Frequency Of Events Research Articles

A randomized trial of pharmacological ascorbate, gemcitabine, and nab-paclitaxel for metastatic pancreatic cancer

BackgroundPatients with metastatic pancreatic ductal adenocarcinoma (PDAC) have poor 5-year survival. Pharmacological ascorbate (P-AscH-, high dose, intravenous, vitamin C) has shown promise as an adjunct to chemotherapy. We hypothesized adding P-AscH- to gemcitabine and nab-paclitaxel would increase survival in patients with metastatic PDAC. MethodsPatients diagnosed with stage IV pancreatic cancer randomized 1:1 to gemcitabine and nab-paclitaxel only (SOC, control) or to SOC with concomitant P-AscH−, 75 g three times weekly (ASC, investigational). The primary outcome was overall survival with secondary objectives of determining progression-free survival and adverse event incidence. Quality of life and patient reported outcomes for common oncologic symptoms were captured as an exploratory objective. Thirty-six participants were randomized; of this 34 received their assigned study treatment. All analyses were based on data frozen on December 11, 2023. ResultsIntravenous P-AscH- increased serum ascorbate levels from micromolar to millimolar levels. P-AscH- added to the gemcitabine + nab-paclitaxel (ASC) increased overall survival to 16 months compared to 8.3 months with gemcitabine + nab-paclitaxel (SOC) (HR = 0.46; 90 % CI 0.23, 0.92; p = 0.030). Median progression free survival was 6.2 (ASC) vs. 3.9 months (SOC) (HR = 0.43; 90 % CI 0.20, 0.92; p = 0.029). Adding P-AscH- did not negatively impact quality of life or increase the frequency or severity of adverse events. ConclusionsP-AscH− infusions of 75 g three times weekly in patients with metastatic pancreatic cancer prolongs overall and progression free survival without detriment to quality of life or added toxicity (ClinicalTrials.gov number NCT02905578).

Metabolic surgery in severely obese adolescents: which technique provides the best benefits?

Obesity is a public health and global health problem due to the disease burden it generates across all age groups, as well as being a pandemic due to its high prevalence worldwide. Bariatric surgery has traditionally been described as an aggressive option in the adolescent population. However, as the evolution of these patients over time and the improvement in health outcomes have been rigorously analyzed, it is positioned as an effective and safe intervention. Recently, novel high-quality evidence has emerged, sparking international scientific discourse on which techniques provide the most benefits and are safer in bariatric surgery for adolescents with severe obesity. Then, the aim of this review was to analyze the most recent clinical evidence, based on study designs, regarding clinical and surgical outcomes obtained by surgical techniques used during bariatric surgery in the management of severe obesity in adolescents. After the literature review, it was identified that surgical resolution for severe obesity in adolescents is effective and safe, with better benefits observed when using Roux-en-Y gastric bypass. There is a similar frequency of adverse events compared to sleeve gastrectomy and gastric banding. Micronutrient deficiency is the primary adverse event, which is potentially preventable and treatable.

Building community resilience to extreme heat: Lessons learned from Spokane, WA community conversations

Abstract Heat is the primary cause of weather-related mortality in the United States. The 2021 Northwest heat dome highlighted this susceptibility. In Washington State, 159 excess deaths were attributed to the 7-day period of unprecedented extreme heat between June 26th and July 2nd. This impact was felt even in some of the more acclimatized parts of the state, like Spokane County, where 19 heat-related deaths were reported. As climate change increases the frequency, duration, and intensity of extreme heat events, creating and sustaining heat-resilient communities has become an urgent public health priority. On 6 June 2023, Gonzaga University, in partnership with the University of Washington, hosted the Spokane Extreme Heat Risk Intervention Stakeholder Synthesis Symposium. The goals of the symposium were to debrief from recent heat events, identify extreme heat risk reduction interventions used in the region, and characterize remaining practice-relevant research priorities. The symposium convened 45 stakeholders including representatives from local and state agencies, academia, and community-based and Tribal organizations. Symposium participants engaged in small group discussions using the World Café MethodTM. Notes from each discussion were coded using a content analysis approach. Symposium participants identified strengths, barriers to heat resilience, and solutions to reduce risk throughout the Spokane community. We present these findings by practice topic, including risk communication, intervention, collaboration, policy, and research. Additionally, we utilize the socio-ecological model as a conceptual framework to illustrate the complex interplay of factors that govern an individual’s experience of, and ability to respond to, extreme heat events. Given extreme heat’s impact on global public health, the methods used to increase community resilience in Spokane, WA, USA could be used by other communities worldwide to increase their own heat-resilience.

