Free Vascularized Research Articles

The Use of Free Vascularized Fibular Grafts in Skeletal Reconstruction for Bone Tumors in Children

The reconstruction of large skeletal defects in children following resection of a bone tumor presents a unique challenge to the orthopaedic surgeon. Issues in this population that are not present in the adult population include significant remaining growth potential, the desire for biologic preservation of the joint surface, and the need for a long-term viable reconstruction in patients who are anticipated to survive for decades. The use of a free vascularized fibular graft, supplied by the peroneal vessels in intercalary fibular grafts and the anterior tibial vessels in proximal fibular grafts, has been shown to provide biologic reconstruction that successfully addresses these issues in the pediatric population. Specific techniques are applied in the upper and lower extremity to provide long-term excellent functional results. Experience in microvascular surgery and careful postoperative care are required for the success of these procedures.

Modern reconstruction techniques for oral and pharyngeal defects after tumor resection

Several techniques have been developed to reconstruct oral and pharyngeal defects following surgery, in order to restore function and cosmesis. These are primary closure, skin grafts, local transposition of skin, mucosa and/or muscle, regional flaps and free vascularized flaps. Because of the 'bulky', pedicled nature and problems with the donor area of locoregional flaps, and consequently frequently unsatisfactory functional results, free vascularized flaps have gained popularity during the last decade. The authors review the current options available to give physicians, who are not experienced in the field of reconstruction in the head and neck, an impression of the range of techniques available for reconstruction of oral and pharyngeal defects following tumor resection. For reconstruction of oral cavity and pharyngeal defects, fasciocutaneous (e.g. radial forearm and anterolateral thigh flaps) and myocutaneous free flaps (e.g. rectus abdominis and latissimus dorsi) have proven to be very reliable. Free vascularized osteocutaneous flaps (e.g. fibula and iliac crest) permit reconstructive options for bony defects of the mandible or maxilla that can be adapted to a variety of defects. Depending on the site, size and involved tissues of the surgical defect and patient factors, a variety of reconstructive options are available. For both soft tissue and bony defects of the upper aerodigestive tract, microvascular free flaps provide good functional outcomes.

Segmental Bony Defect of the Proximal Phalanx in the Great Toe Reconstructed by Free Vascularized Bone Graft From the Supracondylar Region of the Femur: A Case Report

We report the case of a 24-year-old man with a segmental bone defect of the proximal phalanx of the great toe that was successfully reconstructed by free vascularized bone graft (FVBG) from the supracondylar region of the femur after initial stabilization with external fixation and temporary antibiotic-impregnated bone cement. His functional outcome at 22 months follow-up was excellent. On the basis of this experience, FVBG from the supracondylar region of the femur can be used as an option for treating segmental bone defects of the great toe.

Reconstruction de l'articulation trapézométacarpienne et du premier métacarpe par un lambeau ostéocutané retourné de deuxième métatarsien

A case of reconstruction after first metacarpal resection by reversed free vascularized osteocutaneous pedis flap is presented. This procedure avoids bone resorption and preserves the trapezio metacarpal joint contrary to conventional bone graft. A double rotation is applied to the flap: the head of the metatarsal becomes proximal and the palmar side becomes dorsal. The metacarpo-phalangeal joint undergo arthrodesis. With a follow up of three years, there is no pain, the Kapandji score is 8/10 (very good range of motion), there is no osteoarthritis.

