Abstract Background COVID-19 and subsequent lockdowns had an impact on the mental health of students, who had already been identified as a vulnerable population prior to this pandemic. At the end of the first COVID-19 lockdown, 15% of students reported suffering from moderate to severe anxiety. Psychological resilience is defined as the ability to bounce back from a stressful event and has been shown to have a positive impact on mental health parameters. This study aimed to identify factors associated with low resilience in the student population of the Grand Est region of France, at the end of the first national containment related to COVID-19. Methods The PIMS-CoV19 study: A cross-sectional online survey was conducted among students at the University of Lorraine to collect sociodemographic data, living and learning conditions, as well as levels of resilience and perceived health. Bivariable and multivariable logistic regression analyses were performed. Model robustness was assessed using bootstrap resampling. Results Among 3708 students, 50.6% had normal resilience, while 37.3% reported low resilience. Female gender (OR = 2.1, 95% CI: 1.8-2.6) and low social support (OR = 1.7, 95% CI: 1.1-2.6) were the main risk factors for low resilience. Negative thoughts (OR = 1.4, 95% CI: 1.4-1.5), lower quality of relationships with people in general (OR = 1.5, 95% CI: 1.3-1.8), and studying arts, humanities, or languages (OR = 1.4, 95% CI: 1.0-1.8) were identified as risk factors. Increased age (OR = 0.9, 95% CI: 0.9-1.0) and flat sharing (OR = 0.6, 95% CI: 0.4-0.9) were protective factors against low resilience. Conclusions Resilience seems to be impacted primarily by internal and micro-environmental factors. Consolidating levels of individual resilience of at-risk populations by acting on these factors could be the key to improving their mental health. Key messages • Resilience seems to be impacted primarily by internal and micro-environmental factors. • Consolidating levels of individual resilience of at-risk populations by acting on these factors could be the key to improving their mental health.
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