Design and Rationale of MYOFLAME-19 RCT: MYOcardial protection to reduce inFLAMmatory heart disease due to COVID-19 Infection using CMR Endpoints.

Cardiac symptoms due to postacute inflammatory cardiac involvement affect a broad segment of previously well people with only mild acute COVID-19 illness and without overt structural heart disease. Cardiac magnetic resonance (CMR) imaging can identify the underlying subclinical disease process, which is associated with chronic cardiac symptoms. Specific therapy directed at reducing postacute cardiac inflammatory involvement prior to development of myocardial injury and impairment is missing. Prospective multicentre randomised placebo-controlled study of myocardial protection therapy (combined immunosuppressive/antiremodelling) of low-dose prednisolone and losartan. Consecutive symptomatic individuals with a prior COVID-19 infection, no preexisting significant comorbidities or structural heart disease, undergo standardised assessments with questionnaires, CMR imaging and cardiopulmonary exercise testing (CPET). Eligible participants fulfilling the criteria of subclinical Post-COVID inflammatory involvement on baseline CMR examination are randomised to treatment with either verum or placebo for a total of 16 weeks (W16). Participants and investigators remain blinded to the group allocation throughout the study duration. The primary efficacy endpoint is the absolute change of left ventricular ejection fraction (LVEF) to baseline at W16, measured by CMR, between the verum treatment and placebo group by absolute difference, using unpaired t-test confirmatively at the 5% significance level. Secondary endpoints include assessment of changes of symptoms, CMR parameters, and CPET after W16, and frequency of major adverse cardiac events after 1 year. Safety data will be analysed for frequency, severity and types of adverse events (AEs) for all treatment groups. The proportion of AEs related to the contrast agent gadobutrol will also be analysed. A calculated sample size is a total of 280 participants (accounting for 8% drop-out), randomised in 1:1 fashion to 140 in the verum and 140 placebo group. Myoflame-19 study will examine the efficacy of a myocardial protection therapy in symptomatic participants with post-COVID inflammatory cardiac involvement determined by CMR. The aim of the intervention is to reduce the symptoms and inflammatory myocardial injury, to improve exercise tolerance and preclude the development of cardiac impairment. NCT05619653.

Seeding young entrepreneurs: The role of business incubators

This study focusses on young entrepreneurs and considers the extent of business incubators’ impact on the development and visibility of projects headed by young people. To do so, we analyse incubators’ role as ecosystems for entrepreneurship in Spain based on the 2023 Funcas survey. First, we categorised incubators according to entrepreneurs’ age, defining young incubators as those in which most of the businesses are run by individuals under 35, excluding those over that age. We analyse variables that include the services offered and the frequency of events or training within the incubators to determine which approaches benefit or harm young entrepreneurs. This study uses a statistical approach, with quantitative data from the questionnaire as a starting point to characterise and identify young entrepreneurial profiles in business incubators. We develop and test two hypotheses using the chi-squared test, which is a non-parametric (distribution free) technique. Finally, we include a brief analysis of young entrepreneurs’ personality traits to shed light on some defining characteristics, concluding that personal initiative is a key feature amongst entrepreneurs under the age of 35. We conclude that the incubator system in Spain harms young entrepreneurs and propose some relevant recommendations to reverse this trend.

Droughts Amplify Soil Moisture Losses in Burned Forests of Southeastern Amazonia

AbstractSoil moisture is a crucial variable mediating soil‐vegetation‐atmosphere water exchange. As climate and land use change, the increased frequency and intensity of extreme weather events and disturbances will likely alter feedbacks between ecosystem functions and soil moisture. In this study, we evaluated how extreme drought (2015/2016) and postfire vegetation regrowth affected the seasonality of soil water content (0–8 m depth) in a transitional forest in southeastern Amazonia. The experiment included three treatment plots: an unburned Control, an area burned every three years (B3yr), and an area burned annually (B1yr) between 2004 and 2010. We hypothesized that (a) soil moisture at B1yr and B3yr would be higher than the Control in the first years postfire due to lower transpiration rates, but differences between burned plots would decrease as postfire vegetation regrew; (b) during drought years, the soil water deficit in the dry season would be significantly greater in all plots as plants responded to greater evaporative demand; and (c) postfire recovery in the burned plots would cause an increase in evapotranspiration over time, especially in the topsoil. Contrary to the first expectation, the burned plots had lower volumetric water content than the Control plot. However, we found that droughts significantly reduced soil moisture in all plots compared to non‐drought years (15.6%), and this effect was amplified in the burned plots (19%). Our results indicate that, while compounding disturbances such as wildfires and extreme droughts alter forest dynamics, deep soil moisture is an essential water source for vegetation recovery.

