Daily Frequency Research Articles

Using proximity loggers in studies of sheep behavior: an estimation of the daily frequency of water consumption

BackgroundProximity loggers are a biotelemetry technology used to quantify animal–animal interactions non-invasively. They are small devices can be affixed to a target animal and detects and records if another device is within a certain distance, which can provide unprecedented insights into individual behavior and interactions with other animals or other aspects of the environment. Proximity loggers also can record the duration and distance between the two or more individuals detected, and have been used to study a diverse array of interactions. Studying drinking behavior in sheep is important for several critical reasons, such as improving animal welfare, enhancing productivity, managing resources efficiently, and ensuring sustainable agricultural practices. The objective of this study was to test the capacity for Bluetooth Low Energy proximity loggers to quantify drinking habits in sheep (n = 7 adult females). At all times, they had access to water from two drinking troughs. Animals wore neck collars that contained a mobile logger, and two stationary loggers were placed under the drinking troughs. To store the records downloaded from the stationary loggers, a gateway was placed close to the troughs. The mobile loggers were programmed as beacons to transmit their ID to the stationary loggers, which were programmed as receivers to scan the proximity of the mobile loggers, record the time, the IDs of the mobile loggers, and the received signal strength of the contact with the mobile loggers.ResultsEwes visited the drinking troughs 2.4 ± 0.5 times per day (rank 1.4–2.9), most frequently (42%) between 0800 and 1000 h, and 84% occurred in the daytime. Mean length of each water intake was 1.72 ± 0.30 min. The cosinor analysis of the distribution of drinking events revealed a significant (P < 0.0001) 24-h circadian rhythm in drinking events, and the acrophase (time of the highest proportion of events) occurred at 1054 h.ConclusionsConsidering that studying water intake in sheep is crucial for optimizing their health, welfare, and management, the proximity loggers were demonstrated to be appropriate for documenting the drinking habits of sheep, and probably, would be suitable for studies of other behaviors that involve approaching other animals or objects.

The Relationship between Credit Rating and Environmental, Social, and Governance Score in Banking

The present paper investigates the relationship between stock prices, credit ratings, and ESG scores for banks internationally. First, it describes stock prices and ESG scores at an annual frequency, as well as stock price and credit risk at a daily frequency. The relationships between (a) stock price and credit rating returns with ESG score returns and (b) among ESG scores are examined by pairwise annual correlation, and daily correlations are examined between price and credit rating returns. Furthermore, Granger causality is used to examine the relationships between the following: (a) price and ESG score annual returns; (b) price and credit rating daily returns; and (c) total and pillar annual ESG scores. This study makes a significant contribution to the literature by providing a detailed temporal analysis using both annual and daily data frequencies, which is relatively rare in the field. There is evidence of statistically and empirically important relations in the form of pairwise correlations. The regressions reveal a low significance of few ESG score changes in explaining credit rating changes. A unique aspect of this paper is the comprehensive analysis of 16 granular ESG scores, including overall scores, pillar scores, and sub-scores, allowing for a multi-faceted understanding of how specific ESG factors impact financial metrics. We found evidence of the significance of COVID-19 in all research questions. Additionally, this paper highlights the impact of the COVID-19 pandemic on the relationships between ESG scores, credit ratings, and stock prices, offering timely insights into the heightened importance and volatility of ESG factors during crisis periods. Future research needs to shed more light on this relationship, however.

A scoping review of the epidemiology and treatment of painful procedures in hospitalized neonates: What has changed in the past three decades?

Care of newborns hospitalized in the neonatal intensive care unit (NICU) includes multiple painful procedures/day. Epidemiologic studies have reported the frequency and nature of procedures and treatment interventions. However, evidence on the changing trends in the nature and frequency of neonatal pain procedures or treatments over time is absent or inconclusive. We aimed to determine the frequency and nature of painful procedures/neonate/day in the NICU. MEDLINE and Embase searches were conducted from database inception to July 2023. Studies that reported the nature and frequency of painful procedures and associated pain treatments in neonates were included. Standard inverse-variance random-effects meta-analyses were used to combine studies. Heterogeneity between studies was quantified using the I2 statistic. Of 2622 unique citations, 64 full-text articles were reviewed; 23 were included. Six additional studies identified in a previous review, and six publications from reference lists were added, resulting in 35 studies. The mean number of painful procedures/neonate/day was 7.38 (95% CI 5.60, 9.17; range <2 to 17). Although the frequency of painful procedures in more recent studies was reduced, it was not statistically significant (p = 0.16). Painful procedures were more frequent during longer observation periods. Needle-related procedures were most common and did not change over time. Procedure-related treatment was suboptimal and inconsistently reported. Frequency of painful procedures in the NICU has shown a clinically important decrease but has not significantly changed over time. A paradigm shift moving responsibility from providers to systems in changing pain practices in the NICU is required. The decrease in the daily frequency of painful procedures in hospitalized neonates might be clinically relevant but is not yet statistically significant. Pain treatment is insufficiently documented and reported. This lack of progress in neonatal care might be a result of the complexity of defining pain and stress; inconsistencies in determining the burden of procedural pain; the influence of barriers and facilitators on practice change; and the focus on an individual rather than system responsibility for pain prevention and treatment.

