In piping systems, hydrodynamic cavitation is well known for its destructive capabilities such as generation of intense noise. The investigation of the effect of the cavitation on acoustic pressure fluctuations and resonance frequencies provides much information about the geometry of the cavitation area, the propagation and the damping characteristics of the cavitation medium. The acoustical effects of cavitation caused by a water flow through a single-hole orifice have been investigated by using Computational Fluid Dynamics (CFD) and Ffowcs Williams–Hawkings (FW-H) formulation. The fluid zone downstream of the orifice where the cavitation happens considered as acoustic source. Time-accurate solutions of the flow-field variables are obtained from large eddy simulation (LES). Two cavitation regimes are investigated and for each regime, the sound pressure signals far downstream of the orifices are computed by applying the Ffowcs Williams–Hawkings (FW-H) formulation. From the results, it can be concluded that the spectral characteristics of the sound pressure fluctuations are influences by the cavitation condition. The super cavitation condition generates significantly more noise than the developed cavitation condition. Moreover, the results demonstrate that a combination of LES and FW-H formulation is a promising tool for acoustical study of cavitating orifices.