Circadian pattern of blood pressure in patients with stable COPD.

To describe the circadian blood pressure (BP) pattern in stable COPD patients. We included stable COPD patients from Internal Medicine Departments. Office BP and ambulatory BP monitoring were performed. Patients were classified as BP reducers (dipper or extreme dipper) or non-reducers (non-dipper or riser). We included 43 patients (5 women, mean age 69.5 ± 9.5 years). Among them, 11 had sustained normotension, 13 sustained hypertension, 2 white coat hypertension, and 17 masked hypertension. Arterial stiffness was observed in 12 (27.9%) patients. Overall, 26 (60.5%) exhibited a non-reducer BP profile. Non-reducers had a higher frequency of previous major cardiovascular events (50% vs. 11.8%, p = 0.020) and long-acting muscarinic antagonist use (84.6% vs. 47.1%, p = 0.009). Hypertension is often masked in COPD patients, who frequently display an altered circadian BP pattern. Longitudinal studies with larger samples are needed to evaluate the impact of these patterns on COPD progression.

Memory bias beyond ego: Selective recall of positive financial outcomes

A recent experimental literature has documented that people are (sometimes) asymmetric updaters: good news is over-weighted relative to bad news. This phenomenon might be due to selective recall (SR), whereby people better recall positive evidence than negative evidence. To test this hypothesis, we ran a balls-and-urns experiment where each subject faced a box with 100 balls, each bearing a different boy or girl name (N = 448). Subjects received a prize for each ’female’ ball but did not know the exact composition of the urn. Each subject then observed 20 consecutive random draws from her urn, with distracting tasks placed between some extractions. In a subsequent incentivized memory task, unexpected by the subjects, they were asked to write down as many extracted names as they could recall. Since female draws were (exogenously manipulated) good news, SR predicts that they are more likely to be remembered, which is exactly what we found. When subjects received a prize per ’male’ ball, in contrast, they recalled significantly better the extracted boy names. This SR effect persisted even after we controlled for other factors that may influence recall in our design, such as the timing of the extraction or the length of the name. When subjects were asked to estimate the share of ’paying’ balls in the urn, however, we observed no biases at the mean level. That is, SR does not always lead to overestimation of the frequency of positive events.

Turbulence characteristics of non-spherical isolated particles with different flatness on a rough bed surface

The transport of non-spherical particles on bed is significantly influenced by flow dynamics and particle shape. To study the impact of changes in the flatness of isolated bed particles on the surrounding flow characteristics, we prefabricated three isovolumetric particles with varying levels of flatness and analyzed the flow field around them using two-dimensional particle image velocimetry measurement methods. The results show that the presence of the particles significantly alters the turbulence parameters of the surrounding flow. Specifically, the influence extends up to 1D upstream of the particles, 0.5D above the particle tops, and throughout most of the downstream region, where D represents the equivalent particle diameter. The particles cause a reduction in Reynolds stress and turbulent kinetic energy in the near-bed upstream region, with a more pronounced effect observed for particles with lower flatness. Increased particle flatness is associated with a smaller difference in the longitudinal time-averaged velocity between upstream and downstream regions. In the wake region, particle flatness shows a negative correlation with Reynolds stress, longitudinal turbulence intensity, and turbulent kinetic energy, with this effect being more pronounced closer to the particles. Quadrant analysis indicates that ejection (Q2) and sweep (Q4) quadrant events remain dominant in the presence of particles, while particle flatness positively correlates with the frequency of outward (Q1) and inward (Q3) events in the wake region and negatively correlates with the frequency of Q2 and Q4 events. This study enhances our understanding of particle-fluid interactions, particularly the response relationship between non-spherical particles and turbulent mechanisms.