Metatarsal Reconstruction with Use of Free Vascularized Osteomyocutaneous Fibular Grafts Following Resection of Malignant Tumors of the Midfoot

Background: Bone and soft-tissue sarcomas are uncommon, and their location in the foot is extremely rare. While limb salvage has become the standard of care in the treatment of sarcoma in an extremity, the unique anatomy of the foot presents challenges in reconstructing a viable and functional limb. Methods: Between 1998 and 2005, we used free microvascularized osteomyocutaneous fibular grafts to reconstruct the defects created after extensive midfoot resection in six consecutive patients with a primary malignant tumor. In all but one patient, the extent of the resection involved at least two metatarsals. The mean age (and standard deviation) at the time of the operation was 30 ± 13 years. At the final follow-up examination, clinical and radiographic evaluations were performed on all patients, and functional outcome and quality of life were assessed with use of the Musculoskeletal Tumor Society score, the American Orthopaedic Foot and Ankle Society Score, and the Toronto Extremity Salvage Score. Results: The median duration of follow-up was 52.2 months. Limb salvage was achieved in five patients. In the remaining patient, amputation was necessary because of flap failure. Revision surgery was necessary in all patients because of complications (skin ulcerations in three patients; hematoma in two patients; and infection, necrosis of the second toe, and flap necrosis in one patient each). At the time of final follow-up, five patients had satisfactory function and reported good quality of life. The average Musculoskeletal Tumor Society, American Orthopaedic Foot and Ankle Society, and Toronto Extremity Salvage scores were 82%, 75 points, and 92%, respectively. At the time of the final follow-up, five patients had no evidence of disease and one patient had disease. Conclusions: Following the resection of a malignant tumor in the midfoot, the use of microvascularized osteomyocutaneous fibular grafts has proven to be a successful surgical technique, offering an alternative to ablative surgery with functional restoration of the salvaged limb. Level of Evidence: Therapeutic Level IV. See Instructions to Authors for a complete description of levels of evidence.

Metatarsal Reconstruction with Use of Free Vascularized Osteomyocutaneous Fibular Grafts Following Resection of Malignant Tumors of the Midfoot

Bone and soft-tissue sarcomas are uncommon, and their location in the foot is extremely rare. While limb salvage has become the standard of care in the treatment of sarcoma in an extremity, the unique anatomy of the foot presents challenges in reconstructing a viable and functional limb. Between 1998 and 2005, we used free microvascularized osteomyocutaneous fibular grafts to reconstruct the defects created after extensive midfoot resection in six consecutive patients with a primary malignant tumor. In all but one patient, the extent of the resection involved at least two metatarsals. The mean age (and standard deviation) at the time of the operation was 30+/-13 years. At the final follow-up examination, clinical and radiographic evaluations were performed on all patients, and functional outcome and quality of life were assessed with use of the Musculoskeletal Tumor Society score, the American Orthopaedic Foot and Ankle Society Score, and the Toronto Extremity Salvage Score. The median duration of follow-up was 52.2 months. Limb salvage was achieved in five patients. In the remaining patient, amputation was necessary because of flap failure. Revision surgery was necessary in all patients because of complications (skin ulcerations in three patients; hematoma in two patients; and infection, necrosis of the second toe, and flap necrosis in one patient each). At the time of final follow-up, five patients had satisfactory function and reported good quality of life. The average Musculoskeletal Tumor Society, American Orthopaedic Foot and Ankle Society, and Toronto Extremity Salvage scores were 82%, 75 points, and 92%, respectively. At the time of the final follow-up, five patients had no evidence of disease and one patient had disease. Following the resection of a malignant tumor in the midfoot, the use of microvascularized osteomyocutaneous fibular grafts has proven to be a successful surgical technique, offering an alternative to ablative surgery with functional restoration of the salvaged limb.

Arthrodesis for ankle osteoarthritis after harvesting of free vascularized fibular bone: a case report