Power Transformer On-Load Capacity-Regulating Control and Optimization Based on Load Forecasting and Hesitant Fuzzy Control

The operational stability of a power transformer exerts an extremely important impact on the power symmetry, balance, and security of power systems. When the grid load fluctuates greatly, if the load factor of the transformer cannot be maintained within a reasonable range, it leads to increased instability in grid operation. Adjusting the transformer capacity based on load changes is of great significance. The existing control methods for on-load capacity-regulating (OLCR) transformers have low timeliness, and the daily switching frequency of the capacity-regulating switch is not controlled. To ensure the safe and stable operation of transformers, this paper proposes a control method for OLCR transformers based on load prediction and fuzzy control. Firstly, the operating principle of OLCR transformers is analyzed, and a multi-strategy enhanced dung beetle optimizer (MSDBO) combined with a CNN−LSTM model is proposed for load forecasting. On this basis, the daily switching frequency of the capacity-regulating transformer is introduced, and hesitant fuzzy control is used to select the optimal capacity-regulating strategy relying on three factors: loss, economy, and switching frequency. Finally, simulation models are constructed using the MATLAB/SIMULINK platform and simulation analysis is conducted to verify the effectiveness and superiority of the proposed control method. For the three scenarios in this paper, the method reduces daily power loss by 28.5% to 56.3% and daily operating costs by 25.4% to 50.8%. The method used in this paper can sacrifice 3.5% to 9.2% of the loss reduction capability in exchange for reducing the number of switch operations by 28.6% to 57.1%, significantly extending the lifespan of the switches and thereby increasing the operational lifespan of the transformer.

Long-Term Response of Floodplain Meadow Normalized Difference Vegetation Index to Hydro-Climate and Grazing Pressure: Tamir River Plains, Mongolia

The greenery of floodplain meadows in arid regions, such as Mongolia, is influenced by climate, hydrology, and land use. In this study, we analyzed the NDVI (Normalized Difference Vegetation Index) of two floodplain meadows located along the South Tamir and Tamir Rivers using LANDSAT images. Our goal was to observe NDVI spatial changes, variations, and mean values in mid-August every six years from 1991 to 2015 and to identify the factors driving these differences. To achieve this, we conducted variance analysis to identify changes in NDVI and implemented Principal Component Analysis to determine the influence of hydro-meteorological factors and grazing intensity. Our findings indicate a significant decrease in greenness, as measured by pixel-scale NDVI, during the late summer period. This decrease was consistently observed, except for a series of harsh winters that followed relatively dry summers, resulting in a disastrous event called dzud, which led to the death of livestock. The decrease in NDVI was amplified by lower precipitation in June, higher temperatures and wind speed in July, and increased precipitation in August, along with a higher frequency of days with convective rain. Our findings have important implications for managing grazing in Mongolia’s grasslands, promoting sustainable land use, and mitigating sandstorms. The variance and average values of NDVI at the pixel level can serve as reliable markers of sustainable pasture management in areas where other vegetation measures are limited.

Situation of Consumption of Seasoning Broths in Three Cities in Côte d&amp;apos;Ivoire: Abidjan, Bouaké and Daloa

