Prefabricated underground stations (PUSs) have been gradually applied as a new approach to urban low-carbon development; however, safe service for the city over the entire PUS life cycle remains a crucial issue. This study therefore investigates the resilience of PUSs with a large-span roof structure in multi-hazard urban environments. A joint vulnerability function is established to represent the PUS physical resilience, and a restorability function is established to represent the local community resilience. The physical resilience and community resilience are integrated to construct a PUS resilience assessment framework (PUS-RAF). The results indicates that: (1) the vulnerability function, experiment and FEA jointly present the PUS assembled joints' contact failure mode; (2) multi-hazard resilience assessment reveals the inherent sensitivity of PUS schemes (3) PUS-RAF predicts a joint scheme highly inclusive of multi-hazard factor; (4) the final PUS scheme accommodates the engineering and community. The PUS-RAF thus provides a practical assessment tool and application value for PUS resilience in multi-hazard environment.