Although free vascularized fibular bone grafting is a good method for the reconstruction of large bone defects, it might cause morbidity of the donor leg. Progression of ankle osteoarthritis, valgus deformity and instability of the donor leg subsequently leading to arthrodesis has rarely been reported. A 53-year-old man suffered from a left tibial comminuted and Gustilo type IIIb open fracture. A folded free vascularized osteoseptocutaneous flap was harvested from the right fibula and transferred to the left tibial bone defect. After the reconstructive surgery, the patient obtained a solid union of the left tibial shaft uneventfully. Ten years later, he suffered intermittent pain on his right ankle. Plain radiographs revealed progressive tibiotalar osteoarthritis. Right ankle arthrodesis with crossed cannulated screws fixation and osteosynthesis of the fibula to the tibia and talus were performed. However, this procedure failed due to a deep infection and osteomyelitis. A revision of the failed ankle fusion was performed by using a vascularized iliac bone flap to strut the anterolateral aspect of the tibiotalar bone defect. A ventral plate fixation and supplementary onlay bone grafting were applied across the anterior aspect of the tibiotalar joint. At the 2-year follow-up, the patient had no pain and resumed his regular daily activities. Harvesting of the fibula may cause longterm ankle osteoarthritis that requires ankle arthrodesis. In revision arthrodesis a ventral plate fixation and vascularized iliac bone flap may be the treatment of choice, neutralizing the large moment due to the long lever arms.

Autologous tissue repair of large abdominal wall defects

Techniques for autologous repair of abdominal wall defects that could not be closed primarily are reviewed. Medline and PubMed were searched for English or German publications using the following keywords: components separation technique (CST), Ramirez, da Silva, fascia lata, tensor fasciae latae, latissimus dorsi, rectus femoris, myocutaneous flap, ((auto)dermal) graft, dermoplasty, cutisplasty, hernia, abdominal wall defect, or combinations thereof. Publications were analysed for methodological quality, and data on surgical technique, mortality, morbidity and reherniation were abstracted. The CST is the best documented procedure; it is associated with a high morbidity rate of 24.0 per cent and a recurrence rate of 18.2 per cent. Although the results of the da Silva technique are good (morbidity 5-20 per cent and reherniation 0-3 per cent), the poor methodological quality of the studies precludes firm conclusions. Repair with free fascia lata or dermal grafts is an alternative if the above techniques cannot be used, but wound complications affect 42 per cent of patients and recurrent hernia up to 29 per cent. Pedicled or free vascularized flaps are reserved for complex situations.

Treatment of Osteonecrosis of the Femoral Head: Everything's New

Since the 1970s, the mantra of those treating osteonecrosis of the femoral head was to save the head at all costs. Total hip arthroplasty (THA), the only effective surgical treatment once the head has mechanically and clinically failed, had a poor track record for young active patients. Recently, THA using highly cross-linked polyethylene, metal-on-metal bearing surfaces, or ceramic-on-ceramic bearing surfaces have given promising results, changing the “save-at-all-costs” paradigm. Operations that have a low success rate, high complication rate or morbidity, or compromise subsequent THA can no longer be justified. This includes femoral osteotomy and free vascularized fibular graft. Core decompression is justified, when indicated, because of its low morbidity and absence of complications with subsequent THA.

The Lesions of the Facial Nerve and a Surgical Reconstruction Algorithm

Paralysis of the facial nerve (FNP) has a widely varied etiology. Pathological lesions of the skull base causing facial nerve paralysis may be divided into three groups: lesions of the brainstem, the posterior fossa, and the temporal bone. In our experience, FNP is seldom caused by removal of posterior fossa lesions such as acoustic neurinomas, especially when the continuity of the nerve was preserved. However, lesions compressing the facial nucleus at the brainstem and infectious infiltration of the FN in the temporal bone are more frequent causes. The surgical reconstruction strategy of the injured FN depends on several factors: unimpaired brainstem facial nucleus, the availability of the proximal FN in the posterior fossa, and functional integrity of the target muscles. It has been shown that primary reconstruction of the facial nerve has its supremacy over secondary reconstructive procedures. Nerve reconstruction procedures include direct sutures and grafting, cross face grafting, XII-VII transfer, and others. Ancillary reconstruction options may be subdivided into two major categories: static and dynamic. Static reconstructions constitute face lifting, netting, and suspension. Dynamic procedures include local muscle transfers and free vascularized and innervated muscle transfer. The free vascularized and innervated muscle transfer may be performed as a two-stage procedure or a one-stage procedure. We use the one-stage procedure in our clinic. Based on our experience with 16 patients with FN reconstructions, 8 patients with secondary static corrections, and 15 patients with secondary dynamic free vascularized and innervated nerve transfers, we conclude the following: (1) XII-VII is best suited for old candidates, where a facial nuclear involvement is present; (2) if ipsilateral XII-N is affected, a VII-VII cross face transfer is the next option; (3) in long-standing FNP a local dynamic procedure is valuable in old candidates and a free vascularized and innervated muscle transfer in the young.