Introduction: Seasoning broths have become an indispensable ingredient of more than 80% of households. The objective of this study is to assess the consumption of seasoning broths in three cities of Côte d&amp;apos;Ivoire: Abidjan, Bouaké and Daloa. Methodology: Survey missions were carried out from 2&amp;lt;sup&amp;gt;nd&amp;lt;/sup&amp;gt; June 2022 to 10th August 2022 in Abidjan, Bouaké and Daloa. Results: Tablet (Maggi), Soumara and shrimp (Maggi) broths were the most consumed with 36%, 18% and 17% of the surveyed households respectively. The most consumed broths are Crevette (Maggi) in Bouaké, Poulet (Maggi) in Daloa and Tablette (Maggi) in Abidjan. The long consumption periods were in Bouaké with Soumara (16.7 years), Poulet (Maggi) (16.5 years) and Tablette (Maggi) (16.3 years). The daily consumption frequencies were between 2 and 3. The recorded frequencies were between 1.12 and 2.13 in Abidjan, between 2.7 and 3 in Bouaké and, 2 and 2.05 in Daloa. Conclusion: The most consumed broths were Tablette (Maggi), Soumara and Crevette (Maggi), respectively. Bouaké recorded the longest consumption periods of 14 to 16.7 years. Daily consumption frequencies ranged from 2 to 3 broths/day. Investigations will be conducted for the enhancement of the traditional broth «Soumara» for its highly appreciated properties in food and traditional medicine.

Development of a High-School Students' Version of the Daily Conversation Scale with Classroom Teachers

Objective This study was intended to develop a "High-School Students' Version of the Daily Conversation Scale with Classroom Teachers" to measure the frequency of daily conversations between high-school students and their classroom teachers.Methods The study consisted of Surveys I and II. Survey I was intended to validate the structural validity and reliability of the "High-School Students' Daily Conversation Scale with Classroom Teachers (Prototype Version)." It measured the frequency of high-school students' daily conversations with classroom teachers using the prototype scale and employed confirmatory factor analysis and item response theory to assess the factor measurement model and item performance, respectively. Internal consistency was evaluated using McDonald's ω (omega) reliability coefficient. Study II was intended to validate the prototype scale through hypothesis testing. The survey assessed daily conversation frequency, teacher support perception, depression/anxiety, and the teacher-student relationship. Two models were constructed: one predicting the impact of daily conversation frequency on support perception and depression/anxiety and the other predicting the impact on the teacher-student relationship. It was hypothesized that both models would fit well, with daily conversation frequency positively associated with support perception and relationship, and depression/anxiety negatively associated with support perception and relationship.Result The sample analyzed in Survey I consisted of 1,394 students in grades 1-3. The results of confirmatory factor analysis, item response theory, and McDonald's omega reliability coefficient met the criteria. The sample for Survey II consisted of 1,688 students in grades 1-3. The results of the analysis supported the hypothesis.Conclusion The results of this study suggest that the prototype version of the scale was conceptually unidimensional and that the difficulty level of each item was well-balanced, indicating the successful development of a "High-School Students' Version of the Daily Conversation Scale with Classroom Teachers." By using this scale and examining the effects of the frequency of daily conversation with homeroom teachers on the psychology and behavior of high-school students, we believe that it will be possible to contribute to an understanding of primary prevention measures that homeroom teachers can take to address mental health problems among their high-school students. We believe that this scale will contribute to future school health activities in the field of public health.

Functional impairment of chronic migraine with medication overuse: Secondary analysis from the Medication Overuse Treatment Strategy (MOTS) trial.

Chronic migraine exerts substantial negative impacts on daily functioning. Efforts to manage impaired functioning may result in medication overuse, which contributes to the worsening profile and chronification of migraine. The Migraine Functional Impact Questionnaire (MFIQ) is a recently developed measure assessing the impact of migraine on physical, social, and emotional function. The objective of this analysis was to assess changes in MFIQ scores following initiation or modification of migraine preventive medication and determine if changes in function are associated with changes in other aspects of migraine burden, such as headache frequency, headache intensity, and symptoms of anxiety and depression. This is a secondary analysis of data from the Medication Overuse Treatment Strategy (MOTS) trial, a prospective pragmatic clinical trial that investigated two treatment strategies for those with chronic migraine and medication overuse. Data from both treatment arms were pooled and analyzed using a pre-post design. Prior to and 12 weeks following initiation or modification of migraine preventive medication, participants completed a series of questionnaires that captured migraine characteristics, medication use, migraine-related physical impairment (MFIQ), anxiety (Generalized Anxiety Disorder-7), and depression (Patient Health Questionnaire 9 [PHQ-9]) symptoms. Changes from baseline in all measures were assessed using the paired t-test. Relationships between changes in MFIQ scores and other measures were assessed using linear regression. Multivariable modeling was performed to determine which additional variables contributed to the change in MFIQ beyond that already explained by an individual variable. Model terms were selected by using elastic net regularization. Only those participants who completed the baseline and 12-week MFIQ were included in this analysis. Of the 537 patients, 88.2% were female, and the average age was 45 years (standard deviation 13). The mean frequency of days with moderate-to-severe headache improved 39.2% from 13.5 per 30 days at baseline to 8.1 per 30 days at week 12. The mean MFIQ Usual Activities Global score improved by 15.0 points (on a 100-point scale). All five domains (Usual Activities Global, Usual Activities, Social Function, Emotional Function, Physical Function) of the MFIQ improved by a mean of at least 13.0 points. Changes in PHQ-9 score, followed by changes in headache frequency, had the strongest associations with change in all domains of the MFIQ. The negative impact of chronic migraine with medication overuse on physical, social, and emotional functioning substantially lessened following initiation or modification of migraine preventive medication. Improved functioning, as measured by the MFIQ, was most strongly associated with reductions in depression scores and headache frequency, highlighting the importance of recognizing and monitoring changes in depressive symptoms, in addition to headache frequency and functional impairment, when evaluating response to preventive medications.