The changing characteristics of torrential rainfall in the Huaihe River Basin from 1961 to 2020

Abstract The Huaihe River Basin (HRB) is one of the most severely affected regions by torrential rain disasters in China. However, with climate warming, it is unclear what new features torrential rain exhibits and how the main modes of torrential rain change in this region. This study analyzes the first two modes of torrential rain in the HRB from 1961 to 2020 and their driving factors. Results show that in the last 30 years, the frequency of torrential rain events in the HRB has clearly increased, especially in southern HRB region during the flood season. The first mode of torrential rain is an entire basin-wide mode, with a period of 2–3 years. The mode is primarily influenced by the low-level westerly jet stream and Jianghuai cyclones, which are closely linked to the stratospheric Quasi-Biennial Oscillation (QBO) through influencing planetary wave propagation and convective activity under different phases of QBO. The second mode is a north-south distribution mode, with a period of 4–6 years. The leading circulation system is the frontal systems. Both the East Asia/Pacific (EAP) teleconnection wave train and ENSO drive the second torrential rain mode. During El Niño years, anomalous subsidence and anticyclone in the western tropical Pacific, induced by sea surface temperature warming in the eastern tropical Pacific through the East Asia/Pacific teleconnection, can trigger the EAP wave train poleward in the East Asian region. This wave train leads to the cold-warm confrontation conducive to the second torrential rain mode.

Frequency of Adverse Events and Relapses after SARS-CoV-2 Vaccination in Patients with Podocytopathies

Frequency of Adverse Events and Relapses after SARS-CoV-2 Vaccination in Patients with Podocytopathies

Enhanced carbon use efficiency and warming resistance of soil microorganisms under organic amendment

The frequency and intensity of extreme weather events, including rapid temperature fluctuations, are increasing because of climate change. Long-term fertilization practices have been observed to alter microbial physiology and community structure, thereby affecting soil carbon sequestration. However, the effects of warming on the carbon sequestration potential of soil microbes adapted to long-term fertilization remain poorly understood. In this study, we utilized 18O isotope labeling to assess microbial carbon use efficiency (CUE) and employed stable isotope probing (SIP) with 18O-H2O to identify growing taxa in response to temperature changes (5–35 °C). Organic amendment with manure or straw residue significantly increased microbial CUE by 86–181 % compared to unfertilized soils. The microorganisms inhabiting organic amended soils displayed greater resistance of microbial CUE to high temperatures (25–35 °C) compared to those inhabiting soils fertilized only with minerals. Microbial growth patterns determined by the classification of taxa into incorporators or non-incorporators based on 18O incorporation into DNA exhibited limited phylogenetic conservation in response to temperature changes. Microbial clusters were identified by grouping taxa with similar growth patterns across different temperatures. Organic amendments enriched microbial clusters associated with increased CUE, whereas clusters in unfertilized or mineral-only fertilized soils were linked to decreased CUE. Specifically, shifts in the composition of growing bacteria were correlated with enhanced microbial CUE, whereas modifications in the composition of growing fungi were associated with diminished CUE. Notably, the responses of microbial CUE to temperature fluctuations were primarily driven by changes in the bacterial composition. Overall, our findings demonstrate that organic amendments enhance soil microbial CUE and promote the enrichment of specific microbial clusters that are better equipped to cope with temperature changes. This study establishes a theoretical foundation for manipulating soil microbes to enhance carbon sequestration under global climate scenarios.

Incidence and outcomes for children with idiopathic inflammatory myopathy in Western Australia-a long-term population-based study.

To determine the incidence and health outcomes for juvenile idiopathic inflammatory myopathy (JIIM) in a long-term whole-population study. We included patients under 18 years hospitalized in Western Australia (WA) from 1985 and 2015 with incident JIIM as defined by pertinent diagnostic codes for dermatomyositis (JDM) polymyositis (JPM), other JIIM and overlap myositis (JOM). We compared clinical outcomes and modified Charlson comorbidity scores with age and gender matched (2:1 ratio) patients with new onset juvenile idiopathic arthritis (JIA). Trends over time for annual incidence rate per million child-population (AIR) were analyzed by least square regression and survival by Kaplan-Meier curves. We included 40 patients with JIIM (63% female, median age 8.5 years) for an average AIR of 2.52 per million (CI 1.09-5.57). AIR was stable over time leading to a point prevalence of 52.61 (CI 40.57-67.06) in 2015. Most patients (80%) were classified as JDM with an AIR for JDM of 2.02 (CI 1.09-5.58) and AIR for the combined other JIIM at 0.51 (CI 0.24-1.15). There was female preponderance (62.5%) in both JIIM groups, but no evidence of seasonality. Over a median follow-up of 13 years, one- and ten-year survival was 94.1%. Compared to JIA patients, readmission (80.4 vs. 63.7, p = .02) and infection rates (15.2 vs. 9.6, p < .01) per 100 person-years were higher for JIIM, with similar frequency of interstitial lung disease, fractures, and thrombotic events. At last observation, nearly all patients in both JIIM cohorts (97.5 vs. 92.5%) had accrued some form of comorbidity. The overall incidence of JIIM leading to hospitalization in WA was stable over 30 years. JIIM prognosis remains suboptimal due to early mortality and accrual of long-term comorbidity.