Influence of Acetabular Coverage on Hip Survival After Free Vascularized Fibular Grafting for Femoral Head Osteonecrosis

To The Editor: I read with great interest the article entitled “Influence of Acetabular Coverage on Hip Survival After Free Vascularized Fibular Grafting for Femoral Head Osteonecrosis,” (2006;88:2152-8), by Roush et al., and the commentary by Steinberg and Steinberg1. Indeed, this article and the commentary by Marvin Steinberg1 represent the views and thoughts of two senior authors with opposing opinions on how to treat osteonecrosis. Urbaniak2 supports vascularized bone-grafting, whereas Steinberg3 supports avascular cancellous bone-grafting. While the intent of the article by Roush et al. was not to document the clinical efficacy of either type of bone-grafting, the conclusions made therein invariably influence one's ability to recognize a potential limitation of free vascularized fibular grafting, and it is from this observation that I would like to offer a few comments. Roush et al. retrospectively reviewed a consecutive series of 200 hips in 160 patients with osteonecrosis of the femoral head who had undergone free vascularized fibular grafting. They found that, of the hips with a center-edge angle of ≤30°, 55% demonstrated progression of collapse and 45% were converted to a total hip arthroplasty. In contrast, of the hips with a center-edge angle of >30°, only 10% demonstrated progression of collapse and only 6% were converted to a total hip arthroplasty. Roush et al. encouraged the reader to consider acetabular dysplasia as an independent risk factor with a negative influence on prognosis and …

Reconstruction for local radiation injuries and proposed regeneration therapy for acute systemic radiation injuries

Skin and soft tissue radiation injuries are life-threatening as well as of esthetic concern in local tissues. As for local radiation injuries, clinically developed procedures such as local flaps and free vascularized flaps result in better and less-invasive reconstructive outcomes for victims of therapeutic radiation of malignant tumors, prolonged fluoroscopic procedures for cardiovascular diseases or possibly direct contact with radioactive waste, while systemic radiation injuries should find other solutions. In systemic radiation injuries, there is a good chance to save lives when the initial treatment is efficient, although donors of the skin grafting after debridement of the radiation-damaged tissue removal are unrealistically autogenous. Thus, exceeding certain extent and degree, systemic radiation injury-induced burns were not the medical objectives. Recent understanding and application of use in adult stem cells, however, create a new insight for severe systemic radiation injuries. Among the adult stem cells, the human mesenchymal stem cells are able to be freeze-dried, easily thawed and able to be cultured in vitro. A basic fibroblast growth factor is already of clinical use and efficient for the human mesenchymal stem cell growth both in vitro and in vivo. An artificial dermis is useful for temporal coverage of the raw surface of severe bedsores. The combined use of these successfully regenerates both dermis and epidermis after 20 Gy whole body irradiation in a nude rat model. Therefore, even severe radiation injuries, local tissue management and therapy are well-handled and systemic radiation injury may be hopeful with understanding and the specialized practice of regenerative medicine.