Indices of diet quality among Polish and Spanish physical education students

Introduction: A healthy diet is an important factor in implementing health, and the way of eating depends on individual and environmental factors. Objective: The aim of the study was to assess diet quality indices among Polish and Spanish physical education students depending on country of residence and gender. Materials and methods: Research was carried out among 219 students from Poland and 280 from Spain. A questionnaire was used to evaluate views on eating and nutritional habits (Kom-PAN). Based on the daily frequency of consuming specific groups of products, 2 indices were calculated: the pro-healthy diet index (pHDI-10) and non-healthy diet index (nHDI-14). Two-way ANOVA was used for statistical analysis. The level of significance was set at p=0.05. Results: The values of the pro-healthy (pHDI-10) and non-healthy diet (nHDI-14) indices in the group of students were 4.65 and 4.05 (times/day), respectively, which means a low level of both favourable and unfavourable food choices. Students from Poland, regardless of gender, showed a higher level of eating a healthy diet (pHDI-10) than students from Spain. However, the level of the non-healthy diet index (nHDI-14) between students from Poland and Spain differed by gender (p&lt;0.001). In the Polish group, men obtained a higher nHDI-14 index than women (p&lt;0.001), while in Spain, these values were at the same level. Furthermore, it was found that differences between countries occurred only in men, with students from Poland obtaining higher values of the nonhealthy diet index (nHDI-14) than those from Spain (p&lt;0.001), while students from both countries demonstrated similar values. Conclusions: Low levels of healthy and unhealthy diet indices were demonstrated in Polish and Spanish physical education students, with the quality of diet differentiated by country and gender.

Risk perception and use of personal care products by race and ethnicity among a diverse population.

Personal care products can contain phthalates, parabens and other endocrine-disrupting chemicals. However, information on perception of risks from personal care product use and how use varies by race and ethnicity is limited. We evaluated differences in personal care product use and risk perception in a diverse sample of participants recruited from a US college campus and online. A self-administered questionnaire captured information on sociodemographic factors, personal care product use trends and perception of risk associated with them. Pearson's chi-square and Fisher's exact tests were used to determine differences in personal care product use and risk perception by race and ethnicity. Ordered logistic regressions were performed to measure associations between personal care product use frequency across racial/ethnic categories. Participant (n = 770) mean age was 22.8 years [standard deviation ± 6.0]. Daily use of make-up (eye = 29.3%; other = 38.0%; all = 33.7%) and skincare products (55%) was most frequently reported among Middle Eastern and North African participants. Non-Hispanic Black participants reported the highest daily use of hairstyling products (52%) and lotion (78%). Daily make-up use was more frequently reported among females (41%) than males (24.6%). Levels of agreement were similar across racial and ethnic groups, that personal care product manufacturers should be required to list all ingredients (≥87%). There were significant associations between the frequency of use of some personal care products and racial/ethnic categories when the use frequencies of participants from other racial/ethnic categories were compared to the use frequency of non-Hispanic White participants. There were significant differences in daily use frequency, levels of trust, perception of safety and health risks associated with personal care products by race and ethnicity, underscoring that there may be different sources of exposure to chemicals in personal care products by race and ethnicity.

