The article analyzes the phenomenon of the Soviet Union’s structural aid to African countries - technical and economic cooperation covering major sectors of the economy to ensure the self-sufficient development of recipient countries and weaken the neocolonial impact of the West. The case of bilateral relations between the USSR and Mali in 1960-1968 was chosen for a number of reasons - the strategic location of this African country, its place in the structure of French interests, the formats and volumes of Soviet aid, and, finally, rather weak coverage of the issue in Russian and foreign historiography. The authors preface the analysis of Soviet aid with an overview of the country’s economic situation in the 1960s and the difficulties faced by the Malian government in establishing an independent economic system through the introduction of its own currency, the Malian franc, and the nationalization of former French enterprises. The research is mostly based on the archival funds of the State Committee on Foreign Economic Relations of the Russian State Archive of Economy. The analysis of Soviet assistance is conducted in a wide range of areas, from industry and agriculture to health care and education. The final section examines the transport issue and the Soviet role in removal of the transport blockade imposed by Senegal. Both successful projects of Soviet-Malian cooperation, as the gold and bauxite exploration, the construction of a cement plant, and a sports stadium, and unrealized ideas are described. Among the most obvious problems that hindered cooperation between the USSR and Mali were the lack of financial resources, excessive caution, and Mali’s rather active cooperation with its neighbors and capitalist countries. Soviet aid to Mali allows us to trace the Soviet Union’s role in the real decolonization of African countries and the strengthening of their sovereignty. Unlike many other donors, who mostly limited their aid to certain projects, the USSR provided support within the framework of a full cycle of work in all sectors of the economy (resource extraction - construction of enterprises for processing resources - training of personnel to service enterprises - export of finished goods). Obviously, such a comprehensive approach had a truly favorable effect on the sovereignization of the Malian economy.