Long‐term cigarette smoking can cause oxygen free radical (ROS) formation and antioxidant capacity depletion, leading to oxidative stress involved in many disorders. Active ROS produces lipid peroxidation generating molecules such as oxidized LDL (oxLDL) and malondialdehyde (MDA) used as indexes of oxidative damage.An adequate diet and/or supplementation may attenuate this condition.To evaluate potential beneficial effects of supplementation with two different encapsulated formulas, consisting primarily of mixed juice powder concentrate, a placebo‐controlled double‐blind study was performed on 61 heavy smokers (>20 cigarettes/d, duration ≥10y, age 40–60y, 35 male). Subjects were randomized into 3 groups: A‐placebo; B‐fruit/vegetable; and, C‐fruit/vegetable/berry. We measured serum oxLDL and plasma free MDA (f‐MDA), the chemically active form, index of recent damage.Values (mean±SD) were compared at baseline (T0) and after 3 months supplementation (T1).Nutritional supplementation produced a decrease in oxidative damage indexes, more evident in group C than B, and seems to attenuate smoking effects.Support: NSA, Collierville, TN