Steps into a Small World: First glimpses on everyday moment‐to‐moment decision making in an ecologically meaningful multi‐choice system for assessing animal preferences

AbstractThe behaviour shown by an animal at any one time is the consolidated output of its behavioural control mechanism. Moreover, what animals “want” is viewed as (the most) important component for individual welfare. Accordingly, studying the motivation of animals helps understanding basic mechanisms and welfare related needs. However, studying wants of animals is notoriously difficult and many previous studies on the preferences of animals have been restricted in the sense that only two choice options were presented in an artificial test environment. Here, an extended approach, the “Small World” is presented, in which the choices of animals between eight ecologically relevant resources can be observed in a long‐term test to reach conclusions with respect to everyday moment‐to‐moment decisions. In this sense, the system offers a quasi‐natural environment. The approach was tested in three experiments with observations of individual female rats, small groups of female rats (Long Evans, Rattus norvegicus) and small groups of female chickens (Lohmann Brown, Gallus gallus domesticus). The animals oriented themselves quickly in the system and it was possible to collect multifaceted data on the use of the resources. These data included the faecal and urinary markings in the Small World cages, the daily frequency and duration of visits to these cages, the sequential analyses of the choices for and decisions among the resources, and the synchrony of the animals in the groups. Given the richness of these data and the lack of a stress response in the tested animals, the use of the Small World approach seems to be highly promising as an extension to previously used procedures. To further improve the approach and more directly reflect the subjective value of the different resources from the animals' point of view, the distances between the resources in a quasi‐natural landscape shall be manipulated in future studies.

Efficacy of nonsolvent flower pollen extracts in healthy women with urinary incontinence: A randomized, double-blind, placebo-controlled, parallel study.

Urinary incontinence (UI) is a debilitating and common condition that adversely affects quality of life. Prescriptive and surgical approaches for managing UI symptoms may result in undesirable risks and complications. This randomized, double-blind, placebo-controlled, parallel study investigated the efficacy of 2 nonsolvent flower pollen extracts on UI in healthy women. One-hundred and fourteen women aged 40-75 years who scored ≥5 on the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-SF) were randomized to receive either Graminex® RCT Fem™ UI, Graminex® PollenBerry®, or placebo for 24 weeks. The primary outcome was the change in the ICIQ-SF score between the trial and placebo groups after 24 weeks of supplementation. The secondary outcomes included changes in the frequency of nocturia (recorded in 3-day void diaries) and 24-hour leakage volume (assessed via pad weight) after 6, 12, 18, and 24 weeks of supplementation and changes in stress-induced urinary leakage volume (after completion of a provocative maneuver challenge) after 24 weeks of supplementation. All the groups demonstrated improvement in ICIQ-SF scores at week 24 (p < 0.001). The RCT Fem™ UI group had the greatest improvement in ICIQ-SF scores (-4.07 ± 3.4), followed by the PollenBerry® group (-3.34 ± 2.87) and placebo group (-2.61 ± 3.52). The RCT Fem™ UI group had corresponding improvements in 24-hour leakage volume (-17.68 ± 39.84 g) and frequency of nocturia (-0.52 ± 1.26) (p ≤ 0.05). PollenBerry® supplementation significantly improved stress-induced urinary leakage volume (-7.12 ± 15.64 g) at week 24. The study products demonstrated safe hematological and chemical profiles. RCT Fem™ UI supplementation resulted in significant and clinically meaningful reductions in UI severity, with corresponding improvements in daily urinary leakage volume and frequency of nocturia. PollenBerry® significantly improved stress-induced urinary leakage volume, suggesting that it may be efficacious in women who are prone to stress UI. The study products were safe and well tolerated in this population.

Spillover effects of energy transition metals in Chile

This paper examines the impact of spillover effects of energy transition metals in Chile. The study aims at identifying the causal relationships among these energy transition metals and other major assets like oil, gold, and bitcoin, and how they shape Chile’s economy, both pre-COVID-19 and during the first months of the pandemic. Our Structural Vector Autoregressive analysis is carried out with daily frequency data for two separate periods, the pre-COVID-19 analysis (the whole of 2018) and the COVID-19 analysis (Feb 2020 to end of 2020). Our results suggest that Chile has been highly responsive to renewable energy shocks during COVID-19, in concert with an increased responsiveness to traditional oil-driven shocks. This lends weight to the idea that traditional energies are still relevant and concomitant with energy transition, especially in a small open resource-oriented economy like Chile. In addition to that, bitcoin shocks seem to have contributed to Chile’s transition, likely as a result of bitcoin’s extensive use of energy and its potential to increase renewable energy capacity. Policywise, our findings call for a watchful eye on regulatory constraints, excessively high royalties, and the maintenance of stabilization funds to mitigate uncertainty, all of which can affect Chile’s competitive edge at an untimely hour.

