The non-reciprocal wave propagation characteristics of 3D random piezoelectric composites with aligned semi-spheroid inclusions are theoretically predicted. The self-consistent equations about the frequency-dependent effective properties are established, in which the volume average of dynamic Green's operators in semi-spheroid domain is involved. Due to the non-centrosymmetric inclusions, the composites macroscopically exhibit non-reciprocity, i.e. the effective properties, wave speed, acoustic impedance, attenuation and resonance frequency under the two waves of identical form but incident in opposite directions are different. The numerical results show that when the aspect ratio of the inclusion is large, the differences of the effective wave speed and impedance in two opposite directions are significant, which provides a possible means for modulation of wave propagation in the 3D random composites.