The particular weed management practice is still know that describes the exact solution for weed control and maximizes the yield and profitability of maize production and weed severs to more than 40% loss in production. So, the field experiment was conducted in Farmer’s field to compare the effects of different weed management practices on weed growth and dynamics, yield, and economic performance in Summer Maize under humid sub-tropical condition at Aswara-5, Tulsipur, and Dang in 2017. The experiment was conducted in Randomized Complete Block Design with seven treatments and three replications. The treatments consisted of (i) Framer practices, (ii) control, (iii) weed free broadcasting (iv) Weed free line sowing (v) power weeded (vi) Manually weeded (vii) herbicides (Temboterine and Atrazine). The different weed managements practice showed significant effect in Yield, test weight, Harvest index, stover yield, shelling percent and sterility percent and cob length. The higher grain yield was obtained in herbicide treated plot (7.620 t/ha) and least in control plot (3.54 t/ha) and farmer practice plot (4.32 t/ha) where other treatment were statistically at par with each other. The highest shelling and cob length was 78.33 and 21.76 cm found highest that leads to highest yield and lower yield in control and farmer plot. The cost of cultivation was higher in weed free line sowing (NRs 89102) and broadcasting (NRs 89106) condition but the production per unit cost was highest in herbicides (109.27 g/Rs) plot and followed by manual (69.73 g/Rs) and power weeded plot(78.11 g/Rs). Similarly, the highest Net revenue, Gross revenue and Benefit cost ratio was obtained in Herbicide treated plot among all the treatment, which is followed by power weeded plot. So, we can conclude that, herbicide treated plot is economically and profitability important in terms of production where there is human labour crisis.