Menopausal Hot Flashes Are Not Associated with Pressor Responses to Cold Stress

Menopausal females who experience frequent hot flashes (episodes of increased body temperature and sweating) have a greater risk of hypertension and cardiovascular disease than females without hot flashes. Individuals with exaggerated blood pressure (BP) responses to cold stress have a higher risk of hypertension than those with lower responses. It is unknown if females who experience hot flashes have exaggerated pressor responses to cold stress, indicating their greater risk of hypertension. The aim of this study was to determine the pressor responses to cold stress in females who experience hot flashes and those who do not. An additional goal was to understand the relation between daily hot flash frequency and pressor responses. We hypothesized that females with hot flashes would have exaggerated pressor responses to cold stress compared to females without hot flashes. We also hypothesized that pressor responses would be positively correlated to daily hot flash frequency. We recruited 17 females, ages 45-60 years, without hypertension or cardiovascular disease, who did and did not have hot flashes. They reported hot flash frequency in a 3-day written diary. On the study day, continuous BP (finger photoplethysmography, calibrated to brachial cuff BP) and heart rate (HR; 3-lead ECG) were recorded while the participant rested during a 2-minute baseline period, then subsequently had an ice-water pack placed on their forehead for 3 minutes. The changes in mean BP (MBP) and HR are calculated as the change in MBP or HR during the cold pressor test minus the average MBP or HR during baseline. Data were analyzed using the Student’s t-test and Pearson correlation. Twelve females reported hot flashes (age: 51±4 years; average number of hot flashes: 3 per day) and five did not (age: 49±5 years). These groups did not differ in age, body mass index, resting MBP, or resting HR (p&gt;0.05 for all). The change in MBP from baseline to the cold pressor test did not differ between females with and without hot flashes (Δ17±10 vs. Δ19±14 mmHg, respectively; p=0.860). The change in HR with the cold pressor test also did not differ between females who did and did not report hot flashes (Δ10±6 vs. Δ12±8 mmHg, respectively; p=0.647). In females with hot flashes, the number of hot flashes reported per day (range: 1-12 per day) was not correlated with the change in MBP (p=0.824) or HR (p=0.460) during the cold pressor test. These current data show that menopausal females who experience hot flashes do not exhibit exaggerated BP or HR responses to cold stress in comparison to females who do not experience hot flashes. In addition, BP and HR responses are not correlated with daily hot flash frequency. There are likely other vascular mechanisms that place menopausal females with hot flashes at an increased risk for hypertension. In addition, incorporating information on the age at which hot flashes began, as well as hot flash severity, might help us to further understand cardiovascular risk in this population. AHA 898649, NIH T32 DK07352, K01 HL148144, NCATS UL1 TR002377. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Efficacy and safety of fezolinetant for moderate to severe vasomotor symptoms associated with menopause among women in East Asia: a phase 3 randomized study (MOONLIGHT I).

To evaluate the efficacy and safety of fezolinetant for moderate to severe vasomotor symptoms (VMS) associated with menopause in East Asian women. In this phase 3, randomized, double-blind study, postmenopausal women with moderate to severe VMS (minimum average frequency in the 10 days before randomization, ≥7/day or 50/week) received fezolinetant 30 mg/day or placebo (weeks 1-12), followed by an open-label extension phase with fezolinetant 30 mg/day (weeks 13-24). The co-primary endpoints were the mean changes in the daily frequency and severity of VMS at weeks 4 and 12. Among 301 participants, the difference in the least squares mean change (95% confidence interval) from baseline in the daily frequency of moderate to severe VMS versus placebo was -0.65 (-1.41 to 0.12) at week 4 and -0.55 (-1.35 to 0.26) at week 12. The differences in the least squares mean change from baseline in the VMS severity score versus placebo were -0.06 (-0.14 to 0.03) and -0.13 (-0.27 to 0.01) at weeks 4 and 12, respectively. Serious adverse events occurred in 0.7% of participants receiving fezolinetant in weeks 1 to 12, compared with 1.3% of those receiving placebo. Fezolinetant was generally safe but did not reduce the frequency or severity of VMS versus placebo in postmenopausal women in this study.ClinicalTrials.Gov Identifier: NCT04234204.