Climate change influence on the trends of BFRs in the environment and food.

Climate change poses new challenges for environmental protection and food safety. With reported consequences including warmer temperatures, melting of Alpine glaciers, higher sea levels, droughts, extreme rainfall events and increased surface UV radiation, concerns about the impact on food contaminants have been raised. While the effects of climate change on POPs were initially expected to have the biggest impact in the arctic region, given the intensity, frequency and spread of extreme weather events, global influence on environmental pollution and food safety is currently anticipated. Warmer temperatures are expected to enhance the volatilization of POPs and influence their partitioning between soil, sediment, water and atmosphere, enhancing their mobility and their potential for long-range atmospheric transport. Floods and strong winds can cause dilution but also spread of pollutants to wider areas. Limited data are available for the impact of climate change on BFRs levels, trends and toxicity. BFRs are widely used to protect people from fire hazards. Numerous BFR containing products are disposed in landfills where climate change could possibly induce increased leaching and resulting impacts on the food chain. Heat and UV exposure can lead to degradation of novel polymeric BFRs with adverse environmental effects. Long-term monitoring data are needed for feed, food and environmental compartments in order to evaluate climate change influence, which will also enable the development of prediction models specific for legacy and novel BFRs, for various climate change scenarios. Furthermore, there is a need to promote further discussion in the scientific community for the design of risk management and remediation activities for contaminated areas, in response to potential future conditions as the climate continues to change.

Regional-scale disturbances drive long-term decline of inshore coral reef fish assemblages in the Great Barrier Reef Marine Park.

Anthropogenic pressure is increasing the variety and frequency of environmental disturbance events, limiting recovery and leading to long-term declines in wild plant and animal populations. Coral reefs and associated fish assemblages are inherently dynamic due to their susceptibility to a host of disturbances, but regional-scale nuances in the drivers of long-term change frequently remain poorly resolved. Here, we examine the effects of multiple potential drivers of change in coral reef fish assemblages across 4 inshore regions of the Great Barrier Reef Marine Park (GBRMP), Australia, over 12-14 years (2007-2021). Each region had a unique disturbance history, in conjunction with long-term changes in physical and habitat variables. Phases of recovery were apparent in the years between disturbance events at all locations, but these were not long enough to prevent substantial declines in reef fish density (by 33%-72%) and species richness (by 41%-75%) throughout the study period. The main drivers of change in fish assemblages varied among regions; however, the most rapid changes followed cyclone and flood events. Limited recovery periods resulted in temporal shifts in fish species composition from typically coral-associated to algae-associated. Most trophic groups declined in density except farmers, grazers, omnivores and parrotfish. No-take marine reserves (NTMRs) had small and inconsistent effects on total fish assemblages, but delivered benefits for fishery-targeted piscivores. Our findings suggest that coral reef responses to local stressors and cumulative escalating climate change impacts are highly variable at regional scales, and that small NTMRs are unlikely to mitigate the impacts of increasingly frequent climatic disturbances. Nearshore coral reefs worldwide are high-value habitats that are either already degraded or vulnerable to degradation and the loss of important fish groups. Global efforts to reduce greenhouse gas emissions must be coupled with effective local management that can support the functioning and adaptive capacity of coral reefs.

Mapping uterine calcium dynamics during the ovulatory cycle in live mice.

Uterine contraction patterns vary during the ovulatory cycle and throughout pregnancy, but prior measurements have produced limited and conflicting information on these patterns. We combined a virally delivered genetically encoded calcium reporter (GCaMP8m) and ultra-widefield imaging in live nonpregnant mice to characterize uterine calcium dynamics at organ scale throughout the estrous cycle. Prior to ovulation (proestrus and estrus), uterine excitations primarily initiated in a region near the oviduct, but after ovulation (metestrus and diestrus), excitations initiated at loci homogeneously distributed throughout the organ. The frequency of excitation events was lowest in proestrus and estrus, higher in metestrus, and highest in diestrus. These results establish a platform for mapping uterine activity and demonstrate that an anatomically localized trigger for uterine excitations depends on the estrous cycle phase.

