Abstract Most existing salient object detection methods are sensitive to background noise and rely on prior information in UAV obstacle avoidance applications despite detection methods witnessing rapid progress. In this paper, we propose an efficient framework for salient object detection based on radar-camera fusion and iterative Bayesian optimization. A rough salient object (RSO) image is first built through radar and camera calibration. Next, the RSO image is used to calculate the edge response based on the receptive field mechanism of the primary visual cortex to construct the contour image. Finally, the above two images and the 2D Gaussian distribution are jointly integrated into an iterative Bayesian optimization scheme to get the final salient object image. Different from typical detection methods, this method suppresses background noise by filtering out irrelevant pixels using fusion information. The Bayesian inference framework's detection performance is improved by precise spatial prior, consisting of optimized contour and RSO images. Experimental results indicate that the presented algorithm performs well against state-of-the-art salient object detection methods on several reference datasets in different evaluation metrics.