Total Hip Arthroplasty Following Failure of Free Vascularized Fibular Graft

Total Hip Arthroplasty Following Failure of Free Vascularized Fibular Graft

Results of Free Vascularized Fibula Grafting for Allograft Nonunion After Limb Salvage Surgery for Malignant Bone Tumors

Results of Free Vascularized Fibula Grafting for Allograft Nonunion After Limb Salvage Surgery for Malignant Bone Tumors

Tissue‐engineered Approach for the Treatment of Steroid‐induced Osteonecrosis of the Femoral Head: Transplantation of Autologous Mesenchymal Stem Cells Cultured With Beta‐Tricalcium Phosphate Ceramics and Free Vascularized Fibula

Autologous mesenchymal stem cells (MSCs) cultured with beta-tricalcium phosphate (beta-TCP) ceramics and with a free vascularized fibula were transplanted into three patients with steroid-induced osteonecrosis of the femoral head. The average follow-up period was 34 months and the average patient age at the time of surgery was 28 years old. Fifteen milliliters of bone marrow was obtained from the patients 4 weeks before surgery, and was used for in vitro proliferation of MSCs. beta-TCP granules were immersed in the MSC suspension and the cells were further cultured for 2 weeks. Cultured MSCs/beta-TCP composite granules were implanted into the cavity that remained after curettage of necrotic bone; and finally, a free vascularized fibula was grafted. All hips showed preoperative collapse and radiographic progression was observed in two hips postoperatively. Osteonecrosis did not progress any further and early bone regeneration was observed. This tissue-engineered approach has potentials for the treatment of osteonecrosis. However, our results suggested that the present procedure could not be used for cases with severe preoperative collapse.

Total Hip Arthroplasty Following Failure of Free Vascularized Fibular Graft

Many treatments for osteonecrosis of the femoral head, including the use of a free vascularized fibular graft, have been advocated in an attempt to delay the need for hip arthroplasty. The purpose of this study was to document the clinical and radiographic results of total hip arthroplasty performed following failure of a free vascularized fibular grafting procedure. Twenty total hip arthroplasties in eighteen patients who had previously undergone a free vascularized fibular grafting procedure for the treatment of osteonecrosis were retrospectively reviewed. A straight-stem femoral component was used in twelve hips, a tapered femoral component with removal of residual fibular graft was used in five hips, and a tapered stem without graft removal was used in three hips. The twelve hips with a straight-stem femoral component and previous vascularized fibular grafting were compared with thirty-six osteonecrotic hips in thirty other patients who had undergone total hip arthroplasty but had not had previous free vascularized fibular grafting. The radiographic outcomes with respect to initial femoral component alignment and subsequent migration and the clinical outcomes were compared. Analysis of the immediate postoperative radiographs demonstrated significantly improved alignment of the femoral component when a high-speed burr had been used to remove residual fibular graft (p = 0.001), although doing so did significantly increase both the intraoperative blood loss (p = 0.017) and the operative time (p = 0.0002). There was no significant difference in the amount of migration of either the acetabular or the femoral component between the control and study groups at the time of the most recent follow-up. When comparing patients with or without a previous free vascularized fibular graft, the mean postoperative scores at three years were significantly worse in patients who had undergone a previous free vascularized fibular graft (p = 0.03). One revision occurred in the study group at seventy-two months due to acetabular wear, and one revision occurred in the control group at 108 months due to aseptic loosening. This study raises concern that the outcome of total hip arthroplasty in patients who previously underwent a free vascularized fibular graft for the treatment of osteonecrosis of the femoral head may be worse than that in patients without previous free vascularized fibular grafting. The intraoperative use of a high-speed burr can improve the alignment of the femoral component by removing more of the residual graft. However, this technique does increase intraoperative blood loss and operative time. Therapeutic Level IV. See Instructions to Authors on jbjs.org for a complete description of levels of evidence.

