). In 220 patients of solitary thyroid nodules, 93 patients were diagnosed as carcinoma of thyroid (42.27%). Others diagnosed in solitary thyroid nodule were thyroid adenoma, colloid goiter, thyroiditis and multi-nodular goiter. The frequency of papillary carcinoma in 65.95% occuring females of 12-30 years of age and being multifocal in 6.45%, follicular carcinoma in 23.40%, medullary carcinoma in 7.44%, anaplastic carcinoma in 2.12% and lymphoma in 1.01%. Female were predominantly involved and papillary carcinoma was common in 12-30 years of age (71.63%) and follicular was common in 30-40 years of age (68.18%). 6.45% of papillary carcinoma was found to be multifocal in nature. Frequency of carcinoma of thyroid is very high in solitary thyroid nodule (42.27%), but markedly low in multinodular goiter. Papillary carcinoma is the most common variety, most of in younger female.

Incidence of thyroid cancer in Norway 1970–1985

In the Norwegian population, a total of 1977 females and 648 males had a diagnosis of thyroid cancer and were reported to the Cancer Registry during 1970-85. Most of the cases (98%) were histologically or cytologically confirmed, and 141 cases were diagnosed at autopsy (5.4%). Of the patients with information available, 13% had not been subjected to radical surgery. The actual number and annual incidence rate of thyroid cancer increased during the period, especially among females, although a possible levelling off was observed at the end. The frequency of papillary carcinoma clearly increased with time, and tumours were more often localized at presentation in later years. Improved detection of smaller tumours and differences in histopathological judgement may in part explain these results, but our findings are so notable that etiological factors must also be accounted for and researched. Associations between sex, age, histology and stage were further studied in a multivariate log-linear model. The results confirm the importance of sex and age when exploring the observed incidence pattern and also show that various histological types are unique with respect to metastatic patterns, when confounding factors have been adjusted for.

High relative frequency of thyroid papillary carcinoma in northern Portugal.

Two hundred and twelve papillary and 40 follicular carcinomas were found in 3002 thyroid glands examined from 1931 to 1975 in four Laboratories of Pathology that fairly cover northern Portugal. There was a striking preponderance of women both in papillary (female:male = 6.9:1) and follicular carcinoma (5.7:1). Sex-specific frequency of malignancy was significantly greater in men (13.3%) than in women (8.8%). The overall papillary/follicular ratio was 5.3:1 and did not significantly change throughout the study period. Papillary/follicular ratio was not significantly greater in litoral (5.5:1) than in regions with a low iodine intake and a relatively high prevalence of goiter (3.5:1). It is advanced that this high relative frequency of papillary carcinoma in northern Portugal, even in goiter areas, may reflect the existence of a racial factor since there is not enough evidence to support the influence of dietary iodine, previous irradiation and concurrent thyroiditis.