Daily glucose pattern and physical activity levels in cancer survivors: preliminary results from remote monitoring

Background: Cancer survivors have elevated risk for type 2 diabetes. Increasing physical activity improves glucose control. However, this evidence is majorly based on blood glucose metrics (e.g., glucose or hemoglobin A1c) at a single point in time. Little is known about the effect of physical activity on blood glucose changes throughout a day in cancer survivors. Thus, we tested the hypothesis that higher physical activity levels is associated with a more favorable daily glucose pattern in cancer survivors in free-living settings. Methods: This is a preliminary analysis of an ongoing randomized controlled trial (Project KNOWN) to examine the effect of physical activity on daily glucose pattern via continuous remote monitoring. A total of 11 cancer survivors were included in this analysis (90% female, 90% white, average age 62.5 years [range 44-76 yr], 67% obese, and 75% hypertension). Participants wore a wrist-worn accelerometer (for daily steps) and a blinded continuous glucose monitor (CGM; for daily glucose averages [interstitial glucose was measured at every 15 minutes] and daily frequency of glucose spikes [defined as glucose level &gt;140 mg/dL]) for two weeks. Multilevel regression model was used to account for multiple observations within each individual and to separate the within-person (WP) and between-person (BP) effects. The WP effect represents deviation from one’s own mean on any given day, and the BP effect represents the individual mean deviation from the study sample mean. To explore moderating effect on the relationship between physical activity and daily glucose, inflammatory biomarkers, blood lipids, blood pressure and body fatness (DEXA scan) were measured. Results: At the WP level, participants with elevated (&gt;4 mg/L) systemic C-reactive protein (marker of inflammatory status), on the day when they had higher-than-usual step count, their glucose average was also lower than their usual level ( p=0.04). At the BP level, daily steps were negatively associated with daily frequency of glucose spikes in participants with less severe hypertension, lower % gynoid fat, and higher android/gynoid ratio than others in the study sample (all p&lt;0.05). Further, daily steps were negatively associated with daily glucose average in participants with higher trunk-to-total fat ratio than others (p&lt;0.05). Discussion: This preliminary study demonstrated the use of data from wearable sensors to analyze intra- and inter-person variability in daily glucose patterns in cancer survivors. Results suggested the impact of physical activity on daily glucose patterns might differ by a person’s physiological status. Future research can further characterize meaningful daily glucose dynamics from CGM data in cancer survivors to better understand how physical activity may have downstream effect on their health outcomes. American Institute for Cancer Research. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Results of a study examining the use of onabotulinumtoxinA in pediatric patients with overactive bladder

There is a lack of approved treatments for pediatric patients with overactive bladder (OAB) with inadequate response to anticholinergic therapy. OnabotulinumtoxinA 100U is approved to treat OAB in adults based on data from randomized, pivotal trials. To investigate the efficacy and safety of onabotulinumtoxinA treatment of OAB in children aged 12-17 years who were not adequately managed with anticholinergics. In this multinational, multicenter, randomized, double-blind, parallel-group, multiple-dose study (NCT02097121), pediatric patients with OAB were randomized 1:1:1 to receive onabotulinumtoxinA 25U, 50U, or 100U (≤6U/kg). Patients could request retreatment starting at week 12. The primary endpoint was change from baseline to week 12 after treatment 1 in daily frequency of daytime urinary incontinence (UI) episodes. Safety assessments evaluated treatment-emergent adverse events (TEAEs). Of 68 screened patients, 55 received ≥1 treatment. Mean age was 14 years; 85.5% of patients were female. At week 12 after treatment 1, least squares mean change from baseline in daily frequency of daytime UI episodes showed a numerically greater reduction in the 100U arm (-2.4) versus the 25U arm (-1.4; P=0.38), with a significant within-group change from baseline in the 100U arm (P=0.0027). Achievement of treatment response was significantly greater with onabotulinumtoxinA 100U vs 25U (Figure). Median time to request retreatment was ≥16 weeks in all groups. The most frequently reported TEAEs were nasopharyngitis (10.9%) and urinary tract infection (UTI; 10.9%). Urinary retention was observed in 1 patient during treatment cycle 2; there were no serious TEAEs of UTI or urinary retention. Throughout 2 additional treatment cycles continued efficacy for the 100U dose arm was observed along with a consistent safety profile. Change in daily frequency of UI episodes at week 12 in treatment cycle 1 was not significantly different between arms. However, ≥50% response rate was significantly higher with onabotulinumtoxinA 100U versus 25U. Enrollment challenges that lowered the sample size could have reduced statistical power. Also, the lack of a placebo arm and the observed benefit with the 25U comparator limited interpretation. OnabotulinumtoxinA injections were well tolerated in children with OAB at all doses studied. Although the primary endpoint was not met, the significantly greater treatment response rate observed with onabotulinumtoxinA 100U versus 25U suggests additional benefit of the higher dose, without additional safety concerns.

