Express freight train occupies an important position in the railway freight transportation market due to its stable transportation process and good timeliness. In order to ensure the transportation stability and timeliness of express freight trains, the selection of train paths is an extremely important procedure. A scientific and reasonable selection method of train paths is a necessary guarantee for express freight trains to ex ert their unique advantages as freight products, and influences the quality of freight services and economic benefits. The train timetable was transformed into a space-time network. With the minimum entire transportation time as the optimization objective, and the influence factors of train trip time, transit time in the stations and freight transit period as constraints, a train paths selection model of express freight trains was constructed. The model can realize the reasonable selection of train paths. Finally, an example was given to demonstrate the feasibility and effectiveness of the model and provide a theoretical basis for the railway operation department.