Effect of nuts on lipid profile and inflammatory biomarkers in atherosclerotic cardiovascular disease: a systematic review and meta-analysis of randomized controlled trials.

Nut-enriched diets are related to improve lipid and inflammatory biomarkers in meta-analyses in the context of primary cardiovascular prevention. However, primary studies on secondary cardiovascular prevention are scarce and controversial. This systematic review and meta-analysis aimed to evaluate the effect of nut supplementation on lipid and inflammatory profiles in individuals with atherosclerotic cardiovascular disease, and the frequency of adverse events. Six databases were used for research: PubMed, EMBASE, BVS, Cochrane Library, Web of Science, and ClinicalTrials.gov, until February 2023, with no language restrictions. We performed random-effects meta-analyses to compare nut-enriched diets vs. control diets for pre-post intervention changes. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system assessed the evidence's certainty. From the 5187 records identified, eight publications containing data referring to five randomized clinical trials involving 439 participants were included in the final analyses. The nuts evaluated were almonds, pecans, Brazil nuts, and mixed nuts, with doses ranging between 5g and 85g (median: 30g/day). The intervention time varied between 6 and 12 weeks. Compared to nut-free diets, nut intake did not have a statistically significant effect on lipid profile biomarkers, except on the atherogenic index (MD: -0.32 [95% CI -0.58 to -0.06], I2 = 0% - moderate certainty of the evidence). Similarly, there was no effect of nuts on inflammatory profile biomarkers. It was not possible to aggregate data on adverse events. Nut supplementation did not change lipid and inflammatory profiles in the secondary cardiovascular prevention setting.

Best practices and rationale for expanding Medicaid access to continuous glucose monitoring.

Numerous studies have demonstrated that use of continuous glucose monitoring (CGM) significantly improves overall glycemic control and reduces the frequency and severity of hypoglycemic events in individuals treated with intensive insulin, nonintensive insulin, and noninsulin therapies, with reductions in both all-cause and diabetes-related health care resource utilization and lower costs. However, implementation of CGM including prescribing and assessment of the ambulatory glucose profile to make clinical decisions in primary care settings is low. A recent pilot program was initiated at MetroHealth System (Cleveland, Ohio) to implement a CGM integration program for primary care offices throughout the system. Based on the experience and successes from this health system as well as current literature, rationale will be discussed to support the expansion of CGM to individuals enrolled in all Medicaid programs.

Innovative tools and protocols for the regeneration of urban and peri-urban districts towards climate neutrality

Abstract Cities represent the foremost contributor to the escalating growth in energy consumption, constituting a substantial portion of global greenhouse gas (GHG) emissions. In the face of climate change and the heightened frequency and severity of extreme events, urgent policies and actions are imperative for cities to enhance resilience and instill a sense of responsibility among their inhabitants. Additionally, establishing monitoring and reporting models to track progress in implementing sustainable urban development measures is crucial. The calculation of CO2 emissions in cities demands a multidimensional approach, encompassing sectors such as energy, buildings, water, green spaces, transport, waste, and others. Models and diagnostic tools are available for the different fields of interest. These are valuable elements; however, they often necessitate specialized expertise and prolonged processing times for accurate result interpretation, sometimes conflicting with the need for prompt, reliable guidance. This contribution aims to define innovative tools and protocols, along with a specific performance verification model (easy model), concerning mitigation and adaptation to climate change. These tools are designed to be easy to apply and usable from the preliminary project stages for the redevelopment/regeneration of existing architecture and urban districts.

Global Wind-Power Generation Capacity in the Context of Climate Change

Establishing power systems with a high share of renewable energy sources is a pivotal step toward achieving a globally sustainable transition to green and low-carbon energy. This study focuses on low-output wind power that affects the generation capacity of power systems with a high share of renewable energy sources. Utilizing the Coupled Model Intercomparison Project Phase 6 datasets, a predictive model for low-output wind power was employed to investigate regional trends worldwide. The frequency and duration of low-output wind-power events exhibited increasing trends globally, particularly in East Asia and South America, but not in North America. By 2060, the annual total days with low-output wind power in East Asia and South America could rise to 13 and 5 d, and the maximum continuous duration of low-output wind power could reach 5 and 2 d, respectively. As wind power becomes a primary electricity source, such low output could lead to shortages in energy supply within the power system, triggering large-scale power outages. This issue calls for critical attention when establishing power systems with a high share of renewable energy sources. The conclusions provide a basis for analyzing power supply risks and configuring flexible power sources for scenarios with a high share of renewable energy.