Efficacy of Acupuncture on Pain Severity and Frequency of Calf Cramps in Dialysis Patients: a Randomized Clinical Trial.

Patients with chronic kidney disease, as a common disorder, usually necessitate the implementation of hemodialysis. Muscle cramps are one of the most disabling complications affecting their quality of life. We aimed to investigate the efficacy of acupuncture as a safe alternative to the management of pain severity and frequency of calf cramps in dialysis patients compared to a control group. Fifty dialysis patients experiencing calf cramps who met the eligibility criteria were randomly allocated to two groups. Group A received routine management, including analgesic consumption, stretching exercises, and nine acupuncture sessions, including acupoints BL57, GV26, CV4, CV6, LV3, KI 1, LU7, LU9, and GB34. Group B underwent sham acupuncture therapy at locations other than the primary acupoints in addition to following the specified routine management. The pain severity was measured using the visual analog scale (VAS), and the daily frequency of calf cramps was evaluated at baseline and one month after treatment completion. VAS scores and the frequency of calf cramps were improved one month after treatment completion in both groups. However, the improvement was significant in group A (p < 0.001), while it was not statistically significant in group B (p > 0.05). There was also a significant difference between both groups regarding reducing pain and the frequency of calf cramps, which showed the efficacy of acupuncture compared to the control group (p < 0.0001). Acupuncture can decrease pain and frequency of calf cramps in dialysis patients.

An AFD-based adaptive impulse response model of time series

In this paper, an adaptive impulse response model of time series is proposed based on adaptive Fourier decomposition (AFD), which characterizes the data-driven impulse response model with “energy-resolution” and is applied to the effect analysis of shocks on time series. First, according to the observed time series, the frequency points of impulse response function are estimated, and the approximate expression of impulse response function in frequency domain is given. Second, AFD is carried out on the approximate impulse response function level by level, and the poles and coefficients of basis function of each level are obtained adaptively by using the criterion of energy maximization. Third, when the goodness of fit is greater than a certain threshold, all decomposition levels are determined and the adaptive impulse response model is established. Each decomposition level depicts the energy-based resolution characteristics of the impulse response model. Based on gold price return and US dollar index return in daily frequency from 2017 to 2022, this paper carried out AFD-based effect analysis with energy-resolution year by year. Results show that the proposed AFD-based adaptive impulse response model in this paper can describe the persistence effect of shocks of gold price on the US dollar index, and further measure the plainness of linkage relationship between these two time series. Decomposing impulse response to each decomposition level reveals consistence, convergency, and sufficiency of the impulse response model. The AFD-based adaptive data-driven model provides a new way for the analysis of time series in time-frequency domain.

Frequency of missed doses and its effects on the regulation of glucose levels in patients with type 2 diabetes: A retrospective analysis.

This study aimed to investigate the association between medication adherence to oral hypoglycemic agents (OHAs) and HbA1c levels in patients with type 2 diabetes mellitus (T2DM) for more than 48 weeks, as well as the factors affecting long-term adherence to OHAs. This retrospective study included 83 patients who had been receiving OHAs for T2DM for ≥48 weeks. Medication adherence values (MAVs) were calculated using the following formula: (total prescription days - prescription days of OHAs brought at admission)/(days from the initiation of OHAs to hospitalization). We assessed the association between HbA1c and MAVs using the Jonckheere-Terpstra test. Furthermore, we examined the association between patient- and medication-related factors and MAVs affecting HbA1c levels. Based on the results, MAVs were categorized as MAV ≤0.86 and MAV >0.86, and factors affecting MAVs were analyzed. Logistic regression analysis revealed that the total number of medications, the number of nonhypoglycemic agents, and a family history of diabetes were independent determinants of MAV ≤0.86 (P < .05). Multiple regression analyses indicated that the number of dosages per day and the timing of OHA administration at lunch were independent determinants of lower MAVs (P < .05). Our findings suggest that poor medication adherence is associated with elevated HbA1c levels in T2DM patients. Independent factors contributing to poor adherence include a lower number of prescribed medications, fewer nonhypoglycemic agents, no family history, a higher daily dosage frequency, and the administration of OHAs at lunch.