Results of Free Vascularized Fibula Grafting for Allograft Nonunion After Limb Salvage Surgery for Malignant Bone Tumors

The purpose of this study was to assess the results of free vascularized fibula grafting (FVFG) in the treatment of allograft fracture nonunion after limb salvage surgery for malignant bone tumors.A retrospective study was performed on 8 patients who underwent FVFG for allograft fracture nonunions. All had prior tumor resection and allograft reconstruction for osteosarcoma (n = 6) or Ewing sarcoma (n = 2) of the femur (n = 3), tibia (n = 2), humerus (n = 2), or ulna (n = 1). All patients failed an initial course of immobilization; 4 patients failed prior open reduction and internal fixation with autogenous nonvascularized bone grafting. Average age at the time of FVFG was 14 years. Average follow-up was 44 months. The FVFG resulted in successful bony healing in 7 of 8 patients, providing pain relief, limb preservation, and restoration of function. One patient developed an infection requiring fibula removal and staged prosthetic reconstruction. Additional complications requiring further treatment included limb-length discrepancy, additional allograft fracture, and wound infection. The FVFG is an effective treatment option for allograft nonunion after limb salvage surgery because it provides both the mechanical stability and biological stimulus for bony healing. Attention to internal fixation, limb alignment, and microvascular principles is essential to prevent complications and allow for the best functional outcomes.

TOTAL HIP ARTHROPLASTY FOLLOWING FAILURE OF FREE VASCULARIZED FIBULAR GRAFT

Background: Many treatments for osteonecrosis of the femoral head, including the use of a free vascularized fibular graft, have been advocated in an attempt to delay the need for hip arthroplasty. The purpose of this study was to document the clinical and radiographic results of total hip arthroplasty performed following failure of a free vascularized fibular grafting procedure. Methods: Twenty total hip arthroplasties in eighteen patients who had previously undergone a free vascularized fibular grafting procedure for the treatment of osteonecrosis were retrospectively reviewed. A straight-stem femoral component was used in twelve hips, a tapered femoral component with removal of residual fibular graft was used in five hips, and a tapered stem without graft removal was used in three hips. The twelve hips with a straight-stem femoral component and previous vascularized fibular grafting were compared with thirty-six osteonecrotic hips in thirty other patients who had undergone total hip arthroplasty but had not had previous free vascularized fibular grafting. The radiographic outcomes with respect to initial femoral component alignment and subsequent migration and the clinical outcomes were compared. Results: Analysis of the immediate postoperative radiographs demonstrated significantly improved alignment of the femoral component when a high-speed burr had been used to remove residual fibular graft (p = 0.001), although doing so did significantly increase both the intraoperative blood loss (p = 0.017) and the operative time (p = 0.0002). There was no significant difference in the amount of migration of either the acetabular or the femoral component between the control and study groups at the time of the most recent follow-up. When comparing patients with or without a previous free vascularized fibular graft, the mean postoperative scores at three years were significantly worse in patients who had undergone a previous free vascularized fibular graft (p = 0.03). One revision occurred in the study group at seventy-two months due to acetabular wear, and one revision occurred in the control group at 108 months due to aseptic loosening. Conclusions: This study raises concern that the outcome of total hip arthroplasty in patients who previously underwent a free vascularized fibular graft for the treatment of osteonecrosis of the femoral head may be worse than that in patients without previous free vascularized fibular grafting. The intraoperative use of a high-speed burr can improve the alignment of the femoral component by removing more of the residual graft. However, this technique does increase intraoperative blood loss and operative time. Level of Evidence: Therapeutic Level IV. See Instructions to Authors on jbjs.org for a complete description of levels of evidence.

