This study presents a systematical site selection framework for a wide-range survey. Spatial data mining was used to delimit three classes of pollution potential areas. Results show that pollution samples highly correlate with the classified potentially contaminated areas. For example, most of the soil pollution and water pollution appear under the high potentially contaminated area (HPCA). In contrast, under the low potentially contaminated area (LPCA), no pollution was discovered. These findings shows that the proposed approach is fairly reliable and can be applied to wide-range of areas within a river watershed to determine site selections for performing field sampling.