INFLUENCE OF ACETABULAR COVERAGE ON HIP SURVIVAL AFTER FREE VASCULARIZED FIBULAR GRAFTING FOR FEMORAL HEAD OSTEONECROSIS

Background: Osteonecrosis of the femoral head frequently results in collapse of the head and subsequent arthrosis of the joint. Surgical treatment has been based entirely on the evaluation of the femoral side of the hip joint, with little consideration given to the possible influence on outcome of the orientation of the acetabulum. Methods: We retrospectively reviewed a consecutive series of 200 hips in 160 patients with osteonecrosis of the femoral head who had undergone free vascularized fibular grafting between 1997 and 1998. The mean duration of clinical follow-up was 7.5 years. Ninety-one hips in seventy-one patients were evaluated radiographically for evidence of progression of femoral head collapse at a minimum of two years, and a mean of three years, postoperatively. We defined conversion to a total hip arthroplasty and progression of femoral head collapse as the failure end points, and we analyzed the association of the acetabular center-edge angle of Wiberg, the area and laterality of the lesion, the amount of preoperative collapse of the femoral head, and the etiology of the osteonecrosis with the likelihood of failure. Results: Forty-eight (24%) of the 200 hips had undergone conversion to a total hip arthroplasty at the time of the final clinical follow-up. In addition, 15% (fourteen) of the ninety-one hips with sufficient radiographic follow-up demonstrated progression of femoral head collapse at the time of the final radiographic examination. Of the hips with a center-edge angle of ≤30°, 55% (of those with sufficient radiographic follow-up) demonstrated progressive collapse and 45% were converted to a total hip arthroplasty. In contrast, of the hips with a center-edge angle of >30°, 10% had progressive collapse (p = 0.002) and 6% were converted to a total hip arthroplasty (p < 0.001). Neither the etiology nor the size of the lesion was significantly correlated with progression of collapse or conversion to a total hip arthroplasty. Conclusions: Patients with osteonecrosis of the femoral head and a suboptimal center-edge angle of the hip are at substantial risk for progression of femoral head collapse and conversion to a total hip arthroplasty following free vascularized fibular grafting. An estimation of the degree of hip dysplasia should be included in the preoperative assessment of patients with osteonecrosis of the femoral head for prognostic and possibly surgical planning purposes. Level of Evidence: Therapeutic Level IV. See Instructions to Authors for a complete description of levels of evidence.

Influence of Acetabular Coverage on Hip Survival After Free Vascularized Fibular Grafting for Femoral Head Osteonecrosis

Osteonecrosis of the femoral head frequently results in collapse of the head and subsequent arthrosis of the joint. Surgical treatment has been based entirely on the evaluation of the femoral side of the hip joint, with little consideration given to the possible influence on outcome of the orientation of the acetabulum. We retrospectively reviewed a consecutive series of 200 hips in 160 patients with osteonecrosis of the femoral head who had undergone free vascularized fibular grafting between 1997 and 1998. The mean duration of clinical follow-up was 7.5 years. Ninety-one hips in seventy-one patients were evaluated radiographically for evidence of progression of femoral head collapse at a minimum of two years, and a mean of three years, postoperatively. We defined conversion to a total hip arthroplasty and progression of femoral head collapse as the failure end points, and we analyzed the association of the acetabular center-edge angle of Wiberg, the area and laterality of the lesion, the amount of preoperative collapse of the femoral head, and the etiology of the osteonecrosis with the likelihood of failure. Forty-eight (24%) of the 200 hips had undergone conversion to a total hip arthroplasty at the time of the final clinical follow-up. In addition, 15% (fourteen) of the ninety-one hips with sufficient radiographic follow-up demonstrated progression of femoral head collapse at the time of the final radiographic examination. Of the hips with a center-edge angle of </=30 degrees , 55% (of those with sufficient radiographic follow-up) demonstrated progressive collapse and 45% were converted to a total hip arthroplasty. In contrast, of the hips with a center-edge angle of >30 degrees , 10% had progressive collapse (p = 0.002) and 6% were converted to a total hip arthroplasty (p < 0.001). Neither the etiology nor the size of the lesion was significantly correlated with progression of collapse or conversion to a total hip arthroplasty. Patients with osteonecrosis of the femoral head and a suboptimal center-edge angle of the hip are at substantial risk for progression of femoral head collapse and conversion to a total hip arthroplasty following free vascularized fibular grafting. An estimation of the degree of hip dysplasia should be included in the preoperative assessment of patients with osteonecrosis of the femoral head for prognostic and possibly surgical planning purposes.